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The map label for this gene is trpC [H]

Identifier: 170749504

GI number: 170749504

Start: 3276956

End: 3277843

Strand: Reverse

Name: trpC [H]

Synonym: Mrad2831_3099

Alternate gene names: 170749504

Gene position: 3277843-3276956 (Counterclockwise)

Preceding gene: 170749505

Following gene: 170749503

Centisome position: 53.93

GC content: 72.3

Gene sequence:

>888_bases
ATGAGCTCGCTGACGCACGAGGCGACCCCGGAGACCGGCGCCGGGACCCCGACCGAGCGGCCGAACGTCCTCGCCCGCAT
CGAGGCCTACAAGCGCCGCGAGATCGCCGAGGCGAAGCTGCGCGTGCCGCTCGCCAAGCTGGAGCGGAAGGTCGCTCAGG
CGGAGCCGGTGCGCGGATTCGCGGCGGCGATCCGGACCCATCTGGCCGCGGATCGCCCGGCGCTCATCGCCGAGGTGAAG
AAGGCCTCGCCGTCGAAGGGCCTGATCCGCGCCGATTTCGATCCGGCGACCCTCGCCGCCGCCTACGAGGCCGGCGGCGC
CACCTGCCTGTCGGTGCTGACCGACGAGCCCTCGTTCCAGGGTCGTCCCGAGTACCTGACGGCGGCGCGCGCGGCCTGCG
GGCTGCCGGTGCTGCGCAAGGACTTCCTGTTCGAGCCCTATCAGGTCTACGAGGCCCGGGCCTGGGGCGCCGACTGCATC
CTCGTCATCATGGCCTGCCTCGACGACGACGAGGCCGAGGCCCTGGTCGAGACGGCGCACCTCCTCGGGATGGATGTCCT
GGTCGAGGTGCACGACGAGGCCGAACTCGCGCGGGCAATCACCCTCGGCACGGCGCTGATCGGTATCAACAATCGGAACC
TCAAGACCTTCGAGGTCTCGTTCGAGACCGCGATCCGGCTGGCGCCGGGGATCCCGGCGGACCGGATCGCCGTGGCCGAG
AGCGGGATCGGCGGCCACGCCGACGTGGCGCGGCTGCGGGACAACGGCCTCGGCGTGGTCTTGGTCGGCGAGAGCCTGAT
GCGGCAGCCGGACGTCGCGGCAGCGGCCCGCGCCCTGCTGTTCGGCGACGCGGGGGCCACGGGCGGCAAGCCGCGGAAGA
AGGCGTAA

Upstream 100 bases:

>100_bases
TCGCGCAGGCGCAGGATGCCGTCGATTCCGGGGCCGCCCGGGCGACGCTCGCCCGCCTCGTCCGGGCCTCGAACGACCAC
TCCAACGGGCAGGAGGGCCG

Downstream 100 bases:

>100_bases
GGCATGCGGCCGGGCTCGACGCTGACCCATCTCGACACCAGCGGCGCGGCCAACATGGTCGACGTCACCGACAAGCCCGC
CACCGACCGGACCGCCCGGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSSLTHEATPETGAGTPTERPNVLARIEAYKRREIAEAKLRVPLAKLERKVAQAEPVRGFAAAIRTHLAADRPALIAEVK
KASPSKGLIRADFDPATLAAAYEAGGATCLSVLTDEPSFQGRPEYLTAARAACGLPVLRKDFLFEPYQVYEARAWGADCI
LVIMACLDDDEAEALVETAHLLGMDVLVEVHDEAELARAITLGTALIGINNRNLKTFEVSFETAIRLAPGIPADRIAVAE
SGIGGHADVARLRDNGLGVVLVGESLMRQPDVAAAARALLFGDAGATGGKPRKKA

Sequences:

>Translated_295_residues
MSSLTHEATPETGAGTPTERPNVLARIEAYKRREIAEAKLRVPLAKLERKVAQAEPVRGFAAAIRTHLAADRPALIAEVK
KASPSKGLIRADFDPATLAAAYEAGGATCLSVLTDEPSFQGRPEYLTAARAACGLPVLRKDFLFEPYQVYEARAWGADCI
LVIMACLDDDEAEALVETAHLLGMDVLVEVHDEAELARAITLGTALIGINNRNLKTFEVSFETAIRLAPGIPADRIAVAE
SGIGGHADVARLRDNGLGVVLVGESLMRQPDVAAAARALLFGDAGATGGKPRKKA
>Mature_294_residues
SSLTHEATPETGAGTPTERPNVLARIEAYKRREIAEAKLRVPLAKLERKVAQAEPVRGFAAAIRTHLAADRPALIAEVKK
ASPSKGLIRADFDPATLAAAYEAGGATCLSVLTDEPSFQGRPEYLTAARAACGLPVLRKDFLFEPYQVYEARAWGADCIL
VIMACLDDDEAEALVETAHLLGMDVLVEVHDEAELARAITLGTALIGINNRNLKTFEVSFETAIRLAPGIPADRIAVAES
GIGGHADVARLRDNGLGVVLVGESLMRQPDVAAAARALLFGDAGATGGKPRKKA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=276, Percent_Identity=41.304347826087, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322638, Length=284, Percent_Identity=33.4507042253521, Blast_Score=138, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 31268; Mature: 31137

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTHEATPETGAGTPTERPNVLARIEAYKRREIAEAKLRVPLAKLERKVAQAEPVRGF
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
AAAIRTHLAADRPALIAEVKKASPSKGLIRADFDPATLAAAYEAGGATCLSVLTDEPSFQ
HHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCC
GRPEYLTAARAACGLPVLRKDFLFEPYQVYEARAWGADCILVIMACLDDDEAEALVETAH
CCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHH
LLGMDVLVEVHDEAELARAITLGTALIGINNRNLKTFEVSFETAIRLAPGIPADRIAVAE
HHHHHHEEEECCHHHHHHHHHHHHEEEEECCCCEEEEEEEHHHHEEECCCCCHHHEEEEC
SGIGGHADVARLRDNGLGVVLVGESLMRQPDVAAAARALLFGDAGATGGKPRKKA
CCCCCCHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure 
SSLTHEATPETGAGTPTERPNVLARIEAYKRREIAEAKLRVPLAKLERKVAQAEPVRGF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
AAAIRTHLAADRPALIAEVKKASPSKGLIRADFDPATLAAAYEAGGATCLSVLTDEPSFQ
HHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCC
GRPEYLTAARAACGLPVLRKDFLFEPYQVYEARAWGADCILVIMACLDDDEAEALVETAH
CCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHH
LLGMDVLVEVHDEAELARAITLGTALIGINNRNLKTFEVSFETAIRLAPGIPADRIAVAE
HHHHHHEEEECCHHHHHHHHHHHHEEEEECCCCEEEEEEEHHHHEEECCCCCHHHEEEEC
SGIGGHADVARLRDNGLGVVLVGESLMRQPDVAAAARALLFGDAGATGGKPRKKA
CCCCCCHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA