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The map label for this gene is moeA [H]

Identifier: 170749502

GI number: 170749502

Start: 3275235

End: 3276464

Strand: Reverse

Name: moeA [H]

Synonym: Mrad2831_3097

Alternate gene names: 170749502

Gene position: 3276464-3275235 (Counterclockwise)

Preceding gene: 170749503

Following gene: 170749500

Centisome position: 53.91

GC content: 76.91

Gene sequence:

>1230_bases
ATGAGCGGCCTGATCCCGGTCGCGGAGGCGCTGGCCCGGGTGCTCGCGAGCGTCGCCGCGCCGGTCGAGGCCGAGACCGT
CCCGCTGGCTCGGGCCGGCGGCCGGACGCTCGCGGCCGACGTCGTCGCCTCGCGGACCCAGCCGCCATTTCCGGCCTCGG
CCATGGACGGCTACGCCGTGCGTAGCGCCGACGCCGCAATGGTCGGGGCGACCCTGCGGCTCATCGGCACCAGCGCGGCC
GGCCACGGCTTCCCGGGACGCATCGGCGCGGGTGAGGCGGTCCGGATCTTCACCGGCGCGCCGGTTCCGGAGGGCGCGGA
CGCGATCCTCATCCAGGAGGACGCCGCCGCCGAGGCGGGCGCGGTGCGGGTCCTGGAGCCCGTGGAGCCGGCACGGTTCA
TTCGCCGGGCCGGCCTCGACTTCACCGCGGGCCAGACCCTGATCCCGGCCGGCACGAGCCTCGACGCGCGGCGCCTCGCG
CTCGCCGCGGCGGCCGGTCATCCGCGGCTCCCGGTCCGTCGCCGGCCGCGCGTCGCGATCCTCGCCACCGGCGACGAGCT
GGTGGAGCCGGGCGCGACGCCGGGCTGGGACCAGATCGTCGCCTCGAACAGCCTCGCGCTCGGCGCACTCGCCGCGGAGG
CGGGCGCCGACATCGTCGATCTCGGCATCGCCGGGGACGACCACGACGCCCTGGCGGACGCGTTCCGTCGCGCCCGCGCG
GCGCGGGCCGACCTGCTGGTCACCCTCGGAGGAGCCTCCGTGGGCGACCACGATCTGGTACAGGCCGCGCTCGCCAAGGA
GGGGTTGGAGCTCGGCTTCTGGCGGGTCGCCCTCCGGCCGGGCAAGCCGCTGATGCACGGCCGTCTCGGCGACATGCTGG
TGATCGGGCTGCCGGGCAATCCGGTCTCGTCCATCGTGTGCGGGCTGCTGTTCGTGGTGCCGGCGATCCGCGCGCTCCAG
GGCGATCCGCGGGCGGGCGCCGACCGGAGCGAGCCGGCCACGCTCGGCCGCGACATGCCGGAGAATGACGGGCGGGCCGA
CTACATGCGGGCGAGCCTCGCCCTCGAGCCCGGCCGGCTGCCGGTCGCGACCGCCGAGCAGCGCCAGGATTCGTCGATGC
TCGCCGTCCTCGGCCGGTCCGAGGCCCTGCTGCTCCGCGCCCCGCACGCGCCGGCCGCGCGCGCCGGCGATCCCTGCCGG
ATCATCCGCCTCGATCGCCGCCTGCTCTGA

Upstream 100 bases:

>100_bases
ACGACATGGTGAAGGCGGTCGATCGCGGCATGCGGATCGAGGGGATCCGGCTGACCGCAAAGGATGGCGGCCGCTCGGGC
GCCTACCGGGCACCGGCGGA

Downstream 100 bases:

>100_bases
TCGTCAGGGCACCACGCGCCAGGCCTTGAGCGGGCCGGGCACGTCCAGCGGCAAGAGGCGCGCGCTCCGGGCCGCGCCCT
CGGCGAGTCGCGTGGCGTAA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSGLIPVAEALARVLASVAAPVEAETVPLARAGGRTLAADVVASRTQPPFPASAMDGYAVRSADAAMVGATLRLIGTSAA
GHGFPGRIGAGEAVRIFTGAPVPEGADAILIQEDAAAEAGAVRVLEPVEPARFIRRAGLDFTAGQTLIPAGTSLDARRLA
LAAAAGHPRLPVRRRPRVAILATGDELVEPGATPGWDQIVASNSLALGALAAEAGADIVDLGIAGDDHDALADAFRRARA
ARADLLVTLGGASVGDHDLVQAALAKEGLELGFWRVALRPGKPLMHGRLGDMLVIGLPGNPVSSIVCGLLFVVPAIRALQ
GDPRAGADRSEPATLGRDMPENDGRADYMRASLALEPGRLPVATAEQRQDSSMLAVLGRSEALLLRAPHAPAARAGDPCR
IIRLDRRLL

Sequences:

>Translated_409_residues
MSGLIPVAEALARVLASVAAPVEAETVPLARAGGRTLAADVVASRTQPPFPASAMDGYAVRSADAAMVGATLRLIGTSAA
GHGFPGRIGAGEAVRIFTGAPVPEGADAILIQEDAAAEAGAVRVLEPVEPARFIRRAGLDFTAGQTLIPAGTSLDARRLA
LAAAAGHPRLPVRRRPRVAILATGDELVEPGATPGWDQIVASNSLALGALAAEAGADIVDLGIAGDDHDALADAFRRARA
ARADLLVTLGGASVGDHDLVQAALAKEGLELGFWRVALRPGKPLMHGRLGDMLVIGLPGNPVSSIVCGLLFVVPAIRALQ
GDPRAGADRSEPATLGRDMPENDGRADYMRASLALEPGRLPVATAEQRQDSSMLAVLGRSEALLLRAPHAPAARAGDPCR
IIRLDRRLL
>Mature_408_residues
SGLIPVAEALARVLASVAAPVEAETVPLARAGGRTLAADVVASRTQPPFPASAMDGYAVRSADAAMVGATLRLIGTSAAG
HGFPGRIGAGEAVRIFTGAPVPEGADAILIQEDAAAEAGAVRVLEPVEPARFIRRAGLDFTAGQTLIPAGTSLDARRLAL
AAAAGHPRLPVRRRPRVAILATGDELVEPGATPGWDQIVASNSLALGALAAEAGADIVDLGIAGDDHDALADAFRRARAA
RADLLVTLGGASVGDHDLVQAALAKEGLELGFWRVALRPGKPLMHGRLGDMLVIGLPGNPVSSIVCGLLFVVPAIRALQG
DPRAGADRSEPATLGRDMPENDGRADYMRASLALEPGRLPVATAEQRQDSSMLAVLGRSEALLLRAPHAPAARAGDPCRI
IRLDRRLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=373, Percent_Identity=36.7292225201072, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI66932975, Length=373, Percent_Identity=36.7292225201072, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1787049, Length=365, Percent_Identity=39.1780821917808, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI25147659, Length=368, Percent_Identity=30.7065217391304, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=321, Percent_Identity=26.1682242990654, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=424, Percent_Identity=28.7735849056604, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24638841, Length=424, Percent_Identity=28.7735849056604, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42024; Mature: 41893

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLIPVAEALARVLASVAAPVEAETVPLARAGGRTLAADVVASRTQPPFPASAMDGYAV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
RSADAAMVGATLRLIGTSAAGHGFPGRIGAGEAVRIFTGAPVPEGADAILIQEDAAAEAG
ECCCHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCC
AVRVLEPVEPARFIRRAGLDFTAGQTLIPAGTSLDARRLALAAAAGHPRLPVRRRPRVAI
CEEEECCCCHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEE
LATGDELVEPGATPGWDQIVASNSLALGALAAEAGADIVDLGIAGDDHDALADAFRRARA
EECCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ARADLLVTLGGASVGDHDLVQAALAKEGLELGFWRVALRPGKPLMHGRLGDMLVIGLPGN
HCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCC
PVSSIVCGLLFVVPAIRALQGDPRAGADRSEPATLGRDMPENDGRADYMRASLALEPGRL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHEEECCCCC
PVATAEQRQDSSMLAVLGRSEALLLRAPHAPAARAGDPCRIIRLDRRLL
CCCCCHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SGLIPVAEALARVLASVAAPVEAETVPLARAGGRTLAADVVASRTQPPFPASAMDGYAV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
RSADAAMVGATLRLIGTSAAGHGFPGRIGAGEAVRIFTGAPVPEGADAILIQEDAAAEAG
ECCCHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCC
AVRVLEPVEPARFIRRAGLDFTAGQTLIPAGTSLDARRLALAAAAGHPRLPVRRRPRVAI
CEEEECCCCHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEE
LATGDELVEPGATPGWDQIVASNSLALGALAAEAGADIVDLGIAGDDHDALADAFRRARA
EECCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ARADLLVTLGGASVGDHDLVQAALAKEGLELGFWRVALRPGKPLMHGRLGDMLVIGLPGN
HCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCC
PVSSIVCGLLFVVPAIRALQGDPRAGADRSEPATLGRDMPENDGRADYMRASLALEPGRL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHEEECCCCC
PVATAEQRQDSSMLAVLGRSEALLLRAPHAPAARAGDPCRIIRLDRRLL
CCCCCHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]