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The map label for this gene is fabF [H]

Identifier: 170749475

GI number: 170749475

Start: 3242179

End: 3243462

Strand: Reverse

Name: fabF [H]

Synonym: Mrad2831_3070

Alternate gene names: 170749475

Gene position: 3243462-3242179 (Counterclockwise)

Preceding gene: 170749476

Following gene: 170749474

Centisome position: 53.37

GC content: 73.75

Gene sequence:

>1284_bases
ATGAGCGCGCGATCCTACCGCGACGCCAGGGGCCGGCCGCTCGTCGCGGTCACCGGCCTCGGCGTCGTCTCCTCCCTCGG
TCAGGGACAGGCCGACACCTGGGCGGCCATGACCGAGGGCCGGTCGGGTATCCACACCATCGCGCGGTTCCCGACCGACA
ACCTGCGCACGCGCATCGCCGGGACGGTGGACTTCCTCGACACCGACCCTCTCGTCGCGCCGCTCCTGTCCGAGCGGTTC
GCCGCCGTCGCCGCCGAGGAGGCGGTGGCGCAGGCCGGGATCGGCGCCAGGGGCGATTTCCCGGGCGCCCTGTTCATCGC
GGTCCCGCCGGTCGAGATGGAGTGGCCCCAGCGCCAGGCCCTGGCCGAGGCCGCGGGCGGCGACGGTCCGGTCGACTACG
CCGGTCTCCTGCGGGCGGCGGCGACGCGCCGCTTCGATCCCTGGCACGACCTGTTCATCTTCGGCACGGTCGCCGACCGC
ATCGCCGACCGCTTCGGCACGAAGGGCTCCCCGATCTCGCTCTCGACCGCCTGCTCGTCGGGGGCCACGGCGATCCAGCT
CGGCGTCGAGGCGATCCGGCGCGGCGAGACCGCGGCGGCGCTCTGCATCGGCACGGACGGCTCGGTGAACCCGGAATCGC
TGATCCGCTTCTCGCTGCTCTCCGCGCTCTCGACCCGCAACGACGACCCCGCGACCGCCTCGAAGCCGTTCTCGAAGGAC
CGGGACGGGTTCGTCATGGGCGAGGGCGCGGCCGCCCTCGTGCTCGAGGACGCCGAGGCCGCCGTCGCCCGGGGCGCCGC
GATCCTCGGCTACGTCCTCGGCTGCGGCGAGAAGGGCGACGGCTTCCACCGCACCCGCTCCAGCCCCGACGGCGCCCCGA
TCATCGCGGCGATCCGGGCGAGCCTGGACGATGCCGGCGTGGCGGCCGAGGCGATAGACACGGTGAACGCGCACGGCACG
TCGACGCCGGAGAACGACAAGATGGAGGCCCTGGGCCTCGCGGCGGTGTTCGGCGACCGCGCTGCCGCCCTGCCGGTCAC
CTCCAACAAGTCGATGATCGGCCACACGCTGACGGCGGCCGGCGCCATCGAGGCGGCGGTCTCGCTGCTGACGATCCGCC
ACGGCCGCATCCCGCCGACCATCAACCACCGGGTGCCGGACCCGACCATCGCCCTCGACATCGTGGAGACTGCCCGCGAC
CTGCCGGTGCGGACCGTGCTGTCGAACTCGTTCGGCTTCGGCGGCCAGAACACCTGCCTGGTCCTCGGCGCGGAGCCCGC
GTGA

Upstream 100 bases:

>100_bases
GCCGGGCGCCTGAGCCGCCCTGCTGTCACGGCGGTGCCCCGCGCGCGGCACCACCCGCGCGGAGGTGTACCGCGGCGGAA
AATCCCGTAAGGACCGCTCC

Downstream 100 bases:

>100_bases
GCGTCGCCGTCACACCGCGCCGGGTCCTCGTGACCGGCGGCGCGTCCGGGATCGGCGCCGCGATCGTCCGCGCCCTGGCG
GGAGCCGGTCTCGGCGTCGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSARSYRDARGRPLVAVTGLGVVSSLGQGQADTWAAMTEGRSGIHTIARFPTDNLRTRIAGTVDFLDTDPLVAPLLSERF
AAVAAEEAVAQAGIGARGDFPGALFIAVPPVEMEWPQRQALAEAAGGDGPVDYAGLLRAAATRRFDPWHDLFIFGTVADR
IADRFGTKGSPISLSTACSSGATAIQLGVEAIRRGETAAALCIGTDGSVNPESLIRFSLLSALSTRNDDPATASKPFSKD
RDGFVMGEGAAALVLEDAEAAVARGAAILGYVLGCGEKGDGFHRTRSSPDGAPIIAAIRASLDDAGVAAEAIDTVNAHGT
STPENDKMEALGLAAVFGDRAAALPVTSNKSMIGHTLTAAGAIEAAVSLLTIRHGRIPPTINHRVPDPTIALDIVETARD
LPVRTVLSNSFGFGGQNTCLVLGAEPA

Sequences:

>Translated_427_residues
MSARSYRDARGRPLVAVTGLGVVSSLGQGQADTWAAMTEGRSGIHTIARFPTDNLRTRIAGTVDFLDTDPLVAPLLSERF
AAVAAEEAVAQAGIGARGDFPGALFIAVPPVEMEWPQRQALAEAAGGDGPVDYAGLLRAAATRRFDPWHDLFIFGTVADR
IADRFGTKGSPISLSTACSSGATAIQLGVEAIRRGETAAALCIGTDGSVNPESLIRFSLLSALSTRNDDPATASKPFSKD
RDGFVMGEGAAALVLEDAEAAVARGAAILGYVLGCGEKGDGFHRTRSSPDGAPIIAAIRASLDDAGVAAEAIDTVNAHGT
STPENDKMEALGLAAVFGDRAAALPVTSNKSMIGHTLTAAGAIEAAVSLLTIRHGRIPPTINHRVPDPTIALDIVETARD
LPVRTVLSNSFGFGGQNTCLVLGAEPA
>Mature_426_residues
SARSYRDARGRPLVAVTGLGVVSSLGQGQADTWAAMTEGRSGIHTIARFPTDNLRTRIAGTVDFLDTDPLVAPLLSERFA
AVAAEEAVAQAGIGARGDFPGALFIAVPPVEMEWPQRQALAEAAGGDGPVDYAGLLRAAATRRFDPWHDLFIFGTVADRI
ADRFGTKGSPISLSTACSSGATAIQLGVEAIRRGETAAALCIGTDGSVNPESLIRFSLLSALSTRNDDPATASKPFSKDR
DGFVMGEGAAALVLEDAEAAVARGAAILGYVLGCGEKGDGFHRTRSSPDGAPIIAAIRASLDDAGVAAEAIDTVNAHGTS
TPENDKMEALGLAAVFGDRAAALPVTSNKSMIGHTLTAAGAIEAAVSLLTIRHGRIPPTINHRVPDPTIALDIVETARDL
PVRTVLSNSFGFGGQNTCLVLGAEPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=426, Percent_Identity=34.9765258215962, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI41872631, Length=276, Percent_Identity=32.9710144927536, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=40.5405405405405, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=35, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=34.8448687350835, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=29.2161520190024, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=34.4827586206897, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI212642053, Length=276, Percent_Identity=30.0724637681159, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=27.9850746268657, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=28.7640449438202, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24644341, Length=442, Percent_Identity=34.3891402714932, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=30.4659498207885, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=30.4659498207885, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24581345, Length=276, Percent_Identity=28.6231884057971, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44001; Mature: 43870

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARSYRDARGRPLVAVTGLGVVSSLGQGQADTWAAMTEGRSGIHTIARFPTDNLRTRIA
CCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHCCCCCHHHHHHCCCCHHHHHHE
GTVDFLDTDPLVAPLLSERFAAVAAEEAVAQAGIGARGDFPGALFIAVPPVEMEWPQRQA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LAEAAGGDGPVDYAGLLRAAATRRFDPWHDLFIFGTVADRIADRFGTKGSPISLSTACSS
HHHHCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHHHHHCCCCCCEEEEHHCCC
GATAIQLGVEAIRRGETAAALCIGTDGSVNPESLIRFSLLSALSTRNDDPATASKPFSKD
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RDGFVMGEGAAALVLEDAEAAVARGAAILGYVLGCGEKGDGFHRTRSSPDGAPIIAAIRA
CCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
SLDDAGVAAEAIDTVNAHGTSTPENDKMEALGLAAVFGDRAAALPVTSNKSMIGHTLTAA
CCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
GAIEAAVSLLTIRHGRIPPTINHRVPDPTIALDIVETARDLPVRTVLSNSFGFGGQNTCL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHCCCHHHHHHCCCCCCCCCEEE
VLGAEPA
EEECCCC
>Mature Secondary Structure 
SARSYRDARGRPLVAVTGLGVVSSLGQGQADTWAAMTEGRSGIHTIARFPTDNLRTRIA
CCCCCCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHCCCCCHHHHHHCCCCHHHHHHE
GTVDFLDTDPLVAPLLSERFAAVAAEEAVAQAGIGARGDFPGALFIAVPPVEMEWPQRQA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LAEAAGGDGPVDYAGLLRAAATRRFDPWHDLFIFGTVADRIADRFGTKGSPISLSTACSS
HHHHCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEHHHHHHHHHHHCCCCCCEEEEHHCCC
GATAIQLGVEAIRRGETAAALCIGTDGSVNPESLIRFSLLSALSTRNDDPATASKPFSKD
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RDGFVMGEGAAALVLEDAEAAVARGAAILGYVLGCGEKGDGFHRTRSSPDGAPIIAAIRA
CCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
SLDDAGVAAEAIDTVNAHGTSTPENDKMEALGLAAVFGDRAAALPVTSNKSMIGHTLTAA
CCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
GAIEAAVSLLTIRHGRIPPTINHRVPDPTIALDIVETARDLPVRTVLSNSFGFGGQNTCL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHCCCHHHHHHCCCCCCCCCEEE
VLGAEPA
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]