Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 170749326

GI number: 170749326

Start: 3077749

End: 3079065

Strand: Reverse

Name: hom [H]

Synonym: Mrad2831_2919

Alternate gene names: 170749326

Gene position: 3079065-3077749 (Counterclockwise)

Preceding gene: 170749327

Following gene: 170749325

Centisome position: 50.66

GC content: 73.73

Gene sequence:

>1317_bases
ATGACAGTGAGCTTTCGCCTCGGGATCGCCGGACTCGGGACCGTCGGTGCGTCCGTGGTCCGGATGGTCGAGCGCCGCCG
CGCCGCCTTCGCTGCGGCGGGCCTCGACATCCGCGTCACCGCGGTCTCCTCGCGCGACCGCGGCCGGGACCGCGGCCTCG
ACCTGTCCGGCATCGCGTGGTTCGACGACCCGGTGGCGCTCGCCCGGTCGGAAGCCGTCGACTGCGTGGTCGAGCTGATC
GGCGGCGCCGAGGGGCCCGCCAAGGCGGTGGTCGAGGCGGCGCTCGAGGCGGGCAAGCCGGTGGTGACCGCCAACAAGGC
GCTGCTGGCCCGCCACGGCGCCGCCCTGGCCGCGCAGGCCGAGGCGAAGGGCGTGGCCCTCGCCTTCGAGGCGGCGGTGG
CCGGCGGCATCCCGGTGATCAAGACCCTGCGCGAGGGCCTGCCGGGCAACGCGGTCTCCCGCGTCTACGGGATCCTCAAC
GGCACCTGCAATTACATCCTCAGCCGCATGGAGCGCGAGGGGCTGACCTTCGAGGCCTGCCTGAAGGACGCGCAGGCCCT
GGGCTACGCCGAGGCGGACCCGACCTTCGACGTCGAGGGGTTCGACACCGCGCACAAGCTCGCGATCCTGACGAGCCTCG
CCTTCGGGACCGCGGTCGACGCGGACGGCGTGTCAGTGGAGGGCATCTCCCGGGTGCAACCCCTCGACCTCCGCATGGCG
GACGAGCTCGGCTACCGGATCAAGCTGCTCGGCGTCGCGCAGGCGACCGAGGCCGGCATCGAGCAGCGGGTCCACCCGAC
CATGGTGCCGAAATCCTCGGCGATCGCGCAGGTCATGGGCGTCACGAACGCCGTGACGATCGACGCGGACGCGGTGGGCG
AGCTCACCCTGATCGGTCCCGGCGCCGGCGGCGAGGCCACGGCCTCCGCGGTGGTGGCCGACATCGCCGACGTGGCGCGC
GGCGTGATCCGCCCGACCTTCGGCGTTCCGGCCGCGGCGATGCGCGCCAGCGAGCGCGTGGAGATGCAGCGTCACGAGGG
CGGCTACTACATCCGCCTCACCGTCCACGACCGCCCCGGCGTCGCGGCCGGCGTCGCGCAGCGGATGGCCGAGCGATCCA
TCTCCCTGGAGAGCATCCTGCAGCGCCGCGTCGAGGGGCCGGAGGCCGATCCGCGCGGCCGCTCCGGCCGGCCCGTGCCG
CTGGTGCTGATCACCTACGCGGCGACCGAGGGCAACATCCGCGACGCGCTCGACGCCATCGGCGCCGACGGGCTGCTGGC
GGAGCCGCCGCAGCTGATCCGGATCGAGCGTGAATAA

Upstream 100 bases:

>100_bases
CGGTCCCGGGCCAATTCCTTGCGGGCGGGGCGGAATTCTTGCAGAAGTGCGCCGCATCGGGCGCCCGGCCCAACACGGTC
GCCCGGGCACGGAAGGGGTC

Downstream 100 bases:

>100_bases
CAGTGCATACGGTAGCGTGACCCGCCACCGCTTGATGCAGGATAGTGGGCCTTAGCGAACCGGCGTATACGCTGCGCGGC
CGTCATCCGACGGTATCCAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTVSFRLGIAGLGTVGASVVRMVERRRAAFAAAGLDIRVTAVSSRDRGRDRGLDLSGIAWFDDPVALARSEAVDCVVELI
GGAEGPAKAVVEAALEAGKPVVTANKALLARHGAALAAQAEAKGVALAFEAAVAGGIPVIKTLREGLPGNAVSRVYGILN
GTCNYILSRMEREGLTFEACLKDAQALGYAEADPTFDVEGFDTAHKLAILTSLAFGTAVDADGVSVEGISRVQPLDLRMA
DELGYRIKLLGVAQATEAGIEQRVHPTMVPKSSAIAQVMGVTNAVTIDADAVGELTLIGPGAGGEATASAVVADIADVAR
GVIRPTFGVPAAAMRASERVEMQRHEGGYYIRLTVHDRPGVAAGVAQRMAERSISLESILQRRVEGPEADPRGRSGRPVP
LVLITYAATEGNIRDALDAIGADGLLAEPPQLIRIERE

Sequences:

>Translated_438_residues
MTVSFRLGIAGLGTVGASVVRMVERRRAAFAAAGLDIRVTAVSSRDRGRDRGLDLSGIAWFDDPVALARSEAVDCVVELI
GGAEGPAKAVVEAALEAGKPVVTANKALLARHGAALAAQAEAKGVALAFEAAVAGGIPVIKTLREGLPGNAVSRVYGILN
GTCNYILSRMEREGLTFEACLKDAQALGYAEADPTFDVEGFDTAHKLAILTSLAFGTAVDADGVSVEGISRVQPLDLRMA
DELGYRIKLLGVAQATEAGIEQRVHPTMVPKSSAIAQVMGVTNAVTIDADAVGELTLIGPGAGGEATASAVVADIADVAR
GVIRPTFGVPAAAMRASERVEMQRHEGGYYIRLTVHDRPGVAAGVAQRMAERSISLESILQRRVEGPEADPRGRSGRPVP
LVLITYAATEGNIRDALDAIGADGLLAEPPQLIRIERE
>Mature_437_residues
TVSFRLGIAGLGTVGASVVRMVERRRAAFAAAGLDIRVTAVSSRDRGRDRGLDLSGIAWFDDPVALARSEAVDCVVELIG
GAEGPAKAVVEAALEAGKPVVTANKALLARHGAALAAQAEAKGVALAFEAAVAGGIPVIKTLREGLPGNAVSRVYGILNG
TCNYILSRMEREGLTFEACLKDAQALGYAEADPTFDVEGFDTAHKLAILTSLAFGTAVDADGVSVEGISRVQPLDLRMAD
ELGYRIKLLGVAQATEAGIEQRVHPTMVPKSSAIAQVMGVTNAVTIDADAVGELTLIGPGAGGEATASAVVADIADVARG
VIRPTFGVPAAAMRASERVEMQRHEGGYYIRLTVHDRPGVAAGVAQRMAERSISLESILQRRVEGPEADPRGRSGRPVPL
VLITYAATEGNIRDALDAIGADGLLAEPPQLIRIERE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=122, Percent_Identity=33.6065573770492, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45566; Mature: 45434

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSFRLGIAGLGTVGASVVRMVERRRAAFAAAGLDIRVTAVSSRDRGRDRGLDLSGIAW
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEE
FDDPVALARSEAVDCVVELIGGAEGPAKAVVEAALEAGKPVVTANKALLARHGAALAAQA
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHCCCHHEEHH
EAKGVALAFEAAVAGGIPVIKTLREGLPGNAVSRVYGILNGTCNYILSRMEREGLTFEAC
CCCCEEEEEHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LKDAQALGYAEADPTFDVEGFDTAHKLAILTSLAFGTAVDADGVSVEGISRVQPLDLRMA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCEEH
DELGYRIKLLGVAQATEAGIEQRVHPTMVPKSSAIAQVMGVTNAVTIDADAVGELTLIGP
HHCCCEEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCEEEEEEC
GAGGEATASAVVADIADVARGVIRPTFGVPAAAMRASERVEMQRHEGGYYIRLTVHDRPG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
VAAGVAQRMAERSISLESILQRRVEGPEADPRGRSGRPVPLVLITYAATEGNIRDALDAI
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHH
GADGLLAEPPQLIRIERE
CCCCCCCCCCHHEEEECC
>Mature Secondary Structure 
TVSFRLGIAGLGTVGASVVRMVERRRAAFAAAGLDIRVTAVSSRDRGRDRGLDLSGIAW
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEE
FDDPVALARSEAVDCVVELIGGAEGPAKAVVEAALEAGKPVVTANKALLARHGAALAAQA
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHCCCHHEEHH
EAKGVALAFEAAVAGGIPVIKTLREGLPGNAVSRVYGILNGTCNYILSRMEREGLTFEAC
CCCCEEEEEHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LKDAQALGYAEADPTFDVEGFDTAHKLAILTSLAFGTAVDADGVSVEGISRVQPLDLRMA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCEEH
DELGYRIKLLGVAQATEAGIEQRVHPTMVPKSSAIAQVMGVTNAVTIDADAVGELTLIGP
HHCCCEEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCEEEEEEC
GAGGEATASAVVADIADVARGVIRPTFGVPAAAMRASERVEMQRHEGGYYIRLTVHDRPG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
VAAGVAQRMAERSISLESILQRRVEGPEADPRGRSGRPVPLVLITYAATEGNIRDALDAI
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHH
GADGLLAEPPQLIRIERE
CCCCCCCCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]