Click here to switch to the map view.

The map label for this gene is dgdA [H]

Identifier: 170749285

GI number: 170749285

Start: 3028852

End: 3030156

Strand: Reverse

Name: dgdA [H]

Synonym: Mrad2831_2878

Alternate gene names: 170749285

Gene position: 3030156-3028852 (Counterclockwise)

Preceding gene: 170749287

Following gene: 170749283

Centisome position: 49.86

GC content: 72.49

Gene sequence:

>1305_bases
ATGACGACGCGGAACGACGACCCCGATTTCTGGACGCGCGCCCGCCGGCACCTGGTGCGCTACGGCGGCACCTTCGCGCC
GGTGATCATCGAGCGGGCCGAGGGCAGCTTCGTCTACGACGCGGACGGCCGGGAGATCCTGGACTTCACCTCCGGCCAGA
TGAGCGCGATCCTGGGGCACGGGCATCCCGAGATCGCCGCCGTCGTCTCGGACCACGTTGGCCGCCTGGATCACCTGTTC
AGCGGCATGCTGAGCCGGCCGGTGGTGGACCTCGCGACGGAGCTGGCCGGCCTCGCCCCCGGCGGGCTGGAGCGGACGCT
TCTCCTGACCACCGGCGCCGAGGCCAACGAGGCCGCCCTGCGCATGGCCAAGCTCGCCACCGGCGGCTGGGAGATCGTGA
GCTTCGCGCAGTCCTGGCACGGCATGACGGCGGGCGCCGCCTCGGCGACCTACAGCGCCGGCCGCAAGGGCTACGGCCCG
GCCCCCGTCGGCTCCTTCGCGATTCCCGCACCGAACGCCTACCGCCCCACCTTCGCGCGGGACGGGGCCGCCGACTGGCA
GACCGAGCTCGACTACGCCTTCGCGCTGGTGGATCGGCAGTCGACCGGCAACCTCGCGGCCTTCCTGGCCGAGCCGATCC
TCAGTTCCGGCGGCATCCTCGAACTTCCGCCCGGCTACCTCGCGGCCCTCAAGCGCAAGTGCACCGAGCGGGGCATGCTG
CTGATCCTCGACGAGGCTCAGACGGGTATCGGCCGCACCGGCCTGATGTTCGCCTGCGAGCGCGACGGGGTGGTGCCCGA
CATCCTGACCCTGTCGAAGACCCTGGGCGCCGGCCTGCCGCTCGCGGCGGTCCTGACCACGCCGGAGATCGAGGATCTCT
GTCACGCCCGCGGCTTCCTGTTCTACACGACGCACGTCTCCGACCCGCTTCCCGCCGCGGTGGGGCTCAAGGTGCTGGAG
ATCGTCCGGCGCGACGGCCTGGTCGGCCGGGCCGAGGCGGCCGGCGCGCGGCTCGCGGCGCGGCTGCGGGCGCTCCAGCA
GCGCTTCGCCTGCATCGGCGACGTGCGCGGGCGCGGGCTCCTTCAGGGCATGGAGATCGTGGCCGACCGGGACACGAAGG
TGCCGGCACCGGAGCTGGGCGACGCGATCACGCGGCGCTGCCTCGAACTCGGGCTGAGCATGAACATCGTGCAGCTGCCC
GGCATGGGCGGCGTGTTCCGCATCGCCCCGCCGCTGACCGCCACCGACGCGGAGATCGATCTCGGCGTCGACATCCTGGA
GCGGGCGATCGAAGGTGCGGTCTGA

Upstream 100 bases:

>100_bases
TGGGCCATCAGGATCGCTGAACCCTCGGTTGAGAACTATAAGCTTCTCTGGGGTCTTCGGTCGTCCTAGCATGGGCCGGC
CTGCCACGGGACCCGGATCG

Downstream 100 bases:

>100_bases
GGCGGCCGCCGCGCCGGTCGCCCGCGCCGGCCGGCCCGCGCGCTCGGCCGAGTCGCGCGGGCCGGCGCGTCACGCCGCCT
CGATCTCGGTGCTGACCGTC

Product: class-III aminotransferase

Products: NA

Alternate protein names: DGD [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTRNDDPDFWTRARRHLVRYGGTFAPVIIERAEGSFVYDADGREILDFTSGQMSAILGHGHPEIAAVVSDHVGRLDHLF
SGMLSRPVVDLATELAGLAPGGLERTLLLTTGAEANEAALRMAKLATGGWEIVSFAQSWHGMTAGAASATYSAGRKGYGP
APVGSFAIPAPNAYRPTFARDGAADWQTELDYAFALVDRQSTGNLAAFLAEPILSSGGILELPPGYLAALKRKCTERGML
LILDEAQTGIGRTGLMFACERDGVVPDILTLSKTLGAGLPLAAVLTTPEIEDLCHARGFLFYTTHVSDPLPAAVGLKVLE
IVRRDGLVGRAEAAGARLAARLRALQQRFACIGDVRGRGLLQGMEIVADRDTKVPAPELGDAITRRCLELGLSMNIVQLP
GMGGVFRIAPPLTATDAEIDLGVDILERAIEGAV

Sequences:

>Translated_434_residues
MTTRNDDPDFWTRARRHLVRYGGTFAPVIIERAEGSFVYDADGREILDFTSGQMSAILGHGHPEIAAVVSDHVGRLDHLF
SGMLSRPVVDLATELAGLAPGGLERTLLLTTGAEANEAALRMAKLATGGWEIVSFAQSWHGMTAGAASATYSAGRKGYGP
APVGSFAIPAPNAYRPTFARDGAADWQTELDYAFALVDRQSTGNLAAFLAEPILSSGGILELPPGYLAALKRKCTERGML
LILDEAQTGIGRTGLMFACERDGVVPDILTLSKTLGAGLPLAAVLTTPEIEDLCHARGFLFYTTHVSDPLPAAVGLKVLE
IVRRDGLVGRAEAAGARLAARLRALQQRFACIGDVRGRGLLQGMEIVADRDTKVPAPELGDAITRRCLELGLSMNIVQLP
GMGGVFRIAPPLTATDAEIDLGVDILERAIEGAV
>Mature_433_residues
TTRNDDPDFWTRARRHLVRYGGTFAPVIIERAEGSFVYDADGREILDFTSGQMSAILGHGHPEIAAVVSDHVGRLDHLFS
GMLSRPVVDLATELAGLAPGGLERTLLLTTGAEANEAALRMAKLATGGWEIVSFAQSWHGMTAGAASATYSAGRKGYGPA
PVGSFAIPAPNAYRPTFARDGAADWQTELDYAFALVDRQSTGNLAAFLAEPILSSGGILELPPGYLAALKRKCTERGMLL
ILDEAQTGIGRTGLMFACERDGVVPDILTLSKTLGAGLPLAAVLTTPEIEDLCHARGFLFYTTHVSDPLPAAVGLKVLEI
VRRDGLVGRAEAAGARLAARLRALQQRFACIGDVRGRGLLQGMEIVADRDTKVPAPELGDAITRRCLELGLSMNIVQLPG
MGGVFRIAPPLTATDAEIDLGVDILERAIEGAV

Specific function: The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=31.5420560747664, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=29.3689320388349, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI226442705, Length=414, Percent_Identity=28.743961352657, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=29.3963254593176, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI24119277, Length=395, Percent_Identity=30.379746835443, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.9855072463768, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI284507298, Length=332, Percent_Identity=30.1204819277108, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1789016, Length=441, Percent_Identity=31.5192743764172, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1788044, Length=419, Percent_Identity=31.7422434367542, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI145693181, Length=425, Percent_Identity=32.2352941176471, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787560, Length=429, Percent_Identity=29.8368298368298, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789759, Length=422, Percent_Identity=28.6729857819905, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786991, Length=330, Percent_Identity=32.4242424242424, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=31.6279069767442, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=424, Percent_Identity=29.0094339622642, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=25.8454106280193, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=457, Percent_Identity=25.601750547046, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=29.1139240506329, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=418, Percent_Identity=28.9473684210526, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=29.9528301886792, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324386, Length=340, Percent_Identity=25.5882352941176, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=32.4009324009324, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161085790, Length=430, Percent_Identity=31.1627906976744, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21356575, Length=401, Percent_Identity=29.426433915212, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=28.2608695652174, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281366494, Length=448, Percent_Identity=24.5535714285714, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24667139, Length=448, Percent_Identity=24.5535714285714, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24667143, Length=448, Percent_Identity=24.5535714285714, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =4.1.1.64 [H]

Molecular weight: Translated: 46022; Mature: 45891

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRNDDPDFWTRARRHLVRYGGTFAPVIIERAEGSFVYDADGREILDFTSGQMSAILGH
CCCCCCCCHHHHHHHHHHHHHCCCEEHEEEEECCCCEEECCCCCEEECCCCCCHHHHHCC
GHPEIAAVVSDHVGRLDHLFSGMLSRPVVDLATELAGLAPGGLERTLLLTTGAEANEAAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHH
RMAKLATGGWEIVSFAQSWHGMTAGAASATYSAGRKGYGPAPVGSFAIPAPNAYRPTFAR
HHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGAADWQTELDYAFALVDRQSTGNLAAFLAEPILSSGGILELPPGYLAALKRKCTERGML
CCCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCEE
LILDEAQTGIGRTGLMFACERDGVVPDILTLSKTLGAGLPLAAVLTTPEIEDLCHARGFL
EEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCEE
FYTTHVSDPLPAAVGLKVLEIVRRDGLVGRAEAAGARLAARLRALQQRFACIGDVRGRGL
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LQGMEIVADRDTKVPAPELGDAITRRCLELGLSMNIVQLPGMGGVFRIAPPLTATDAEID
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCCCC
LGVDILERAIEGAV
CCHHHHHHHHHCCC
>Mature Secondary Structure 
TTRNDDPDFWTRARRHLVRYGGTFAPVIIERAEGSFVYDADGREILDFTSGQMSAILGH
CCCCCCCHHHHHHHHHHHHHCCCEEHEEEEECCCCEEECCCCCEEECCCCCCHHHHHCC
GHPEIAAVVSDHVGRLDHLFSGMLSRPVVDLATELAGLAPGGLERTLLLTTGAEANEAAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHH
RMAKLATGGWEIVSFAQSWHGMTAGAASATYSAGRKGYGPAPVGSFAIPAPNAYRPTFAR
HHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGAADWQTELDYAFALVDRQSTGNLAAFLAEPILSSGGILELPPGYLAALKRKCTERGML
CCCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCEE
LILDEAQTGIGRTGLMFACERDGVVPDILTLSKTLGAGLPLAAVLTTPEIEDLCHARGFL
EEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCEE
FYTTHVSDPLPAAVGLKVLEIVRRDGLVGRAEAAGARLAARLRALQQRFACIGDVRGRGL
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LQGMEIVADRDTKVPAPELGDAITRRCLELGLSMNIVQLPGMGGVFRIAPPLTATDAEID
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCCCC
LGVDILERAIEGAV
CCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180928; 8342040; 7947767; 7799433; 10556038 [H]