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The map label for this gene is crtE [H]

Identifier: 170749228

GI number: 170749228

Start: 2964618

End: 2965487

Strand: Reverse

Name: crtE [H]

Synonym: Mrad2831_2821

Alternate gene names: 170749228

Gene position: 2965487-2964618 (Counterclockwise)

Preceding gene: 170749231

Following gene: 170749227

Centisome position: 48.79

GC content: 76.21

Gene sequence:

>870_bases
ATGGAGTCCGGTCAGCGGATCGAGATGGCGCTCGATCGCGCCGTTGCGCACGCGGAGGCGCCCGGCGCGCCGCCCCTCCT
GGCGGAGGCTCTCCGCTACGCGGTGTTTCCCGGCGGCCACCGGATCCGACCGCGCCTGTGCCTCTCGGTGGCCCGCGCCT
GCGGCGACGACGACCCGGCAGGATCCGTCGCGGCCGCCGCCGCCATCGAGTTCCTGCACTGCGCTTCCCTGGTCCACGAC
GACCTGCCGTGCTTCGACGACGCGCCGATGCGGCGGCAGAAGCCCTCCGTCCACGTCGCCTTCGGCGAGCCGATCGCCGT
CCTGACCGGCGACGCCCTCATCGTCCTCGCCTTCGAGACCCTGGCGCGATCCGTCGGGCGGCATCCGGCGCGCCTCGGCC
GCCTCGTCGGGCTTCTCGGCCGCGCCGCCGGGTCGCCGTCGGGCATCGCGGCCGGGCAGGCCTGGGAATCGGAGGCGCAT
ATCAGCCTGAGCGACTACCAGCAGGCGAAGACCGGCGCGCTGTTCGCCGCCGCCACCGTGGCAGGCGCTGCCGCGGCGGG
GGCTGAGCCGGAGCCCTGGCGTCGCCTCGGCGAGTGCCTGGGAGAGGCCTATCAGGTCGCCGACGACCTGCGCGACGTCG
CCTGCCGGCAGGAGGAGATCGGCAAGCCCGCCGGGCGCGACGCGACGCTGGGCCGCCCCAACGCCGCAGCCCTCCTGGGC
ACCGGCGGGGCGATGGAGCGCCTGTCCCGGCTGACACGCGAGGCGGTCGCGGCGATCCCGGCCTGTCCGGGCGCGGCCGC
GCTCACCGCCGAGATCGAGGCGCAGGCGCGGCTGTTCCTGCCCGCGAGCCTGCGGGCGGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
CCGAACTCCCCCGACCACGGGATTGATCTCGCCTCGCCGAAGTGTCAATAAGAAATGACACCTGTTGCTGACAACCGCAT
ACAACACGGGAGGCAACGCG

Downstream 100 bases:

>100_bases
GCGCCGGATCGCTCCCCGGAACCGGCACGGTGCCGCCTGCCCCGTCCGCCTGGGCGGACAGGTGGCTCGCGTGGCGCAAT
CGCCTCGTCGCGAGCCCCCG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MESGQRIEMALDRAVAHAEAPGAPPLLAEALRYAVFPGGHRIRPRLCLSVARACGDDDPAGSVAAAAAIEFLHCASLVHD
DLPCFDDAPMRRQKPSVHVAFGEPIAVLTGDALIVLAFETLARSVGRHPARLGRLVGLLGRAAGSPSGIAAGQAWESEAH
ISLSDYQQAKTGALFAAATVAGAAAAGAEPEPWRRLGECLGEAYQVADDLRDVACRQEEIGKPAGRDATLGRPNAAALLG
TGGAMERLSRLTREAVAAIPACPGAAALTAEIEAQARLFLPASLRAVVA

Sequences:

>Translated_289_residues
MESGQRIEMALDRAVAHAEAPGAPPLLAEALRYAVFPGGHRIRPRLCLSVARACGDDDPAGSVAAAAAIEFLHCASLVHD
DLPCFDDAPMRRQKPSVHVAFGEPIAVLTGDALIVLAFETLARSVGRHPARLGRLVGLLGRAAGSPSGIAAGQAWESEAH
ISLSDYQQAKTGALFAAATVAGAAAAGAEPEPWRRLGECLGEAYQVADDLRDVACRQEEIGKPAGRDATLGRPNAAALLG
TGGAMERLSRLTREAVAAIPACPGAAALTAEIEAQARLFLPASLRAVVA
>Mature_289_residues
MESGQRIEMALDRAVAHAEAPGAPPLLAEALRYAVFPGGHRIRPRLCLSVARACGDDDPAGSVAAAAAIEFLHCASLVHD
DLPCFDDAPMRRQKPSVHVAFGEPIAVLTGDALIVLAFETLARSVGRHPARLGRLVGLLGRAAGSPSGIAAGQAWESEAH
ISLSDYQQAKTGALFAAATVAGAAAAGAEPEPWRRLGECLGEAYQVADDLRDVACRQEEIGKPAGRDATLGRPNAAALLG
TGGAMERLSRLTREAVAAIPACPGAAALTAEIEAQARLFLPASLRAVVA

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=216, Percent_Identity=31.4814814814815, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789578, Length=211, Percent_Identity=35.5450236966825, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786623, Length=288, Percent_Identity=32.9861111111111, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 29810; Mature: 29810

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGQRIEMALDRAVAHAEAPGAPPLLAEALRYAVFPGGHRIRPRLCLSVARACGDDDPA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
GSVAAAAAIEFLHCASLVHDDLPCFDDAPMRRQKPSVHVAFGEPIAVLTGDALIVLAFET
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHH
LARSVGRHPARLGRLVGLLGRAAGSPSGIAAGQAWESEAHISLSDYQQAKTGALFAAATV
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
AGAAAAGAEPEPWRRLGECLGEAYQVADDLRDVACRQEEIGKPAGRDATLGRPNAAALLG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
TGGAMERLSRLTREAVAAIPACPGAAALTAEIEAQARLFLPASLRAVVA
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEECCHHHHHHCC
>Mature Secondary Structure
MESGQRIEMALDRAVAHAEAPGAPPLLAEALRYAVFPGGHRIRPRLCLSVARACGDDDPA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
GSVAAAAAIEFLHCASLVHDDLPCFDDAPMRRQKPSVHVAFGEPIAVLTGDALIVLAFET
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHH
LARSVGRHPARLGRLVGLLGRAAGSPSGIAAGQAWESEAHISLSDYQQAKTGALFAAATV
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
AGAAAAGAEPEPWRRLGECLGEAYQVADDLRDVACRQEEIGKPAGRDATLGRPNAAALLG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
TGGAMERLSRLTREAVAAIPACPGAAALTAEIEAQARLFLPASLRAVVA
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]