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The map label for this gene is fabB [H]

Identifier: 170749091

GI number: 170749091

Start: 2827202

End: 2828428

Strand: Reverse

Name: fabB [H]

Synonym: Mrad2831_2684

Alternate gene names: 170749091

Gene position: 2828428-2827202 (Counterclockwise)

Preceding gene: 170749092

Following gene: 170749090

Centisome position: 46.54

GC content: 69.85

Gene sequence:

>1227_bases
ATGCGCCGTGTCGTCATCACCGGGATGGGCATCGTCTCGTCCATCGGCAACAACACGCAGGAGGTGCTCGCCTCCCTGCG
CGAGGCCCGCTCGGGCATCGCGCGCGACGCCAGCTACGCCGAGCACGGCTTCCGCAGCCAGGTCTCCGGCGCGCCCACTC
TCGATCCGGAGGGCGTGGTGGACCGGCGCGCGATGCGCTTCCACGGCGGCGGCACCGCCTGGAATCACGTCGCCATGGAT
CAGGCGATCCAGGATGCCGGCCTGGAGCAGGGCGACGTCTCGAACGAGCGCACCGGCATCATCATGGGCTCGGGCGGCCC
CTCGACCCGCGTGATCGTCGAGGCCGCCGCCATCGCGCGGGACAAGGGTCCCAAGCGAATCGGGCCGTTCGCCGTGCCGA
AGGCGATGTCGTCGACCGCGTCGGCGACGCTGGCGACGTGGTTCAAGATCCGCGGCGTGAACTACTCGATCTCCTCCGCC
TGCGCGACCTCGAACCACTGCATCGGCAACGCCGCCGAGATCATCCAGGGCGGCCGGCAGGACATCATCTTCGCGGGCGG
CTGCGAGGATCTCGACTGGACCCTCTCGGTGCTGTTCGACGCCATGGGCGCCATGTCGTCGAAGTACAACGACACACCGT
CCCGGGCCTCCCGCGCCTACGACGCCAACCGCGACGGCTTCGTCATCGCGGGCGGCGCGGGCGTGCTGGTCCTCGAGGAG
CTGGAGCACGCCAAGGCGCGCGGCGCCCGGATCTACGGCGAGGTCGCGGGCTACGGCGCCACCTCGGACGGGCACGACAT
GGTCGCGCCGTCGGGCGAGGGCGCCGTGCGCTGCATGCGCCAGGCGCTGGACGGTCTGAAGGGCGCGCGGATCGACTACA
TCAACCCGCACGCCACCTCGACCCCGGTCGGCGACGACAAGGAGATCGAGGCGATCCGCGAGGTGTTCGGCCGCGGCGAG
GATTGCCCGCCGATCTCGGCCACGAAGTCGCTGACCGGCCATTCGCTGGGCGCCACCGGCGTGCAGGAGGCGATCTACAG
CCTGCTGATGATGAACAACGGCTTCATCTGCGAGAGCGCGCACATCGACACCCTCGATCCGGCCTTCGCCGACATGCCGA
TCCTGCAGCAGCGCCGCGACAACGCGCAGCTCGGCCACGTGCTGACCAATTCCTTCGGATTCGGCGGCACCAACGCCACC
CTCGTCCTGAAGCACGTCGACGCCTGA

Upstream 100 bases:

>100_bases
CGCCGGACGTTCTCGGCGGTTGAGATTGTGTCCGCGTCACCTTAGCTGACCGTGACGCGGCCCGGGCGACCGGGACCGCG
ACGGAGGTAGTGTCACCATC

Downstream 100 bases:

>100_bases
TCGCCCTACGCGGAACCGCCGGCCTCGGGCCGGCGTTTACCCGCTGTTGAGATCTGGTGGTGGCGATGGGGACTTTCATC
TTCGGAACGCTGGGCGGCCT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MRRVVITGMGIVSSIGNNTQEVLASLREARSGIARDASYAEHGFRSQVSGAPTLDPEGVVDRRAMRFHGGGTAWNHVAMD
QAIQDAGLEQGDVSNERTGIIMGSGGPSTRVIVEAAAIARDKGPKRIGPFAVPKAMSSTASATLATWFKIRGVNYSISSA
CATSNHCIGNAAEIIQGGRQDIIFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSRASRAYDANRDGFVIAGGAGVLVLEE
LEHAKARGARIYGEVAGYGATSDGHDMVAPSGEGAVRCMRQALDGLKGARIDYINPHATSTPVGDDKEIEAIREVFGRGE
DCPPISATKSLTGHSLGATGVQEAIYSLLMMNNGFICESAHIDTLDPAFADMPILQQRRDNAQLGHVLTNSFGFGGTNAT
LVLKHVDA

Sequences:

>Translated_408_residues
MRRVVITGMGIVSSIGNNTQEVLASLREARSGIARDASYAEHGFRSQVSGAPTLDPEGVVDRRAMRFHGGGTAWNHVAMD
QAIQDAGLEQGDVSNERTGIIMGSGGPSTRVIVEAAAIARDKGPKRIGPFAVPKAMSSTASATLATWFKIRGVNYSISSA
CATSNHCIGNAAEIIQGGRQDIIFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSRASRAYDANRDGFVIAGGAGVLVLEE
LEHAKARGARIYGEVAGYGATSDGHDMVAPSGEGAVRCMRQALDGLKGARIDYINPHATSTPVGDDKEIEAIREVFGRGE
DCPPISATKSLTGHSLGATGVQEAIYSLLMMNNGFICESAHIDTLDPAFADMPILQQRRDNAQLGHVLTNSFGFGGTNAT
LVLKHVDA
>Mature_408_residues
MRRVVITGMGIVSSIGNNTQEVLASLREARSGIARDASYAEHGFRSQVSGAPTLDPEGVVDRRAMRFHGGGTAWNHVAMD
QAIQDAGLEQGDVSNERTGIIMGSGGPSTRVIVEAAAIARDKGPKRIGPFAVPKAMSSTASATLATWFKIRGVNYSISSA
CATSNHCIGNAAEIIQGGRQDIIFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSRASRAYDANRDGFVIAGGAGVLVLEE
LEHAKARGARIYGEVAGYGATSDGHDMVAPSGEGAVRCMRQALDGLKGARIDYINPHATSTPVGDDKEIEAIREVFGRGE
DCPPISATKSLTGHSLGATGVQEAIYSLLMMNNGFICESAHIDTLDPAFADMPILQQRRDNAQLGHVLTNSFGFGGTNAT
LVLKHVDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=36.4285714285714, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI223972627, Length=162, Percent_Identity=40.1234567901235, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI41872631, Length=339, Percent_Identity=26.2536873156342, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=60.7843137254902, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=36.5617433414044, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=34.916864608076, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=269, Percent_Identity=39.4052044609665, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=338, Percent_Identity=26.6272189349112, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=24.4604316546763, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=31.8385650224215, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=35.8173076923077, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI221330659, Length=335, Percent_Identity=27.7611940298507, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI19920632, Length=335, Percent_Identity=27.7611940298507, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581345, Length=344, Percent_Identity=26.453488372093, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42928; Mature: 42928

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGIVSSIGNNTQEVLASLREARSGIARDASYAEHGFRSQVSGAPTLDPEGVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCCCCCCHH
DRRAMRFHGGGTAWNHVAMDQAIQDAGLEQGDVSNERTGIIMGSGGPSTRVIVEAAAIAR
HHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHH
DKGPKRIGPFAVPKAMSSTASATLATWFKIRGVNYSISSACATSNHCIGNAAEIIQGGRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHHCCCCCCCCCHHHHHCCCCC
DIIFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSRASRAYDANRDGFVIAGGAGVLVLEE
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHAKARGARIYGEVAGYGATSDGHDMVAPSGEGAVRCMRQALDGLKGARIDYINPHATS
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC
TPVGDDKEIEAIREVFGRGEDCPPISATKSLTGHSLGATGVQEAIYSLLMMNNGFICESA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
HIDTLDPAFADMPILQQRRDNAQLGHVLTNSFGFGGTNATLVLKHVDA
CCCCCCCHHHCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVITGMGIVSSIGNNTQEVLASLREARSGIARDASYAEHGFRSQVSGAPTLDPEGVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCCCCCCHH
DRRAMRFHGGGTAWNHVAMDQAIQDAGLEQGDVSNERTGIIMGSGGPSTRVIVEAAAIAR
HHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHH
DKGPKRIGPFAVPKAMSSTASATLATWFKIRGVNYSISSACATSNHCIGNAAEIIQGGRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEHHHHHCCCCCCCCCHHHHHCCCCC
DIIFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSRASRAYDANRDGFVIAGGAGVLVLEE
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHAKARGARIYGEVAGYGATSDGHDMVAPSGEGAVRCMRQALDGLKGARIDYINPHATS
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC
TPVGDDKEIEAIREVFGRGEDCPPISATKSLTGHSLGATGVQEAIYSLLMMNNGFICESA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
HIDTLDPAFADMPILQQRRDNAQLGHVLTNSFGFGGTNATLVLKHVDA
CCCCCCCHHHCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]