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The map label for this gene is lon2 [H]

Identifier: 170749064

GI number: 170749064

Start: 2800555

End: 2802213

Strand: Reverse

Name: lon2 [H]

Synonym: Mrad2831_2657

Alternate gene names: 170749064

Gene position: 2802213-2800555 (Counterclockwise)

Preceding gene: 170749065

Following gene: 170749063

Centisome position: 46.11

GC content: 72.21

Gene sequence:

>1659_bases
ATGACGAACGCACGCGCCCGCAGCGCGCACCCGACGACGCGCGCCCTTTTGTGCGGCGCCCGCCCCACCGGCGACACCGC
ACACCGCGACCTCTACGAGCACCTCGTCACCGAGTGGCCTGACGTCGTGGCCCTAGACCGGCCCGCCCTGGTCGAGGCGG
TGGGCGGCTCCGAGGTTATGGCGGAGCTCCTCAGCAGCACGTACCTCACATGTGCCGAGCTTGTCGGGGCGCGGCACGGC
ATCGACCGCGTGGCGCGCCGCGTCTTCCAGACGAGACTGCTGAGCGCATCGACCGAGCTCGAACGCCTGCTGGCGCTCCG
CCCGGCCGAGGACGTCGAGCTCGACCTTGGCTACGGCATCCACAATCCGCTCGACGACCTCGACGAGCGGATTGTCTACC
ACCGCGCCTCCCTGGGCGACCGGTTGGCGGCCGACCGCCTCCGGGGCGTCGTGGCTCGTCACGCCCGCCGGGATGGCAAC
GTGGACGGCCGCCCCGCGCTCATCGCCACGCTCCTCGGGGCGGAGATGCTGGACGGCTATGTCGAGCCGCGGTGCATCCC
CGGCACGCACCGCTACGACGTCGTCGGGCAGTGGCGGGAGGCCGGAGAGGAGTACGTTGCGCAGGCCGCGCTGGCTACTC
GCGAACGCATCCGAGACGCCATCGTCGAGGCCAGGGCCAGTGCCAGCGAGCGGGAGGCCGAGGAGCCGGCGCCGAAGCGC
GCGTCGCTCGCGGGTTTCCGGAAGGCCGTAGCCGTCGTGCCGACCCCGCCGCCGGGCGCGGTCGTTGTGTTCCCCGCCCT
GTCGAAGTCCTCCGCCGGAAAGCCGGACAACCTGCGCGACATCAAGGCCGCCCTCGGCGACGCCCTTGGCGCTGCGCTGC
CGGGCGTGCCCGTCCCCGACGACTGGGACGCCTGGGAAGCCGCGGCCGTGGCCCGGTGGCCGCACATGCCCGGCGTCCCG
CGCGCCATCCGCGAGGCTCAGGCCGGGCGCACGCACTGGGGGAGCATGCGCCTCTGCCTCGTCGGGCCCGCCGGCATCGG
CAAGACGGCCATCGGCCGCTTCATTGCCGAACATTCGGGCTTACCGTTCTCGCGCTACAATGCCGACAATTCGACCGATA
ATAGCTACGGAGGGACAAGTATTCGCTGGAATAGCGGCCACCTTGGCACCGTCGCGGCCATGCTCGCCGAGCACATGCGC
GCGACCGGCCTGGCGCAGGTCGACGAGATCGAGAAGGCCTCCGGCCACCGCGGCACTAACGGGGGCAGGCTGCACGACGT
CCTTCACGGGCTGTGGGACGACGAGACGTCCAGTCGGTGGGCCTGCCCCTTCTCGGCCATGACCCTGGACCTGTCGAACG
TCGCGTATCTGGCGACGGCCAACTCCCTCGCCGGGATCCCTTCGAGCCTGCGCGACCGCATGCGTGTGCTGGAGGTCAGC
GCCCCTGGCTCCGAGCACCTCGCCGCCCTGGTCCCGCAGGTCGCCGCGCAGGCTTGCCGGGAGCAGGGCCTCGACCCGGC
ATGGGGCGTCCTGGACGGCGTCGAGTGGCAAGCCCTGCGCGGTGCGTGGGGCCAGGGTGGCTCGATCCGCCGGCTGCAGC
GCCTGGTCTCCACGATCCTCCGGGCCCGCGACGCGGACCCGTCCACCCCCCGTCACTGA

Upstream 100 bases:

>100_bases
GAAGGACGACCCGTTAACCGGGAAGTAGGGATTCGTCTGATACGACGGCCCTTGAGCTACGCCCGCGGAACGTCCGGGGC
GGCGGCCCTGGAGACCGAAG

Downstream 100 bases:

>100_bases
TCCCGGAGATCTCCGTGCAGCACATCGAGACCGCCGCCGACCGCCGCGAGGCCTTGGCCTCCCTGGCGCTCCACGTCCTG
AAGCTGGCCTGCGCCGGCCA

Product: ATP-dependent Lon protease-like protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTNARARSAHPTTRALLCGARPTGDTAHRDLYEHLVTEWPDVVALDRPALVEAVGGSEVMAELLSSTYLTCAELVGARHG
IDRVARRVFQTRLLSASTELERLLALRPAEDVELDLGYGIHNPLDDLDERIVYHRASLGDRLAADRLRGVVARHARRDGN
VDGRPALIATLLGAEMLDGYVEPRCIPGTHRYDVVGQWREAGEEYVAQAALATRERIRDAIVEARASASEREAEEPAPKR
ASLAGFRKAVAVVPTPPPGAVVVFPALSKSSAGKPDNLRDIKAALGDALGAALPGVPVPDDWDAWEAAAVARWPHMPGVP
RAIREAQAGRTHWGSMRLCLVGPAGIGKTAIGRFIAEHSGLPFSRYNADNSTDNSYGGTSIRWNSGHLGTVAAMLAEHMR
ATGLAQVDEIEKASGHRGTNGGRLHDVLHGLWDDETSSRWACPFSAMTLDLSNVAYLATANSLAGIPSSLRDRMRVLEVS
APGSEHLAALVPQVAAQACREQGLDPAWGVLDGVEWQALRGAWGQGGSIRRLQRLVSTILRARDADPSTPRH

Sequences:

>Translated_552_residues
MTNARARSAHPTTRALLCGARPTGDTAHRDLYEHLVTEWPDVVALDRPALVEAVGGSEVMAELLSSTYLTCAELVGARHG
IDRVARRVFQTRLLSASTELERLLALRPAEDVELDLGYGIHNPLDDLDERIVYHRASLGDRLAADRLRGVVARHARRDGN
VDGRPALIATLLGAEMLDGYVEPRCIPGTHRYDVVGQWREAGEEYVAQAALATRERIRDAIVEARASASEREAEEPAPKR
ASLAGFRKAVAVVPTPPPGAVVVFPALSKSSAGKPDNLRDIKAALGDALGAALPGVPVPDDWDAWEAAAVARWPHMPGVP
RAIREAQAGRTHWGSMRLCLVGPAGIGKTAIGRFIAEHSGLPFSRYNADNSTDNSYGGTSIRWNSGHLGTVAAMLAEHMR
ATGLAQVDEIEKASGHRGTNGGRLHDVLHGLWDDETSSRWACPFSAMTLDLSNVAYLATANSLAGIPSSLRDRMRVLEVS
APGSEHLAALVPQVAAQACREQGLDPAWGVLDGVEWQALRGAWGQGGSIRRLQRLVSTILRARDADPSTPRH
>Mature_551_residues
TNARARSAHPTTRALLCGARPTGDTAHRDLYEHLVTEWPDVVALDRPALVEAVGGSEVMAELLSSTYLTCAELVGARHGI
DRVARRVFQTRLLSASTELERLLALRPAEDVELDLGYGIHNPLDDLDERIVYHRASLGDRLAADRLRGVVARHARRDGNV
DGRPALIATLLGAEMLDGYVEPRCIPGTHRYDVVGQWREAGEEYVAQAALATRERIRDAIVEARASASEREAEEPAPKRA
SLAGFRKAVAVVPTPPPGAVVVFPALSKSSAGKPDNLRDIKAALGDALGAALPGVPVPDDWDAWEAAAVARWPHMPGVPR
AIREAQAGRTHWGSMRLCLVGPAGIGKTAIGRFIAEHSGLPFSRYNADNSTDNSYGGTSIRWNSGHLGTVAAMLAEHMRA
TGLAQVDEIEKASGHRGTNGGRLHDVLHGLWDDETSSRWACPFSAMTLDLSNVAYLATANSLAGIPSSLRDRMRVLEVSA
PGSEHLAALVPQVAAQACREQGLDPAWGVLDGVEWQALRGAWGQGGSIRRLQRLVSTILRARDADPSTPRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=254, Percent_Identity=30.3149606299213, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI31377667, Length=239, Percent_Identity=26.3598326359833, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1786643, Length=149, Percent_Identity=33.5570469798658, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17505831, Length=214, Percent_Identity=26.6355140186916, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17556486, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319449, Length=206, Percent_Identity=30.5825242718447, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221513036, Length=232, Percent_Identity=26.7241379310345, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24666867, Length=232, Percent_Identity=26.7241379310345, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 59363; Mature: 59231

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNARARSAHPTTRALLCGARPTGDTAHRDLYEHLVTEWPDVVALDRPALVEAVGGSEVM
CCCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCHHHH
AELLSSTYLTCAELVGARHGIDRVARRVFQTRLLSASTELERLLALRPAEDVELDLGYGI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
HNPLDDLDERIVYHRASLGDRLAADRLRGVVARHARRDGNVDGRPALIATLLGAEMLDGY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
VEPRCIPGTHRYDVVGQWREAGEEYVAQAALATRERIRDAIVEARASASEREAEEPAPKR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ASLAGFRKAVAVVPTPPPGAVVVFPALSKSSAGKPDNLRDIKAALGDALGAALPGVPVPD
HHHHHHHHCEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
DWDAWEAAAVARWPHMPGVPRAIREAQAGRTHWGSMRLCLVGPAGIGKTAIGRFIAEHSG
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
LPFSRYNADNSTDNSYGGTSIRWNSGHLGTVAAMLAEHMRATGLAQVDEIEKASGHRGTN
CCCHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
GGRLHDVLHGLWDDETSSRWACPFSAMTLDLSNVAYLATANSLAGIPSSLRDRMRVLEVS
CCHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCEEEEEECHHHHCCCHHHHHHHHEEEEC
APGSEHLAALVPQVAAQACREQGLDPAWGVLDGVEWQALRGAWGQGGSIRRLQRLVSTIL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RARDADPSTPRH
HHCCCCCCCCCC
>Mature Secondary Structure 
TNARARSAHPTTRALLCGARPTGDTAHRDLYEHLVTEWPDVVALDRPALVEAVGGSEVM
CCCCCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCHHHH
AELLSSTYLTCAELVGARHGIDRVARRVFQTRLLSASTELERLLALRPAEDVELDLGYGI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
HNPLDDLDERIVYHRASLGDRLAADRLRGVVARHARRDGNVDGRPALIATLLGAEMLDGY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
VEPRCIPGTHRYDVVGQWREAGEEYVAQAALATRERIRDAIVEARASASEREAEEPAPKR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ASLAGFRKAVAVVPTPPPGAVVVFPALSKSSAGKPDNLRDIKAALGDALGAALPGVPVPD
HHHHHHHHCEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
DWDAWEAAAVARWPHMPGVPRAIREAQAGRTHWGSMRLCLVGPAGIGKTAIGRFIAEHSG
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
LPFSRYNADNSTDNSYGGTSIRWNSGHLGTVAAMLAEHMRATGLAQVDEIEKASGHRGTN
CCCHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
GGRLHDVLHGLWDDETSSRWACPFSAMTLDLSNVAYLATANSLAGIPSSLRDRMRVLEVS
CCHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCEEEEEECHHHHCCCHHHHHHHHEEEEC
APGSEHLAALVPQVAAQACREQGLDPAWGVLDGVEWQALRGAWGQGGSIRRLQRLVSTIL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHH
RARDADPSTPRH
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]