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The map label for this gene is sdaA [H]

Identifier: 170748901

GI number: 170748901

Start: 2648286

End: 2649638

Strand: Reverse

Name: sdaA [H]

Synonym: Mrad2831_2483

Alternate gene names: 170748901

Gene position: 2649638-2648286 (Counterclockwise)

Preceding gene: 170748902

Following gene: 170748891

Centisome position: 43.6

GC content: 73.02

Gene sequence:

>1353_bases
ATGATCAGCGCCTTCGATCTGTTCAAGATCGGCATCGGCCCGTCGAGTTCCCACACGATCGGACCCATGGTGGCCGCGCG
CCGATTCCGCGACCGCGTCGCCGGCCGGCCCGGCCTCGCGCGGGTGAGCGCGGAGATCTTCGGCTCCCTCGCCTGGACCG
GGCGCGGCCACGGCACCGACGTGGCGATCTTCCTCGGCCTGCTCGGCCACGAGCCCGCGACCGTCGACCCGGACGCCGTG
GCGGGCTACACGCGGTCCCTCGCCGAGACCGGCGCCATCGGCCTGCCGGGCGTCGCCTTCGACACGACGAAGGACCTGCT
GTTCAACTTCACCGAGGTCCTGCCCGGCCACACCAACGGCATGCGCTTCCGCGCCCACGACGCCGGCGGCGCCGTGCTGG
ACGAGGTGGTCTGCTACTCGGTCGGCGGCGGCTTCGTCGAGGAGGAGGGCGCGGCGGAGACCGCCGGGCTCGACGCCGTC
GCGGTGCCCTACCCGTTCGAGAGCGGCGCCGACCTGCTGCGGATCTGCGCCGAGACCGGCCTGACCATCCCGCAGGTCCA
GATGGCCAACGAGCGCGCCCTGCGCACCGAGGCCGAGATCGAGGCCGGGCTCGACGCCGTCCGCGACGCCATGCTGGCCT
GCATCGCCCGAGGCCTGCGCATGGACGGCGAGCTGCCCGGCGGCCTCAAGGTCCGGCGGCGCGCGAAGCGCCTGCACGAG
ACACTCGACGCGAACCGCCTGACGAACAGCCGGCCGGCCCACGAGATCATGGACTGGATCAGCCTGTTCGCCCTGGCGGT
GAACGAGGAGAACGCGTCCGGCGGCCGGATCGTCACGGCGCCGACCAACGGCGCGGCCGGGATCGTGCCGGCGGTGCTGC
GCTACATCGTCGACTTCTGCCCCGGCTGGACCGAGACCCGTGGCCGGGACTACCTCCTGGCCGCCGCCGCGATCGGCGGT
CTGATCAAGCGCCGGGCCTCGATCTCGGGCGCCGAGGTCGGCTGCCAGGGCGAGGTCGGCTCCGCGGCCGCCATGGCGGC
CGCCGGGCTCGCGTCCGTCCTCGGGGGCGACGCGCGGCAGGTCGCCAACGCCGCCGAGATCGCCATGGAGCACCATCTGG
GCATGACCTGCGACCCGATCGGCGGGCTCGTCCAGATCCCCTGCATCGAGCGCAACGCCTTCGGCGCCAACAAGGCGGTG
GCGGCCGCCTCCCTCGCCCTCCACGGCGACGGGGTGCACTTCGTGAGCCTCGACCAGGTCATCGAGACGATGCGCCAGAC
CGGGCACGACATGCAGGCCAAGTACAAGGAAACCTCCCTGGGCGGCCTCGCGGTCAACGTCGCCGCCTGCTGA

Upstream 100 bases:

>100_bases
CATACCGGGTTGAGTGCTGGCGGTCCTTCGCGACCTACGTGTATGGCTTGCTGCAGGAGGCCGCCTTCGGGGCCGGCCCG
CTGGAGAGAGCCGCCGCGCG

Downstream 100 bases:

>100_bases
GCGCGACCTCCCGCGCCGGCCGCGCGCCCTGGAGCGCGGGGCCGCCGATCCCGCCAGGGCGGCGTCAGGCCGCCTGCGCC
GCCTCGGGCAGCGCGAACGG

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MISAFDLFKIGIGPSSSHTIGPMVAARRFRDRVAGRPGLARVSAEIFGSLAWTGRGHGTDVAIFLGLLGHEPATVDPDAV
AGYTRSLAETGAIGLPGVAFDTTKDLLFNFTEVLPGHTNGMRFRAHDAGGAVLDEVVCYSVGGGFVEEEGAAETAGLDAV
AVPYPFESGADLLRICAETGLTIPQVQMANERALRTEAEIEAGLDAVRDAMLACIARGLRMDGELPGGLKVRRRAKRLHE
TLDANRLTNSRPAHEIMDWISLFALAVNEENASGGRIVTAPTNGAAGIVPAVLRYIVDFCPGWTETRGRDYLLAAAAIGG
LIKRRASISGAEVGCQGEVGSAAAMAAAGLASVLGGDARQVANAAEIAMEHHLGMTCDPIGGLVQIPCIERNAFGANKAV
AAASLALHGDGVHFVSLDQVIETMRQTGHDMQAKYKETSLGGLAVNVAAC

Sequences:

>Translated_450_residues
MISAFDLFKIGIGPSSSHTIGPMVAARRFRDRVAGRPGLARVSAEIFGSLAWTGRGHGTDVAIFLGLLGHEPATVDPDAV
AGYTRSLAETGAIGLPGVAFDTTKDLLFNFTEVLPGHTNGMRFRAHDAGGAVLDEVVCYSVGGGFVEEEGAAETAGLDAV
AVPYPFESGADLLRICAETGLTIPQVQMANERALRTEAEIEAGLDAVRDAMLACIARGLRMDGELPGGLKVRRRAKRLHE
TLDANRLTNSRPAHEIMDWISLFALAVNEENASGGRIVTAPTNGAAGIVPAVLRYIVDFCPGWTETRGRDYLLAAAAIGG
LIKRRASISGAEVGCQGEVGSAAAMAAAGLASVLGGDARQVANAAEIAMEHHLGMTCDPIGGLVQIPCIERNAFGANKAV
AAASLALHGDGVHFVSLDQVIETMRQTGHDMQAKYKETSLGGLAVNVAAC
>Mature_450_residues
MISAFDLFKIGIGPSSSHTIGPMVAARRFRDRVAGRPGLARVSAEIFGSLAWTGRGHGTDVAIFLGLLGHEPATVDPDAV
AGYTRSLAETGAIGLPGVAFDTTKDLLFNFTEVLPGHTNGMRFRAHDAGGAVLDEVVCYSVGGGFVEEEGAAETAGLDAV
AVPYPFESGADLLRICAETGLTIPQVQMANERALRTEAEIEAGLDAVRDAMLACIARGLRMDGELPGGLKVRRRAKRLHE
TLDANRLTNSRPAHEIMDWISLFALAVNEENASGGRIVTAPTNGAAGIVPAVLRYIVDFCPGWTETRGRDYLLAAAAIGG
LIKRRASISGAEVGCQGEVGSAAAMAAAGLASVLGGDARQVANAAEIAMEHHLGMTCDPIGGLVQIPCIERNAFGANKAV
AAASLALHGDGVHFVSLDQVIETMRQTGHDMQAKYKETSLGGLAVNVAAC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=50.4405286343612, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1789161, Length=458, Percent_Identity=50.8733624454148, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI48994925, Length=457, Percent_Identity=50.9846827133479, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 46862; Mature: 46862

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAFDLFKIGIGPSSSHTIGPMVAARRFRDRVAGRPGLARVSAEIFGSLAWTGRGHGTD
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCH
VAIFLGLLGHEPATVDPDAVAGYTRSLAETGAIGLPGVAFDTTKDLLFNFTEVLPGHTNG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
MRFRAHDAGGAVLDEVVCYSVGGGFVEEEGAAETAGLDAVAVPYPFESGADLLRICAETG
EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCEEEECCCCCCCHHHHHHHHHCC
LTIPQVQMANERALRTEAEIEAGLDAVRDAMLACIARGLRMDGELPGGLKVRRRAKRLHE
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
TLDANRLTNSRPAHEIMDWISLFALAVNEENASGGRIVTAPTNGAAGIVPAVLRYIVDFC
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
PGWTETRGRDYLLAAAAIGGLIKRRASISGAEVGCQGEVGSAAAMAAAGLASVLGGDARQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
VANAAEIAMEHHLGMTCDPIGGLVQIPCIERNAFGANKAVAAASLALHGDGVHFVSLDQV
HHHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCHHHHHHHEEEECCCEEEEEHHHH
IETMRQTGHDMQAKYKETSLGGLAVNVAAC
HHHHHHCCCHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MISAFDLFKIGIGPSSSHTIGPMVAARRFRDRVAGRPGLARVSAEIFGSLAWTGRGHGTD
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCH
VAIFLGLLGHEPATVDPDAVAGYTRSLAETGAIGLPGVAFDTTKDLLFNFTEVLPGHTNG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
MRFRAHDAGGAVLDEVVCYSVGGGFVEEEGAAETAGLDAVAVPYPFESGADLLRICAETG
EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCEEEECCCCCCCHHHHHHHHHCC
LTIPQVQMANERALRTEAEIEAGLDAVRDAMLACIARGLRMDGELPGGLKVRRRAKRLHE
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
TLDANRLTNSRPAHEIMDWISLFALAVNEENASGGRIVTAPTNGAAGIVPAVLRYIVDFC
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
PGWTETRGRDYLLAAAAIGGLIKRRASISGAEVGCQGEVGSAAAMAAAGLASVLGGDARQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
VANAAEIAMEHHLGMTCDPIGGLVQIPCIERNAFGANKAVAAASLALHGDGVHFVSLDQV
HHHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCHHHHHHHEEEECCCEEEEEHHHH
IETMRQTGHDMQAKYKETSLGGLAVNVAAC
HHHHHHCCCHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]