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The map label for this gene is aaeA [H]

Identifier: 170748822

GI number: 170748822

Start: 2563113

End: 2564039

Strand: Reverse

Name: aaeA [H]

Synonym: Mrad2831_2404

Alternate gene names: 170748822

Gene position: 2564039-2563113 (Counterclockwise)

Preceding gene: 170748823

Following gene: 170748821

Centisome position: 42.19

GC content: 73.25

Gene sequence:

>927_bases
ATGACCGCCCTGTTCTCCACCCTCGGCCGCCTCCTGGTCACCCTCGGCATGGTCGCCGCGGCGCTGATCGTCGGCCTCGG
CCTGTGGGACTACTACATGGACGCTCCCTGGACCCGGGACGGGCGCGTGCGCGCCGACGTGGTGGCGGTGGCCCCCGACG
TCTCCGGCCTCGTCACCGAGGTGCTGGTCGAGGACAATCAGGTCGTCCGGAAGGGCGACGTCCTGTTCCGGATCGATCCG
GACCGGTTCCGACTCGGGCTGCGGCAGGCGGAGGCGATGGTGCAGAACCGCAAGGCCACCGCCGAGCAGAACGCGGCCGA
CTACGCCCGCTACAGCAGGCTCTCCGACGCGGCGGTGTCGCAGCAGAAGGTCGAGGCCGCCAAGGCCGCCGACCTCTCCG
CGGAGGCCGCCTACGAGCAGGCCCTGGCGGATCGCGACCTCGCCAAGCTCAACCTGGAGCGCTCGGCGGTGCGCGCCTCG
GTCAACGGCCGGATCACCAACATGGAGCTGCGGCCGGGCGCCTACGTCACCACGGGCCGCGGAGTCATGGCGCTGATCGA
CAGCGATACCCTGCGGATCGAGGGCTACTTCGAGGAGACCAAGCTGCCGCGGATCCGCGTCGGCGCGCCGGTGACGGTCC
AGCTCATGGGCGAGGACGGGGTGCTCAGCGGCCGAGTCGCCAGCATCGCCGGCGGCATCGGCGAGTCGGGCCGCAGCGAC
GCCGCCAACCTGCTCGCGAACGTGAACCCGACCTTCTCGTGGGTGCGCCTCGCCCAGCGCATCCCGGTGCGGATCGCCCT
CGACGGCGGCACGGCGGATCCGCGGCTGGTGAGCGGCCGGACCGCGACGGTCTCGATCGCGCCGGCGGCCGGCGGGGCGG
CGCTGCGCTGGCCCTGGACGGGGTGGCGCGAGGCGCTCGCCCGCTGA

Upstream 100 bases:

>100_bases
CCGGCTTCTACCGCCTCGTCTGGCACAGGCCGCTCTTCGACCTCGCCCTCTACGTCGTCCTGCTCGGCGGCGTCGTGACC
CTCGCCCACCGGATCCTGCA

Downstream 100 bases:

>100_bases
AGGCGCCCGAACCATCCTGGCGCCCCCGAGTTGGCCTGACACGACAGCGCGACGTCAGCAGCGCACCGTCATGTCAGGAG
GTCCCATGTCGAAGACGATC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: pHBA efflux pump protein A [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTALFSTLGRLLVTLGMVAAALIVGLGLWDYYMDAPWTRDGRVRADVVAVAPDVSGLVTEVLVEDNQVVRKGDVLFRIDP
DRFRLGLRQAEAMVQNRKATAEQNAADYARYSRLSDAAVSQQKVEAAKAADLSAEAAYEQALADRDLAKLNLERSAVRAS
VNGRITNMELRPGAYVTTGRGVMALIDSDTLRIEGYFEETKLPRIRVGAPVTVQLMGEDGVLSGRVASIAGGIGESGRSD
AANLLANVNPTFSWVRLAQRIPVRIALDGGTADPRLVSGRTATVSIAPAAGGAALRWPWTGWREALAR

Sequences:

>Translated_308_residues
MTALFSTLGRLLVTLGMVAAALIVGLGLWDYYMDAPWTRDGRVRADVVAVAPDVSGLVTEVLVEDNQVVRKGDVLFRIDP
DRFRLGLRQAEAMVQNRKATAEQNAADYARYSRLSDAAVSQQKVEAAKAADLSAEAAYEQALADRDLAKLNLERSAVRAS
VNGRITNMELRPGAYVTTGRGVMALIDSDTLRIEGYFEETKLPRIRVGAPVTVQLMGEDGVLSGRVASIAGGIGESGRSD
AANLLANVNPTFSWVRLAQRIPVRIALDGGTADPRLVSGRTATVSIAPAAGGAALRWPWTGWREALAR
>Mature_307_residues
TALFSTLGRLLVTLGMVAAALIVGLGLWDYYMDAPWTRDGRVRADVVAVAPDVSGLVTEVLVEDNQVVRKGDVLFRIDPD
RFRLGLRQAEAMVQNRKATAEQNAADYARYSRLSDAAVSQQKVEAAKAADLSAEAAYEQALADRDLAKLNLERSAVRASV
NGRITNMELRPGAYVTTGRGVMALIDSDTLRIEGYFEETKLPRIRVGAPVTVQLMGEDGVLSGRVASIAGGIGESGRSDA
ANLLANVNPTFSWVRLAQRIPVRIALDGGTADPRLVSGRTATVSIAPAAGGAALRWPWTGWREALAR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789637, Length=288, Percent_Identity=38.1944444444444, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87081951, Length=277, Percent_Identity=36.4620938628159, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1790519, Length=309, Percent_Identity=31.0679611650485, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789041, Length=280, Percent_Identity=25.3571428571429, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788711, Length=308, Percent_Identity=26.6233766233766, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790012, Length=264, Percent_Identity=28.4090909090909, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790024, Length=270, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082036, Length=175, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022871
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 33033; Mature: 32902

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALFSTLGRLLVTLGMVAAALIVGLGLWDYYMDAPWTRDGRVRADVVAVAPDVSGLVTE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHH
VLVEDNQVVRKGDVLFRIDPDRFRLGLRQAEAMVQNRKATAEQNAADYARYSRLSDAAVS
HHHCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QQKVEAAKAADLSAEAAYEQALADRDLAKLNLERSAVRASVNGRITNMELRPGAYVTTGR
HHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECC
GVMALIDSDTLRIEGYFEETKLPRIRVGAPVTVQLMGEDGVLSGRVASIAGGIGESGRSD
CEEEEEECCEEEEEEEECCCCCCEEEECCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCH
AANLLANVNPTFSWVRLAQRIPVRIALDGGTADPRLVSGRTATVSIAPAAGGAALRWPWT
HHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCCCEEECCCEEEEEEECCCCCCEEECCCC
GWREALAR
HHHHHHCC
>Mature Secondary Structure 
TALFSTLGRLLVTLGMVAAALIVGLGLWDYYMDAPWTRDGRVRADVVAVAPDVSGLVTE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHH
VLVEDNQVVRKGDVLFRIDPDRFRLGLRQAEAMVQNRKATAEQNAADYARYSRLSDAAVS
HHHCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QQKVEAAKAADLSAEAAYEQALADRDLAKLNLERSAVRASVNGRITNMELRPGAYVTTGR
HHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECC
GVMALIDSDTLRIEGYFEETKLPRIRVGAPVTVQLMGEDGVLSGRVASIAGGIGESGRSD
CEEEEEECCEEEEEEEECCCCCCEEEECCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCH
AANLLANVNPTFSWVRLAQRIPVRIALDGGTADPRLVSGRTATVSIAPAAGGAALRWPWT
HHHHHHCCCCHHHHHHHHHHCCEEEEECCCCCCCEEECCCEEEEEEECCCCCCEEECCCC
GWREALAR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA