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The map label for this gene is barA [H]

Identifier: 170748811

GI number: 170748811

Start: 2546509

End: 2548539

Strand: Reverse

Name: barA [H]

Synonym: Mrad2831_2393

Alternate gene names: 170748811

Gene position: 2548539-2546509 (Counterclockwise)

Preceding gene: 170748814

Following gene: 170748810

Centisome position: 41.93

GC content: 75.63

Gene sequence:

>2031_bases
ATGATCGACACGATGGCGCCTGTCCTGGCGCTCCTGACAGCGGCCGCTCTGGCCTTCGGCCTCTGGCGCCTGCTCGGCAC
GCGGCGCGCCGAGCGCGAGGCCGAGCGGCTGCAGGACCGCATCTGGCGGATCAGCGAGAGCGAGGACCGCTACCGGGCCC
TGGTGGCCGCCACCACCGAGATCATCGTCCAGCGCGATGCCCGCGGACGCATCACCTACGCCAACGAGGATTTCGCCCGC
CTGCTCGGCCGCGAGCCGATCGCGCTGATCGGCTCCCGGGACGATCTCGAGATCCTCGACCGGAACGCCGTGGAGATCGG
GCCGGACGGGGTCCGCCGCCTGGAGGCGCAGGTCCGGACGGCGGACGGGCGGGCGCGCTGGTTCGCCTTCGTGGAGATGC
CGGTGGCGCACGGCGACGCGACGCACTGGCTGCGCGCGGGCCGGGACGTGACCGCGCGGGTCGAGGCGATCCGCAGCCGC
GACGCGGCCCTGGAGCGCGCCGAGGCGGCGAGCGTCGCGAAATCCCGCTTCCTCGCGACGGTGAGCCACGAGATGCGGAC
GCCGCTCAACGGCATCCTGGGCATGGCCGACCTCGTGCTCGGGACCGAGCTGAATCCGGAGCAGCGCACCTACGTTGAGG
CGGTCCGCACCAGCGGCCAGGCGCTGCTCGGCCTGATCGACGGGGTCCTCGACTTCTCGCGGATCGAGGCCGGGCGCCTC
GACCTCGCGGCCGAGCCCTTCGACCTGCCGGCGCTCTCCGAGGGGGTCGTCGAGCTGCTGGCGCCCCGCGCCCAGGACAA
GGGCATCGAGATCGCCCTCGACGTGGCCGAGGACTTCCCGGCCGCCGTGCTGGGCGATGCCGACCGGGTGCGGCAGATCC
TGATCAACCTCGCCGGCAACGCGATCAAGTTCACCGAGCGCGGCGGCGTCGGCGTCAGCCTGGGCTTCGCGCGGGCCGGG
ACCGGCGGCGAGGTCGTGCTCGCCGTGGCGGATACCGGCCCGGGCATCCCGGAGGAGAGGCTGCCGATCCTGTTCGAGGA
GTTCGAGCAGGGCGACGGCAGCGCGAGCCGCAGCCACGAGGGCACCGGCCTGGGGCTCGCCATCACGCGGCGGCTCGTGA
CCCGCATGGGCGGGCGGATCGAGGCGGACTCGCGCCTCGGGCGGGGCTCGACCTTCCGGGTCCTGCTGCCCCTCGCCGAG
GTCGCGGGGGCCGAGGGCGTCGGGCGCGCGCCGCTGCCGACGCTCGCCCCGCGGCGCTGCCTGATCGTCGCCGACTCCCC
GTTCCAGGCGCCCTACCTCGCCCGCAGCCTGTCCCGGGCCGGGGCCGCCACCGTCATCGTCGACAGCCTGGATTCGGGCC
TCGACGCCCTGTCGGGCGCGGCCTTCGACGCGGTGCTGGCCGACCGGGCTCTGGGCGACACGGCGGTGCGGCAGATCGCC
GACGCGGCGCGCGCCTGCGGGGTCCGCACCAGCCTCGTGCTCCTCTCGCCGTTCGACCGGCGCGGCTTCGGGGCCCCCGG
CGCGGCGGGTTTCGACGGCTACCTGATCAAGCCGGTCCGGCCGCGCTCCCTGTTCGAGCGCCTGCTCGCGTCGGCGGGCC
CGGTCGAGGCCGCGGCGGCCCCGCCGGCGGTGCCGCCGCGCGTCGGCAGCAGCCTTCGGGTCCTGCTGGCCGAGGACAAC
CCGATCAACGCCCTGCTGGCGACCCGGGCCCTGGAGCGGCTCGGCGCCACGGTGGTCCACGCCGCCGACGGCCTCGAGGC
CCTCGCGCGTCTGGAGACGGACGGCCCGTTCGACCTCGCGCTGATCGACGTGCGGATGCCCCGCCTCGACGGGCACGAGA
CCGCCCGGCGGATCCGCGCCGCCGAATCGGACGGGGCGCAGCGGCTCCACCTCGTCGCGCTGACCGCGAATGCCGGACGA
GAGGACGAGGCCGCCGCCCGGGCGGCCGGCTTCGACGGGTTCCTGGCCAAGCCGCTGAACCTGAAGCTGCTGCCGCCGCT
GCTGGAGCGGCAGTCCGCGCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGCAAAGTCCGCAACCGGCGGTTAAGGGCCTTTCCCAACGCCGCCTTCAGCTTCGGCTGCGATCCTGCCGCGAACCGGC
CCGACGCCGGGGAGGCCGGA

Downstream 100 bases:

>100_bases
GGGCGCGCGTTGACAGGCGGGCGGGTCCCGCGCCAACAGGACGCCCATGTCGACAGCCAGCCCACCGCCGCCCGCACCGC
GCTCGTCGAGCGGCGCGCTC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MIDTMAPVLALLTAAALAFGLWRLLGTRRAEREAERLQDRIWRISESEDRYRALVAATTEIIVQRDARGRITYANEDFAR
LLGREPIALIGSRDDLEILDRNAVEIGPDGVRRLEAQVRTADGRARWFAFVEMPVAHGDATHWLRAGRDVTARVEAIRSR
DAALERAEAASVAKSRFLATVSHEMRTPLNGILGMADLVLGTELNPEQRTYVEAVRTSGQALLGLIDGVLDFSRIEAGRL
DLAAEPFDLPALSEGVVELLAPRAQDKGIEIALDVAEDFPAAVLGDADRVRQILINLAGNAIKFTERGGVGVSLGFARAG
TGGEVVLAVADTGPGIPEERLPILFEEFEQGDGSASRSHEGTGLGLAITRRLVTRMGGRIEADSRLGRGSTFRVLLPLAE
VAGAEGVGRAPLPTLAPRRCLIVADSPFQAPYLARSLSRAGAATVIVDSLDSGLDALSGAAFDAVLADRALGDTAVRQIA
DAARACGVRTSLVLLSPFDRRGFGAPGAAGFDGYLIKPVRPRSLFERLLASAGPVEAAAAPPAVPPRVGSSLRVLLAEDN
PINALLATRALERLGATVVHAADGLEALARLETDGPFDLALIDVRMPRLDGHETARRIRAAESDGAQRLHLVALTANAGR
EDEAAARAAGFDGFLAKPLNLKLLPPLLERQSARAA

Sequences:

>Translated_676_residues
MIDTMAPVLALLTAAALAFGLWRLLGTRRAEREAERLQDRIWRISESEDRYRALVAATTEIIVQRDARGRITYANEDFAR
LLGREPIALIGSRDDLEILDRNAVEIGPDGVRRLEAQVRTADGRARWFAFVEMPVAHGDATHWLRAGRDVTARVEAIRSR
DAALERAEAASVAKSRFLATVSHEMRTPLNGILGMADLVLGTELNPEQRTYVEAVRTSGQALLGLIDGVLDFSRIEAGRL
DLAAEPFDLPALSEGVVELLAPRAQDKGIEIALDVAEDFPAAVLGDADRVRQILINLAGNAIKFTERGGVGVSLGFARAG
TGGEVVLAVADTGPGIPEERLPILFEEFEQGDGSASRSHEGTGLGLAITRRLVTRMGGRIEADSRLGRGSTFRVLLPLAE
VAGAEGVGRAPLPTLAPRRCLIVADSPFQAPYLARSLSRAGAATVIVDSLDSGLDALSGAAFDAVLADRALGDTAVRQIA
DAARACGVRTSLVLLSPFDRRGFGAPGAAGFDGYLIKPVRPRSLFERLLASAGPVEAAAAPPAVPPRVGSSLRVLLAEDN
PINALLATRALERLGATVVHAADGLEALARLETDGPFDLALIDVRMPRLDGHETARRIRAAESDGAQRLHLVALTANAGR
EDEAAARAAGFDGFLAKPLNLKLLPPLLERQSARAA
>Mature_676_residues
MIDTMAPVLALLTAAALAFGLWRLLGTRRAEREAERLQDRIWRISESEDRYRALVAATTEIIVQRDARGRITYANEDFAR
LLGREPIALIGSRDDLEILDRNAVEIGPDGVRRLEAQVRTADGRARWFAFVEMPVAHGDATHWLRAGRDVTARVEAIRSR
DAALERAEAASVAKSRFLATVSHEMRTPLNGILGMADLVLGTELNPEQRTYVEAVRTSGQALLGLIDGVLDFSRIEAGRL
DLAAEPFDLPALSEGVVELLAPRAQDKGIEIALDVAEDFPAAVLGDADRVRQILINLAGNAIKFTERGGVGVSLGFARAG
TGGEVVLAVADTGPGIPEERLPILFEEFEQGDGSASRSHEGTGLGLAITRRLVTRMGGRIEADSRLGRGSTFRVLLPLAE
VAGAEGVGRAPLPTLAPRRCLIVADSPFQAPYLARSLSRAGAATVIVDSLDSGLDALSGAAFDAVLADRALGDTAVRQIA
DAARACGVRTSLVLLSPFDRRGFGAPGAAGFDGYLIKPVRPRSLFERLLASAGPVEAAAAPPAVPPRVGSSLRVLLAEDN
PINALLATRALERLGATVVHAADGLEALARLETDGPFDLALIDVRMPRLDGHETARRIRAAESDGAQRLHLVALTANAGR
EDEAAARAAGFDGFLAKPLNLKLLPPLLERQSARAA

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=560, Percent_Identity=33.9285714285714, Blast_Score=251, Evalue=2e-67,
Organism=Escherichia coli, GI145693157, Length=535, Percent_Identity=31.588785046729, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI48994928, Length=360, Percent_Identity=34.7222222222222, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87081816, Length=398, Percent_Identity=35.929648241206, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1788713, Length=309, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=9e-43,
Organism=Escherichia coli, GI1786600, Length=266, Percent_Identity=31.203007518797, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=31.6176470588235, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=30.7017543859649, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=30.8016877637131, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=30, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=248, Percent_Identity=26.6129032258064, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=26.5917602996255, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=244, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=28.2700421940928, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=242, Percent_Identity=28.5123966942149, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=77, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71897; Mature: 71897

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTMAPVLALLTAAALAFGLWRLLGTRRAEREAERLQDRIWRISESEDRYRALVAATTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IIVQRDARGRITYANEDFARLLGREPIALIGSRDDLEILDRNAVEIGPDGVRRLEAQVRT
HHEEECCCCCEEECCCHHHHHHCCCCEEEECCCCCHHHHCCCCEEECCHHHHHHHHHHHC
ADGRARWFAFVEMPVAHGDATHWLRAGRDVTARVEAIRSRDAALERAEAASVAKSRFLAT
CCCCEEEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHEMRTPLNGILGMADLVLGTELNPEQRTYVEAVRTSGQALLGLIDGVLDFSRIEAGRL
HHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DLAAEPFDLPALSEGVVELLAPRAQDKGIEIALDVAEDFPAAVLGDADRVRQILINLAGN
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHCCC
AIKFTERGGVGVSLGFARAGTGGEVVLAVADTGPGIPEERLPILFEEFEQGDGSASRSHE
EEEEECCCCCEEEECCEECCCCCCEEEEEECCCCCCCHHHCCHHHHHHHCCCCCCCCCCC
GTGLGLAITRRLVTRMGGRIEADSRLGRGSTFRVLLPLAEVAGAEGVGRAPLPTLAPRRC
CCCHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCEE
LIVADSPFQAPYLARSLSRAGAATVIVDSLDSGLDALSGAAFDAVLADRALGDTAVRQIA
EEEECCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHH
DAARACGVRTSLVLLSPFDRRGFGAPGAAGFDGYLIKPVRPRSLFERLLASAGPVEAAAA
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
PPAVPPRVGSSLRVLLAEDNPINALLATRALERLGATVVHAADGLEALARLETDGPFDLA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEE
LIDVRMPRLDGHETARRIRAAESDGAQRLHLVALTANAGREDEAAARAAGFDGFLAKPLN
EEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCHHCCCCC
LKLLPPLLERQSARAA
CEECCHHHHHHCCCCC
>Mature Secondary Structure
MIDTMAPVLALLTAAALAFGLWRLLGTRRAEREAERLQDRIWRISESEDRYRALVAATTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IIVQRDARGRITYANEDFARLLGREPIALIGSRDDLEILDRNAVEIGPDGVRRLEAQVRT
HHEEECCCCCEEECCCHHHHHHCCCCEEEECCCCCHHHHCCCCEEECCHHHHHHHHHHHC
ADGRARWFAFVEMPVAHGDATHWLRAGRDVTARVEAIRSRDAALERAEAASVAKSRFLAT
CCCCEEEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHEMRTPLNGILGMADLVLGTELNPEQRTYVEAVRTSGQALLGLIDGVLDFSRIEAGRL
HHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DLAAEPFDLPALSEGVVELLAPRAQDKGIEIALDVAEDFPAAVLGDADRVRQILINLAGN
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHCCC
AIKFTERGGVGVSLGFARAGTGGEVVLAVADTGPGIPEERLPILFEEFEQGDGSASRSHE
EEEEECCCCCEEEECCEECCCCCCEEEEEECCCCCCCHHHCCHHHHHHHCCCCCCCCCCC
GTGLGLAITRRLVTRMGGRIEADSRLGRGSTFRVLLPLAEVAGAEGVGRAPLPTLAPRRC
CCCHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCEE
LIVADSPFQAPYLARSLSRAGAATVIVDSLDSGLDALSGAAFDAVLADRALGDTAVRQIA
EEEECCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHH
DAARACGVRTSLVLLSPFDRRGFGAPGAAGFDGYLIKPVRPRSLFERLLASAGPVEAAAA
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
PPAVPPRVGSSLRVLLAEDNPINALLATRALERLGATVVHAADGLEALARLETDGPFDLA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEE
LIDVRMPRLDGHETARRIRAAESDGAQRLHLVALTANAGREDEAAARAAGFDGFLAKPLN
EEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCHHCCCCC
LKLLPPLLERQSARAA
CEECCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]