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The map label for this gene is mmgB [H]

Identifier: 170748357

GI number: 170748357

Start: 2062566

End: 2063516

Strand: Reverse

Name: mmgB [H]

Synonym: Mrad2831_1939

Alternate gene names: 170748357

Gene position: 2063516-2062566 (Counterclockwise)

Preceding gene: 170748358

Following gene: 170748356

Centisome position: 33.95

GC content: 74.97

Gene sequence:

>951_bases
ATGGGCGAGATCGCGATCGTCGGCGGCGGCGTGATGGGGCACGGCATCGCCCTGGTGCTGGCGCTCGCCGGCCACGGCGT
GCGGCTCACCGACACGCGGCCCGAGACCCGCGCGCGGATCCCCGCCCTGATGGACTCGGCCCTCGCGACCCTGCGGGAGG
CCGGCGCCGCCCCGGAGGGCTGGGATGCCGCGCGGCTGGCCCGGGCCGTCCGGGTCGAGGCGGAGCTCGGCGCGGCGGTG
TCGGGCGCCGGTCTCGTGATCGAGGCGATCACCGAGGACCCGGAGGCCAAGGGCGCGCTCTTCTCCGAGCTCGACCGGCT
CTGCCCGGCCGACGCGGTCCTCGCCAGCAACACCAGCTACCTCGACGTCTTCCCGCTGATCCCGGAACGCCGGCAGGCGC
GGGCGCTGATCCTGCACTGGTACACGCCGCCCTACATCGTCGACCTGGTCGACGTGGTGCCGGGGCCCGGCACCGATCCG
GCGGTGATCGCCGCCATGGCCGAGTTCGTGCGCGGCCTCGGCCAGGTCCCGATCGTCCTGAAGCGCTTCATCCCCGGCTA
CGTCGCCAACCGCATCCAGCAGGCGATCAGCGCCGAGGTGTTCCGGCTCCTCGACGAGGGCGTGGCCGCGCCGCGGGACA
TCGACGACGCGATCGTCCACGGGCTCGCCCTGCGCATCCCGATCCTCGGCCACCTCGCCAAGGCCGACTTCACCGGCCTG
GAGCTGACGCAGCGGGCGCTCGCCAACGGCAGCTACGCGCCGCCGCCGCCGCGCACCCGGTCCGAGACCCTCGACGCCCT
CTGCGCCGCCGGCCGGACCGGGGTGATGGCGGGGCGCGGCTACTTCGACTGGGGCGGGCGCGCGCCCGAGGAGCTGTTCC
GCGAGCGCGACCGCAAGCTCCTGGCGCTCAAGGCGGCGATGGCCGGGATCGGCCGGATGGAGGGAACATGA

Upstream 100 bases:

>100_bases
GCCTTCATGATGCGCCGGGACCAGCGCGGCGGCTGAGGCCGGCGGGAAGACCCGAGGACTCCCGCGAGAGGAGCCCGGGA
CAGGGAGAGGAGCGTGCGGC

Downstream 100 bases:

>100_bases
TCGGAGCGGACCTGTCCGGGCGGCGCGTCCTCGTTACCGGGGCCTCCTCGGGCATCGGGCTCGCGACCGTCGCGATCTTC
GCCCGCAACGGCGCCGCGGT

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MGEIAIVGGGVMGHGIALVLALAGHGVRLTDTRPETRARIPALMDSALATLREAGAAPEGWDAARLARAVRVEAELGAAV
SGAGLVIEAITEDPEAKGALFSELDRLCPADAVLASNTSYLDVFPLIPERRQARALILHWYTPPYIVDLVDVVPGPGTDP
AVIAAMAEFVRGLGQVPIVLKRFIPGYVANRIQQAISAEVFRLLDEGVAAPRDIDDAIVHGLALRIPILGHLAKADFTGL
ELTQRALANGSYAPPPPRTRSETLDALCAAGRTGVMAGRGYFDWGGRAPEELFRERDRKLLALKAAMAGIGRMEGT

Sequences:

>Translated_316_residues
MGEIAIVGGGVMGHGIALVLALAGHGVRLTDTRPETRARIPALMDSALATLREAGAAPEGWDAARLARAVRVEAELGAAV
SGAGLVIEAITEDPEAKGALFSELDRLCPADAVLASNTSYLDVFPLIPERRQARALILHWYTPPYIVDLVDVVPGPGTDP
AVIAAMAEFVRGLGQVPIVLKRFIPGYVANRIQQAISAEVFRLLDEGVAAPRDIDDAIVHGLALRIPILGHLAKADFTGL
ELTQRALANGSYAPPPPRTRSETLDALCAAGRTGVMAGRGYFDWGGRAPEELFRERDRKLLALKAAMAGIGRMEGT
>Mature_315_residues
GEIAIVGGGVMGHGIALVLALAGHGVRLTDTRPETRARIPALMDSALATLREAGAAPEGWDAARLARAVRVEAELGAAVS
GAGLVIEAITEDPEAKGALFSELDRLCPADAVLASNTSYLDVFPLIPERRQARALILHWYTPPYIVDLVDVVPGPGTDPA
VIAAMAEFVRGLGQVPIVLKRFIPGYVANRIQQAISAEVFRLLDEGVAAPRDIDDAIVHGLALRIPILGHLAKADFTGLE
LTQRALANGSYAPPPPRTRSETLDALCAAGRTGVMAGRGYFDWGGRAPEELFRERDRKLLALKAAMAGIGRMEGT

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=28.2758620689655, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI115430219, Length=234, Percent_Identity=29.4871794871795, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=26.7100977198697, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI68989263, Length=299, Percent_Identity=26.0869565217391, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=26.0869565217391, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1787661, Length=288, Percent_Identity=30.9027777777778, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788682, Length=209, Percent_Identity=28.2296650717703, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790281, Length=216, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=27.8350515463918, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=299, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=301, Percent_Identity=22.5913621262458, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=26.027397260274, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985930, Length=306, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=307, Percent_Identity=26.0586319218241, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=307, Percent_Identity=26.0586319218241, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=307, Percent_Identity=26.0586319218241, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI115533614, Length=194, Percent_Identity=28.3505154639175, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193203623, Length=168, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=294, Percent_Identity=25.5102040816327, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129993, Length=238, Percent_Identity=33.6134453781513, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=32.0675105485232, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24583077, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583079, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921000, Length=305, Percent_Identity=25.5737704918033, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33429; Mature: 33298

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEIAIVGGGVMGHGIALVLALAGHGVRLTDTRPETRARIPALMDSALATLREAGAAPEG
CCCEEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
WDAARLARAVRVEAELGAAVSGAGLVIEAITEDPEAKGALFSELDRLCPADAVLASNTSY
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCE
LDVFPLIPERRQARALILHWYTPPYIVDLVDVVPGPGTDPAVIAAMAEFVRGLGQVPIVL
EEEECCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHH
KRFIPGYVANRIQQAISAEVFRLLDEGVAAPRDIDDAIVHGLALRIPILGHLAKADFTGL
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELTQRALANGSYAPPPPRTRSETLDALCAAGRTGVMAGRGYFDWGGRAPEELFRERDRKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
LALKAAMAGIGRMEGT
HHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GEIAIVGGGVMGHGIALVLALAGHGVRLTDTRPETRARIPALMDSALATLREAGAAPEG
CCEEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
WDAARLARAVRVEAELGAAVSGAGLVIEAITEDPEAKGALFSELDRLCPADAVLASNTSY
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCE
LDVFPLIPERRQARALILHWYTPPYIVDLVDVVPGPGTDPAVIAAMAEFVRGLGQVPIVL
EEEECCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHH
KRFIPGYVANRIQQAISAEVFRLLDEGVAAPRDIDDAIVHGLALRIPILGHLAKADFTGL
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELTQRALANGSYAPPPPRTRSETLDALCAAGRTGVMAGRGYFDWGGRAPEELFRERDRKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
LALKAAMAGIGRMEGT
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]