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The map label for this gene is thrS [H]

Identifier: 170748342

GI number: 170748342

Start: 2041671

End: 2043698

Strand: Reverse

Name: thrS [H]

Synonym: Mrad2831_1924

Alternate gene names: 170748342

Gene position: 2043698-2041671 (Counterclockwise)

Preceding gene: 170748344

Following gene: 170748341

Centisome position: 33.63

GC content: 69.87

Gene sequence:

>2028_bases
ATGCCGATTCTCACCTTCCCCGACGGCAACACGCGGGAGATCGCCGCCGGCACCACCGGCCGCGCCGTGGTCGAGGGCAT
CGCCAAGTCGCTGGCCAAGCGCACCGTCGCCATGGCGCTCGACGGCACGGTCGCCGACCTCGACGACCCGATCGACCGCG
ATGCCCGCATCGAGTTCCTGGACCGCACCGACCCGCGCAGCCTGGAGCTGATCCGCCACGACTGCGCGCACGTGCTCGCC
GAGGCCGTGCAGGCGCTCTGGCCGGAGACGCAGGTCACGATCGGCCCGGTGATCGAGAACGGCTTCTACTACGACTTCCA
CCGCGAGACCCCGTTCACGCCCGAGGACTTCCCGAAGATCGAGGCGAAGATGCGCGAGATCATCGCGCGCGACGCGCCCT
TCACCAAGGAGGTCTGGACGCGCGACGACGTGCGCGGCCTGTTCGCCGGCAAGGGTGAGGGCTTCAAGGTCGAGCTGGTC
GACGCGATCCCGCCGGGCGAGGACCTGAAGATCTACCGCCAGGGCGACTGGTTCGACCTCTGCCGCGGCCCGCACATGAC
CTCGACCGGCAAGGTCGGCACGGCCTTCAAGCTGATGAAGGTCGCGGGCGCTTACTGGCGGGGTGATTCGAACAACCCGA
TGCTGACCCGCATCTACGGGACGGCCTGGGCGAACCAGGCCGACCTCGACGATTACCTGCACCGGCTGGAGGAGGCCGAG
CGCCGCGACCACCGCCGGCTCGGCCGCGAGATGGACCTGTTCCACTTCCAGGAGGAGGGCCCGGGCGTCGTCTTCTGGCA
CGCCAAGGGCTGGACGATCTTCCAGGAGCTGATCGCCTACATGCGCCGGCGCCTGCGCGGCGACTACGCCGAGGTGAACG
CCCCGCAGATCCTCGACAAGGCCCTGTGGGAGACCTCCGGCCACTGGGGGTGGTACCGGGAGAACATGTTCGCCGCGCAG
TCCGCGGGCGAGGAGGCCGAGGACAAGCGCTGGTTCGCCCTCAAGCCGATGAACTGCCCGGGCCACGTGCAGATCTTCAA
GCACGGCCTGAAATCCTACCGCGACCTGCCCCTGCGCATGGCCGAGTTCGGCATCGTCCACCGCTACGAGCCGTCCGGCG
CCATGCACGGGCTGATGCGCGTGCGCGGCTTCACGCAGGACGACGCCCACGTCTTCTGCACCGAGGACCAGCTCGCCGAC
GAGTGCCTGAAGATCAACGACCTGATCCTCTCGACCTACGCGGATTTCGGCTTCGACCAGATCGTCGTGAAGCTCTCGAC
GCGGCCCGAGAAGCGCGTCGGCTCCGACGCCCTCTGGGACCACGCCGAGGACGTGATGACCCGCGTGCTGGCGCAGATCG
AGGAGCAGTCCGGCGGGCGGATCCGGACCGCGGTCAACCCGGGGGAGGGCGCGTTCTACGGGCCCAAATTCGAGTACGTG
CTGCGCGACGCCATCGGCCGCGACTGGCAGTGCGGGACCACGCAGGTGGATTTCAACCTGCCCGAGCGGTTCGGCGCCTT
CTACATCGACGCCGACGGCGCCCGGAAGCCGCCCGTCATGGTCCACCGGGCGATCTGCGGCTCGATGGAGCGCTTCACCG
GCATCCTGATCGAGCACTTCGCCGGGCACTTCCCCCTGTGGCTGGCGCCGGTCCAGGTCGTGGTGGCGACGATCACCGGC
GAGGCCGACGCCTACGCCCGGGACGTCATCCGCACCCTGGAGCGCGCGGGCCTGCGGGTCGAGGCGGATCTGCGCAACGA
GAAGATCAACTACAAGGTCCGCGAGCACTCGCTGGCCAAGGTGCCGGTGCTGCTGGCGCTCGGCCGCCGCGAGGCGGAGG
AGCGGACGGTCTCGATCCGGCGGCTCGGCAGCCAGCAGACCCGCACGCTGCCGCTGACCGAGGCCGTGGCGGCCTTCGTG
GAGGAGGCGACCGCGCCGGATATCCGCCGCGCCGAGGCGGTCGCCGCGACGGTCCCGACCAGCGACACGGTGCTCGACGC
CCACCACGACCGGCACGACGCGCCCTGA

Upstream 100 bases:

>100_bases
CACCGTTGTTCCCTCGCCCGAGAAATCGGTCTACACGGCCGCTCCCTCGAAATCGCTTACCTGCCCCGTATGCAGGACTG
AGCCCGGAGACGCGCGCACC

Downstream 100 bases:

>100_bases
CGGGGCCTCCGGAAGACGTCGTCCCGGCGCCGCGCGGCGGCGCCCGGGACGACAGCGCGGATCCACCGCGTCGAGGCCGG
GTTCGAGCCGGCGACCGACA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MPILTFPDGNTREIAAGTTGRAVVEGIAKSLAKRTVAMALDGTVADLDDPIDRDARIEFLDRTDPRSLELIRHDCAHVLA
EAVQALWPETQVTIGPVIENGFYYDFHRETPFTPEDFPKIEAKMREIIARDAPFTKEVWTRDDVRGLFAGKGEGFKVELV
DAIPPGEDLKIYRQGDWFDLCRGPHMTSTGKVGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWANQADLDDYLHRLEEAE
RRDHRRLGREMDLFHFQEEGPGVVFWHAKGWTIFQELIAYMRRRLRGDYAEVNAPQILDKALWETSGHWGWYRENMFAAQ
SAGEEAEDKRWFALKPMNCPGHVQIFKHGLKSYRDLPLRMAEFGIVHRYEPSGAMHGLMRVRGFTQDDAHVFCTEDQLAD
ECLKINDLILSTYADFGFDQIVVKLSTRPEKRVGSDALWDHAEDVMTRVLAQIEEQSGGRIRTAVNPGEGAFYGPKFEYV
LRDAIGRDWQCGTTQVDFNLPERFGAFYIDADGARKPPVMVHRAICGSMERFTGILIEHFAGHFPLWLAPVQVVVATITG
EADAYARDVIRTLERAGLRVEADLRNEKINYKVREHSLAKVPVLLALGRREAEERTVSIRRLGSQQTRTLPLTEAVAAFV
EEATAPDIRRAEAVAATVPTSDTVLDAHHDRHDAP

Sequences:

>Translated_675_residues
MPILTFPDGNTREIAAGTTGRAVVEGIAKSLAKRTVAMALDGTVADLDDPIDRDARIEFLDRTDPRSLELIRHDCAHVLA
EAVQALWPETQVTIGPVIENGFYYDFHRETPFTPEDFPKIEAKMREIIARDAPFTKEVWTRDDVRGLFAGKGEGFKVELV
DAIPPGEDLKIYRQGDWFDLCRGPHMTSTGKVGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWANQADLDDYLHRLEEAE
RRDHRRLGREMDLFHFQEEGPGVVFWHAKGWTIFQELIAYMRRRLRGDYAEVNAPQILDKALWETSGHWGWYRENMFAAQ
SAGEEAEDKRWFALKPMNCPGHVQIFKHGLKSYRDLPLRMAEFGIVHRYEPSGAMHGLMRVRGFTQDDAHVFCTEDQLAD
ECLKINDLILSTYADFGFDQIVVKLSTRPEKRVGSDALWDHAEDVMTRVLAQIEEQSGGRIRTAVNPGEGAFYGPKFEYV
LRDAIGRDWQCGTTQVDFNLPERFGAFYIDADGARKPPVMVHRAICGSMERFTGILIEHFAGHFPLWLAPVQVVVATITG
EADAYARDVIRTLERAGLRVEADLRNEKINYKVREHSLAKVPVLLALGRREAEERTVSIRRLGSQQTRTLPLTEAVAAFV
EEATAPDIRRAEAVAATVPTSDTVLDAHHDRHDAP
>Mature_674_residues
PILTFPDGNTREIAAGTTGRAVVEGIAKSLAKRTVAMALDGTVADLDDPIDRDARIEFLDRTDPRSLELIRHDCAHVLAE
AVQALWPETQVTIGPVIENGFYYDFHRETPFTPEDFPKIEAKMREIIARDAPFTKEVWTRDDVRGLFAGKGEGFKVELVD
AIPPGEDLKIYRQGDWFDLCRGPHMTSTGKVGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWANQADLDDYLHRLEEAER
RDHRRLGREMDLFHFQEEGPGVVFWHAKGWTIFQELIAYMRRRLRGDYAEVNAPQILDKALWETSGHWGWYRENMFAAQS
AGEEAEDKRWFALKPMNCPGHVQIFKHGLKSYRDLPLRMAEFGIVHRYEPSGAMHGLMRVRGFTQDDAHVFCTEDQLADE
CLKINDLILSTYADFGFDQIVVKLSTRPEKRVGSDALWDHAEDVMTRVLAQIEEQSGGRIRTAVNPGEGAFYGPKFEYVL
RDAIGRDWQCGTTQVDFNLPERFGAFYIDADGARKPPVMVHRAICGSMERFTGILIEHFAGHFPLWLAPVQVVVATITGE
ADAYARDVIRTLERAGLRVEADLRNEKINYKVREHSLAKVPVLLALGRREAEERTVSIRRLGSQQTRTLPLTEAVAAFVE
EATAPDIRRAEAVAATVPTSDTVLDAHHDRHDAP

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=625, Percent_Identity=39.36, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI38570111, Length=623, Percent_Identity=36.7576243980738, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI20070344, Length=655, Percent_Identity=36.9465648854962, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1788013, Length=654, Percent_Identity=48.4709480122324, Blast_Score=661, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=644, Percent_Identity=38.6645962732919, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71984192, Length=644, Percent_Identity=38.6645962732919, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322112, Length=675, Percent_Identity=37.6296296296296, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=425, Percent_Identity=34.3529411764706, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24583842, Length=624, Percent_Identity=38.9423076923077, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28574141, Length=624, Percent_Identity=38.9423076923077, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583839, Length=624, Percent_Identity=38.9423076923077, Blast_Score=441, Evalue=1e-123,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 76317; Mature: 76186

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILTFPDGNTREIAAGTTGRAVVEGIAKSLAKRTVAMALDGTVADLDDPIDRDARIEFL
CCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEE
DRTDPRSLELIRHDCAHVLAEAVQALWPETQVTIGPVIENGFYYDFHRETPFTPEDFPKI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHH
EAKMREIIARDAPFTKEVWTRDDVRGLFAGKGEGFKVELVDAIPPGEDLKIYRQGDWFDL
HHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCHHHH
CRGPHMTSTGKVGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWANQADLDDYLHRLEEAE
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
RRDHRRLGREMDLFHFQEEGPGVVFWHAKGWTIFQELIAYMRRRLRGDYAEVNAPQILDK
HHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHH
ALWETSGHWGWYRENMFAAQSAGEEAEDKRWFALKPMNCPGHVQIFKHGLKSYRDLPLRM
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHH
AEFGIVHRYEPSGAMHGLMRVRGFTQDDAHVFCTEDQLADECLKINDLILSTYADFGFDQ
HHHCCEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEE
IVVKLSTRPEKRVGSDALWDHAEDVMTRVLAQIEEQSGGRIRTAVNPGEGAFYGPKFEYV
EEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
LRDAIGRDWQCGTTQVDFNLPERFGAFYIDADGARKPPVMVHRAICGSMERFTGILIEHF
HHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
AGHFPLWLAPVQVVVATITGEADAYARDVIRTLERAGLRVEADLRNEKINYKVREHSLAK
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCHHH
VPVLLALGRREAEERTVSIRRLGSQQTRTLPLTEAVAAFVEEATAPDIRRAEAVAATVPT
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEEECCC
SDTVLDAHHDRHDAP
CCCEECCCCCCCCCC
>Mature Secondary Structure 
PILTFPDGNTREIAAGTTGRAVVEGIAKSLAKRTVAMALDGTVADLDDPIDRDARIEFL
CEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEE
DRTDPRSLELIRHDCAHVLAEAVQALWPETQVTIGPVIENGFYYDFHRETPFTPEDFPKI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHH
EAKMREIIARDAPFTKEVWTRDDVRGLFAGKGEGFKVELVDAIPPGEDLKIYRQGDWFDL
HHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCHHHH
CRGPHMTSTGKVGTAFKLMKVAGAYWRGDSNNPMLTRIYGTAWANQADLDDYLHRLEEAE
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
RRDHRRLGREMDLFHFQEEGPGVVFWHAKGWTIFQELIAYMRRRLRGDYAEVNAPQILDK
HHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHH
ALWETSGHWGWYRENMFAAQSAGEEAEDKRWFALKPMNCPGHVQIFKHGLKSYRDLPLRM
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHH
AEFGIVHRYEPSGAMHGLMRVRGFTQDDAHVFCTEDQLADECLKINDLILSTYADFGFDQ
HHHCCEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEE
IVVKLSTRPEKRVGSDALWDHAEDVMTRVLAQIEEQSGGRIRTAVNPGEGAFYGPKFEYV
EEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHH
LRDAIGRDWQCGTTQVDFNLPERFGAFYIDADGARKPPVMVHRAICGSMERFTGILIEHF
HHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
AGHFPLWLAPVQVVVATITGEADAYARDVIRTLERAGLRVEADLRNEKINYKVREHSLAK
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCHHH
VPVLLALGRREAEERTVSIRRLGSQQTRTLPLTEAVAAFVEEATAPDIRRAEAVAATVPT
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEEECCC
SDTVLDAHHDRHDAP
CCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA