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The map label for this gene is rsh [H]

Identifier: 170748312

GI number: 170748312

Start: 2020656

End: 2022917

Strand: Reverse

Name: rsh [H]

Synonym: Mrad2831_1894

Alternate gene names: 170748312

Gene position: 2022917-2020656 (Counterclockwise)

Preceding gene: 170748313

Following gene: 170748311

Centisome position: 33.28

GC content: 70.87

Gene sequence:

>2262_bases
ATGATGCGCCAGTACGAGCTCGTCGAGCGGGTCAAGCGCTACAACCCGGCCGCCGACGAGGCGCTGCTCAACCGCGCCTA
CGTGTACGCCATGCAGGCGCACGGCACGCAGAAGCGCGCCTCGGGCGACCCCTTCTTCGCCCATCCCCTCGAGGTCGCGG
CGATCCTGACGGATCTCCACCTCGACGACGCCACCATCGTGGCCGCGGTCCTGCACGACACCGTCGAGGACACCGAGGCG
ACGCTGGAGGAGATCCGCCGGCTGTTCGGCCCGGAGATCGGCGCCCTGGTCGACGGCCTGACCAAGCTCAAGCGCCTCGA
CCTCGTCTCCAAGCAGGCCGCGCAGGGCGAGAACTTCCGCAAGCTGCTGCTCGCGGTCGCGGCGGATGTCCGCGTGCTGC
TGGTCAAGCTCGCCGACCGCCTGCACAACATGCGCACCCTCCAGCACATGCGCGACGACAAGCGTCGCCGCATCGCGCAG
GAGACGCTCGACATCTACGCGCCGCTCGCCGGCCGCATGGGCATGCAGGAGCTGCGCGAGGAGCTGGAGGACCTGGCCTT
CCGCAACCTGGAGCCGGAGGTCTACGCCACCATCACGCAGCGCCTGACGCGCCTCTCCGCCAAGTCCGAGAGCGTGGTCG
AGACCATCGCGCAGGTGCTCACCGAGAAGCTCGGCGCGCAGGGGATCACCGCCGAGGTCAGCGGCCGGCAGAAGCGCCCG
TTCTCGATCTGGTCGAAGATGGAGCGCAAGTCCGTCGCCTTCGAGCAGCTCTCCGACATCTTCGGCTTCCGCGTGGTCGT
CGACACCGTGCAGGACTGCTACGCGGCTCTGGGCATCGTCCACACCAGCTGGCCGATGGTGCCGGGCCGGTACAAGGACT
ACATCTCGACCCCGAAGCAGAACGATTACCGCTCGATCCACACCACGGTGATCGGGCCGAAGAGCCAGCGCGTCGAGCTG
CAGATCCGCACCCGCGCCATGGACGACATCGCCGAGTACGGCATCGCGGCCCACGCGCAGTACAAGGAAGTCGGCGCCGA
GCTGGTCAAGGACCCGGCCCGCGCCGAGGGCAGCGTGCATCCCCGGCTCGCCGCCGAGAGCGGTGCCTACCAGTGGCTGC
GCCGGACCATCGAGCTCCTCGCCGAGGGCGACAGCCCCGAGGAGTTCTTGGAGCACACCAAGCTGGAGCTGTTCCAGGAC
CAGGTGTTCTGCTTCACCCCGAAGGGCCGGCTGATCGCCCTGCCGCGGGGCGCGACGCCGATCGACTTCGCCTACGCGGT
CCACACCGACGTGGGCAACACCGCGGTGGGCGCCAAGATCAACGGCCGGATGGCGCCGCTCCTGCACGAGCTCGCCAACG
GCGACGAGGTCGAGATCAGCCGCTCCGACGGCGCCTCGCCCCCGGCGGCCTGGGAATCCCTCGTGGTGACCGGCAAGGCC
CGCGCGGCGATCCGGCGGGCGACCCGCACCGCCGTGCGCCGGCAATATGCCGGCCTCGGCCGCCAGATCCTGGACCGGGC
GTTCGAGCGCGCCGCCAAGACCTTCTCGGAGGACAAGCTCCGGGGCGCCCTGCCGCGGCTCGCCCGCGCCACCACCGAGG
ACGTCTTCGCCGCCGTGGGGCGGGGCGAGATGTTCTCGGGCGACGTCGTCCGCGCCGTGTATCCCGACCACCGCGACGAG
CGCCGGCCCTCCGCCGCGCAGGGCGCCGCCAGCGGCGCGGGCCGGCTCGTGCGCTCCTCCGACCAGACCATGCGGCTGAC
CTTCCCGGGGGCCGAGGGCGGCAAGGAGGGGGAGGACGCGGATCGCAGCGACGCCATCCCGATCCGGGGCCTCGCGGGCG
ACCTGCCGGTGACCTTCGCGCCGAACGGCGGCGCGGTCCCGGGCGACCGGATCGTCGGCATCCTGACTCCCGGCGTCGGC
GTGACCGTCTACCCGATCCAGTCGGCGGCGCTCGCGGCCTTCGACAACGAGCCGGAGCGCTGGCTCGACGTCCGCTGGGA
CACGGAGGCGCTCGGCGGCGAGCGCTTCCCGGCCCGGCTGGCGCTCAAGTCGATCAACGAGCCCGGGGTGTTCGCCCAGA
TCGCCCAGGTGATCGCCGACCACGACGGCAACATCGACAACATCTCGATGAAGCGGCGCACCCAGGACTTCACCGACATC
ACCATCGACCTGTCGGTCTGGGATCTCCAGCATCTCAACGCGATCATCGCCGAGCTGCGCGGCAAGCGCCCGGTCAACAG
CGTGGAGCGCGTGAACGGCTGA

Upstream 100 bases:

>100_bases
CGCGCCGCCGGAGGCCGGCGCCGTCCCGGCCGTCGCGGAACAACCGCGCGTGATCCCGGCCCCGCGCACCGCCCCGGACG
CGCCGGCGCCGTCCCGGCGG

Downstream 100 bases:

>100_bases
GGCCGAGAGTCGCGGGGCCCGGTGGATCTGAGGTTTACAGGATCAACTTCCGTAAACCGTCTTCTTCATGATGAATCCCT
GGCGCGGCCAATTATTCCCG

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MMRQYELVERVKRYNPAADEALLNRAYVYAMQAHGTQKRASGDPFFAHPLEVAAILTDLHLDDATIVAAVLHDTVEDTEA
TLEEIRRLFGPEIGALVDGLTKLKRLDLVSKQAAQGENFRKLLLAVAADVRVLLVKLADRLHNMRTLQHMRDDKRRRIAQ
ETLDIYAPLAGRMGMQELREELEDLAFRNLEPEVYATITQRLTRLSAKSESVVETIAQVLTEKLGAQGITAEVSGRQKRP
FSIWSKMERKSVAFEQLSDIFGFRVVVDTVQDCYAALGIVHTSWPMVPGRYKDYISTPKQNDYRSIHTTVIGPKSQRVEL
QIRTRAMDDIAEYGIAAHAQYKEVGAELVKDPARAEGSVHPRLAAESGAYQWLRRTIELLAEGDSPEEFLEHTKLELFQD
QVFCFTPKGRLIALPRGATPIDFAYAVHTDVGNTAVGAKINGRMAPLLHELANGDEVEISRSDGASPPAAWESLVVTGKA
RAAIRRATRTAVRRQYAGLGRQILDRAFERAAKTFSEDKLRGALPRLARATTEDVFAAVGRGEMFSGDVVRAVYPDHRDE
RRPSAAQGAASGAGRLVRSSDQTMRLTFPGAEGGKEGEDADRSDAIPIRGLAGDLPVTFAPNGGAVPGDRIVGILTPGVG
VTVYPIQSAALAAFDNEPERWLDVRWDTEALGGERFPARLALKSINEPGVFAQIAQVIADHDGNIDNISMKRRTQDFTDI
TIDLSVWDLQHLNAIIAELRGKRPVNSVERVNG

Sequences:

>Translated_753_residues
MMRQYELVERVKRYNPAADEALLNRAYVYAMQAHGTQKRASGDPFFAHPLEVAAILTDLHLDDATIVAAVLHDTVEDTEA
TLEEIRRLFGPEIGALVDGLTKLKRLDLVSKQAAQGENFRKLLLAVAADVRVLLVKLADRLHNMRTLQHMRDDKRRRIAQ
ETLDIYAPLAGRMGMQELREELEDLAFRNLEPEVYATITQRLTRLSAKSESVVETIAQVLTEKLGAQGITAEVSGRQKRP
FSIWSKMERKSVAFEQLSDIFGFRVVVDTVQDCYAALGIVHTSWPMVPGRYKDYISTPKQNDYRSIHTTVIGPKSQRVEL
QIRTRAMDDIAEYGIAAHAQYKEVGAELVKDPARAEGSVHPRLAAESGAYQWLRRTIELLAEGDSPEEFLEHTKLELFQD
QVFCFTPKGRLIALPRGATPIDFAYAVHTDVGNTAVGAKINGRMAPLLHELANGDEVEISRSDGASPPAAWESLVVTGKA
RAAIRRATRTAVRRQYAGLGRQILDRAFERAAKTFSEDKLRGALPRLARATTEDVFAAVGRGEMFSGDVVRAVYPDHRDE
RRPSAAQGAASGAGRLVRSSDQTMRLTFPGAEGGKEGEDADRSDAIPIRGLAGDLPVTFAPNGGAVPGDRIVGILTPGVG
VTVYPIQSAALAAFDNEPERWLDVRWDTEALGGERFPARLALKSINEPGVFAQIAQVIADHDGNIDNISMKRRTQDFTDI
TIDLSVWDLQHLNAIIAELRGKRPVNSVERVNG
>Mature_753_residues
MMRQYELVERVKRYNPAADEALLNRAYVYAMQAHGTQKRASGDPFFAHPLEVAAILTDLHLDDATIVAAVLHDTVEDTEA
TLEEIRRLFGPEIGALVDGLTKLKRLDLVSKQAAQGENFRKLLLAVAADVRVLLVKLADRLHNMRTLQHMRDDKRRRIAQ
ETLDIYAPLAGRMGMQELREELEDLAFRNLEPEVYATITQRLTRLSAKSESVVETIAQVLTEKLGAQGITAEVSGRQKRP
FSIWSKMERKSVAFEQLSDIFGFRVVVDTVQDCYAALGIVHTSWPMVPGRYKDYISTPKQNDYRSIHTTVIGPKSQRVEL
QIRTRAMDDIAEYGIAAHAQYKEVGAELVKDPARAEGSVHPRLAAESGAYQWLRRTIELLAEGDSPEEFLEHTKLELFQD
QVFCFTPKGRLIALPRGATPIDFAYAVHTDVGNTAVGAKINGRMAPLLHELANGDEVEISRSDGASPPAAWESLVVTGKA
RAAIRRATRTAVRRQYAGLGRQILDRAFERAAKTFSEDKLRGALPRLARATTEDVFAAVGRGEMFSGDVVRAVYPDHRDE
RRPSAAQGAASGAGRLVRSSDQTMRLTFPGAEGGKEGEDADRSDAIPIRGLAGDLPVTFAPNGGAVPGDRIVGILTPGVG
VTVYPIQSAALAAFDNEPERWLDVRWDTEALGGERFPARLALKSINEPGVFAQIAQVIADHDGNIDNISMKRRTQDFTDI
TIDLSVWDLQHLNAIIAELRGKRPVNSVERVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=134, Percent_Identity=37.3134328358209, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790082, Length=736, Percent_Identity=37.2282608695652, Blast_Score=492, Evalue=1e-140,
Organism=Escherichia coli, GI1789147, Length=744, Percent_Identity=31.5860215053763, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=38.8059701492537, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=37.0967741935484, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83126; Mature: 83126

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVKRYNPAADEALLNRAYVYAMQAHGTQKRASGDPFFAHPLEVAAILTDLH
CCCHHHHHHHHHHCCCHHHHHHHHHHHHEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDDATIVAAVLHDTVEDTEATLEEIRRLFGPEIGALVDGLTKLKRLDLVSKQAAQGENFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KLLLAVAADVRVLLVKLADRLHNMRTLQHMRDDKRRRIAQETLDIYAPLAGRMGMQELRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEDLAFRNLEPEVYATITQRLTRLSAKSESVVETIAQVLTEKLGAQGITAEVSGRQKRP
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
FSIWSKMERKSVAFEQLSDIFGFRVVVDTVQDCYAALGIVHTSWPMVPGRYKDYISTPKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC
NDYRSIHTTVIGPKSQRVELQIRTRAMDDIAEYGIAAHAQYKEVGAELVKDPARAEGSVH
CCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCCCC
PRLAAESGAYQWLRRTIELLAEGDSPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATP
CCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCC
IDFAYAVHTDVGNTAVGAKINGRMAPLLHELANGDEVEISRSDGASPPAAWESLVVTGKA
CEEEEEEECCCCCCEECCEECCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHEEECHH
RAAIRRATRTAVRRQYAGLGRQILDRAFERAAKTFSEDKLRGALPRLARATTEDVFAAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGEMFSGDVVRAVYPDHRDERRPSAAQGAASGAGRLVRSSDQTMRLTFPGAEGGKEGEDA
CCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCHHEECCCCEEEEEECCCCCCCCCCCC
DRSDAIPIRGLAGDLPVTFAPNGGAVPGDRIVGILTPGVGVTVYPIQSAALAAFDNEPER
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCCCCCC
WLDVRWDTEALGGERFPARLALKSINEPGVFAQIAQVIADHDGNIDNISMKRRTQDFTDI
EEEEEECHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEHHHHCCCCCEE
TIDLSVWDLQHLNAIIAELRGKRPVNSVERVNG
EEEEEHHHHHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MMRQYELVERVKRYNPAADEALLNRAYVYAMQAHGTQKRASGDPFFAHPLEVAAILTDLH
CCCHHHHHHHHHHCCCHHHHHHHHHHHHEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDDATIVAAVLHDTVEDTEATLEEIRRLFGPEIGALVDGLTKLKRLDLVSKQAAQGENFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KLLLAVAADVRVLLVKLADRLHNMRTLQHMRDDKRRRIAQETLDIYAPLAGRMGMQELRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEDLAFRNLEPEVYATITQRLTRLSAKSESVVETIAQVLTEKLGAQGITAEVSGRQKRP
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
FSIWSKMERKSVAFEQLSDIFGFRVVVDTVQDCYAALGIVHTSWPMVPGRYKDYISTPKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC
NDYRSIHTTVIGPKSQRVELQIRTRAMDDIAEYGIAAHAQYKEVGAELVKDPARAEGSVH
CCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHCCCCCC
PRLAAESGAYQWLRRTIELLAEGDSPEEFLEHTKLELFQDQVFCFTPKGRLIALPRGATP
CCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEECCCCCC
IDFAYAVHTDVGNTAVGAKINGRMAPLLHELANGDEVEISRSDGASPPAAWESLVVTGKA
CEEEEEEECCCCCCEECCEECCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHEEECHH
RAAIRRATRTAVRRQYAGLGRQILDRAFERAAKTFSEDKLRGALPRLARATTEDVFAAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGEMFSGDVVRAVYPDHRDERRPSAAQGAASGAGRLVRSSDQTMRLTFPGAEGGKEGEDA
CCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCHHEECCCCEEEEEECCCCCCCCCCCC
DRSDAIPIRGLAGDLPVTFAPNGGAVPGDRIVGILTPGVGVTVYPIQSAALAAFDNEPER
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCCCCCC
WLDVRWDTEALGGERFPARLALKSINEPGVFAQIAQVIADHDGNIDNISMKRRTQDFTDI
EEEEEECHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEHHHHCCCCCEE
TIDLSVWDLQHLNAIIAELRGKRPVNSVERVNG
EEEEEHHHHHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA