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The map label for this gene is hemA [H]

Identifier: 170748254

GI number: 170748254

Start: 1962819

End: 1964036

Strand: Reverse

Name: hemA [H]

Synonym: Mrad2831_1836

Alternate gene names: 170748254

Gene position: 1964036-1962819 (Counterclockwise)

Preceding gene: 170748255

Following gene: 170748253

Centisome position: 32.31

GC content: 70.85

Gene sequence:

>1218_bases
ATGGATTACGAGACCTTCTTCGAAGGCGAGATCGCCGGGCTCCACCGGGAGGGCCGCTACCGGGTCTTCACCGACCTCGA
GCGCCACGCGGGCAACTTCCCGCACGCCACCCACCACCACGCCTCCGGCACGCGGCCGGTCACGGTCTGGTGCTCCAACG
ACTATCTCGGCATGGGCCAGCACCCGGCCGTGACGGGGGCGATGCACGCGGCGATCGACCGCTGCGGCGCCGGGGCCGGC
GGCACCCGCAACATCTCGGGGACGAACCACTACCACGTGCTGCTGGAGCGCGAGCTCGCCGACCTCCACGGCAAGGAGGC
GGCCCTGCTGTTCACCTCCGGCTACGTGTCGAACTGGGCGGCGCTGGGGACCCTGGCGTCGCGCCTGCCGAACTGCGCGG
TCTTCTCCGATTCCGAGAACCACGCCTCGATGATCGAGGGCATCCGGTTCTCCCGCGCCGAGCGCCACATCTTCCGCCAC
AACGACCCGGAGGACCTGAACCGCAAGCTCGCGCTGGTCGACCCGGCCCGGCCGAAGCTGGTGGCCTTCGAGTCGGTCTA
CTCGATGGACGGCGACATCGCGCCGATCGCCGAGATCTGCGACGTGGCCGAGGCCCACGGGGCGCTCACCTATCTCGACG
AGGTCCACGCGGTCGGCCTCTACGGCGCGCGCGGCGGCGGCATCTCGGAGCGGGACGGCGTCGCCCACCGGCTCGACGTG
ATCGAGGGCACGCTCGGCAAGGCCTTCGCGGTGCACGGCGGCTACATCACGGCCTCCGAGAAGCTCTGCGACTTCGTGCG
CAGCTTCGCCTCGGGCTTCATCTTCACGACCTCGCTGCCCCCGGCCGTCGCGGCGGGCGCGGCGGCGAGCATCCGCCACC
TCAAGGAGAGCGGCGCCGAGCGCGCCCGGCATCAGGAGCGCGTGGCGAAGGTCCGGCAGGCCCTGGAGGCCGCCGACATC
CCGACCATGCCCAACGACAGCCACATCGTGCCGGTGATGGTCTGCGATCCCGTGCTCTGCAAGGGGATCTCCGACACCCT
GCTCGACGAGTTCGGCATCTACGTGCAGCCGATCAACTACCCGACCGTCGCCCGCGGCACCGAGCGCCTGCGGATCACGC
CGTCGCCGCTGCACACGGACGCCGACATCGCCCATCTGGTCCAGGCGCTCACCACGATCTGGGGGCGGATCGGGCTCCGG
CAGAAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
TCGCGGGGCGACGCACGTCCACCAATCTGGAACTGGTCTTGTGCGAAGTCCGGTGTCACAGGCGGGATCAACCCGCAGGA
TTTGTTCGGGGAGAGGCGAC

Downstream 100 bases:

>100_bases
GGCTTCCCTTCTCCGACCCACCCCCTCATCCTGAGGTGCCCGCGGCGGCGGGCCTCGAGGGAGGGCTCGGGCCGGCCGCG
CGATCCCTGGAGCTCTCCTT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDYETFFEGEIAGLHREGRYRVFTDLERHAGNFPHATHHHASGTRPVTVWCSNDYLGMGQHPAVTGAMHAAIDRCGAGAG
GTRNISGTNHYHVLLERELADLHGKEAALLFTSGYVSNWAALGTLASRLPNCAVFSDSENHASMIEGIRFSRAERHIFRH
NDPEDLNRKLALVDPARPKLVAFESVYSMDGDIAPIAEICDVAEAHGALTYLDEVHAVGLYGARGGGISERDGVAHRLDV
IEGTLGKAFAVHGGYITASEKLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKESGAERARHQERVAKVRQALEAADI
PTMPNDSHIVPVMVCDPVLCKGISDTLLDEFGIYVQPINYPTVARGTERLRITPSPLHTDADIAHLVQALTTIWGRIGLR
QKAAE

Sequences:

>Translated_405_residues
MDYETFFEGEIAGLHREGRYRVFTDLERHAGNFPHATHHHASGTRPVTVWCSNDYLGMGQHPAVTGAMHAAIDRCGAGAG
GTRNISGTNHYHVLLERELADLHGKEAALLFTSGYVSNWAALGTLASRLPNCAVFSDSENHASMIEGIRFSRAERHIFRH
NDPEDLNRKLALVDPARPKLVAFESVYSMDGDIAPIAEICDVAEAHGALTYLDEVHAVGLYGARGGGISERDGVAHRLDV
IEGTLGKAFAVHGGYITASEKLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKESGAERARHQERVAKVRQALEAADI
PTMPNDSHIVPVMVCDPVLCKGISDTLLDEFGIYVQPINYPTVARGTERLRITPSPLHTDADIAHLVQALTTIWGRIGLR
QKAAE
>Mature_405_residues
MDYETFFEGEIAGLHREGRYRVFTDLERHAGNFPHATHHHASGTRPVTVWCSNDYLGMGQHPAVTGAMHAAIDRCGAGAG
GTRNISGTNHYHVLLERELADLHGKEAALLFTSGYVSNWAALGTLASRLPNCAVFSDSENHASMIEGIRFSRAERHIFRH
NDPEDLNRKLALVDPARPKLVAFESVYSMDGDIAPIAEICDVAEAHGALTYLDEVHAVGLYGARGGGISERDGVAHRLDV
IEGTLGKAFAVHGGYITASEKLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKESGAERARHQERVAKVRQALEAADI
PTMPNDSHIVPVMVCDPVLCKGISDTLLDEFGIYVQPINYPTVARGTERLRITPSPLHTDADIAHLVQALTTIWGRIGLR
QKAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=51.8610421836228, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=51.8610421836228, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=51.8610421836228, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI4502025, Length=406, Percent_Identity=52.9556650246305, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=406, Percent_Identity=52.9556650246305, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=394, Percent_Identity=36.8020304568528, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI284448556, Length=369, Percent_Identity=37.940379403794, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4758668, Length=380, Percent_Identity=28.4210526315789, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI119220554, Length=425, Percent_Identity=24.9411764705882, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI5454084, Length=291, Percent_Identity=26.4604810996564, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1790046, Length=357, Percent_Identity=36.4145658263305, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1786993, Length=343, Percent_Identity=34.6938775510204, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=32.5, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=29.4444444444444, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=390, Percent_Identity=27.4358974358974, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=390, Percent_Identity=27.4358974358974, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=278, Percent_Identity=25.5395683453237, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=278, Percent_Identity=25.5395683453237, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=421, Percent_Identity=47.2684085510689, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320267, Length=387, Percent_Identity=26.6149870801034, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=23.2472324723247, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=50.8728179551122, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=36.5714285714286, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17136286, Length=342, Percent_Identity=29.2397660818713, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653280, Length=252, Percent_Identity=27.3809523809524, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653276, Length=252, Percent_Identity=27.3809523809524, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653278, Length=252, Percent_Identity=27.3809523809524, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43895; Mature: 43895

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYETFFEGEIAGLHREGRYRVFTDLERHAGNFPHATHHHASGTRPVTVWCSNDYLGMGQ
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPAVTGAMHAAIDRCGAGAGGTRNISGTNHYHVLLERELADLHGKEAALLFTSGYVSNWA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCEEEEEECCHHHHHH
ALGTLASRLPNCAVFSDSENHASMIEGIRFSRAERHIFRHNDPEDLNRKLALVDPARPKL
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCE
VAFESVYSMDGDIAPIAEICDVAEAHGALTYLDEVHAVGLYGARGGGISERDGVAHRLDV
EEHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHH
IEGTLGKAFAVHGGYITASEKLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKESGAE
HHCCCCCEEEEECCEEEHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RARHQERVAKVRQALEAADIPTMPNDSHIVPVMVCDPVLCKGISDTLLDEFGIYVQPINY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCHHHHHHHCCCEEEECCC
PTVARGTERLRITPSPLHTDADIAHLVQALTTIWGRIGLRQKAAE
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDYETFFEGEIAGLHREGRYRVFTDLERHAGNFPHATHHHASGTRPVTVWCSNDYLGMGQ
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPAVTGAMHAAIDRCGAGAGGTRNISGTNHYHVLLERELADLHGKEAALLFTSGYVSNWA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCEEEEEECCHHHHHH
ALGTLASRLPNCAVFSDSENHASMIEGIRFSRAERHIFRHNDPEDLNRKLALVDPARPKL
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCE
VAFESVYSMDGDIAPIAEICDVAEAHGALTYLDEVHAVGLYGARGGGISERDGVAHRLDV
EEHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHH
IEGTLGKAFAVHGGYITASEKLCDFVRSFASGFIFTTSLPPAVAAGAAASIRHLKESGAE
HHCCCCCEEEEECCEEEHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RARHQERVAKVRQALEAADIPTMPNDSHIVPVMVCDPVLCKGISDTLLDEFGIYVQPINY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCCHHHHHHHCCCEEEECCC
PTVARGTERLRITPSPLHTDADIAHLVQALTTIWGRIGLRQKAAE
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]