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The map label for this gene is mntH [H]

Identifier: 170748036

GI number: 170748036

Start: 1724132

End: 1725460

Strand: Reverse

Name: mntH [H]

Synonym: Mrad2831_1618

Alternate gene names: 170748036

Gene position: 1725460-1724132 (Counterclockwise)

Preceding gene: 170748038

Following gene: 170748034

Centisome position: 28.39

GC content: 73.44

Gene sequence:

>1329_bases
ATGGTGGCGCCGAACGCCGCGACGGCCCCCGGGCGCGCCGCGCCCGGGGCGATGAGCCGGCGGACCGAGGGCGCGATCCG
CGACGTCCTCGACGGCCGTCCCGGCGGCCGGGCCCGGTTCCTGCTGTTCGCCGGCCCCGCCGTGACGGCGTCGATCGCCT
ACATGGACCCCGGGAATTTCGCGACCAACATCCAGGCCGGCGCCCGCTACGGCTACGGCCTGCTCTGGGTGGTGCTGCTC
GCCAACCTGACGGCGATGCTGTTCCAGGCCCTGTCGGCCAAGCTCGGCATCGTCACGGGCAAGAACCTCGCCGAGCATTG
CCGGGACGCGACGACGCGACCGGTGCGCCTCGCCCTGTGGGGCATCAGCGAGGTCGCCGCCATGGCGACCGACCTCGCGG
AGTTCCTCGGCGGCGCCATCGGCCTGTCGCTGCTCACCGGCATGCCGCTCATGGCCGGCATGGGCATCACCGCGGTGGTC
ACCTACGCGATCCTGCTCCTGGAGAACGAGGGCTTCCGGCCGCTGGAGATCGCCATCGGCGCGATGGTCGGCACGATCGG
CCTCTGCTACGCGGTCGAGCTCCTGGTCGCGCCCGTGGCCTGGGGCGAGGCGGCCAAGGGTCTCGTCACCCCGCGGATCC
CGGACGCGCAGGCGCTCACCATCGCGGTCGGGATCATCGGCGCCACCGTGATGCCGCACGCGCTGTTCCTGCATTCGGGC
CTGACCCAGGGACGGGGCAATCCCCGCACCGAGGCCGACCGGCGCCTGCTGGTGCGCTACTCGAACCGCGAGGTGGTGGT
GGCGCTGCTGCTGGCGGGCCTCGTCAACATGGCGATGGTGATCATGGCGGCGGCGGCCTTCCACGTCGGCCACAGCGAGG
TGGCGGAGATCGGCGAGGCCTACCGCACCCTGACGCCGCTCCTCGGGCCCGCCGCGGGGGCGGCCTTCCTGGTGTCGCTG
CTCGCCTCCGGGATCTCCTCCTCGGTGGTGGGCACGCTCGCCGGGCAATTGGTGATGCAGGGCTTCACCGGCTGGCGCAT
CCCGCTCCTCGCCCGCCGGCTCGTGACCATGCTGCCGGCCTTCGCGGTGGTGGCGATCGGGGTCGACCCGACCCAGGCGC
TGGTCCTGTCGCAGGTGGTGCTGTCGCTCGCCCTGCCGGTCCCGATGGTGGCGCTGGTGGTGTTCACCCGCCGCCGCAGC
GTGATGGGGCCCTTCGCCAACGGCCCGCTCACCCAGGCCGCCGCCGTGGCGGGGGCGGCTCTGGTGCTCGCCCTCAACAT
GGTGCTGCTGGCGGCGGCCTTCGGGCTGCCGGTGCCGGGGCTGGAGTGA

Upstream 100 bases:

>100_bases
AATCCCGATCCTGGAATCCCGATCCTGGGATCCGGGCCCTTGAATCCCGGCGCCGAACCCTGAATATAGCCTCCGCTATA
TCTTTGAGGAGAGGGTGAGC

Downstream 100 bases:

>100_bases
GCGCCCCCTGACGGCCCCGCTCAGGTCGCCCGCACCACCACCTCCACGAGGTTGGCGCCGCCGGACCGGATCCCGGCCTC
GATCGCCGGGGCGATGTCGG

Product: Mn2+/Fe2+ transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MVAPNAATAPGRAAPGAMSRRTEGAIRDVLDGRPGGRARFLLFAGPAVTASIAYMDPGNFATNIQAGARYGYGLLWVVLL
ANLTAMLFQALSAKLGIVTGKNLAEHCRDATTRPVRLALWGISEVAAMATDLAEFLGGAIGLSLLTGMPLMAGMGITAVV
TYAILLLENEGFRPLEIAIGAMVGTIGLCYAVELLVAPVAWGEAAKGLVTPRIPDAQALTIAVGIIGATVMPHALFLHSG
LTQGRGNPRTEADRRLLVRYSNREVVVALLLAGLVNMAMVIMAAAAFHVGHSEVAEIGEAYRTLTPLLGPAAGAAFLVSL
LASGISSSVVGTLAGQLVMQGFTGWRIPLLARRLVTMLPAFAVVAIGVDPTQALVLSQVVLSLALPVPMVALVVFTRRRS
VMGPFANGPLTQAAAVAGAALVLALNMVLLAAAFGLPVPGLE

Sequences:

>Translated_442_residues
MVAPNAATAPGRAAPGAMSRRTEGAIRDVLDGRPGGRARFLLFAGPAVTASIAYMDPGNFATNIQAGARYGYGLLWVVLL
ANLTAMLFQALSAKLGIVTGKNLAEHCRDATTRPVRLALWGISEVAAMATDLAEFLGGAIGLSLLTGMPLMAGMGITAVV
TYAILLLENEGFRPLEIAIGAMVGTIGLCYAVELLVAPVAWGEAAKGLVTPRIPDAQALTIAVGIIGATVMPHALFLHSG
LTQGRGNPRTEADRRLLVRYSNREVVVALLLAGLVNMAMVIMAAAAFHVGHSEVAEIGEAYRTLTPLLGPAAGAAFLVSL
LASGISSSVVGTLAGQLVMQGFTGWRIPLLARRLVTMLPAFAVVAIGVDPTQALVLSQVVLSLALPVPMVALVVFTRRRS
VMGPFANGPLTQAAAVAGAALVLALNMVLLAAAFGLPVPGLE
>Mature_442_residues
MVAPNAATAPGRAAPGAMSRRTEGAIRDVLDGRPGGRARFLLFAGPAVTASIAYMDPGNFATNIQAGARYGYGLLWVVLL
ANLTAMLFQALSAKLGIVTGKNLAEHCRDATTRPVRLALWGISEVAAMATDLAEFLGGAIGLSLLTGMPLMAGMGITAVV
TYAILLLENEGFRPLEIAIGAMVGTIGLCYAVELLVAPVAWGEAAKGLVTPRIPDAQALTIAVGIIGATVMPHALFLHSG
LTQGRGNPRTEADRRLLVRYSNREVVVALLLAGLVNMAMVIMAAAAFHVGHSEVAEIGEAYRTLTPLLGPAAGAAFLVSL
LASGISSSVVGTLAGQLVMQGFTGWRIPLLARRLVTMLPAFAVVAIGVDPTQALVLSQVVLSLALPVPMVALVVFTRRRS
VMGPFANGPLTQAAAVAGAALVLALNMVLLAAAFGLPVPGLE

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=449, Percent_Identity=34.075723830735, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI295293167, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI295293178, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI295293175, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI295293173, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI10835169, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI295293171, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI295293169, Length=427, Percent_Identity=33.0210772833724, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1788736, Length=404, Percent_Identity=49.5049504950495, Blast_Score=353, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI193210616, Length=462, Percent_Identity=29.8701298701299, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17569473, Length=374, Percent_Identity=30.2139037433155, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71999499, Length=470, Percent_Identity=28.5106382978723, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71993856, Length=229, Percent_Identity=35.3711790393013, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323062, Length=393, Percent_Identity=36.3867684478371, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324450, Length=449, Percent_Identity=31.8485523385301, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6321841, Length=426, Percent_Identity=32.6291079812207, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24648607, Length=433, Percent_Identity=31.4087759815243, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI281362176, Length=433, Percent_Identity=31.4087759815243, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24648609, Length=433, Percent_Identity=31.4087759815243, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45553443, Length=411, Percent_Identity=32.6034063260341, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45502; Mature: 45502

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPNAATAPGRAAPGAMSRRTEGAIRDVLDGRPGGRARFLLFAGPAVTASIAYMDPGNF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHEEEEEEECCCCC
ATNIQAGARYGYGLLWVVLLANLTAMLFQALSAKLGIVTGKNLAEHCRDATTRPVRLALW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHCCCCCCEEEEEH
GISEVAAMATDLAEFLGGAIGLSLLTGMPLMAGMGITAVVTYAILLLENEGFRPLEIAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AMVGTIGLCYAVELLVAPVAWGEAAKGLVTPRIPDAQALTIAVGIIGATVMPHALFLHSG
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
LTQGRGNPRTEADRRLLVRYSNREVVVALLLAGLVNMAMVIMAAAAFHVGHSEVAEIGEA
CCCCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YRTLTPLLGPAAGAAFLVSLLASGISSSVVGTLAGQLVMQGFTGWRIPLLARRLVTMLPA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FAVVAIGVDPTQALVLSQVVLSLALPVPMVALVVFTRRRSVMGPFANGPLTQAAAVAGAA
HHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVLALNMVLLAAAFGLPVPGLE
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVAPNAATAPGRAAPGAMSRRTEGAIRDVLDGRPGGRARFLLFAGPAVTASIAYMDPGNF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHEEEEEEECCCCC
ATNIQAGARYGYGLLWVVLLANLTAMLFQALSAKLGIVTGKNLAEHCRDATTRPVRLALW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHCCCCCCEEEEEH
GISEVAAMATDLAEFLGGAIGLSLLTGMPLMAGMGITAVVTYAILLLENEGFRPLEIAIG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AMVGTIGLCYAVELLVAPVAWGEAAKGLVTPRIPDAQALTIAVGIIGATVMPHALFLHSG
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
LTQGRGNPRTEADRRLLVRYSNREVVVALLLAGLVNMAMVIMAAAAFHVGHSEVAEIGEA
CCCCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YRTLTPLLGPAAGAAFLVSLLASGISSSVVGTLAGQLVMQGFTGWRIPLLARRLVTMLPA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FAVVAIGVDPTQALVLSQVVLSLALPVPMVALVVFTRRRSVMGPFANGPLTQAAAVAGAA
HHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LVLALNMVLLAAAFGLPVPGLE
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA