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The map label for this gene is prs [H]

Identifier: 170747905

GI number: 170747905

Start: 1553828

End: 1554772

Strand: Reverse

Name: prs [H]

Synonym: Mrad2831_1487

Alternate gene names: 170747905

Gene position: 1554772-1553828 (Counterclockwise)

Preceding gene: 170747906

Following gene: 170747902

Centisome position: 25.58

GC content: 69.1

Gene sequence:

>945_bases
ATGAAATCCTCGATCAAGATCATCGCCGGGAATGCCAGCCGGCCCCTGGCCGAGGCGATCGCGGCCTATCTCGAATTGCC
GCTCGCCAAGTGCATGGTCCGGCGCTTCGCCGACATGGAGATCTTCGTCGAGCTCCAGGAGAACGTGCGCGGCGAGGACG
TGTTCATCGTCCAGTCGACCTCGTTCCCGGCGAACGACCACCTGATGGAGCTGCTGATCATGATCGACGCCGCGCGCCGG
TCCTCGGCCCGGCGCATCACGGCGGTGATCCCGTATTTCGGCTACGCGCGGCAGGACCGGCGCACCTCCGGCCGCACCCC
GATCTCGGCCAAGCTGGTGGCGAACCTCATCACCGAGGCCGGCGCCGACCGCGTCCTGACCCTCGACCTCCACGCCGGCC
AGATCCAGGGCTTCTTCGACATCCCCACCGACAACCTGTTCGCCGCCCCCGTGATGGTGCGCGACATCAAGGAGCGGCTG
CCGAGCGCCGACCGGATGGTGGTGTCGCCGGACGTGGGCGGCGTGGTCCGGGCCCGCGCCATCGCCAAGCGGATCGACTG
CCCGCTGGCCATCGTCGACAAGCGCCGCGAGCGCCCGGGCGAGTCCGAGGTGATGAACATCATCGGCGAGGTCGAGGGCC
GCTCCTGCATCCTCGTCGACGACATCGTCGATTCGGGCGGCACCCTGGTCAACGCCGCCGAGGCCCTGCTCAACGCCGGC
GCCAAGGACGTCTCGGCCTACATCACGCACGGCGTCCTGTCGGGGGGCGCGGTCTCCCGCATCGCCGCCTCGCGGATGAA
GGAACTGGTGATCACCGACTCGATCCAGCCGACGCAGGCCGTCAAGCTCGCCCGCAACATCCGGGTGGCGACGATCGCGC
CGCTGCTCGGCGAGGCGATCGGCCGGACCGCGACCGAGTCCAGCGTGTCCAGCCTGTTCGACTGA

Upstream 100 bases:

>100_bases
GCTGCTAAGAGCCTCGCCCGTCATCGGATCGTTCCGGCTCCTCGGGAGACCGGTCTGAACAAGAGCGGCGGGAGGTCCGG
CCGCCAGCGAGCGGTCGCCC

Downstream 100 bases:

>100_bases
CGGCGCCTCCCGGCCGATCCCGGGGGCGCCCCGCCCCTACCGGCCCTGCACCCAGCCGCCCCGGTCGCCGGTCTCCGTTC
CCGGCGCGGTGAGCACCAGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKSSIKIIAGNASRPLAEAIAAYLELPLAKCMVRRFADMEIFVELQENVRGEDVFIVQSTSFPANDHLMELLIMIDAARR
SSARRITAVIPYFGYARQDRRTSGRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERL
PSADRMVVSPDVGGVVRARAIAKRIDCPLAIVDKRRERPGESEVMNIIGEVEGRSCILVDDIVDSGGTLVNAAEALLNAG
AKDVSAYITHGVLSGGAVSRIAASRMKELVITDSIQPTQAVKLARNIRVATIAPLLGEAIGRTATESSVSSLFD

Sequences:

>Translated_314_residues
MKSSIKIIAGNASRPLAEAIAAYLELPLAKCMVRRFADMEIFVELQENVRGEDVFIVQSTSFPANDHLMELLIMIDAARR
SSARRITAVIPYFGYARQDRRTSGRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERL
PSADRMVVSPDVGGVVRARAIAKRIDCPLAIVDKRRERPGESEVMNIIGEVEGRSCILVDDIVDSGGTLVNAAEALLNAG
AKDVSAYITHGVLSGGAVSRIAASRMKELVITDSIQPTQAVKLARNIRVATIAPLLGEAIGRTATESSVSSLFD
>Mature_314_residues
MKSSIKIIAGNASRPLAEAIAAYLELPLAKCMVRRFADMEIFVELQENVRGEDVFIVQSTSFPANDHLMELLIMIDAARR
SSARRITAVIPYFGYARQDRRTSGRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERL
PSADRMVVSPDVGGVVRARAIAKRIDCPLAIVDKRRERPGESEVMNIIGEVEGRSCILVDDIVDSGGTLVNAAEALLNAG
AKDVSAYITHGVLSGGAVSRIAASRMKELVITDSIQPTQAVKLARNIRVATIAPLLGEAIGRTATESSVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=47.588424437299, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=47.2668810289389, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=45.9807073954984, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=45.5414012738853, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI4506133, Length=331, Percent_Identity=35.3474320241692, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI194018537, Length=349, Percent_Identity=33.810888252149, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=53.8461538461538, Blast_Score=328, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=45.9807073954984, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=45.9807073954984, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=45.9807073954984, Blast_Score=287, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=45.7792207792208, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=32.3529411764706, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=45.5128205128205, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=45.2229299363057, Blast_Score=268, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=43.1309904153355, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.3265306122449, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=47.6744186046512, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.9807073954984, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=42.814371257485, Blast_Score=270, Evalue=9e-73,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=32.8651685393258, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=32.8651685393258, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=32.8651685393258, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=32.8651685393258, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24651462, Length=375, Percent_Identity=32, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24651464, Length=375, Percent_Identity=32, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552010, Length=375, Percent_Identity=32, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSIKIIAGNASRPLAEAIAAYLELPLAKCMVRRFADMEIFVELQENVRGEDVFIVQST
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCCCEEEEEECC
SFPANDHLMELLIMIDAARRSSARRITAVIPYFGYARQDRRTSGRTPISAKLVANLITEA
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLPSADRMVVSPDVGGVVRARA
CCCCEEEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHH
IAKRIDCPLAIVDKRRERPGESEVMNIIGEVEGRSCILVDDIVDSGGTLVNAAEALLNAG
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCC
AKDVSAYITHGVLSGGAVSRIAASRMKELVITDSIQPTQAVKLARNIRVATIAPLLGEAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GRTATESSVSSLFD
CCCCHHHHHHHHCC
>Mature Secondary Structure
MKSSIKIIAGNASRPLAEAIAAYLELPLAKCMVRRFADMEIFVELQENVRGEDVFIVQST
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCCCEEEEEECC
SFPANDHLMELLIMIDAARRSSARRITAVIPYFGYARQDRRTSGRTPISAKLVANLITEA
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GADRVLTLDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLPSADRMVVSPDVGGVVRARA
CCCCEEEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHH
IAKRIDCPLAIVDKRRERPGESEVMNIIGEVEGRSCILVDDIVDSGGTLVNAAEALLNAG
HHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCC
AKDVSAYITHGVLSGGAVSRIAASRMKELVITDSIQPTQAVKLARNIRVATIAPLLGEAI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
GRTATESSVSSLFD
CCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]