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The map label for this gene is livH [H]

Identifier: 170747855

GI number: 170747855

Start: 1502697

End: 1503590

Strand: Reverse

Name: livH [H]

Synonym: Mrad2831_1437

Alternate gene names: 170747855

Gene position: 1503590-1502697 (Counterclockwise)

Preceding gene: 170747856

Following gene: 170747854

Centisome position: 24.74

GC content: 72.48

Gene sequence:

>894_bases
ATGAGCCCGGACCTCGCCTTCCTGATCGAGGTCGTGGTCGGCGGCCTCCTCTCGGGCGTCATGTACGCCCTCGTGGCGAT
CGGCTTCGTGCTGATCTACAAGACCTCGGGCGTGCTCAACTTCGCGCAGGGCGCGATGGTGCTGCTCGCCGCCCTCACCT
TCGTGAGCCTGACCGAGCGCGGGCTGCCCTTCCCGGCGGCCCTGGCGGCGACGCTCGCCGCGATGGTGGTGGTCGGCCTC
GCGGTGGAGCGGGCGGTGCTGCGGCCGCTGGTCAACCAGCCGCCGATCACCTTGTTCATGGCGACGCTGGGCGTCGCCTA
CGTGATCGAGGGCGCGGCCCAGCTCGCCTGGGGCACCCAGGTCCACGGGCTGGACCTCGGCATCGACGACACGCCGATCG
ACCTCGGCGGCGTGCTGGTCAGCCGGTTCGACCTGTTCGCCGCCGCGGTCGCGGGCCTGATGGTGGCGCTCCTCTCCGCC
TTCTTCCGCTACACCCGTACCGGCCTCGCCTTCCGGGCGGTGGCGGACGATCCGCTCGCCGCCCTCAACACCGGCCTGCG
CCTGCCCCGGATCTGGTCGGCGGTCTGGATCGCCGCCGGGATCGTCGCCCTGGTGGCGGGGCTGCTCTGGGGCGCGCGGC
TCGGCGTGCAGTTCTCCCTGTCGCTGGTGGTGCTGAAGGCCCTGCCGGTGCTCGTGCTCGGCGGCTTCGACTCCATCGCC
GGGGCGATCGTGGCCGGGCTGATCGTCGGCGCGGCGGAGAAGCTGTCCGAAGTCTATCTCGGGCCGGTCATCGGCGGCGG
GATCGAGGGCTGGATCGCCTACGTGGCGGCCCTGGGCTTCCTGCTGGTCCGGCCGTCGGGCCTGTTCGGCCTGCGCGCCG
TCGAGCGGGTCTGA

Upstream 100 bases:

>100_bases
TTCGGGCGGACCCGGCTGTCATCGCGGCCTATCTGGGGCTCGCGGACGGGGATGCGGATGGAGATGCGGACGCGGATATC
GACGCGGACGCGGCCGCCGC

Downstream 100 bases:

>100_bases
GGACACCATGGACGCCCTCCCCCTCGCCGCACCGCGCGCCCGCCTGTCCGCCCGCACCCTCGGTCTCGGTGCCCTGCTGG
TCCTGGCCTACGGGATCGTG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSPDLAFLIEVVVGGLLSGVMYALVAIGFVLIYKTSGVLNFAQGAMVLLAALTFVSLTERGLPFPAALAATLAAMVVVGL
AVERAVLRPLVNQPPITLFMATLGVAYVIEGAAQLAWGTQVHGLDLGIDDTPIDLGGVLVSRFDLFAAAVAGLMVALLSA
FFRYTRTGLAFRAVADDPLAALNTGLRLPRIWSAVWIAAGIVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDSIA
GAIVAGLIVGAAEKLSEVYLGPVIGGGIEGWIAYVAALGFLLVRPSGLFGLRAVERV

Sequences:

>Translated_297_residues
MSPDLAFLIEVVVGGLLSGVMYALVAIGFVLIYKTSGVLNFAQGAMVLLAALTFVSLTERGLPFPAALAATLAAMVVVGL
AVERAVLRPLVNQPPITLFMATLGVAYVIEGAAQLAWGTQVHGLDLGIDDTPIDLGGVLVSRFDLFAAAVAGLMVALLSA
FFRYTRTGLAFRAVADDPLAALNTGLRLPRIWSAVWIAAGIVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDSIA
GAIVAGLIVGAAEKLSEVYLGPVIGGGIEGWIAYVAALGFLLVRPSGLFGLRAVERV
>Mature_296_residues
SPDLAFLIEVVVGGLLSGVMYALVAIGFVLIYKTSGVLNFAQGAMVLLAALTFVSLTERGLPFPAALAATLAAMVVVGLA
VERAVLRPLVNQPPITLFMATLGVAYVIEGAAQLAWGTQVHGLDLGIDDTPIDLGGVLVSRFDLFAAAVAGLMVALLSAF
FRYTRTGLAFRAVADDPLAALNTGLRLPRIWSAVWIAAGIVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDSIAG
AIVAGLIVGAAEKLSEVYLGPVIGGGIEGWIAYVAALGFLLVRPSGLFGLRAVERV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=318, Percent_Identity=27.0440251572327, Blast_Score=90, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30635; Mature: 30504

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPDLAFLIEVVVGGLLSGVMYALVAIGFVLIYKTSGVLNFAQGAMVLLAALTFVSLTER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GLPFPAALAATLAAMVVVGLAVERAVLRPLVNQPPITLFMATLGVAYVIEGAAQLAWGTQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
VHGLDLGIDDTPIDLGGVLVSRFDLFAAAVAGLMVALLSAFFRYTRTGLAFRAVADDPLA
ECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
ALNTGLRLPRIWSAVWIAAGIVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDSIA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GAIVAGLIVGAAEKLSEVYLGPVIGGGIEGWIAYVAALGFLLVRPSGLFGLRAVERV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
SPDLAFLIEVVVGGLLSGVMYALVAIGFVLIYKTSGVLNFAQGAMVLLAALTFVSLTER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
GLPFPAALAATLAAMVVVGLAVERAVLRPLVNQPPITLFMATLGVAYVIEGAAQLAWGTQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
VHGLDLGIDDTPIDLGGVLVSRFDLFAAAVAGLMVALLSAFFRYTRTGLAFRAVADDPLA
ECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHH
ALNTGLRLPRIWSAVWIAAGIVALVAGLLWGARLGVQFSLSLVVLKALPVLVLGGFDSIA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GAIVAGLIVGAAEKLSEVYLGPVIGGGIEGWIAYVAALGFLLVRPSGLFGLRAVERV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]