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The map label for this gene is mepA [H]

Identifier: 170747765

GI number: 170747765

Start: 1405503

End: 1406915

Strand: Reverse

Name: mepA [H]

Synonym: Mrad2831_1344

Alternate gene names: 170747765

Gene position: 1406915-1405503 (Counterclockwise)

Preceding gene: 170747766

Following gene: 170747764

Centisome position: 23.15

GC content: 78.77

Gene sequence:

>1413_bases
GTGAGGCGGCCGGTCGACCTCGACCAGGACCGGGTCGTCGGCCTGGTCCTCCGGCTGTCCGGGCCGGCGATCCTCGGCAT
CTCGGCGCACGCGCTGCAGATGCTGGTCAACGCGTGGTTCGTGGCCGATCTCGGGGCCGCCGCGATCGCCACCATCGCCC
TGGCATACCCGGTGACGCTGCTCGTCGCGGCGCTCGGCTACGGGGCCGGGATCGCGGCGGCCTCGCAGGTCTCCCGCGCC
CTCGGGTCGGGGGACCGCGACCGGGCCGCGGCCGCCGCCGGCCTGGGCTTCTGGCTGAGCCTGCCGGCGGGGCTCGCCGT
GACGGCCGCGATCGTGGCCGACACGCCGTTCTGGCTCCGCCTCCTCGGCGCCGATGCCGCCCTCGCCGCGGAGGCCGCGC
CCTACACGGCCCTCGCCACGGTCGGCACGGCCCTGATGCTGGTGATGATCGTCGGCGGCTTCGTCGTGCGCGGCCAGGGC
CACGCGCGCCTCAGCGGCGCCGTCATGGTCGGCAGCTTCGGCCTCAACATCCTGCTCGACGCGGTGCTGATCCGGGTCTG
CGGCCTCGGCACCGTCGGCGCCGGCTGGGCGGCGATCGGCGCGCAGCTCGCGGGCGCGGCCGCCTACGGCCTGCACTTCG
CCCGGGCGCGGGGGGCGGACCGGGTGTCGCTCCGGTGGCCCGGCGGTCGGATCGGGCGCGGGGCCCTCGCCGAGGCCCTG
ACGCTCGCGCTGCCCGCCACCGGCTCCAGCCTGCTCGCGGCCGTCGCGATGGCGCTGTTCGTGGAGGCGGCCGCGCCCTA
CGGCGACGCCGCGGTCGCCGCGCAGGGCATCGCCCTGCGCCTGACCCTGGTGGCGGCGCTGCCGCTCCTCGGGACGATGG
CGGGCGCCCAGGCGGTGCTCGGCCACGCCGCCGGCGCCGGCCGCCGGGACCGGCTGCACCGCGCCCTCGCCTTCGTGCTC
GCCGCCGCCCTCGCCTACGGCCTCGTCGTCGGCGGCCTGATGATCGCCTGCGCCGAGCCCCTCGCGGGCCTGTTCGCGCA
GGATCCCGCGACCGCCCGCGCGGGCGCGCGCGCCACCGCGCTCTTCGCCGTCGCCTTCATGCCGGTGGGCCTACAGCTCA
CGGCCGCGACCCTGTTCCAGGCGATCGGCGCGCCGCGCCGGGCCGCCGCCGTGTCGCTGGCGGCGCAGGGGCTGGCGCTG
ATCCCGCCGCTCCTGATCCTGCCGCCGCTCCTCGGCTACGCGGGGGTGCTCGCCAGCCGGGTCGCGGCCGAGTTCCTGGC
CGACGGGCTCGGCCTGGCGCTGCTGCTGGCCTGGGGCCTGGACGCGCGCCGGGCAGGCGGCGCAGCGCCGGTCGAGGGCC
GCGAGGCAGTGCAGGTGGCCGCGGCGCACGAGACCGCACACCAGGGCGCGTGA

Upstream 100 bases:

>100_bases
TGCTGTCGATCCTGCCCGTGCGGGCCGGCGCCATCGCGCAGACCATCCTCGCCGAGGAGCGGGCCGCCCGCGCGGCGATC
CGCTCGGCCGCCTCGATCCC

Downstream 100 bases:

>100_bases
GACCCCGAGCCGGGCCGCGATCTCGACCTGCGGCACGCCCTCGACCCGGTGGAGCTGGAAGGCCGTGCGCACCGGCTCCG
GCAGCTCGGCCACCGCGGCC

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRRPVDLDQDRVVGLVLRLSGPAILGISAHALQMLVNAWFVADLGAAAIATIALAYPVTLLVAALGYGAGIAAASQVSRA
LGSGDRDRAAAAAGLGFWLSLPAGLAVTAAIVADTPFWLRLLGADAALAAEAAPYTALATVGTALMLVMIVGGFVVRGQG
HARLSGAVMVGSFGLNILLDAVLIRVCGLGTVGAGWAAIGAQLAGAAAYGLHFARARGADRVSLRWPGGRIGRGALAEAL
TLALPATGSSLLAAVAMALFVEAAAPYGDAAVAAQGIALRLTLVAALPLLGTMAGAQAVLGHAAGAGRRDRLHRALAFVL
AAALAYGLVVGGLMIACAEPLAGLFAQDPATARAGARATALFAVAFMPVGLQLTAATLFQAIGAPRRAAAVSLAAQGLAL
IPPLLILPPLLGYAGVLASRVAAEFLADGLGLALLLAWGLDARRAGGAAPVEGREAVQVAAAHETAHQGA

Sequences:

>Translated_470_residues
MRRPVDLDQDRVVGLVLRLSGPAILGISAHALQMLVNAWFVADLGAAAIATIALAYPVTLLVAALGYGAGIAAASQVSRA
LGSGDRDRAAAAAGLGFWLSLPAGLAVTAAIVADTPFWLRLLGADAALAAEAAPYTALATVGTALMLVMIVGGFVVRGQG
HARLSGAVMVGSFGLNILLDAVLIRVCGLGTVGAGWAAIGAQLAGAAAYGLHFARARGADRVSLRWPGGRIGRGALAEAL
TLALPATGSSLLAAVAMALFVEAAAPYGDAAVAAQGIALRLTLVAALPLLGTMAGAQAVLGHAAGAGRRDRLHRALAFVL
AAALAYGLVVGGLMIACAEPLAGLFAQDPATARAGARATALFAVAFMPVGLQLTAATLFQAIGAPRRAAAVSLAAQGLAL
IPPLLILPPLLGYAGVLASRVAAEFLADGLGLALLLAWGLDARRAGGAAPVEGREAVQVAAAHETAHQGA
>Mature_470_residues
MRRPVDLDQDRVVGLVLRLSGPAILGISAHALQMLVNAWFVADLGAAAIATIALAYPVTLLVAALGYGAGIAAASQVSRA
LGSGDRDRAAAAAGLGFWLSLPAGLAVTAAIVADTPFWLRLLGADAALAAEAAPYTALATVGTALMLVMIVGGFVVRGQG
HARLSGAVMVGSFGLNILLDAVLIRVCGLGTVGAGWAAIGAQLAGAAAYGLHFARARGADRVSLRWPGGRIGRGALAEAL
TLALPATGSSLLAAVAMALFVEAAAPYGDAAVAAQGIALRLTLVAALPLLGTMAGAQAVLGHAAGAGRRDRLHRALAFVL
AAALAYGLVVGGLMIACAEPLAGLFAQDPATARAGARATALFAVAFMPVGLQLTAATLFQAIGAPRRAAAVSLAAQGLAL
IPPLLILPPLLGYAGVLASRVAAEFLADGLGLALLLAWGLDARRAGGAAPVEGREAVQVAAAHETAHQGA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46618; Mature: 46618

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPVDLDQDRVVGLVLRLSGPAILGISAHALQMLVNAWFVADLGAAAIATIALAYPVTL
CCCCCCCCCHHHHEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAALGYGAGIAAASQVSRALGSGDRDRAAAAAGLGFWLSLPAGLAVTAAIVADTPFWLR
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
LLGADAALAAEAAPYTALATVGTALMLVMIVGGFVVRGQGHARLSGAVMVGSFGLNILLD
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCEECCEEEEEHHHHHHHHH
AVLIRVCGLGTVGAGWAAIGAQLAGAAAYGLHFARARGADRVSLRWPGGRIGRGALAEAL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
TLALPATGSSLLAAVAMALFVEAAAPYGDAAVAAQGIALRLTLVAALPLLGTMAGAQAVL
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GHAAGAGRRDRLHRALAFVLAAALAYGLVVGGLMIACAEPLAGLFAQDPATARAGARATA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHH
LFAVAFMPVGLQLTAATLFQAIGAPRRAAAVSLAAQGLALIPPLLILPPLLGYAGVLASR
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHH
VAAEFLADGLGLALLLAWGLDARRAGGAAPVEGREAVQVAAAHETAHQGA
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRPVDLDQDRVVGLVLRLSGPAILGISAHALQMLVNAWFVADLGAAAIATIALAYPVTL
CCCCCCCCCHHHHEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAALGYGAGIAAASQVSRALGSGDRDRAAAAAGLGFWLSLPAGLAVTAAIVADTPFWLR
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
LLGADAALAAEAAPYTALATVGTALMLVMIVGGFVVRGQGHARLSGAVMVGSFGLNILLD
HHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCEECCEEEEEHHHHHHHHH
AVLIRVCGLGTVGAGWAAIGAQLAGAAAYGLHFARARGADRVSLRWPGGRIGRGALAEAL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
TLALPATGSSLLAAVAMALFVEAAAPYGDAAVAAQGIALRLTLVAALPLLGTMAGAQAVL
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GHAAGAGRRDRLHRALAFVLAAALAYGLVVGGLMIACAEPLAGLFAQDPATARAGARATA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHH
LFAVAFMPVGLQLTAATLFQAIGAPRRAAAVSLAAQGLALIPPLLILPPLLGYAGVLASR
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHH
VAAEFLADGLGLALLLAWGLDARRAGGAAPVEGREAVQVAAAHETAHQGA
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA