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The map label for this gene is galE [C]

Identifier: 170747743

GI number: 170747743

Start: 1379535

End: 1380647

Strand: Reverse

Name: galE [C]

Synonym: Mrad2831_1322

Alternate gene names: 170747743

Gene position: 1380647-1379535 (Counterclockwise)

Preceding gene: 170747744

Following gene: 170747742

Centisome position: 22.72

GC content: 73.67

Gene sequence:

>1113_bases
GTGCCGGAATCTGTGCTCATTACCGGTGGCGCCGGCTTCATCGGCCGCCATCTCGCCGCCGAATTGCTGCGCCGCGGCTA
CCGCGTGCGGGTGCTCGACAGTCTGATCGAGCAGGTCCACGGCGGCGAGAGCGGCGCCGACGCGCTGCCGTCGGACGTCG
AGTTCCAGGCGGGCGACGTCCGCGACGGTGCGGCCGTGGCGCGCGCCCTGTCGGGCATCGACCGGGTCGTGCACCTCGCC
GCCGAGGTCGGCGTCGGCCAGAGCATGTACGCGGTCGAGCGCTACGTCTCGGTCAACGATTGCGGCACGGCGGTGCTGTT
CCAGCAGCTCATCGACGCCCCGGTGAGGCGCGTGGTCGTCGCCTCCTCGATGAGCATCTACGGCGAGGGGCTGTACCGCA
CCTCCGACGGGTCGACCGCCGAGGAGGTGGTGCGCCGCCCGCGCCGGCCCGGGGAGCCCTGGGACCCCCTCGACGGGCGC
GGGCAGCCCATGCGGCCGATCCCGACGCCCGAGACGAAGCGCCCGGCCCTCGCCTCCGTCTACGCCCTGACCAAGTACAT
GCAGGAGCGCCTGACGCTCACCCTCGCCCCCGCCTACGGGATGGAGGGCGTGGCGCTCCGCCTGTGGAACGCCTACGGGC
CGGGCCAGGCGCTCTCGAACCCCTATACCGGCGTGCTGGCGATCTTCGCGGCGCGGCTCCACAACGGCCAGCCGCCGATG
ATCTTCGAGGACGGCGCGCAGCGGCGCGACTTCGTCCACGTCGAGGACGTCGCGCAGGCCTTCGCGCTGGCCCTGGAGCA
CCCGGCCGCCGCCGGTCAGGTCTACAACGTCGGCAGCGGCCAGGACCGCACGGTCAGCGAGGTCGCCCGCCTGCTCGCCC
GCGCGATGGGCCGCGAGGAGATCGGGCCGGAGGTGACCGGTCAGGCGCGGCTCGGCGACATCCGCCACTGCATCGCCGAT
ATCGGCAAGATCCAGCGGGAGCTCGGCTACGCGCCGCGCCGCGACTTCGCCGAGGGGCTCGCCGAACTCGCCGCCTGGGT
GGCCGAGCAGCAGGCCGTCGACCGCGTCGCCGAGGCGCGGCGCGAACTCGAAGCGCGCGGTCTCGTCGCGTGA

Upstream 100 bases:

>100_bases
TTTCGGCGCAGAAATCCGGCTCTTAACCTGAGTTATTTCATCGAGACGGGATTCCCGATCTACATAGCTTTAAGTCCTCG
CAGGGGAGTTTCCACGCCTC

Downstream 100 bases:

>100_bases
GCGGCCGGCCGATCCTCGTCACCGGGGGCGCCGGGTTCATCGGTGCCAACCTGTCCGACAGCCTCGCGGCCGACGGCCAC
GCGGTGATCGTCTACGACAT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MPESVLITGGAGFIGRHLAAELLRRGYRVRVLDSLIEQVHGGESGADALPSDVEFQAGDVRDGAAVARALSGIDRVVHLA
AEVGVGQSMYAVERYVSVNDCGTAVLFQQLIDAPVRRVVVASSMSIYGEGLYRTSDGSTAEEVVRRPRRPGEPWDPLDGR
GQPMRPIPTPETKRPALASVYALTKYMQERLTLTLAPAYGMEGVALRLWNAYGPGQALSNPYTGVLAIFAARLHNGQPPM
IFEDGAQRRDFVHVEDVAQAFALALEHPAAAGQVYNVGSGQDRTVSEVARLLARAMGREEIGPEVTGQARLGDIRHCIAD
IGKIQRELGYAPRRDFAEGLAELAAWVAEQQAVDRVAEARRELEARGLVA

Sequences:

>Translated_370_residues
MPESVLITGGAGFIGRHLAAELLRRGYRVRVLDSLIEQVHGGESGADALPSDVEFQAGDVRDGAAVARALSGIDRVVHLA
AEVGVGQSMYAVERYVSVNDCGTAVLFQQLIDAPVRRVVVASSMSIYGEGLYRTSDGSTAEEVVRRPRRPGEPWDPLDGR
GQPMRPIPTPETKRPALASVYALTKYMQERLTLTLAPAYGMEGVALRLWNAYGPGQALSNPYTGVLAIFAARLHNGQPPM
IFEDGAQRRDFVHVEDVAQAFALALEHPAAAGQVYNVGSGQDRTVSEVARLLARAMGREEIGPEVTGQARLGDIRHCIAD
IGKIQRELGYAPRRDFAEGLAELAAWVAEQQAVDRVAEARRELEARGLVA
>Mature_369_residues
PESVLITGGAGFIGRHLAAELLRRGYRVRVLDSLIEQVHGGESGADALPSDVEFQAGDVRDGAAVARALSGIDRVVHLAA
EVGVGQSMYAVERYVSVNDCGTAVLFQQLIDAPVRRVVVASSMSIYGEGLYRTSDGSTAEEVVRRPRRPGEPWDPLDGRG
QPMRPIPTPETKRPALASVYALTKYMQERLTLTLAPAYGMEGVALRLWNAYGPGQALSNPYTGVLAIFAARLHNGQPPMI
FEDGAQRRDFVHVEDVAQAFALALEHPAAAGQVYNVGSGQDRTVSEVARLLARAMGREEIGPEVTGQARLGDIRHCIADI
GKIQRELGYAPRRDFAEGLAELAAWVAEQQAVDRVAEARRELEARGLVA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=376, Percent_Identity=27.3936170212766, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI56118217, Length=376, Percent_Identity=27.3936170212766, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI189083684, Length=376, Percent_Identity=27.3936170212766, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI7657641, Length=356, Percent_Identity=25, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI239745448, Length=310, Percent_Identity=25.1612903225806, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786974, Length=373, Percent_Identity=27.0777479892761, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788353, Length=364, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=371, Percent_Identity=27.4932614555256, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982038, Length=373, Percent_Identity=27.0777479892761, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319493, Length=370, Percent_Identity=26.2162162162162, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19923002, Length=376, Percent_Identity=26.063829787234, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 39943; Mature: 39812

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESVLITGGAGFIGRHLAAELLRRGYRVRVLDSLIEQVHGGESGADALPSDVEFQAGDV
CCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
RDGAAVARALSGIDRVVHLAAEVGVGQSMYAVERYVSVNDCGTAVLFQQLIDAPVRRVVV
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASSMSIYGEGLYRTSDGSTAEEVVRRPRRPGEPWDPLDGRGQPMRPIPTPETKRPALASV
HHHHHHHCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
YALTKYMQERLTLTLAPAYGMEGVALRLWNAYGPGQALSNPYTGVLAIFAARLHNGQPPM
HHHHHHHHHHHEEEEECCCCCCCHHEEEECCCCCCHHHCCCHHHHHHHHHHHHHCCCCCE
IFEDGAQRRDFVHVEDVAQAFALALEHPAAAGQVYNVGSGQDRTVSEVARLLARAMGREE
EECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCHHH
IGPEVTGQARLGDIRHCIADIGKIQRELGYAPRRDFAEGLAELAAWVAEQQAVDRVAEAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELEARGLVA
HHHHHCCCCC
>Mature Secondary Structure 
PESVLITGGAGFIGRHLAAELLRRGYRVRVLDSLIEQVHGGESGADALPSDVEFQAGDV
CCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
RDGAAVARALSGIDRVVHLAAEVGVGQSMYAVERYVSVNDCGTAVLFQQLIDAPVRRVVV
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ASSMSIYGEGLYRTSDGSTAEEVVRRPRRPGEPWDPLDGRGQPMRPIPTPETKRPALASV
HHHHHHHCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
YALTKYMQERLTLTLAPAYGMEGVALRLWNAYGPGQALSNPYTGVLAIFAARLHNGQPPM
HHHHHHHHHHHEEEEECCCCCCCHHEEEECCCCCCHHHCCCHHHHHHHHHHHHHCCCCCE
IFEDGAQRRDFVHVEDVAQAFALALEHPAAAGQVYNVGSGQDRTVSEVARLLARAMGREE
EECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCHHH
IGPEVTGQARLGDIRHCIADIGKIQRELGYAPRRDFAEGLAELAAWVAEQQAVDRVAEAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELEARGLVA
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]