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The map label for this gene is gmhB [H]

Identifier: 170747651

GI number: 170747651

Start: 1288139

End: 1289377

Strand: Reverse

Name: gmhB [H]

Synonym: Mrad2831_1224

Alternate gene names: 170747651

Gene position: 1289377-1288139 (Counterclockwise)

Preceding gene: 170747652

Following gene: 170747648

Centisome position: 21.21

GC content: 70.14

Gene sequence:

>1239_bases
GTGACCGAGCCAGAGTGGAAGGGTGGAGGCCCCGTCCGGCAAGCCATGATCCTGTGCGGCGGCTTCGGCACGCGCCTCGG
CGCGCTGACCTCGGCCATGCCCAAGCCGCTGCTGCCGGTATCGGGTGAGCCGTTCCTGGACGTGCTGCTGTTCGAACTCG
GCCGCCACGGCATCACCGAGATCGTGCTGCTGGCCTCGTTCCACAGCGAGAAGATCCGCGCCTACGCCGCCGACAACCTG
GTCGCGCGACGCTTCGGCATGACGCTGCGGGTCTCGGTCGAGCCGGAGCAGGCCGGGACCGGGGGCGCCGTCATGCACGC
CCTTCCCGAGGCCCACGCGACCTTTCTCCTGCTGAACGGCGACTCGTGGTTCGACGTGAACCTGCTGTCCTTGGCCGCCA
TGGCGGCGCGTCACCCCGATGCGGCGATGGTCCTGTCGCTCCGCCGGGTGGCGGACGCCGCGCGCTACGGCGTCGCGCTC
CTCGACGGCGTCCGGATCACAGCCTTCCTCGAGCGGCCGCCTGAGCCGGGACCCGGTCTCGTCAACGCCGGCGTCTATTT
GGTGCGCCGCGATGCACTCACCGACCTGCCACCGGCCTGCTCACTGGAACGGGACGTCCTGCCCGCGCTGGTCGCCGAGG
GCCGCGTGGTCGGCGAGGCCCATGACGGCTACTTCCTCGATATCGGCGTGCCCGAGAGCTACGCCCGGGCCCAGGAAGAG
ATCCCGGCCCGTCGGAGGAGACCGGCCGCCTTCCTCGATCGCGACGGCGTTCTCAATCACGACCACGGGCATGTCGGTTC
CGTGGACCGGTTCCAGTGGATGGCGGGCGCGCGCGACGCCGTCCGCGCGCTGAATGATGCCGGCTACTTCGTGTTCGTCG
TCACGAACCAGGCGGGGGTCGCCCGCGGCTTCTACACCGAGGCCGACGTCGCCCGTCTGACCGCCTGGATGCGGGACGAC
CTGCGCGAGGCCGGCGCGCATATCGATGATCTCCGCTACTGCCCCTATCATCCGGACGGGACGGTCGAGGCCTACAGGGC
GGTCCACGGATGGCGAAAGCCCGAGCCCGGCATGATCCTCGACCTGATGGCCCATTGGGACATCGACCGTGTGCGCAGCT
TCCTGGTCGGCGATCAGGAAACGGATCTCGCCGCCGGCCGTGCGGCGGGGCTCGCCGTGCATCACTTCAGGTCGGACGAC
CTGCTCGCCTTCCTGCGGGAGGTCGCGCTGACGGGGTAG

Upstream 100 bases:

>100_bases
CCGCTGATCCAGCAGATCCACATCACCGCCGCGCACATCGTCTGCGGCCTCGTCGAGGAAAGCCTGTTCCCGCGCGGGAC
GGCAGCGTGAGGGACGGCCT

Downstream 100 bases:

>100_bases
GAAGGGGCCCAGGAGGTGTGGGTCCTCGCCGGGGCGCTTCGCCGTCCGCCACGCTCAGTCGTGCGACTGGATCGAGAGTT
CCGCTTCCGCGGCCTCGCAC

Product: HAD superfamily hydrolase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTEPEWKGGGPVRQAMILCGGFGTRLGALTSAMPKPLLPVSGEPFLDVLLFELGRHGITEIVLLASFHSEKIRAYAADNL
VARRFGMTLRVSVEPEQAGTGGAVMHALPEAHATFLLLNGDSWFDVNLLSLAAMAARHPDAAMVLSLRRVADAARYGVAL
LDGVRITAFLERPPEPGPGLVNAGVYLVRRDALTDLPPACSLERDVLPALVAEGRVVGEAHDGYFLDIGVPESYARAQEE
IPARRRRPAAFLDRDGVLNHDHGHVGSVDRFQWMAGARDAVRALNDAGYFVFVVTNQAGVARGFYTEADVARLTAWMRDD
LREAGAHIDDLRYCPYHPDGTVEAYRAVHGWRKPEPGMILDLMAHWDIDRVRSFLVGDQETDLAAGRAAGLAVHHFRSDD
LLAFLREVALTG

Sequences:

>Translated_412_residues
MTEPEWKGGGPVRQAMILCGGFGTRLGALTSAMPKPLLPVSGEPFLDVLLFELGRHGITEIVLLASFHSEKIRAYAADNL
VARRFGMTLRVSVEPEQAGTGGAVMHALPEAHATFLLLNGDSWFDVNLLSLAAMAARHPDAAMVLSLRRVADAARYGVAL
LDGVRITAFLERPPEPGPGLVNAGVYLVRRDALTDLPPACSLERDVLPALVAEGRVVGEAHDGYFLDIGVPESYARAQEE
IPARRRRPAAFLDRDGVLNHDHGHVGSVDRFQWMAGARDAVRALNDAGYFVFVVTNQAGVARGFYTEADVARLTAWMRDD
LREAGAHIDDLRYCPYHPDGTVEAYRAVHGWRKPEPGMILDLMAHWDIDRVRSFLVGDQETDLAAGRAAGLAVHHFRSDD
LLAFLREVALTG
>Mature_411_residues
TEPEWKGGGPVRQAMILCGGFGTRLGALTSAMPKPLLPVSGEPFLDVLLFELGRHGITEIVLLASFHSEKIRAYAADNLV
ARRFGMTLRVSVEPEQAGTGGAVMHALPEAHATFLLLNGDSWFDVNLLSLAAMAARHPDAAMVLSLRRVADAARYGVALL
DGVRITAFLERPPEPGPGLVNAGVYLVRRDALTDLPPACSLERDVLPALVAEGRVVGEAHDGYFLDIGVPESYARAQEEI
PARRRRPAAFLDRDGVLNHDHGHVGSVDRFQWMAGARDAVRALNDAGYFVFVVTNQAGVARGFYTEADVARLTAWMRDDL
REAGAHIDDLRYCPYHPDGTVEAYRAVHGWRKPEPGMILDLMAHWDIDRVRSFLVGDQETDLAAGRAAGLAVHHFRSDDL
LAFLREVALTG

Specific function: Converts the D-glycero-alpha-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=228, Percent_Identity=29.8245614035088, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI11761619, Length=228, Percent_Identity=29.8245614035088, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786399, Length=147, Percent_Identity=44.8979591836735, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI133931050, Length=228, Percent_Identity=28.5087719298246, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320148, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: NA

Molecular weight: Translated: 44923; Mature: 44792

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPEWKGGGPVRQAMILCGGFGTRLGALTSAMPKPLLPVSGEPFLDVLLFELGRHGITE
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHH
IVLLASFHSEKIRAYAADNLVARRFGMTLRVSVEPEQAGTGGAVMHALPEAHATFLLLNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEC
DSWFDVNLLSLAAMAARHPDAAMVLSLRRVADAARYGVALLDGVRITAFLERPPEPGPGL
CCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
VNAGVYLVRRDALTDLPPACSLERDVLPALVAEGRVVGEAHDGYFLDIGVPESYARAQEE
CCCCEEEEEECHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCCEEEEECCCHHHHHHHHH
IPARRRRPAAFLDRDGVLNHDHGHVGSVDRFQWMAGARDAVRALNDAGYFVFVVTNQAGV
CCHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCC
ARGFYTEADVARLTAWMRDDLREAGAHIDDLRYCPYHPDGTVEAYRAVHGWRKPEPGMIL
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEE
DLMAHWDIDRVRSFLVGDQETDLAAGRAAGLAVHHFRSDDLLAFLREVALTG
HHHHHCCHHHHHHHHCCCCCCHHHCCHHHCEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TEPEWKGGGPVRQAMILCGGFGTRLGALTSAMPKPLLPVSGEPFLDVLLFELGRHGITE
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHH
IVLLASFHSEKIRAYAADNLVARRFGMTLRVSVEPEQAGTGGAVMHALPEAHATFLLLNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEC
DSWFDVNLLSLAAMAARHPDAAMVLSLRRVADAARYGVALLDGVRITAFLERPPEPGPGL
CCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
VNAGVYLVRRDALTDLPPACSLERDVLPALVAEGRVVGEAHDGYFLDIGVPESYARAQEE
CCCCEEEEEECHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCCEEEEECCCHHHHHHHHH
IPARRRRPAAFLDRDGVLNHDHGHVGSVDRFQWMAGARDAVRALNDAGYFVFVVTNQAGV
CCHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCC
ARGFYTEADVARLTAWMRDDLREAGAHIDDLRYCPYHPDGTVEAYRAVHGWRKPEPGMIL
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEE
DLMAHWDIDRVRSFLVGDQETDLAAGRAAGLAVHHFRSDDLLAFLREVALTG
HHHHHCCHHHHHHHHCCCCCCHHHCCHHHCEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11279237; 12101286 [H]