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The map label for this gene is rkpK [H]

Identifier: 170747386

GI number: 170747386

Start: 1009171

End: 1010514

Strand: Reverse

Name: rkpK [H]

Synonym: Mrad2831_0953

Alternate gene names: 170747386

Gene position: 1010514-1009171 (Counterclockwise)

Preceding gene: 170747390

Following gene: 170747385

Centisome position: 16.63

GC content: 71.06

Gene sequence:

>1344_bases
ATGCGGATTGCGATGATTGGGGCCGGATATGTCGGCCTGGTCTCCGGCGCCTGCCTGGCCGATTTCGGCCACACGGTCGT
GTGCGTCGACCGGGACCCCGACAAGATCGCCAGCCTGAACGCCGGCCGCATGCCGATCTACGAGCCGGGCCTCGACGTCC
TGGTCGCCGAGAACGTGCGCCAGGGCCGGCTCGCGTTCAGCACGTCCATGCGGGAGGCCGTGGCCGAGGCCGACGCGGTG
TTCATCGCGGTGGGCACGCCCTCCCGCCGCGGCGACGGCTTCGCCGACCTGAGCTTCGTGTTCGACGCCGCCCGGGAGAT
CGCCGGCGCGCTGTCCGGCTTCACCGTGGTGGTGACCAAGTCGACCGTGCCGGTCGGCACCGGCGACGAGGTCGAGCGCA
TCATCCGCGAGACCAACCCCGGGGCGCAGTTCGCGGTCGCGTCGAACCCCGAGTTCCTGCGCGAGGGCGCGGCCATCGCC
GACTTCAAGCGCCCCGACCGCATCGTCGTCGGTGCCGAGGAGGCCAGCGCCGAGGCGGTGATGCGCGAGGTCTACCGGCC
GCTCTACCTCAACCAGGCGCCGATCATGGTCACGTCGCGGCGCACGGCCGAGCTGACCAAGTACGCGGCGAACGCGTTCC
TGGCGGCGAAGATCACGTTCATCAACGAGGTCGCGGACCTGTGCGAGGCGGTGGGCGCGGACGTGCAGGCGGTCGCGCGC
GGCATCGGCCTGGACAACCGGATCGGGTCGAAGTTCCTGCACGCCGGGCCGGGCTACGGCGGCTCGTGCTTCCCCAAGGA
CACGCTGGCGCTGGTCAAGACGGCGCAGGACGCCGGCACGCCGCTGCGGCTGGTCGAGACGGTGGTGGCGGTCAACGACC
AGCGCAAGCGCGCGATGGCGCGCAAGGTGATCAGGGCCTGCGGCGGCTCGGTGCGGGGCAAGACGGTGGCGCTGCTCGGC
CTGACCTTCAAGCCGAACACCGACGACATGCGCGACGCGCCCTCGCTGGCGATCGTGGCCGGCCTGCAGGATGCCGGCGC
CGTGGTCCGCGCCTACGATCCCGAGGGCATGGAGCAGGCCCGGATCCTGATGCCGGCTGTGGATTACGCCGAGAACGCCT
ACGCCTGCGCCGAGGGCGCGGATGCGGTGGTGATCGTCACCGAGTGGAACGCGTTCCGGGCCCTCGACCTCGACCGGCTG
CGTCGGGCCATGTCGTCCGGCGAGGCGGCTCCCGTGCTGATCGACCTGCGCAACATCTACGACCCGGTGAGCGCCGCCCG
TCACGGTTTCACCTATTGCGGGGTCGGACGAACCAAGGAGAGCGTCGCCCGGATCGGGTCTTGA

Upstream 100 bases:

>100_bases
ACAGACTGGAGCAGATCCAGGCTGGCCCGGGTTGCATCCGCGTGCGCCCCGGATCATGTTGCATCGCAGCAAGCCGAGGG
CGAGCTGCCGGGAGGGCCCG

Downstream 100 bases:

>100_bases
TCGTCGCCGCGCGAGCTCGCGGACCCGGATTCCTGTGCGGGATCTGCCCGACACCGCGAAGATTTCTTCCGGAATCGGCA
TCGATGCCGCTAGACGGGCG

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRIAMIGAGYVGLVSGACLADFGHTVVCVDRDPDKIASLNAGRMPIYEPGLDVLVAENVRQGRLAFSTSMREAVAEADAV
FIAVGTPSRRGDGFADLSFVFDAAREIAGALSGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVASNPEFLREGAAIA
DFKRPDRIVVGAEEASAEAVMREVYRPLYLNQAPIMVTSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARILMPAVDYAENAYACAEGADAVVIVTEWNAFRALDLDRL
RRAMSSGEAAPVLIDLRNIYDPVSAARHGFTYCGVGRTKESVARIGS

Sequences:

>Translated_447_residues
MRIAMIGAGYVGLVSGACLADFGHTVVCVDRDPDKIASLNAGRMPIYEPGLDVLVAENVRQGRLAFSTSMREAVAEADAV
FIAVGTPSRRGDGFADLSFVFDAAREIAGALSGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVASNPEFLREGAAIA
DFKRPDRIVVGAEEASAEAVMREVYRPLYLNQAPIMVTSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARILMPAVDYAENAYACAEGADAVVIVTEWNAFRALDLDRL
RRAMSSGEAAPVLIDLRNIYDPVSAARHGFTYCGVGRTKESVARIGS
>Mature_447_residues
MRIAMIGAGYVGLVSGACLADFGHTVVCVDRDPDKIASLNAGRMPIYEPGLDVLVAENVRQGRLAFSTSMREAVAEADAV
FIAVGTPSRRGDGFADLSFVFDAAREIAGALSGFTVVVTKSTVPVGTGDEVERIIRETNPGAQFAVASNPEFLREGAAIA
DFKRPDRIVVGAEEASAEAVMREVYRPLYLNQAPIMVTSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMARKVIRACGGSVRGKTVALLG
LTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQARILMPAVDYAENAYACAEGADAVVIVTEWNAFRALDLDRL
RRAMSSGEAAPVLIDLRNIYDPVSAARHGFTYCGVGRTKESVARIGS

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=428, Percent_Identity=39.2523364485981, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI296040438, Length=329, Percent_Identity=38.9057750759878, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI296040443, Length=423, Percent_Identity=34.0425531914894, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=30.0561797752809, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=29.6912114014252, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=468, Percent_Identity=37.3931623931624, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=37.5, Blast_Score=288, Evalue=8e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47394; Mature: 47394

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAMIGAGYVGLVSGACLADFGHTVVCVDRDPDKIASLNAGRMPIYEPGLDVLVAENVR
CEEEEEECCHHHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCEECCCCCEEEECCCC
QGRLAFSTSMREAVAEADAVFIAVGTPSRRGDGFADLSFVFDAAREIAGALSGFTVVVTK
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPGAQFAVASNPEFLREGAAIADFKRPDRIVVGAEEASAEAV
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCHHHHHHH
MREVYRPLYLNQAPIMVTSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMA
HCCCCCHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
RKVIRACGGSVRGKTVALLGLTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
RILMPAVDYAENAYACAEGADAVVIVTEWNAFRALDLDRLRRAMSSGEAAPVLIDLRNIY
HEEHHHHHHCCCCEEECCCCCEEEEEEECCCEEECCHHHHHHHHHCCCCCEEEEEHHHHH
DPVSAARHGFTYCGVGRTKESVARIGS
CHHHHHHCCCEEECCCCCHHHHHHCCC
>Mature Secondary Structure
MRIAMIGAGYVGLVSGACLADFGHTVVCVDRDPDKIASLNAGRMPIYEPGLDVLVAENVR
CEEEEEECCHHHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCEECCCCCEEEECCCC
QGRLAFSTSMREAVAEADAVFIAVGTPSRRGDGFADLSFVFDAAREIAGALSGFTVVVTK
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIRETNPGAQFAVASNPEFLREGAAIADFKRPDRIVVGAEEASAEAV
CCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEECCHHHHHHH
MREVYRPLYLNQAPIMVTSRRTAELTKYAANAFLAAKITFINEVADLCEAVGADVQAVAR
HHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALVKTAQDAGTPLRLVETVVAVNDQRKRAMA
HCCCCCHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
RKVIRACGGSVRGKTVALLGLTFKPNTDDMRDAPSLAIVAGLQDAGAVVRAYDPEGMEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
RILMPAVDYAENAYACAEGADAVVIVTEWNAFRALDLDRLRRAMSSGEAAPVLIDLRNIY
HEEHHHHHHCCCCEEECCCCCEEEEEEECCCEEECCHHHHHHHHHCCCCCEEEEEHHHHH
DPVSAARHGFTYCGVGRTKESVARIGS
CHHHHHHCCCEEECCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]