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The map label for this gene is yxnA [H]

Identifier: 170747341

GI number: 170747341

Start: 950935

End: 951945

Strand: Reverse

Name: yxnA [H]

Synonym: Mrad2831_0908

Alternate gene names: 170747341

Gene position: 951945-950935 (Counterclockwise)

Preceding gene: 170747346

Following gene: 170747340

Centisome position: 15.66

GC content: 73.29

Gene sequence:

>1011_bases
ATGGCACGGGTTGCGGTCGTTACCGGGGGCACGGCCGGAATCGGTCTCGCCACCGCGCATGAATTCGCCGCGCGCGGCTG
GTCGGTGGCGGTGATCGCGCGGGATCCTGGCCGTCTCGCCGCCGCCGAGCGGGCGCTGGCCGCCTACGGCCAGCCGGTGC
TGGCGATCGGCGCCGACGTCGCCGAGCCGGAGGCCGTGGACGCCGCCGCCGAGCGGGTGGAGCGCGAACTCGGCCCGATC
CGCGCGTGGGTCAACAACGCCATGTCGACGGTGGTGAACCCGGCCGACCGAATCACTCCGGACGAGTACCGGCGGGTCAC
CGAGACCACCTATCTCAGCCAGGTCTACGGGACGCTCGCCGCCCTGCGCTTCATGAAGCGCCGCGACCGCGGCGCGATCA
TCCAGGTCTCGTCGGGACTCGCGATCCGGGCGGCGCCGCTGCAGGCACCCTACTGCGCGGCGAAGTTCGCGGTCTCGGGC
TTCACCGACGCCCTGCGCTGCGAGCTGCTGCACGACCGGGTCAATGTCAGCCTCAGCGTGATCTACCTGCCGGCGGTCAA
CACGCCCCAGTTTAACTGGGCGCGCAACCGCACCGGCCACCGCCAGTACGCGCCGGATCCGGTCTTCGACCCGCGGCTCT
GCGCCGAGGCGATCCTGTACGCGGTCGAGCACCCGCGCCGCGAGGTCTGGGTCGGACGGTCGTCGGCGATGATGGCGGCT
GCCCAGGCGCTGGCGCCGGCGCTCGCCGACCGCAAGGCCGCCTCCATGTGGGCGGCGCAGCTCTCCGACGAGACCATCCC
CGAGATGGACGGCAACCTCTACGAAGCTGTGCCCGGCCCGGTCGGGATCGACGGGCGCTTCATCGGCCGGACCAAGGCGA
GCCGCGGAGAGTTCGTCACGAGCCGGACCCGCGACGTCGTGGTCGGCGGCCTCGTCGGGCTGGCCCTCGTCGGCCTCGCC
GGCACCGTCCACGCCGCCCGCTCGGCGCGCCGGCGGCCGGAGCGGATCTGA

Upstream 100 bases:

>100_bases
GCGAAATCGGCGGCCCCCGTGACGTTCCGGACCGGCCCGGCGGCGCAACCGAGCGCGCCGCACCGGGTTGCCGGTTCGGT
CTCTCGAGGATGAGGTGGGT

Downstream 100 bases:

>100_bases
CGGCTGCGCCCGTGCGCGCCGCCTGCTAAGCCCGTTCCGATCGATAGGCCCGCCGCCGTCGTCGCGAGCGGTGCGAAGCC
ATCCCGTTGCGCCGCCCCCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MARVAVVTGGTAGIGLATAHEFAARGWSVAVIARDPGRLAAAERALAAYGQPVLAIGADVAEPEAVDAAAERVERELGPI
RAWVNNAMSTVVNPADRITPDEYRRVTETTYLSQVYGTLAALRFMKRRDRGAIIQVSSGLAIRAAPLQAPYCAAKFAVSG
FTDALRCELLHDRVNVSLSVIYLPAVNTPQFNWARNRTGHRQYAPDPVFDPRLCAEAILYAVEHPRREVWVGRSSAMMAA
AQALAPALADRKAASMWAAQLSDETIPEMDGNLYEAVPGPVGIDGRFIGRTKASRGEFVTSRTRDVVVGGLVGLALVGLA
GTVHAARSARRRPERI

Sequences:

>Translated_336_residues
MARVAVVTGGTAGIGLATAHEFAARGWSVAVIARDPGRLAAAERALAAYGQPVLAIGADVAEPEAVDAAAERVERELGPI
RAWVNNAMSTVVNPADRITPDEYRRVTETTYLSQVYGTLAALRFMKRRDRGAIIQVSSGLAIRAAPLQAPYCAAKFAVSG
FTDALRCELLHDRVNVSLSVIYLPAVNTPQFNWARNRTGHRQYAPDPVFDPRLCAEAILYAVEHPRREVWVGRSSAMMAA
AQALAPALADRKAASMWAAQLSDETIPEMDGNLYEAVPGPVGIDGRFIGRTKASRGEFVTSRTRDVVVGGLVGLALVGLA
GTVHAARSARRRPERI
>Mature_335_residues
ARVAVVTGGTAGIGLATAHEFAARGWSVAVIARDPGRLAAAERALAAYGQPVLAIGADVAEPEAVDAAAERVERELGPIR
AWVNNAMSTVVNPADRITPDEYRRVTETTYLSQVYGTLAALRFMKRRDRGAIIQVSSGLAIRAAPLQAPYCAAKFAVSGF
TDALRCELLHDRVNVSLSVIYLPAVNTPQFNWARNRTGHRQYAPDPVFDPRLCAEAILYAVEHPRREVWVGRSSAMMAAA
QALAPALADRKAASMWAAQLSDETIPEMDGNLYEAVPGPVGIDGRFIGRTKASRGEFVTSRTRDVVVGGLVGLALVGLAG
TVHAARSARRRPERI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=198, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7706318, Length=170, Percent_Identity=32.9411764705882, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40254992, Length=178, Percent_Identity=30.8988764044944, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI7657478, Length=180, Percent_Identity=29.4444444444444, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI20149619, Length=182, Percent_Identity=31.3186813186813, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4557649, Length=172, Percent_Identity=32.5581395348837, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI210032110, Length=172, Percent_Identity=32.5581395348837, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI32455239, Length=207, Percent_Identity=30.9178743961353, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI5031765, Length=207, Percent_Identity=30.9178743961353, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI142976729, Length=247, Percent_Identity=23.8866396761134, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI223718074, Length=185, Percent_Identity=32.972972972973, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=176, Percent_Identity=30.1136363636364, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786701, Length=227, Percent_Identity=27.7533039647577, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=183, Percent_Identity=30.0546448087432, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=183, Percent_Identity=30.0546448087432, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=242, Percent_Identity=28.099173553719, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281364892, Length=168, Percent_Identity=31.547619047619, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355631, Length=168, Percent_Identity=29.7619047619048, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 36007; Mature: 35875

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVAVVTGGTAGIGLATAHEFAARGWSVAVIARDPGRLAAAERALAAYGQPVLAIGADV
CCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCC
AEPEAVDAAAERVERELGPIRAWVNNAMSTVVNPADRITPDEYRRVTETTYLSQVYGTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
ALRFMKRRDRGAIIQVSSGLAIRAAPLQAPYCAAKFAVSGFTDALRCELLHDRVNVSLSV
HHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEE
IYLPAVNTPQFNWARNRTGHRQYAPDPVFDPRLCAEAILYAVEHPRREVWVGRSSAMMAA
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEECCCHHHHHHH
AQALAPALADRKAASMWAAQLSDETIPEMDGNLYEAVPGPVGIDGRFIGRTKASRGEFVT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCHH
SRTRDVVVGGLVGLALVGLAGTVHAARSARRRPERI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ARVAVVTGGTAGIGLATAHEFAARGWSVAVIARDPGRLAAAERALAAYGQPVLAIGADV
CEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCC
AEPEAVDAAAERVERELGPIRAWVNNAMSTVVNPADRITPDEYRRVTETTYLSQVYGTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHH
ALRFMKRRDRGAIIQVSSGLAIRAAPLQAPYCAAKFAVSGFTDALRCELLHDRVNVSLSV
HHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEE
IYLPAVNTPQFNWARNRTGHRQYAPDPVFDPRLCAEAILYAVEHPRREVWVGRSSAMMAA
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEECCCHHHHHHH
AQALAPALADRKAASMWAAQLSDETIPEMDGNLYEAVPGPVGIDGRFIGRTKASRGEFVT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCHH
SRTRDVVVGGLVGLALVGLAGTVHAARSARRRPERI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]