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The map label for this gene is gfo [H]

Identifier: 170747259

GI number: 170747259

Start: 869278

End: 870576

Strand: Reverse

Name: gfo [H]

Synonym: Mrad2831_0826

Alternate gene names: 170747259

Gene position: 870576-869278 (Counterclockwise)

Preceding gene: 170747260

Following gene: 170747254

Centisome position: 14.32

GC content: 72.67

Gene sequence:

>1299_bases
ATGGCGGACGACACCCGGCTCTCACGACGCACTCTCCTCGCGGCCGGAGGCGCCCTGGCCGGCGCCGCGGTGGGCGGCGG
CGCGCAGGCCGCCCCGCCTGGCCCCTCGGTTCCCGCCGATACCGGCGCCGTTCAGGGCGGACGGGTGATGTTCCCGAACT
GGCGCGGGCCGGGCGACAGGCCGCCCGCCCCGAGCCCGGCGCCGCAGCCGCCGGCCCAGCGCGTCGGCTACTGCGTCGTG
GGTCTCGGGCGCCTGAGCCTCGACGAGATCCTGCCGGCCTTCGGCGAGACCAAGCGCGCCCGTCTCGCGGCGGTGATGTC
GGGCTCACCCGACAAGGCGAAGCTCGTGGCGCGGCAGTACGGGCTGCCGGAGGACGCCGTCTACGGCTACGACGCGTGGG
ACCGCCTGAAGGCCAACCCCGATGTCCAGGCGGTCTACATCGTCACGCCGAACGGCGTGCACCGGGACAACGTCGTGGCG
GCCGCGGCGGCCGGCAAGCAGGTCCTCTGCGAGAAGCCGATGGCCGTGAACTCGGACGAGTGCCGGGAGATGATCGCGGC
CTGCGCGAAGGCCGGCGTCAAGCTGATGATCGCCTACCGGTGCCAGTACGAGCCCCACAACCGGGCCGTGATCAAGCTCG
CCCGCTCGGGCGAGTTCGGCCGGCCCCGGCTGATCCAGGCGTTCAACGGCCAGACCACGGGACTGCCGGAGCAGTGGCGC
CTGCGGAAGGCGCTGGCGGGCGGCGGATCCCTGCCGGATATCGGGCTCTACTGCCTGAACACCGCCCGCGCGGTGCTCGG
CGAGGAGCCGAACCTGATCCAGGCCCAGATCCACTCGCCGCCGGACGATCCCAAGTACCGCGAGGTCGAGGAGACGGCGA
GCTTCACCCTCCACTTCCCGTCCGGCGTGATCGCCCAGTGCCTGTCGAGCTACGGGGTCTACGAGGCGCGGAGCCTGACC
CTGCACACCGGGACCGCCTCCGTCGATCTCCAGAACGCCTTCGCCTACCAGGGCCAGCGTCTCTATGTCGGCCACCGCGA
CGGCAAGAATGCCGCCCGGGACGAGAAGGTCCTGAGCCCGAAGAACCAGTTCGCCCTGGAGCTGGACCATTTCGCGCGGT
GCATCCAGGAGAACCTGCGGCCGCGCACGCCCGGCGAGGAGGGGCTGCAGGACCAGGTCCTGATGGAGGCGATCTACGAG
GCGGCCCGGACCGGCACGCCGGTCAAGGTCGGGCCGCCCCCCGGCGCCGGTTCCGGCCTCGACGTCACGCGCGGGCCGGA
GCCGGAGGAGCCGGGTTGA

Upstream 100 bases:

>100_bases
GTCGCGTTCACTGAGGGCGCGCGGTCCCGCCACCCGGCGGTTCCCGGCGCGGGCGGCGCCCCGGGCGCGGCCCTCCCGAT
CCGGCAACACGGCGAGGCAC

Downstream 100 bases:

>100_bases
GGGGCCTCAGAACGGCAGCAGGATGTCGACGATCTGCTGGCCGTAGCGCGGCTGCTGCACGTCGGTGATCTGGCCCCGGC
CGCCGTAGGCGATGCGGGCC

Product: oxidoreductase domain-containing protein

Products: NA

Alternate protein names: GFOR [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MADDTRLSRRTLLAAGGALAGAAVGGGAQAAPPGPSVPADTGAVQGGRVMFPNWRGPGDRPPAPSPAPQPPAQRVGYCVV
GLGRLSLDEILPAFGETKRARLAAVMSGSPDKAKLVARQYGLPEDAVYGYDAWDRLKANPDVQAVYIVTPNGVHRDNVVA
AAAAGKQVLCEKPMAVNSDECREMIAACAKAGVKLMIAYRCQYEPHNRAVIKLARSGEFGRPRLIQAFNGQTTGLPEQWR
LRKALAGGGSLPDIGLYCLNTARAVLGEEPNLIQAQIHSPPDDPKYREVEETASFTLHFPSGVIAQCLSSYGVYEARSLT
LHTGTASVDLQNAFAYQGQRLYVGHRDGKNAARDEKVLSPKNQFALELDHFARCIQENLRPRTPGEEGLQDQVLMEAIYE
AARTGTPVKVGPPPGAGSGLDVTRGPEPEEPG

Sequences:

>Translated_432_residues
MADDTRLSRRTLLAAGGALAGAAVGGGAQAAPPGPSVPADTGAVQGGRVMFPNWRGPGDRPPAPSPAPQPPAQRVGYCVV
GLGRLSLDEILPAFGETKRARLAAVMSGSPDKAKLVARQYGLPEDAVYGYDAWDRLKANPDVQAVYIVTPNGVHRDNVVA
AAAAGKQVLCEKPMAVNSDECREMIAACAKAGVKLMIAYRCQYEPHNRAVIKLARSGEFGRPRLIQAFNGQTTGLPEQWR
LRKALAGGGSLPDIGLYCLNTARAVLGEEPNLIQAQIHSPPDDPKYREVEETASFTLHFPSGVIAQCLSSYGVYEARSLT
LHTGTASVDLQNAFAYQGQRLYVGHRDGKNAARDEKVLSPKNQFALELDHFARCIQENLRPRTPGEEGLQDQVLMEAIYE
AARTGTPVKVGPPPGAGSGLDVTRGPEPEEPG
>Mature_431_residues
ADDTRLSRRTLLAAGGALAGAAVGGGAQAAPPGPSVPADTGAVQGGRVMFPNWRGPGDRPPAPSPAPQPPAQRVGYCVVG
LGRLSLDEILPAFGETKRARLAAVMSGSPDKAKLVARQYGLPEDAVYGYDAWDRLKANPDVQAVYIVTPNGVHRDNVVAA
AAAGKQVLCEKPMAVNSDECREMIAACAKAGVKLMIAYRCQYEPHNRAVIKLARSGEFGRPRLIQAFNGQTTGLPEQWRL
RKALAGGGSLPDIGLYCLNTARAVLGEEPNLIQAQIHSPPDDPKYREVEETASFTLHFPSGVIAQCLSSYGVYEARSLTL
HTGTASVDLQNAFAYQGQRLYVGHRDGKNAARDEKVLSPKNQFALELDHFARCIQENLRPRTPGEEGLQDQVLMEAIYEA
ARTGTPVKVGPPPGAGSGLDVTRGPEPEEPG

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Homo sapiens, GI7657212, Length=263, Percent_Identity=28.1368821292776, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1787574, Length=353, Percent_Identity=24.6458923512748, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082405, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323975, Length=274, Percent_Identity=27.3722627737226, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581117, Length=176, Percent_Identity=28.4090909090909, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24581115, Length=198, Percent_Identity=26.2626262626263, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008354
- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.99.28 [H]

Molecular weight: Translated: 45971; Mature: 45839

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDTRLSRRTLLAAGGALAGAAVGGGAQAAPPGPSVPADTGAVQGGRVMFPNWRGPGDR
CCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
PPAPSPAPQPPAQRVGYCVVGLGRLSLDEILPAFGETKRARLAAVMSGSPDKAKLVARQY
CCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHC
GLPEDAVYGYDAWDRLKANPDVQAVYIVTPNGVHRDNVVAAAAAGKQVLCEKPMAVNSDE
CCCHHHEECCCHHHHHCCCCCCEEEEEECCCCCCCCCEEEEHHCCCHHHHCCCCCCCHHH
CREMIAACAKAGVKLMIAYRCQYEPHNRAVIKLARSGEFGRPRLIQAFNGQTTGLPEQWR
HHHHHHHHHHCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHH
LRKALAGGGSLPDIGLYCLNTARAVLGEEPNLIQAQIHSPPDDPKYREVEETASFTLHFP
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCEEEEECC
SGVIAQCLSSYGVYEARSLTLHTGTASVDLQNAFAYQGQRLYVGHRDGKNAARDEKVLSP
CHHHHHHHHHCCCCEEEEEEEECCCCEEEHHHHHHHCCCEEEEECCCCCCCHHHHHHCCC
KNQFALELDHFARCIQENLRPRTPGEEGLQDQVLMEAIYEAARTGTPVKVGPPPGAGSGL
CHHHEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
DVTRGPEPEEPG
CCCCCCCCCCCC
>Mature Secondary Structure 
ADDTRLSRRTLLAAGGALAGAAVGGGAQAAPPGPSVPADTGAVQGGRVMFPNWRGPGDR
CCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCC
PPAPSPAPQPPAQRVGYCVVGLGRLSLDEILPAFGETKRARLAAVMSGSPDKAKLVARQY
CCCCCCCCCCHHHHCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHC
GLPEDAVYGYDAWDRLKANPDVQAVYIVTPNGVHRDNVVAAAAAGKQVLCEKPMAVNSDE
CCCHHHEECCCHHHHHCCCCCCEEEEEECCCCCCCCCEEEEHHCCCHHHHCCCCCCCHHH
CREMIAACAKAGVKLMIAYRCQYEPHNRAVIKLARSGEFGRPRLIQAFNGQTTGLPEQWR
HHHHHHHHHHCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHH
LRKALAGGGSLPDIGLYCLNTARAVLGEEPNLIQAQIHSPPDDPKYREVEETASFTLHFP
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCEEEEECC
SGVIAQCLSSYGVYEARSLTLHTGTASVDLQNAFAYQGQRLYVGHRDGKNAARDEKVLSP
CHHHHHHHHHCCCCEEEEEEEECCCCEEEHHHHHHHCCCEEEEECCCCCCCHHHHHHCCC
KNQFALELDHFARCIQENLRPRTPGEEGLQDQVLMEAIYEAARTGTPVKVGPPPGAGSGL
CHHHEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
DVTRGPEPEEPG
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537789; 8472911; 8994968 [H]