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The map label for this gene is degP [H]

Identifier: 170747227

GI number: 170747227

Start: 832053

End: 833183

Strand: Reverse

Name: degP [H]

Synonym: Mrad2831_0793

Alternate gene names: 170747227

Gene position: 833183-832053 (Counterclockwise)

Preceding gene: 170747229

Following gene: 170747226

Centisome position: 13.71

GC content: 73.3

Gene sequence:

>1131_bases
GTGCCGGATCGTACCGTGCGCATCCTGTTCGCCGCGGTCGTGGTCCTGCTGGCGCTCTACGTCGCCCAGCCCTACCTGCA
GCCGCTGCTCTACGCGGCCGACACCCCCCGGGCCGTGACGGCCCGCGGCGATCTGGCGCCGGCCGAGGCCTCGACGGTGG
CGCTGTTCGAGCGCGCGAGCCCGTCCGTCGTTCACGTTTTCGCGCAGAGCGCCGCCCAGAACCGCGACCTCCTCGACCTC
GACGACCAGGGCGGCGAGCAGGGCGGGACCCAGACCGGCACCGGCTTCGTCTGGGACGGCGCCGGCCACATCGTCACCAA
CACCCATGTCGTGCAGAACGCCGCGCGGAGCGGCGGCTCGGTCTCGGTCCGGATGAGCGACGGCGAGGTCGTGCCCGCCA
CCCTCGTCGGGATGGCGCCGTCCTACGACCTCGCGGTCCTGCAGCTCGGGCGGGTGCGGAACATGCCGCCGCCGCTGGCG
ATCGGCACCTCGGCGGATCTCAAGGTCGGGCAGTCGGCCTTCGCCATCGGCAACCCGTTCGGCCTCGACCACACGCTGAC
GACCGGCGTCATCAGCGCCGTGCGGCGGCGGATGCCGACGAGCGAGGGCCGCGAATTGTCCGGCGTGATCCAGACGGACG
CGGCGATCAACCCCGGCAATTCCGGCGGCCCGCTCCTCGATTCAGCGGGCCGGCTGATCGGGGTCAACACCGCCATCGTG
TCGCCGTCCGGCGCCAGCGCCGGGATCGGGTTCGCGATCCCCGTCGACGTGGTGAACCGGATCGTGCCGGAGCTGATCAA
GGCCGGACGGGTGCGCAATCCCGGCATCGGCATCATCGCCGCCCAGGAGGCGGCCACCGCGCGGCTCGGCATCGACGGCG
TGGTGATCGTGCGGGTGCTGCCCGGCTCCCCGGCCGCGCAGGCCGGCCTGCGCGGCGTCGATCCGCAGACCGGCGACATC
GGCGACGTGATCGTCGAGGCCAATGACCGCCCCGTCCACCGCCTCGCCGACCTGACGGCGGCCATCGAGGAGGCCGGCCT
CGGCGCCGGCGTGACCCTCAAGGTCGAGCGCGATGGCCGGATCCGGCAGGTCCGCGTCACCACCGCCGAGGTCGCGGAGA
ACCGGCGATGA

Upstream 100 bases:

>100_bases
CCTCTGTGTTGACGCCCCGATCCTGAACGCGCACTTAAGGCTCCGCCCGTCGCGGGCCCGCCCGCGCGCGTTCCCGCGCG
CCCATGCATCGGAGACACCC

Downstream 100 bases:

>100_bases
CGCACCCGAACCGCCGCCTGACCCTGCCCCTGCCCCTGCTGCTGATCCTCGTCGCCGGCGCCGCGCAGGCCGGCGAGGTC
CCCACCCGCGCGCGCCTCTG

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MPDRTVRILFAAVVVLLALYVAQPYLQPLLYAADTPRAVTARGDLAPAEASTVALFERASPSVVHVFAQSAAQNRDLLDL
DDQGGEQGGTQTGTGFVWDGAGHIVTNTHVVQNAARSGGSVSVRMSDGEVVPATLVGMAPSYDLAVLQLGRVRNMPPPLA
IGTSADLKVGQSAFAIGNPFGLDHTLTTGVISAVRRRMPTSEGRELSGVIQTDAAINPGNSGGPLLDSAGRLIGVNTAIV
SPSGASAGIGFAIPVDVVNRIVPELIKAGRVRNPGIGIIAAQEAATARLGIDGVVIVRVLPGSPAAQAGLRGVDPQTGDI
GDVIVEANDRPVHRLADLTAAIEEAGLGAGVTLKVERDGRIRQVRVTTAEVAENRR

Sequences:

>Translated_376_residues
MPDRTVRILFAAVVVLLALYVAQPYLQPLLYAADTPRAVTARGDLAPAEASTVALFERASPSVVHVFAQSAAQNRDLLDL
DDQGGEQGGTQTGTGFVWDGAGHIVTNTHVVQNAARSGGSVSVRMSDGEVVPATLVGMAPSYDLAVLQLGRVRNMPPPLA
IGTSADLKVGQSAFAIGNPFGLDHTLTTGVISAVRRRMPTSEGRELSGVIQTDAAINPGNSGGPLLDSAGRLIGVNTAIV
SPSGASAGIGFAIPVDVVNRIVPELIKAGRVRNPGIGIIAAQEAATARLGIDGVVIVRVLPGSPAAQAGLRGVDPQTGDI
GDVIVEANDRPVHRLADLTAAIEEAGLGAGVTLKVERDGRIRQVRVTTAEVAENRR
>Mature_375_residues
PDRTVRILFAAVVVLLALYVAQPYLQPLLYAADTPRAVTARGDLAPAEASTVALFERASPSVVHVFAQSAAQNRDLLDLD
DQGGEQGGTQTGTGFVWDGAGHIVTNTHVVQNAARSGGSVSVRMSDGEVVPATLVGMAPSYDLAVLQLGRVRNMPPPLAI
GTSADLKVGQSAFAIGNPFGLDHTLTTGVISAVRRRMPTSEGRELSGVIQTDAAINPGNSGGPLLDSAGRLIGVNTAIVS
PSGASAGIGFAIPVDVVNRIVPELIKAGRVRNPGIGIIAAQEAATARLGIDGVVIVRVLPGSPAAQAGLRGVDPQTGDIG
DVIVEANDRPVHRLADLTAAIEEAGLGAGVTLKVERDGRIRQVRVTTAEVAENRR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=307, Percent_Identity=32.8990228013029, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4506141, Length=302, Percent_Identity=31.4569536423841, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI7019477, Length=345, Percent_Identity=32.463768115942, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24308541, Length=320, Percent_Identity=30.3125, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786356, Length=290, Percent_Identity=37.9310344827586, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789629, Length=333, Percent_Identity=35.7357357357357, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789630, Length=377, Percent_Identity=33.1564986737401, Blast_Score=137, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646839, Length=355, Percent_Identity=29.5774647887324, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 38725; Mature: 38593

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRTVRILFAAVVVLLALYVAQPYLQPLLYAADTPRAVTARGDLAPAEASTVALFERAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEECCCC
PSVVHVFAQSAAQNRDLLDLDDQGGEQGGTQTGTGFVWDGAGHIVTNTHVVQNAARSGGS
CCEEHHHHHHHHCCCCCEECCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCCCE
VSVRMSDGEVVPATLVGMAPSYDLAVLQLGRVRNMPPPLAIGTSADLKVGQSAFAIGNPF
EEEEECCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEECCCCC
GLDHTLTTGVISAVRRRMPTSEGRELSGVIQTDAAINPGNSGGPLLDSAGRLIGVNTAIV
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCEEEEEEEEE
SPSGASAGIGFAIPVDVVNRIVPELIKAGRVRNPGIGIIAAQEAATARLGIDGVVIVRVL
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHCCCCEEEEEEEE
PGSPAAQAGLRGVDPQTGDIGDVIVEANDRPVHRLADLTAAIEEAGLGAGVTLKVERDGR
CCCCHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
IRQVRVTTAEVAENRR
EEEEEEEHHHHHCCCC
>Mature Secondary Structure 
PDRTVRILFAAVVVLLALYVAQPYLQPLLYAADTPRAVTARGDLAPAEASTVALFERAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEECCCC
PSVVHVFAQSAAQNRDLLDLDDQGGEQGGTQTGTGFVWDGAGHIVTNTHVVQNAARSGGS
CCEEHHHHHHHHCCCCCEECCCCCCCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCCCE
VSVRMSDGEVVPATLVGMAPSYDLAVLQLGRVRNMPPPLAIGTSADLKVGQSAFAIGNPF
EEEEECCCCCCCHHEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEECCCCC
GLDHTLTTGVISAVRRRMPTSEGRELSGVIQTDAAINPGNSGGPLLDSAGRLIGVNTAIV
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCEEEEEEEEE
SPSGASAGIGFAIPVDVVNRIVPELIKAGRVRNPGIGIIAAQEAATARLGIDGVVIVRVL
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHCCCCEEEEEEEE
PGSPAAQAGLRGVDPQTGDIGDVIVEANDRPVHRLADLTAAIEEAGLGAGVTLKVERDGR
CCCCHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
IRQVRVTTAEVAENRR
EEEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]