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The map label for this gene is ttuC [H]

Identifier: 170747204

GI number: 170747204

Start: 811561

End: 812640

Strand: Reverse

Name: ttuC [H]

Synonym: Mrad2831_0770

Alternate gene names: 170747204

Gene position: 812640-811561 (Counterclockwise)

Preceding gene: 170747209

Following gene: 170747202

Centisome position: 13.37

GC content: 68.52

Gene sequence:

>1080_bases
ATGACGAAGACCTACACCATCGCGGCCATTCCCGCGGACGGCATCGGCGTCGAGGTCATCGCCGCCGGCATCGAGGTGCT
CGACGCGCTGGCCGAGAAGGCCGGCTCCTTCGCCTTCCGGTTCGACCATTTCGACTGGGGCTCGGACTACTACAAGAAGC
ACGGCGTGATGATGCCGGCCGACGGCCGCGAGCAGATCCGGAACCACGACGCGATCTTCTTCGGCGCCGTGGGGGCGCCG
GACGTGCCCGATCACATCACCCTCTGGGGCCTGCGGCTCGCGATCTGCCAGCCCTTCGACCAATACGCCAATGTCCGCCC
GACCCGGATCCTGCCGGGCATCACCAGCCCGCTGCGCAACGTCTCGGGTCCGGAACTCGACTGGGTGATCGTGCGCGAGA
ACTCGGAGGGCGAGTATGCGGGCGTCGGCGGCCGGGTCCACCAGGGCCATCCCAACGAGGTCGCCACCGACGTCTCGATG
ATGACCCGCTCGGGCGTGGACCGGATCATCCGCTACGCCTTCGAGCTCGCCCGCACCCGCCCGCGCAAGTTGCTCACCGT
CGTCACCAAGTCCAACGCCCAGCGCCACGCCATGGTGATGTGGGACGAGATCGCCGCCGAGGTCGCGAAGGACTTCCCGG
ACGTGACCTGGGACAAGATGCTGGTCGACGCCATGACGATGCGGATGGTGACGAAGCCCGAGACCCTCGACACGATCGTG
GCGACGAACCTGCACGCCGACATCCTGTCGGACCTCGCGGCGGCGCTCGCCGGGTCGCTCGGCATCGCACCGACCGCCAA
CATCAACCCGGAGCGGACCTTCCCGTCGATGTTCGAGCCGATCCACGGCTCGGCCTTCGACATCACCGGCAAGGGCATCG
CCAACCCGATCGCGACCTTCTGGACGGCGTGTCAGATGCTCGAGCACCTCGGCGAGAAGCCGGCGGCCGACCGGCTGATG
CGCGCGGTCGAGCGGGTCACGGCGGATCCAGAGTTGCACACGCCGGACCTCGGCGGCACGGCGACGACCCGTCAGGTCAC
CGACGCGGTCATCGCGGCGATCCGGGGCGACAACGCCTGA

Upstream 100 bases:

>100_bases
TGTCACAAAACGTTACACGTCCCGATCCGGACGCCGAGCCCGCGCCACCGTCAGGGTTCGCTTACTCGCCTCGCCCCCGA
AGACGCTCGAGAAGACACCC

Downstream 100 bases:

>100_bases
GGCGCAACCGGGTGTCCGGGCGGCCTCAGGTCACCGCGCTCGCGAGATCCGGGCTCCGGGTGCCGCAGGCGCGGCAGAAG
CGCTCGAAGGTGCTCTTGCG

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTKTYTIAAIPADGIGVEVIAAGIEVLDALAEKAGSFAFRFDHFDWGSDYYKKHGVMMPADGREQIRNHDAIFFGAVGAP
DVPDHITLWGLRLAICQPFDQYANVRPTRILPGITSPLRNVSGPELDWVIVRENSEGEYAGVGGRVHQGHPNEVATDVSM
MTRSGVDRIIRYAFELARTRPRKLLTVVTKSNAQRHAMVMWDEIAAEVAKDFPDVTWDKMLVDAMTMRMVTKPETLDTIV
ATNLHADILSDLAAALAGSLGIAPTANINPERTFPSMFEPIHGSAFDITGKGIANPIATFWTACQMLEHLGEKPAADRLM
RAVERVTADPELHTPDLGGTATTRQVTDAVIAAIRGDNA

Sequences:

>Translated_359_residues
MTKTYTIAAIPADGIGVEVIAAGIEVLDALAEKAGSFAFRFDHFDWGSDYYKKHGVMMPADGREQIRNHDAIFFGAVGAP
DVPDHITLWGLRLAICQPFDQYANVRPTRILPGITSPLRNVSGPELDWVIVRENSEGEYAGVGGRVHQGHPNEVATDVSM
MTRSGVDRIIRYAFELARTRPRKLLTVVTKSNAQRHAMVMWDEIAAEVAKDFPDVTWDKMLVDAMTMRMVTKPETLDTIV
ATNLHADILSDLAAALAGSLGIAPTANINPERTFPSMFEPIHGSAFDITGKGIANPIATFWTACQMLEHLGEKPAADRLM
RAVERVTADPELHTPDLGGTATTRQVTDAVIAAIRGDNA
>Mature_358_residues
TKTYTIAAIPADGIGVEVIAAGIEVLDALAEKAGSFAFRFDHFDWGSDYYKKHGVMMPADGREQIRNHDAIFFGAVGAPD
VPDHITLWGLRLAICQPFDQYANVRPTRILPGITSPLRNVSGPELDWVIVRENSEGEYAGVGGRVHQGHPNEVATDVSMM
TRSGVDRIIRYAFELARTRPRKLLTVVTKSNAQRHAMVMWDEIAAEVAKDFPDVTWDKMLVDAMTMRMVTKPETLDTIVA
TNLHADILSDLAAALAGSLGIAPTANINPERTFPSMFEPIHGSAFDITGKGIANPIATFWTACQMLEHLGEKPAADRLMR
AVERVTADPELHTPDLGGTATTRQVTDAVIAAIRGDNA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=355, Percent_Identity=32.112676056338, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4758582, Length=353, Percent_Identity=29.1784702549575, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI28178816, Length=357, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI28178821, Length=358, Percent_Identity=27.3743016759777, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI28178838, Length=321, Percent_Identity=28.3489096573209, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=29.6482412060301, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788101, Length=361, Percent_Identity=52.6315789473684, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87081683, Length=336, Percent_Identity=36.9047619047619, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1787381, Length=362, Percent_Identity=29.5580110497238, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71986051, Length=350, Percent_Identity=33.1428571428571, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17550882, Length=358, Percent_Identity=31.2849162011173, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=277, Percent_Identity=31.0469314079422, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17505779, Length=356, Percent_Identity=28.3707865168539, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=36.7123287671233, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324709, Length=354, Percent_Identity=35.5932203389831, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324291, Length=355, Percent_Identity=29.5774647887324, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319830, Length=371, Percent_Identity=29.3800539083558, Blast_Score=135, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24643268, Length=355, Percent_Identity=31.5492957746479, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24643270, Length=355, Percent_Identity=31.5492957746479, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24661184, Length=355, Percent_Identity=30.4225352112676, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI281362242, Length=350, Percent_Identity=29.7142857142857, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24648872, Length=350, Percent_Identity=29.7142857142857, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161078639, Length=264, Percent_Identity=31.4393939393939, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161078633, Length=263, Percent_Identity=31.5589353612167, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24650122, Length=263, Percent_Identity=31.5589353612167, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI161078635, Length=263, Percent_Identity=31.5589353612167, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI161078637, Length=263, Percent_Identity=31.5589353612167, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI20130355, Length=259, Percent_Identity=27.7992277992278, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45550436, Length=269, Percent_Identity=23.4200743494424, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39128; Mature: 38997

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTYTIAAIPADGIGVEVIAAGIEVLDALAEKAGSFAFRFDHFDWGSDYYKKHGVMMPA
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCEECCC
DGREQIRNHDAIFFGAVGAPDVPDHITLWGLRLAICQPFDQYANVRPTRILPGITSPLRN
CCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHC
VSGPELDWVIVRENSEGEYAGVGGRVHQGHPNEVATDVSMMTRSGVDRIIRYAFELARTR
CCCCCEEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKLLTVVTKSNAQRHAMVMWDEIAAEVAKDFPDVTWDKMLVDAMTMRMVTKPETLDTIV
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
ATNLHADILSDLAAALAGSLGIAPTANINPERTFPSMFEPIHGSAFDITGKGIANPIATF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHH
WTACQMLEHLGEKPAADRLMRAVERVTADPELHTPDLGGTATTRQVTDAVIAAIRGDNA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKTYTIAAIPADGIGVEVIAAGIEVLDALAEKAGSFAFRFDHFDWGSDYYKKHGVMMPA
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCEECCC
DGREQIRNHDAIFFGAVGAPDVPDHITLWGLRLAICQPFDQYANVRPTRILPGITSPLRN
CCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHC
VSGPELDWVIVRENSEGEYAGVGGRVHQGHPNEVATDVSMMTRSGVDRIIRYAFELARTR
CCCCCEEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKLLTVVTKSNAQRHAMVMWDEIAAEVAKDFPDVTWDKMLVDAMTMRMVTKPETLDTIV
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
ATNLHADILSDLAAALAGSLGIAPTANINPERTFPSMFEPIHGSAFDITGKGIANPIATF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHH
WTACQMLEHLGEKPAADRLMRAVERVTADPELHTPDLGGTATTRQVTDAVIAAIRGDNA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]