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The map label for this gene is ffh [H]

Identifier: 170684039

GI number: 170684039

Start: 2841292

End: 2842653

Strand: Reverse

Name: ffh [H]

Synonym: EcSMS35_2762

Alternate gene names: 170684039

Gene position: 2842653-2841292 (Counterclockwise)

Preceding gene: 170681212

Following gene: 170682475

Centisome position: 56.09

GC content: 54.11

Gene sequence:

>1362_bases
ATGTTTGATAATTTAACCGATCGTTTGTCGCGCACGCTGCGCAATATCAGTGGCCGTGGACGCCTCACTGAAGACAACGT
AAAAGATACGCTGCGCGAAGTGCGCATGGCGCTGCTGGAGGCGGACGTCGCTCTGCCGGTAGTGCGTGAGTTTATCAATC
GCGTAAAAGAGAAAGCGGTTGGTCATGAAGTTAATAAGAGCCTGACGCCGGGGCAGGAGTTCGTCAAAATCGTCCGTAAC
GAACTGGTTGCGGCGATGGGCGAAGAGAACCAGACCCTGAATCTGGCTGCGCAACCGCCAGCGGTGGTACTGATGGCGGG
CCTGCAAGGTGCCGGTAAAACAACCAGCGTGGGCAAGCTCGGTAAGTTCCTGCGCGAGAAGCACAAGAAAAAAGTGTTGG
TGGTTTCTGCCGACGTTTATCGTCCGGCGGCAATCAAACAGCTGGAGACGCTGGCAGAGCAGGTGGGCGTTGATTTCTTC
CCTTCTGATGTTGGTCAGAAGCCGGTAGATATCGTTAACGCGGCGCTGAAAGAAGCCAAACTGAAATTCTACGACGTGCT
GCTGGTGGATACCGCCGGTCGTCTGCACGTTGACGAAGCGATGATGGACGAGATCAAACAAGTCCATGCGTCGATTAATC
CGGTTGAAACCCTGTTTGTGGTTGACGCCATGACCGGTCAGGATGCGGCCAATACGGCAAAAGCATTTAATGAAGCGTTA
TCGCTTACCGGCGTAGTGTTGACCAAAGTGGACGGCGATGCCCGCGGCGGTGCGGCGCTGTCTATTCGTCACATCACTGG
CAAACCGATCAAGTTCCTCGGTGTTGGCGAGAAAACTGAGGCGCTGGAGCCGTTCCATCCGGACCGCATCGCGTCGCGCA
TTCTCGGCATGGGCGACGTACTGTCACTGATCGAAGATATTGAAAGCAAAGTTGACCGCGCGCAGGCAGAGAAATTAGCC
AGCAAGCTGAAAAAAGGCGACGGCTTCGATCTCAACGATTTTCTTGAGCAACTGCGCCAGATGAAAAATATGGGCGGCAT
GGCCAGCCTGATGGGCAAACTGCCGGGCATGGGGCAGATCCCGGATAACGTCAAGTCGCAGATGGACGATAAAGTGCTGG
TGCGTATGGAAGCCATCATCAACTCGATGACGATGAAAGAGCGCGCTAAGCCAGAAATCATCAAAGGTTCGCGTAAACGC
CGTATCGCTGCCGGTTGCGGTATGCAGGTGCAGGACGTTAACCGTCTTCTGAAACAGTTCGACGACATGCAGCGCATGAT
GAAGAAAATGAAGAAGGGCGGAATGGCAAAGATGATGAGAAGCATGAAAGGGATGATGCCGCCGGGATTTCCTGGTCGCT
AA

Upstream 100 bases:

>100_bases
CCGTTGCATAACAACAAAGACGCCTTCATGTTATACTGCGGCAAAATACTGATGATGTGTCGCGATTGCGGCCAACCGTT
TCCACCCCAGGCGAGAGACA

Downstream 100 bases:

>100_bases
ATGACCTTATGCGACAGAGTTATTAACTGCTGATTGCATTTTCTCCAGAAATCAGTAAAATTTTCGGGCTTTTAATATGA
CACCGGACTCCGTTCCTCGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
SLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Sequences:

>Translated_453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
SLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
>Mature_453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
SLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=470, Percent_Identity=32.1276595744681, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI226371618, Length=372, Percent_Identity=34.1397849462366, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=38.125, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI295424842, Length=296, Percent_Identity=27.3648648648649, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI23308697, Length=296, Percent_Identity=27.3648648648649, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=99.7792494481236, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.2075471698113, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=30.3240740740741, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=30.4054054054054, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=30.8558558558559, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=207, Percent_Identity=29.951690821256, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=29.5555555555556, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49778; Mature: 49778

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHH
SLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDV
HHHHHEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHH
SLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDV
HHHHHEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]