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The map label for this gene is murR [H]

Identifier: 170683537

GI number: 170683537

Start: 2636075

End: 2636932

Strand: Reverse

Name: murR [H]

Synonym: EcSMS35_2582

Alternate gene names: 170683537

Gene position: 2636932-2636075 (Counterclockwise)

Preceding gene: 170680598

Following gene: 170683796

Centisome position: 52.03

GC content: 52.33

Gene sequence:

>858_bases
ATGTTGTACCTGACGAAAATACGCAATGCGGAAAGTGAATTTACCGGGAACGAGCAAAAAATTGCTGACTTTCTGCGGGC
CAACGTGAGTGAGCTGAAATCCGTCTCTTCGCGCAAGATGGCGAAACAGCTCGGCATCAGCCAGTCGAGTATTGTGAAGT
TTGCCCAGAAGCTCGGCGCGCAAGGATTTACTGAATTGCGTATGGCGTTAATTGGCGAATACAGTGCCAGCCGGGAGAAA
ACGAATGCCACGGCGCTGCACCTGCACAGTTCGATTACCAGTGATGATTCGCTGGAAGTGATTGCCCGTAAACTGAATCG
CGAAAAAGAGCAGGCGCTGGAGCAAACCTGCGCGTTGTTTGACTACGCGCGGCTGCAAAAAATCATTGAGGTCATCAGTA
AAGCACCGTTTATCCAGATAACGGGCCTGGGCGGGTCGGCGCTGGTGGGGCGCGATCTGTCGTTCAAACTGATGAAAATT
GGTTATCGCGTGGCCTGTGAGGCCGACACCCACGTACAAGCCACCGTTTCTCAGGCGCTAAAAAAAGGCGATGTACAAAT
CGCTATCTCTTACAGTGGCAGTAAAAAAGAGATTGTCTTGTGCGCCGAGGCAGCGCGAAAGCAGGGGGCGACGGTGATTG
CCATTACCTCATTAACCGATTCCCCGCTGCGGCGGCTGGCGCATTACACCCTCGATACCGTTTCTGGCGAAACCGAATGG
CGCAGCTCGTCGATGTCCACCCGCACGGCGCAAAATTCTGTTACCGATTTACTGTTTGTTGGCCTTGTGCAACTCAATGA
TGTGGAGTCATTGAAAATGATTGAGCGCAGCAGTGAGCTAACGCAACGCCTGAAATGA

Upstream 100 bases:

>100_bases
TGACAGACTTAAAGGAATCATTGAGTCTACACTCGCAGAGTGTGAAGAGCGTCATAAGAACTTAAGCGGAATTTTTGCTG
CCAGCCCAGGAGAGTGGAAG

Downstream 100 bases:

>100_bases
TGCATAAAGCAGCGACTGGATTGAGATTTTCCTGAATTAGTGAGCTGATCCGCAGCAATATTTTGTTTATCCTGTATTTT
CAGAGGGAATGGAGTGTAAC

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: MurPQ operon repressor [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK

Sequences:

>Translated_285_residues
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK
>Mature_285_residues
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK
TNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI
GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK

Specific function: Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of murQ, is the specific inducer tha

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788767, Length=285, Percent_Identity=96.4912280701754, Blast_Score=555, Evalue=1e-160,
Organism=Escherichia coli, GI87082130, Length=282, Percent_Identity=35.1063829787234, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082369, Length=262, Percent_Identity=26.7175572519084, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788159, Length=264, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022821
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31355; Mature: 31355

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGA
CEEEEECCCCCHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALF
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
DYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQAL
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCHHHHHHCCEEEEECCCCHHHHHHHHHH
KKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
HCCCEEEEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHH
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGA
CEEEEECCCCCHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALF
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
DYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQAL
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCHHHHHHCCEEEEECCCCHHHHHHHHHH
KKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
HCCCEEEEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHH
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA