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The map label for this gene is cobC [H]

Identifier: 170683166

GI number: 170683166

Start: 669900

End: 670511

Strand: Reverse

Name: cobC [H]

Synonym: EcSMS35_0658

Alternate gene names: 170683166

Gene position: 670511-669900 (Counterclockwise)

Preceding gene: 170682626

Following gene: 170681282

Centisome position: 13.23

GC content: 50.98

Gene sequence:

>612_bases
ATGCGACTGTGGTTAATTCGTCATGGCGAAACGCAAGCGAATGTCGATGGTCTGTACAGCGGTCATGCGCCCACTCCCCT
GACCGCACGCGGTATTGAGCAAGCGCAAAATCTGCATACGCTGCTACATGATGTTTCCTTTGACCTGGTTTTATGCAGTG
AACTGGAACGGGCACAGCATACCGCGCGACGGGTTCTCAGTGATCGCCAGCTCCCCGTGCAAATCATCCCTGAACTCAAC
GAAATGTTTTTTGGCGACTGGGAGATGCGACATCATCGCGACCTCATGCAAGAAGATGCCGAAAACTATAGCGCGTGGTG
CAATGACTGGCAGCATGCTATCCCCACGAACGGTGAAGGATTTCAGGCATTTTCACAACGTGTGGAACGGTTTATCGCAA
GGCTTAGTGAATTTCAGCACTATCAGAATATTTTAGTCGTCAGCCATCAGGGTGTACTGAGTCTGTTAATCGCTCGTTTA
ATTGGCATGCCTGCCGAGGCTATGTGGCATTTTCGCGTTGATCAAGGGTGTTGGAGCGCCATTGATATCAACCAAAAATT
CGCGACGCTACGCGTCCTCAATAGCCGTGCCATCGGGGTCGAGAATGCATGA

Upstream 100 bases:

>100_bases
AAAACGGTGAATCGTGTGAGGATTTATTGCCGGAACCGGTACTGACTTACATTAACCAACAAGGCTTGTATCGCTGATAC
CTGTCGTTACGGAGGGCATG

Downstream 100 bases:

>100_bases
CTTTTCTGTTTTTTTACGGGTAAGCCGCAACGACCATTGACAGCCCCGGGCAGGCTGATATTCTCCGCAGCCAGACTTTT
TCCGCCAGACACGACTTTGT

Product: alpha-ribazole phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRLWLIRHGETQANVDGLYSGHAPTPLTARGIEQAQNLHTLLHDVSFDLVLCSELERAQHTARRVLSDRQLPVQIIPELN
EMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEGFQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARL
IGMPAEAMWHFRVDQGCWSAIDINQKFATLRVLNSRAIGVENA

Sequences:

>Translated_203_residues
MRLWLIRHGETQANVDGLYSGHAPTPLTARGIEQAQNLHTLLHDVSFDLVLCSELERAQHTARRVLSDRQLPVQIIPELN
EMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEGFQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARL
IGMPAEAMWHFRVDQGCWSAIDINQKFATLRVLNSRAIGVENA
>Mature_203_residues
MRLWLIRHGETQANVDGLYSGHAPTPLTARGIEQAQNLHTLLHDVSFDLVLCSELERAQHTARRVLSDRQLPVQIIPELN
EMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEGFQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARL
IGMPAEAMWHFRVDQGCWSAIDINQKFATLRVLNSRAIGVENA

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=203, Percent_Identity=98.5221674876847, Blast_Score=415, Evalue=1e-118,
Organism=Escherichia coli, GI1790856, Length=187, Percent_Identity=26.7379679144385, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324857, Length=217, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23396; Mature: 23396

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLWLIRHGETQANVDGLYSGHAPTPLTARGIEQAQNLHTLLHDVSFDLVLCSELERAQH
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TARRVLSDRQLPVQIIPELNEMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEG
HHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARLIGMPAEAMWHFRVDQGCWSA
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHEEEEECCCCCCE
IDINQKFATLRVLNSRAIGVENA
EECCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLWLIRHGETQANVDGLYSGHAPTPLTARGIEQAQNLHTLLHDVSFDLVLCSELERAQH
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TARRVLSDRQLPVQIIPELNEMFFGDWEMRHHRDLMQEDAENYSAWCNDWQHAIPTNGEG
HHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FQAFSQRVERFIARLSEFQHYQNILVVSHQGVLSLLIARLIGMPAEAMWHFRVDQGCWSA
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHEEEEECCCCCCE
IDINQKFATLRVLNSRAIGVENA
EECCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]