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The map label for this gene is oxc [H]

Identifier: 170682647

GI number: 170682647

Start: 2581075

End: 2582769

Strand: Reverse

Name: oxc [H]

Synonym: EcSMS35_2523

Alternate gene names: 170682647

Gene position: 2582769-2581075 (Counterclockwise)

Preceding gene: 170682002

Following gene: 170680123

Centisome position: 50.96

GC content: 47.2

Gene sequence:

>1695_bases
ATGTCAGATCAACTTCAAATGACAGATGGTATGCATATCATCGTTGAAGCATTAAAACAGAATAATATTGACACTATTTA
TGGTGTTGTAGGTATTCCTGTGACGGATATGGCACGCCATGCCCAGGCGGAAGGCATTCGTTATATTGGTTTTCGTCATG
AGCAGTCGGCAGGCTATGCCGCTGCGGCAAGCGGTTTTCTTACCCAAAAACCAGGGATCTGCCTGACAGTGTCTGCGCCA
GGATTCCTCAATGGTTTGACCGCATTGGCCAACGCAACGGTAAATGGTTTTCCGATGATCATGATTAGCGGCTCCAGCGA
CCGCGCGATCGTCGACCTACAGCAAGGTGATTATGAAGAGCTGGACCAAATGAATGCGGCAAAACCGTATGCCAAAGCAG
CATTCCGCGTTAATCAGCCGCAGGATCTTGGCATTGCATTGGCACGCGCTATCCGGGTCTCAGTATCGGGTCGCCCTGGC
GGAGTTTATCTTGATTTGCCAGCAAATGTCCTGGCCGCGACGATGGAAAAAGACGAAGCGTTAACCACGATTGTAAAAGT
TGAAAATCCGTCGCCAGCATTATTGCCATGCCCGAAGTCAGTCGCTAGCGCAATTTCGCTTTTAGCAAAAGCTGAACGAC
CATTAGTTATCCTTGGCAAAGGCGCGGCGTATTCACAAGCTGATGAACAGCTTCGTGAATTTATTGAAAGTGCCCAGATT
CCATTCCTGCCAATGTCTATGGCGAAAGGGATCCTGGAAGATACACATCCACTTTCTGCGGCAACTGCGCGTTCGTTTGC
CCTGGCAAATGCTGACGTTGTCATGCTTGTTGGTGCACGACTGAATTGGTTACTGGCACACGGTAAAAAAGGATGGGCGG
CAGATACACAGTTTATTCAACTGGATATTGAACCGCAGGAAATTGACAGCAACCGCCCCATTGCTGTGCCAGTCGTTGGC
GATATTGCATCCAGTATGCAAGGTATGCTGGCAGAACTGAAACAAAACACATTTACGACTCCACTGGTATGGCGCGATAT
TTTAAATATCCACAAGCAGCAAAATGCACAAAAAATGCATGAAAAGTTAAGTACAGATACCCAACCATTAAATTACTTTA
ATGCATTGAGTGCCGTGCGCGATGTTTTGCGCGAGAACCAGGATATTTATTTAGTTAATGAAGGGGCAAATACCCTGGAT
AATGCACGAAATATTATTGATATGTATAAACCACGTCGTCGTCTGGATTGTGGCACCTGGGGTGTCATGGGCATCGGTAT
GGGCTATGCCATCGGTGCTAGCGTGACCTCTGGTTCTCCGGTTGTCGCCATTGAAGGTGATAGTGCTTTTGGTTTCAGTG
GGATGGAGATTGAAACGATTTGTCGATATAACCTGCCGGTGACGATCGTTATTTTTAATAATGGCGGCATCTACAGAGGA
GACGGTGTTGATCTCAGTGGCGCTGGTGCACCATCACCAACAGATCTGTTGCACCATGCAAGGTATGACAAATTAATGGA
TGCGTTTCGTGGCGTTGGCTATAACGTCACCACGACAGATGAACTTCGTCATGCTTTAACCACCGGTATTCAGTCGCGCA
AACCGACCATTATTAATGTGGTCATCGACCCTGCAGCAGGAACTGAAAGTGGCCATATTACCAAACTTAACCCAAAACAA
GTCGCTGGTAATTAA

Upstream 100 bases:

>100_bases
ATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGATATTAACGGGGGCTTCTGGCTCCCAATTTATAA
AAATTTCGAGGTTATTAATC

Downstream 100 bases:

>100_bases
ATACTGACATCGTCTCCTCTTGCCAACTCATTATCGATGGTGAGGGGACCCTTATCGGAAATACTATTATGCTAACATTT
TTTATTGGCGATTTATTGCC

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVASAISLLAKAERPLVILGKGAAYSQADEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAATARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN

Sequences:

>Translated_564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVASAISLLAKAERPLVILGKGAAYSQADEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAATARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN
>Mature_563_residues
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAPG
FLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGG
VYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVASAISLLAKAERPLVILGKGAAYSQADEQLREFIESAQIP
FLPMSMAKGILEDTHPLSAATARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVGD
IASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDN
ARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRGD
GVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQV
AGN

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=38.8888888888889, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI21361361, Length=511, Percent_Identity=26.4187866927593, Blast_Score=176, Evalue=6e-44,
Organism=Escherichia coli, GI1788716, Length=564, Percent_Identity=99.468085106383, Blast_Score=1157, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=556, Percent_Identity=24.8201438848921, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1790104, Length=479, Percent_Identity=27.5574112734864, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786717, Length=478, Percent_Identity=26.5690376569038, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787096, Length=540, Percent_Identity=22.5925925925926, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531301, Length=549, Percent_Identity=38.2513661202186, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17531299, Length=549, Percent_Identity=38.2513661202186, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17542570, Length=514, Percent_Identity=27.2373540856031, Blast_Score=179, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6320816, Length=548, Percent_Identity=35.036496350365, Blast_Score=301, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323755, Length=584, Percent_Identity=24.486301369863, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=39.9286987522282, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 60568; Mature: 60437

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVASAISLLAKAERPLVILGKGAAYSQADEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAATARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQ
CEECHHHHHHHHHCCCCCCHHHHHHHEECCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC
>Mature Secondary Structure 
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVASAISLLAKAERPLVILGKGAAYSQADEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAATARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQ
CEECHHHHHHHHHCCCCCCHHHHHHHEECCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]