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The map label for this gene is actP [H]

Identifier: 170682571

GI number: 170682571

Start: 4629297

End: 4630946

Strand: Reverse

Name: actP [H]

Synonym: EcSMS35_4529

Alternate gene names: 170682571

Gene position: 4630946-4629297 (Counterclockwise)

Preceding gene: 170683632

Following gene: 170681595

Centisome position: 91.37

GC content: 55.27

Gene sequence:

>1650_bases
ATGAAAAGAGTTCTGACGGCGCTTGCCGCCACACTCCCTTTCGCAGCTAACGCCGCGGATGCTATTAGCGGGGCCGTAGA
GCGCCAGCCAACAAACTGGCAGGCGATTATTATGTTCCTGATTTTCGTCGTGTTTACGCTCGGCATTACCTACTGGGCGT
CAAAACGCGTACGTTCGCGTAATGACTACTACACCGCAGGCGGCAATATCACCGGTTTTCAGAACGGGCTGGCGATTGCC
GGGGACTATATGTCCGCCGCCTCATTCTTGGGGATCTCCGCGCTGGTGTTTACCTCCGGCTATGACGGGCTGATCTACTC
GTTGGGCTTCCTGGTGGGCTGGCCAATCATTCTGTTCCTGATTGCCGAACGTCTGCGTAACCTCGGTCGCTACACCTTTG
CCGATGTGGCCTCTTACCGTCTGAAACAAGGGCCGATTCGTATTCTTTCGGCCTGTGGTTCTCTGGTGGTGGTGGCGCTT
TACCTTATCGCCCAGATGGTAGGTGCAGGTAAACTCATCGAGCTGCTGTTTGGCCTTAACTATCACATTGCGGTGGTGCT
GGTCGGCGTGCTGATGATGATGTACGTCCTGTTCGGCGGCATGCTGGCGACCACCTGGGTACAGATTATCAAAGCCGTTC
TGTTGCTGTTCGGTGCCAGCTTTATGGCCTTTATGGTGATGAAACACGTCGGCTTTAGCTTCAACAATCTGTTCAGCGAA
GCGATGGCGGTACACCCGAAAGGTGTCGACATCATGAAGCCGGGCGGGCTGGTGAAAGATCCTATCTCCGCGCTCTCTTT
GGGGCTAGGACTGATGTTTGGTACGGCTGGCTTGCCGCATATTCTGATGCGCTTCTTTACGGTCAGCGATGCCCGCGAAG
CACGTAAGAGCGTGTTCTACGCCACCGGATTTATGGGCTACTTCTACATCCTGACCTTTATTATCGGCTTCGGCGCAATC
ATGCTGGTTGGTGCGAATCCGGAATATAAAGACGCGGCGGGCCATCTGATTGGTGGTAACAACATGGCAGCAGTTCACCT
GGCGAATGCAGTGGGTGGCAACCTGTTCCTCGGCTTTATTTCAGCGGTTGCTTTCGCCACCATTCTTGCGGTGGTTGCGG
GTCTGACGCTGGCGGGCGCATCGGCGGTGTCTCACGACCTGTACGCTAACGTCTTCAAAAAAGGTGCGACCGAACGTGAA
GAGCTGCGGGTATCGAAAATCACCGTACTGATCCTCGGTGTGATTGCCATTATCCTCGGCGTGCTGTTTGAGAATCAGAA
CATCGCCTTTATGGTGGGGCTGGCGTTTGCCATCGCGGCGAGCTGTAACTTCCCGATCATTCTGCTTTCCATGTACTGGT
CGAAACTGACTACCCGTGGCGCGATGCTGGGCGGCTGGTTAGGACTGATTACTGCGGTGGTGCTGATGATCCTCGGCCCG
ACGATTTGGGTACAGATCCTCGGTCACGAAAAAGCCATCTTCCCGTATGAATACCCGGCGCTGTTCTCTATCAGCGTGGC
ATTCCTCGGCATCTGGTTCTTCTCGGCAACCGATAACTCAGCGGAAGGCGCGCGTGAGCGTGAACTGTTCCGTGCGCAGT
TTATCCGTTCCCAGACCGGCTTTGGCGTTGAGCAAGGCCGCGCGCATTAA

Upstream 100 bases:

>100_bases
TAATTGTGATCTCCTTTGTTCTCACTGGTATCTACATCTGGCGGGCGAACGGCGAATTCGACCGTCTTAATAATGAAGTC
CTGCATGAGGTACAAGCATC

Downstream 100 bases:

>100_bases
TCTCCACTAGCCTCTGGTCACCTGACCAACGGTAAAAAGGTGCGATGTACTGCACCTTTTTACCGATTACACCGCCAAGC
GTTATTGGTTCTCTTCAATC

Product: acetate permease

Products: NA

Alternate protein names: Acetate permease; Acetate transporter ActP [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIA
GDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVAL
YLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSE
AMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAI
MLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATERE
ELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGP
TIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH

Sequences:

>Translated_549_residues
MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIA
GDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVAL
YLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSE
AMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAI
MLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATERE
ELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGP
TIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
>Mature_549_residues
MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIA
GDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVAL
YLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSE
AMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAI
MLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATERE
ELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLITAVVLMILGP
TIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH

Specific function: Transports acetate [H]

COG id: COG4147

COG function: function code R; Predicted symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=469, Percent_Identity=26.4392324093817, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1790503, Length=549, Percent_Identity=99.4535519125683, Blast_Score=1088, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=451, Percent_Identity=26.3858093126386, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082237, Length=447, Percent_Identity=21.7002237136465, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014083
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 59193; Mature: 59193

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCC
>Mature Secondary Structure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CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA