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The map label for this gene is dtpD [H]

Identifier: 170682417

GI number: 170682417

Start: 730643

End: 732124

Strand: Reverse

Name: dtpD [H]

Synonym: EcSMS35_0724

Alternate gene names: 170682417

Gene position: 732124-730643 (Counterclockwise)

Preceding gene: 170681894

Following gene: 170681798

Centisome position: 14.44

GC content: 51.96

Gene sequence:

>1482_bases
ATGAATAAACACGCATCACAGCCGCGCGCTATTTACTATGTCGTTGCGCTGCAAATCTGGGAATATTTTAGCTTTTACGG
CATGCGTGCCCTGCTGATTCTCTATCTCACCAATCAACTAAAATACAACGATACTCACGCCTACGAGTTATTTAGCGCCT
ACTGTTCGCTGGTGTATGTCACGCCAATCCTCGGTGGCTTTTTGGCGGATAAAGTTCTCGGCAATCGCATGGCGGTGATG
CTGGGGGCGTTGTTGATGGCGATCGGTCATGTGGTGCTGGGTGCCAGTGAGATCCATCCGTCATTCCTCTATCTGTCACT
GGCGATTATCGTCTGCGGCTATGGTCTGTTTAAATCCAACGTCAGTTGCCTGCTCGGTGAGCTGTATGAGCCAACCGATC
CACGTCGTGATGGCGGTTTCTCGCTGATGTATGCGGCGGGTAACGTGGGGTCTATTATCGCACCTATCGCCTGTGGTTTC
GCCCAGGAAGAATACAGTTGGGCGATGGGCTTTGGCCTGGCGGCGGTGGGTATGATCGCGGGTCTGGTCATTTTCTTATG
TGGCAATCGTCATTTCTCTCATACCCGCGGCGTTAACAAAAAGGTACTGCGTGCGACAAACTTCCTCCTGCCCAACTGGG
GATGGCTGCTGGTTCTGCTGGTGGCAACGCCTGCGCTGATTACCGTGTTGTTCTGGAAAGAGTGGTCGGTATACGCCTTG
ATTGTCGCCACGATCATCGGCCTTGGCGTTCTGGCAAAAATTTATCGCAAAGCAGAAAACCAAAAACAGCGTAAGGAGCT
GGGGCTGATTGTTACCCTCACCTTCTTCAGCATGTTGTTCTGGGCCTTCGCACAACAGGGCGGCAGCTCGATTAGCCTTT
ATATCGACCGCTTCGTTAACCGCGATATGTTTGGTTATACCGTTCCGACTGCTATGTTCCAGTCGATTAATGCCTTCGCA
GTTATGCTGTGCGGTGTGTTCCTGGCGTGGGTGGTTAAAGAGAGCGTCGCAGGTAATCGTACCGTGCGCATCTGGGGAAA
ATTTGCTCTTGGTCTCGGCCTGATGAGCGCCGGATTCTGCATTCTGACCTTAAGCGCCCGCTGGTCCGCAATGTATGGTC
ATTCTTCTCTGCCACTGATGGTGTTAGGCCTGGCGGTGATGGGCTTTGCGGAACTGTTTATCGACCCGGTTGCTATGTCG
CAGATTACGCGCATTGAAATCCCTGGCGTGACTGGCGTATTAACTGGCATTTATATGCTGCTTTCCGGCGCGATTGCGAA
CTATCTGGCTGGCGTTATTGCCGATCAGACATCGCAAGCTTCGTTTGATGCTTCCGGGGCGATCAACTATTCCATCAATG
CATATATTGAAGTGTTTGATCAAATTACCTGGGGCGCACTGGCGTGTGTAGGAGTGGTGTTGATGATTTGGCTGTATCAG
GCGCTGAAATTCAGAAACCGCGCGCTGGCGCTGGAGTCTTAA

Upstream 100 bases:

>100_bases
TTGCATAAATAATCAGATCTGTATCAAAGTTTTAACTTTAAGGAAACACAAGCACGCCGCGCAACTATTACGTGACGTTG
CAGTCAATTGTGGAATTATT

Downstream 100 bases:

>100_bases
TAGGCCAGCACCATACCTGATAAAACGCTCGCTGCGTTTTATCAGGCTCCTTTCCTCGCTTCTTCGTACGCTGCCAGCGT
TCGCAGCCTTGCCTCTTTGT

Product: amino acid/peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGF
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFSHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES

Sequences:

>Translated_493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGF
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFSHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES
>Mature_493_residues
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVM
LGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGF
AQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFSHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
IVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFA
VMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMS
QITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
ALKFRNRALALES

Specific function: Probable proton-dependent permease that transports dipeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=234, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226371746, Length=337, Percent_Identity=25.8160237388724, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI226371748, Length=329, Percent_Identity=24.6200607902736, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786927, Length=493, Percent_Identity=99.1886409736308, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1790572, Length=474, Percent_Identity=57.5949367088608, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1787922, Length=477, Percent_Identity=28.5115303983228, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1789911, Length=479, Percent_Identity=27.1398747390397, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17569141, Length=196, Percent_Identity=31.6326530612245, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987453, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541704, Length=338, Percent_Identity=25.7396449704142, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639581, Length=201, Percent_Identity=32.8358208955224, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639583, Length=201, Percent_Identity=32.8358208955224, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639585, Length=201, Percent_Identity=32.8358208955224, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571098, Length=340, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571102, Length=340, Percent_Identity=25, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571100, Length=340, Percent_Identity=25, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 54102; Mature: 54102

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50850 MFS ; PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPILGGFLADKVLGNRMAVMLGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHC
VSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGFAQEEYSWAMGFGLAAVGMIA
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GLVIFLCGNRHFSHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
HHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHC
RDMFGYTVPTAMFQSINAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHH
ILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYML
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKFRNRALALES
HHHHHCCCCCCCC
>Mature Secondary Structure
MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TPILGGFLADKVLGNRMAVMLGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHC
VSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGFAQEEYSWAMGFGLAAVGMIA
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GLVIFLCGNRHFSHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSVYAL
HHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHC
RDMFGYTVPTAMFQSINAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHH
ILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYML
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
LSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGVVLMIWLYQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALKFRNRALALES
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]