Click here to switch to the map view.

The map label for this gene is adhC [H]

Identifier: 170682377

GI number: 170682377

Start: 402177

End: 403286

Strand: Reverse

Name: adhC [H]

Synonym: EcSMS35_0387

Alternate gene names: 170682377

Gene position: 403286-402177 (Counterclockwise)

Preceding gene: 170680784

Following gene: 170684242

Centisome position: 7.96

GC content: 53.78

Gene sequence:

>1110_bases
ATGAAATCACGTGCTGCCGTTGCATTTGCTCCCGGTAAACCGCTGGAAATCGTTGAAATTGACGTTGCACCACCGAAAAA
AGGTGAAGTGCTGATTAAAGTCACCCATACCGGCGTTTGCCATACCGACGCATTTACCCTCTCCGGCGATGACCCGGAAG
GTGTATTCCCGGTAGTTCTCGGTCACGAAGGGGCCGGCGTTGTGGTTGAAGTCGGTGAAGGCGTAACCAGCGTCAAACCT
GGCGACCATGTGATCCCGCTTTACACCGCAGAGTGCGGCGAGTGTGAGTTCTGTCGTTCCGGCAAAACCAACCTCTGTGT
TGCGGTTCGCGAAACCCAGGGTAAAGGCCTGATGCCAGACGGCACCACCCGTTTTTCTTACAACGGGCAGCCGCTTTATC
ACTACATGGGATGCTCTACATTCAGTGAATACACCGTGGTCGCGGAAGTGTCTCTGGCCAAAATTAATCCAGAGGCAAAC
CACGAACACGTCTGCCTGCTGGGCTGTGGCGTGACCACCGGTATTGGCGCGGTACACAACACGGCTAAAGTCCAGCCAGA
TGATTCTGTTGCCGTATTTGGTCTTGGCGCGATTGGTCTGGCAGTGGTTCAGGGCGCGCGTCAGGCGAAAGCGGGACGGA
TTATCGCTATCGATACGAACCCGAAGAAATTCGATCTGGCGCGTCGCTTCGGTGCTACCGACTGCATTAACCCGAATGAC
TACGACAAACCGATTAAAGATGTCCTGCTGGATATCAACAAATGGGGTATCGACCATACCTTTGAATGCATCGGTAACGT
CAACGTGATGCGTGCGGCGCTGGAAAGTGCGCACCGCGGCTGGGGTCAGTCGGTGATCATCGGGGTAGCTGGTTCTGGTC
AGGAAATCTCCACCCGTCCATTCCAGTTGGTCACCGGTCGCGTATGGAAAGGTTCCGCGTTTGGCGGCGTGAAAGGTCGT
TCCCAGTTACCGGGTATGGTTGAAGATGCGATGAAAGGCGATATCGATCTGGAACCGTTTGTCACGCATACCATGAGCCT
GGATGAAATTAATGACGCCTTTGACCTGATGCATGAAGGCAAATCCATTCGAACCGTAATTCGTTACTGA

Upstream 100 bases:

>100_bases
TACAGCCGCGAAGTCAGCCAATCCGTTGACGACACTATTGAACTGGTTCGTGCCTATCTTAAATAGCTGAATCTATTACC
ATATTGAGGAAGAGCGAGAG

Downstream 100 bases:

>100_bases
TTTCCCGCAGGTTTACCCGTCCAGTTCAGACGGGGTTCTTAATACTCTCCCCGGGCAGCCGTCCGGGGGATTAACCGTGA
GATAATGACTGATGGAACTC

Product: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKP
GDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEHVCLLGCGVTTGIGAVHNTAKVQPDDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPND
YDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGR
SQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY

Sequences:

>Translated_369_residues
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKP
GDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEHVCLLGCGVTTGIGAVHNTAKVQPDDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPND
YDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGR
SQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY
>Mature_369_residues
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVLGHEGAGVVVEVGEGVTSVKP
GDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPDGTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEHVCLLGCGVTTGIGAVHNTAKVQPDDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPND
YDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGVKGR
SQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEGKSIRTVIRY

Specific function: Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=62.5, Blast_Score=470, Evalue=1e-133,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=47.4393530997305, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=47.1849865951743, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=46.900269541779, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=46.3215258855586, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=46.3611859838275, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=46.5373961218837, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=46.070460704607, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=46.070460704607, Blast_Score=347, Evalue=7e-96,
Organism=Homo sapiens, GI156627571, Length=371, Percent_Identity=25.0673854447439, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=99.1869918699187, Blast_Score=751, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=27.6536312849162, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788073, Length=367, Percent_Identity=27.7929155313352, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=386, Percent_Identity=26.1658031088083, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=28.125, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=35, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786825, Length=246, Percent_Identity=27.6422764227642, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788075, Length=356, Percent_Identity=24.1573033707865, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.1455525606469, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788407, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI226510992, Length=241, Percent_Identity=27.3858921161826, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790718, Length=340, Percent_Identity=24.1176470588235, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=57.1045576407507, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=56.8, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.268221574344, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562584, Length=372, Percent_Identity=25.8064516129032, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=31.5068493150685, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=160, Percent_Identity=33.125, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=60.2150537634409, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319621, Length=281, Percent_Identity=31.3167259786477, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=29.8913043478261, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=348, Percent_Identity=30.1724137931034, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=30.2250803858521, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=377, Percent_Identity=27.8514588859416, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=357, Percent_Identity=27.1708683473389, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=27.1708683473389, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=63.3152173913043, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17137530, Length=339, Percent_Identity=24.4837758112094, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39391; Mature: 39391

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCEEEEEE
GHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCC
GTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHN
CCEEEEECCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCHHCCCHHCC
TAKVQPDDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPND
CCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCCCC
YDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRP
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEG
EEEEECEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHEEEECHHHHHHHHHHHHCC
KSIRTVIRY
CCHHHEECC
>Mature Secondary Structure
MKSRAAVAFAPGKPLEIVEIDVAPPKKGEVLIKVTHTGVCHTDAFTLSGDDPEGVFPVVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCEEEEEE
GHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECEFCRSGKTNLCVAVRETQGKGLMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHCCCCEEEEEEEECCCCCCCCC
GTTRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPEANHEHVCLLGCGVTTGIGAVHN
CCEEEEECCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCHHCCCHHCC
TAKVQPDDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPKKFDLARRFGATDCINPND
CCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCCCC
YDKPIKDVLLDINKWGIDHTFECIGNVNVMRAALESAHRGWGQSVIIGVAGSGQEISTRP
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGVKGRSQLPGMVEDAMKGDIDLEPFVTHTMSLDEINDAFDLMHEG
EEEEECEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHEEEECHHHHHHHHHHHHCC
KSIRTVIRY
CCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA