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The map label for this gene is cirA [H]

Identifier: 170682371

GI number: 170682371

Start: 2330491

End: 2332416

Strand: Reverse

Name: cirA [H]

Synonym: EcSMS35_2302

Alternate gene names: 170682371

Gene position: 2332416-2330491 (Counterclockwise)

Preceding gene: 170679799

Following gene: 170680773

Centisome position: 46.02

GC content: 52.96

Gene sequence:

>1926_bases
GTGTTAGCGGTCGATGATGATGGCGAAACGATGGTTGTCACTGCATCTTCCGTTGAGCAAAACCTTAAAGATGCACCCGC
CAGTATCAGCGTCATTACCCAGGAAGACCTGCAGCGAAAACCGGTACAGAATCTGAAGGATGTCCTCAAAGAAGTGCCTG
GCGTACAACTGACGAACGAAGGGGATAACCGTAAGGGCGTAAGTATTCGTGGTCTGGACAGCAGCTACACCCTGATTCTT
GTCGACGGTAAACGCGTTAACTCCCGCAATGCCGTCTTCCGCCACAATGATTTCGATCTGAACTGGATCCCGGTCGATTC
CATCGAACGTATTGAAGTGGTCCGTGGCCCGATGTCGTCGCTGTACGGTTCCGATGCGCTCGGCGGTGTAGTGAATATCA
TCACCAAAAAAATCGGTCAGAAATGGTCGGGCACCGTTACCGTCGATACCACCGTTCAGGAACATCGCGATCGCGGTGAT
ACCTATAACGGTCAGTTCTTTACCAGCGGACCATTAATTGACGGCGTGCTGGGAATGAAAGCTTACGGCAGCCTGGCAAA
ACGTGAAAAGGATGACCCGCAAAACTCAACGACCACCGATACCGGAGAAACGCCGCGTATTGAAGGATTCTCCAGCCGCG
ACGGCAATGTCGAATTTGCCTGGACACCGAATCAAAATCACGATTTTACTGCCGGATACGGTTTCGACCGTCAGGATCGT
GATTCCGACTCGCTGGACAAAAACCGCCTGGAACGCCAGAACTACTCCGTCAGCCATAATGGGCGTTGGGATTACGGCAC
CAGCGAACTGAAATACTACGGTGAGAAAGTCGAGAACAAAAACCCTGGCTACAGCAGCCCGATAACTTCCGAAAGCAATA
CGGTCGACGGCAAATACACGTTGCCGCTGACGGCGATTAATCAGTTTCTCACGGTTGGCGGTGAATGGCGTCACGACAAA
CTTAGCGATGCGGTGAACCTGACCGGGGGAACCAGCTCCAAAACGTCTGCCAGCCAGTACGCGCTGTTTGTGGAAGATGA
ATGGCGGATCTTCGAGCCGCTGGCGCTGACGACCGGCGTACGTATGGACGATCATGAAACCTACGGTGAACACTGGAGTC
CGCGTGCCTACCTGGTTTATAACGCCACCGACACCGTAACGGTGAAAGGGGGCTGGGCGACGGCATTTAAAGCGCCTTCT
CTGTTGCAACTTAGCCCTGACTGGACGAGCAATTCCTGCCGTGGCGCATGTAAGATTGTGGGTAGCCCGGATCTGAAACC
AGAAACCAGCGAAAGTTGGGAACTGGGGCTTTACTACATGGGCGAAGAAGGCTGGCTGGAAGGGGTTGAATCCAGCGTTA
CCGTTTTCCGTAACGATGTGAAAGATCGTATCAGCATTAGCCGTACGTCTGACGTCAACGCTGCACCGGGCTACCAAAAC
TTTGTCGGTTTTGAGACGGGCGCTAACGGACGGCGCATACCGGTATTTAGCTACTACAACGTTAACAAAGCTCGTATTCA
GGGCGTGGAAACCGAACTGAAAATTCCGTTCAACGATGAATGGAAACTGTCGATCAACTACACCTACAACGATGGTCGTG
ATGTCAGCAACGGCGAAAACAAACCGCTATCCGATCTGCCGTTCCATACTGCTAACGGTACGCTGGACTGGAAACCGCTG
GCGCTGGAAGACTGGTCATTCTATGTTTCTGGTCACTATACCGGGCAGAAACGCGCCGACAGCGCGACGGCTAAAACACC
GGGCGGTTATACCATCTGGAATACCGGTGCGGCCTGGCAGGTGACTAAAGACGTCAAACTGCGCGCAGGCGTGCTGAACC
TTGGCGACAAGGATCTCAGTCGTGACGACTACAGCTATAACGAAGACGGACGTCGTTACTTTATGGCAGTGGATTATCGC
TTCTGA

Upstream 100 bases:

>100_bases
TTTTATTTTCGTAGTTACCTCATGGAGATATGGAATGTTTAGGTTGAACCCTTTCGTACGGGTCGGGCTGTGTTTGTCCG
CTATTTCTTGTGCATGGCCT

Downstream 100 bases:

>100_bases
TGAGAAGATGCCCGGCGAACCGGGCGGACTTTCACTTCAGTAAATACTGCGCATGGAAGCGCAGGTGATCCTCTATAAAA
GAGGCGATGAAGTAGTAACT

Product: colicin I receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLIL
VDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTVQEHRDRGD
TYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDR
DSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGYSSPITSESNTVDGKYTLPLTAINQFLTVGGEWRHDK
LSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPS
LLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN
FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPL
ALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYR
F

Sequences:

>Translated_641_residues
MLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLIL
VDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTVQEHRDRGD
TYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDR
DSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGYSSPITSESNTVDGKYTLPLTAINQFLTVGGEWRHDK
LSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPS
LLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN
FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPL
ALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYR
F
>Mature_641_residues
MLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLIL
VDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTVQEHRDRGD
TYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDR
DSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGYSSPITSESNTVDGKYTLPLTAINQFLTVGGEWRHDK
LSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPS
LLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN
FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPL
ALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYR
F

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=641, Percent_Identity=99.5319812792512, Blast_Score=1310, Evalue=0.0,
Organism=Escherichia coli, GI1786798, Length=746, Percent_Identity=32.4396782841823, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1790405, Length=685, Percent_Identity=26.2773722627737, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1787723, Length=139, Percent_Identity=33.8129496402878, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 71500; Mature: 71500

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNE
CEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEEEECC
GDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSS
CCCCCCCEEEECCCCEEEEEEECCEECCCCEEEEECCCCEEEEECCCCHHHHHHHCCHHH
LYGSDALGGVVNIITKKIGQKWSGTVTVDTTVQEHRDRGDTYNGQFFTSGPLIDGVLGMK
HCCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCCCEEEECCCCHHHHHHHH
AYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCC
DSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGYSSPITSESNTVDGKYT
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
LPLTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGV
EEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCCEEEEEEECCCEEECCEEHHCCC
RMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIV
EECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECCCCEEEECCCCCCCCCCEEEEEE
GSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN
CCCCCCCCCCCCEEEEEEEECCCHHHHCHHHHHHHHHHCHHHHEEEEECCCCCCCCCCCC
FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGEN
CEEEECCCCCCEEEEEEEECCCHHHEECCCEEEECCCCCCEEEEEEEEECCCCCCCCCCC
KPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQ
CCCCCCCEECCCCCCCCCCEEEECEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEE
VTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF
EECCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNE
CEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCEEEECC
GDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSS
CCCCCCCEEEECCCCEEEEEEECCEECCCCEEEEECCCCEEEEECCCCHHHHHHHCCHHH
LYGSDALGGVVNIITKKIGQKWSGTVTVDTTVQEHRDRGDTYNGQFFTSGPLIDGVLGMK
HCCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCCCEEEECCCCHHHHHHHH
AYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCC
DSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGYSSPITSESNTVDGKYT
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
LPLTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGV
EEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCCEEEEEEECCCEEECCEEHHCCC
RMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIV
EECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECCCCEEEECCCCCCCCCCEEEEEE
GSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN
CCCCCCCCCCCCEEEEEEEECCCHHHHCHHHHHHHHHHCHHHHEEEEECCCCCCCCCCCC
FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGEN
CEEEECCCCCCEEEEEEEECCCHHHEECCCEEEECCCCCCEEEEEEEEECCCCCCCCCCC
KPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQ
CCCCCCCEECCCCCCCCCCEEEECEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEE
VTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF
EECCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]