BacMap

Definition	Escherichia coli SMS-3-5 chromosome, complete genome.
Accession	NC_010498
Length	5,068,389

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The map label for this gene is ccmA [H]

Identifier: 170682203

GI number: 170682203

Start: 2381306

End: 2381923

Strand: Reverse

Name: ccmA [H]

Synonym: EcSMS35_2349

Alternate gene names: 170682203

Gene position: 2381923-2381306 (Counterclockwise)

Preceding gene: 170683912

Following gene: 170680661

Centisome position: 47.0

GC content: 55.83

Gene sequence:

>618_bases
ATGCTTGAAGCCAGAGAGTTACTTTGCGAGCGGGATGAACGAACCTTATTTAGTGGCTTGTCATTTACGCTGAACGCAGG
AGAGTGGGTACAAATCACCGGTAGCAACGGCGCGGGGAAGACAACGCTTCTCCGTTTGCTGACGGGGTTGTCTCGCCCTG
ATGCGGGTGACGTTCTCTGGCAAGGGCAGCCCTTGCATCAGGTACGCGACAGCTACCATCAAAACCTGTTATGGATAGGC
CATCAGCCGGGGATCAAAACCCGGCTGACGGCGTTAGAAAATCTGCACTTTTATCATCGCGATGGCGATACCGCACAATG
TCTGGAAGCCCTGGCGCAGGCTGGGCTTGCCGGATTCGAAGATATTCCGGTAAATCAACTTTCTGCCGGGCAACAACGCC
GCGTCGCTTTAGCGCGTCTGTGGCTGACCCGTGCCACGTTATGGATCCTCGACGAGCCTTTTACCGCGATTGACGTTAAC
GGCGTCGATCGTCTGACCCAGCGTATGGCGCAGCATACGGAGCAGGGGGGGACTGTGATTCTGACTACCCACCAGCCGCT
CAACGTTGCTGAAAGTAAAATTCGCCGCATTTCACTGACGCAAACGGGGGCCGCATGA

Upstream 100 bases:

>100_bases
AGATGGGCAAACCTGTATTGATTGCCATAAAGGGATAGCGCACAAGCTGCCCGATATGCGCGAAGTCGAGCCAGGTTTTT
AACAGGGTTATTGCGTGGGT

Downstream 100 bases:

>100_bases
TGTTCTGGCGCATTTTCCGTCTTGAGCTGCGCGTGGCGTTTCGCCACAGCGCCGAAATCGCCAACCCGCTGTGGTTCTTC
CTGATTGTCATTACCCTTTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA

Sequences:

>Translated_205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA
>Mature_205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=28.7735849056604, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI153792144, Length=205, Percent_Identity=29.7560975609756, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI9665248, Length=194, Percent_Identity=30.9278350515464, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI27477115, Length=214, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI73747915, Length=215, Percent_Identity=27.4418604651163, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI105990541, Length=191, Percent_Identity=28.7958115183246, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27881501, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30795238, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI73747917, Length=161, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI255708477, Length=192, Percent_Identity=27.6041666666667, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI45446740, Length=182, Percent_Identity=29.6703296703297, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI47078218, Length=182, Percent_Identity=29.6703296703297, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=26.5625, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI21536376, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI148612844, Length=192, Percent_Identity=27.6041666666667, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI31657092, Length=198, Percent_Identity=26.7676767676768, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505771, Length=187, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI150417984, Length=190, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI9961252, Length=187, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=205, Percent_Identity=98.5365853658537, Blast_Score=409, Evalue=1e-116,
Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=29.8076923076923, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=30.7228915662651, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1788225, Length=200, Percent_Identity=29.5, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=30.8900523560209, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787041, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787370, Length=181, Percent_Identity=29.8342541436464, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789891, Length=205, Percent_Identity=30.7317073170732, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788165, Length=153, Percent_Identity=33.9869281045752, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787029, Length=198, Percent_Identity=28.2828282828283, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1786703, Length=188, Percent_Identity=30.8510638297872, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788897, Length=204, Percent_Identity=29.9019607843137, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48995001, Length=177, Percent_Identity=28.8135593220339, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI48994943, Length=208, Percent_Identity=27.8846153846154, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789991, Length=154, Percent_Identity=31.1688311688312, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789032, Length=198, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1789593, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787164, Length=194, Percent_Identity=31.9587628865979, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786345, Length=191, Percent_Identity=31.413612565445, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1786698, Length=176, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790190, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789873, Length=201, Percent_Identity=26.3681592039801, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787547, Length=178, Percent_Identity=29.2134831460674, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787112, Length=178, Percent_Identity=29.7752808988764, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790544, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788644, Length=196, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=29.5918367346939, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788210, Length=180, Percent_Identity=26.1111111111111, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788450, Length=174, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787113, Length=204, Percent_Identity=30.8823529411765, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787772, Length=181, Percent_Identity=30.3867403314917, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789586, Length=197, Percent_Identity=25.8883248730964, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788506, Length=214, Percent_Identity=26.1682242990654, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1786975, Length=184, Percent_Identity=27.7173913043478, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=187, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533608, Length=197, Percent_Identity=28.4263959390863, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25146777, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17543740, Length=206, Percent_Identity=25.7281553398058, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=186, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=186, Percent_Identity=27.9569892473118, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=193, Percent_Identity=27.4611398963731, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=193, Percent_Identity=26.9430051813472, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17533971, Length=193, Percent_Identity=24.8704663212435, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=186, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=193, Percent_Identity=26.4248704663212, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=170, Percent_Identity=30.5882352941176, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=207, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533592, Length=193, Percent_Identity=27.4611398963731, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=190, Percent_Identity=27.8947368421053, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=215, Percent_Identity=24.1860465116279, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=192, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=208, Percent_Identity=25.9615384615385, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=26.775956284153, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=26.775956284153, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574744, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221500365, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI116007184, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574533, Length=188, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666092, Length=172, Percent_Identity=27.3255813953488, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136662, Length=188, Percent_Identity=28.7234042553192, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641342, Length=179, Percent_Identity=30.1675977653631, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648314, Length=208, Percent_Identity=26.4423076923077, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22740; Mature: 22740

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLW
CCCHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
QGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFE
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCC
DIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGTVI
CCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHHCCCCEEE
LTTHQPLNVAESKIRRISLTQTGAA
EEECCCCHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLW
CCCHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
QGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFE
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCC
DIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGTVI
CCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHHCCCCEEE
LTTHQPLNVAESKIRRISLTQTGAA
EEECCCCHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]