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The map label for this gene is ygcS [H]

Identifier: 170681816

GI number: 170681816

Start: 2970432

End: 2971769

Strand: Reverse

Name: ygcS [H]

Synonym: EcSMS35_2900

Alternate gene names: 170681816

Gene position: 2971769-2970432 (Counterclockwise)

Preceding gene: 170679795

Following gene: 170680852

Centisome position: 58.63

GC content: 54.26

Gene sequence:

>1338_bases
ATGAACACTTCACCGGTGCGAATGGATGATTTACCACTTAACCGTTTTCACTGCCGCATTGCTGCGCTCACTTTCGGTGC
GCACCTGACCGACGGTTATGTCCTCGGCGTCATTGGTTACGCCATTATTCAGCTTACGCCCGCCATGCAACTGACGCCGT
TTATGGCGGGAATGATTGGCGGCTCAGCACTCCTTGGTTTGTTTCTTGGCAGCCTGGTTCTTGGATGGATCTCCGACCAT
ATTGGTCGGCAAAAAATCTTCACCTTCAGCTTTTTGCTGATTACGCTCGCTTCGTTCTTGCAATTTTTTGCCACCACGCC
AGAGCATCTTATTGGGCTGCGCATTTTGATCGGCATTGGTCTGGGAGGCGATTACTCAGTCGGTCACACCTTGCTGGCTG
AATTTTCCCCGCGCCGCCATCGCGGTATTTTACTGGGCGCATTCAGCGTGGTGTGGACCGTAGGCTATGTGTTGGCAAGT
ATTGCCGGACATCACTTTATTTCCGAAAACCCGGAGGCCTGGCGCTGGCTGCTGGCATCAGCGGCGTTACCAGCCTTGCT
GATTACGCTGCTACGTTGGGGCACGCCGGAATCGCCACGCTGGCTACTGCGCCAGGGACGTTTTGCTGAAGCTCACGCTA
TTGTGCATCGCTATTTGGGGCCACATGTTTTACTGGGCGATGAAGTGGCAGCGGCGACCCATAAACACATCAAAACCTTG
TTTTCTTCGCGCTACTGGCGACGCACGGCGTTTAACAGCGTCTTCTTTGTCTGCCTCGTAATCCCATGGTTTGTGATTTA
TACCTGGCTGCCGACCATCGCCCAGACTATTGGTCTGGAGGATGCGCTGACCGCCAGCCTGATGCTTAATGCGTTGTTAA
TTGTGGGCGCGCTGCTGGGATTAGTTCTGACGCACCTGCTGGCACATCGCAAGTTTTTGCTGGGAAGTTTTTTGCTGCTG
GCGGCAACGCTGGTAGTGATGGCCTGTTTGCCTTCCGGCAGTTCATTAACGCTGCTGCTTTTTGTTCTCTTCAGCACCAC
CATTTCGGCAGTCAGTAATCTGGTGGGCATTTTGCCTGCGGAAAGTTTTCCTACTGACATTCGCTCGCTGGGCGTCGGTT
TTGCCACCGCCATGAGTCGGTTGGGGGCGGCGGTAAGTACTGGCCTGCTGCCGTGGGTGCTGGCGCAGTGGGGAATGCAA
GCCACCTTATTGCTCCTGGCGGCAGTGTTGTTGGTTGGTTTTGTTGTGACCTGGCTATGGGCACCAGAAACCAAAGCACT
CCCGCTGGTGGCGGCGGGAAATGTAGGAGGTGCGAATGAACATTCTGTTAGCGTTTAA

Upstream 100 bases:

>100_bases
AAAATAATGTGTGAGGCAGCGTTCCGCGATGACGGGGCGTTGCCTTTTCGGCTTCTCAGGCGAGAAGCCGTTCTTATTAC
CGGACAATGAAGGGGTAAAG

Downstream 100 bases:

>100_bases
AGCCGAACCGGATGCCGGAATGCTGGCGGAAAAAGAGTGGCAGGCGGCGGCTCAGGGTAATATTGGACCAGATGTTTCGC
TACTGCGAAGTTTACTCGGT

Product: major facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYLGPHVLLGDEVAAATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
ATLLLLAAVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV

Sequences:

>Translated_445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYLGPHVLLGDEVAAATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
ATLLLLAAVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV
>Mature_445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYLGPHVLLGDEVAAATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
ATLLLLAAVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507005, Length=392, Percent_Identity=26.530612244898, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI302148518, Length=365, Percent_Identity=25.2054794520548, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4506999, Length=426, Percent_Identity=26.7605633802817, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI166197673, Length=365, Percent_Identity=28.4931506849315, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI24497490, Length=334, Percent_Identity=26.0479041916168, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI23510410, Length=357, Percent_Identity=24.6498599439776, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI24308167, Length=446, Percent_Identity=23.7668161434978, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI296080721, Length=345, Percent_Identity=27.2463768115942, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI296080734, Length=345, Percent_Identity=27.2463768115942, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI296080719, Length=347, Percent_Identity=27.0893371757925, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI24497499, Length=347, Percent_Identity=27.0893371757925, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI8923870, Length=382, Percent_Identity=25.130890052356, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI213021148, Length=415, Percent_Identity=25.0602409638554, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7662270, Length=209, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI90669191, Length=348, Percent_Identity=27.2988505747126, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24497497, Length=348, Percent_Identity=27.2988505747126, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20070188, Length=380, Percent_Identity=26.0526315789474, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI24497476, Length=380, Percent_Identity=26.0526315789474, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI21553331, Length=312, Percent_Identity=23.7179487179487, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI166064021, Length=330, Percent_Identity=25.7575757575758, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI203098995, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI11415038, Length=384, Percent_Identity=24.21875, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082159, Length=445, Percent_Identity=98.876404494382, Blast_Score=863, Evalue=0.0,
Organism=Escherichia coli, GI1786229, Length=431, Percent_Identity=34.338747099768, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788074, Length=418, Percent_Identity=26.3157894736842, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788068, Length=451, Percent_Identity=24.6119733924612, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789207, Length=444, Percent_Identity=25.6756756756757, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789312, Length=436, Percent_Identity=24.5412844036697, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790463, Length=427, Percent_Identity=23.4192037470726, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082404, Length=405, Percent_Identity=22.4691358024691, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082231, Length=416, Percent_Identity=24.0384615384615, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17556354, Length=409, Percent_Identity=27.6283618581907, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17565976, Length=165, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560496, Length=390, Percent_Identity=23.8461538461538, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564080, Length=407, Percent_Identity=25.0614250614251, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193209824, Length=395, Percent_Identity=25.0632911392405, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71988651, Length=156, Percent_Identity=35.2564102564103, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17565978, Length=327, Percent_Identity=24.7706422018349, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145172, Length=398, Percent_Identity=23.8693467336683, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=183, Percent_Identity=32.2404371584699, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320766, Length=366, Percent_Identity=24.5901639344262, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324400, Length=366, Percent_Identity=24.3169398907104, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322618, Length=366, Percent_Identity=24.0437158469945, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319956, Length=366, Percent_Identity=24.0437158469945, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324469, Length=458, Percent_Identity=20.9606986899563, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24649618, Length=339, Percent_Identity=26.2536873156342, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922616, Length=394, Percent_Identity=25.3807106598985, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649622, Length=387, Percent_Identity=24.2894056847545, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668440, Length=406, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640198, Length=436, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640196, Length=436, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640200, Length=436, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668456, Length=408, Percent_Identity=25, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161078338, Length=399, Percent_Identity=26.0651629072682, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922874, Length=408, Percent_Identity=24.7549019607843, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24649616, Length=359, Percent_Identity=25.6267409470752, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647365, Length=330, Percent_Identity=25.7575757575758, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077756, Length=455, Percent_Identity=23.7362637362637, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644778, Length=400, Percent_Identity=25.25, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48085; Mature: 48085

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIG
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
LGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLAS
CCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHH
AALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYLGPHVLLGDEVAAATHKHIKTL
HHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQATLLLLAAVLLVGFVVTWLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
APETKALPLVAAGNVGGANEHSVSV
CCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIG
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEC
LGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLAS
CCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHH
AALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYLGPHVLLGDEVAAATHKHIKTL
HHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTLLLFVLFSTTISAVSNLVGILPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQATLLLLAAVLLVGFVVTWLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
APETKALPLVAAGNVGGANEHSVSV
CCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]