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The map label for this gene is betA [H]

Identifier: 170681227

GI number: 170681227

Start: 350805

End: 352493

Strand: Reverse

Name: betA [H]

Synonym: EcSMS35_0342

Alternate gene names: 170681227

Gene position: 352493-350805 (Counterclockwise)

Preceding gene: 170681572

Following gene: 170681827

Centisome position: 6.95

GC content: 58.08

Gene sequence:

>1689_bases
TTGCAATTTGACTACATCATTATTGGTGCCGGCTCAGCCGGCAACGTCCTCGCTACCCGTCTGACTGAAGATCCGAACAC
AACCGTGCTGCTGCTTGAAGCAGGCGGCCCGGACTATCGCTTTGACTTCCGCACCCAGATGCCCGCCGCGCTGGCGTTCC
CGCTACAGGGCAAACGCTACAACTGGGCCTATGAGACGGAACCCGAACCGTTTATGAACAACCGCCGCATGGAGTGCGGA
CGCGGCAAAGGTCTGGGCGGTTCATCGCTGATCAACGGCATGTGTTACATCCGTGGTAACGCGCTGGATCTCGATAACTG
GGCGCAAGAACCCGGTCTGGAGAACTGGAGCTACCTCGACTGTCTGCCCTACTACCGCAAGGCCGAGACTCGCGACGTGG
GCGAGAACGACTACCACGGCGGCGACGGCCCGGTGAGCGTCACCACCTCCAAACCCGGCGTCAATCCGCTGTTTGAAGCG
ATGATTGAAGCGGGCGTGCAGGCGGGCTACCCGCGCACGGACGATCTCAACGGCTATCAGCAAGAAGGTTTTGGCCCGAT
GGATCGCACCGTCACGCCGCATGGCCGTCGCGCCAGCACCGCGCGTGGCTATCTCGATCAGGCCAAATCGCGCTCTAACC
TGACCATTCGTACTCACGCCATGACCGATCACATCATTTTTGACGGCAAACGCGCGGTGGGCGTCGAGTGGCTGGAAGGC
GACAGCACCATTCCGACCCGCGCGGCGGCGAATAAAGAAGTGCTGTTATGTGCAGGCGCGATTGCTTCACCGCAGATCCT
GCAACGCTCCGGCGTCGGCAACGCTGGACTGCTGGCGGAGTTTGATATTCCGCTGGTGCATGAATTACCTGGCGTCGGCG
AAAATCTTCAGGATCACCTGGAGATGTATCTGCAATATGAGTGCAAAGAACCGGTTTCCCTCTACCCTGCCCTGCAGTGG
TGGAATCAGCCGAAAATCGGTGCGGAGTGGCTGTTTGGCGGCACCGGCATTGGTGCCAGCAACCACTTTGAAGCAGGCGG
ATTTATTCGCAGCCGTGAGGAATTTGCGTGGCCGAATATTCAGTACCATTTCCTGCCAGTGGCGATTAACTATAACGGCT
CGAACGCAGTGAAAGAGCACGGCTTCCAGTGCCACGTCGGATCGATGCGCTCGCCAAGCCGTGGGCATGTGCGGATTAAA
TCCCGCGCCCCGCACCAGCATCCAGCGATTCTGTTTAACTACATGTCGCACGAGCAGGACTGGCAGGAGTTCCGCGACGC
AATTCGCATCACCCGGGAGATCATGCATCAACCGGCGCTGGATCAGTATCATGGCCGCGAAATCAGCCCCGGTGTCGAAT
GCCAGACGGATGAGCAGCTCGATGAGTTTGTGCGTAATCACGCCGAAACCGCCTTCCACCCATGCGGTACGTGCAAAATG
GGGTACGACGAGATGTCCGTTGTGGATGGCGAAGGCCGCGTGCACGGGCTGGAAGGATTACGCGTAGTCGATGCGTCAAT
TATGCCGCAGATTATCACCGGCAATCTGAACGCCACGACGATTATGATTGGCGAGAAAATGGCGGATATGATTCGCGGGA
AGGATGCGTTGCCGAGGAGCACGGCGGGATATTATGTGGCAAATGGGATGCCGGTGAGAGCGAAAAAAATGAGTCGTGAT
GTGAACTGA

Upstream 100 bases:

>100_bases
CGCGAGAACGGCGTGATGACGCTCCAGAGTTACACCCAGGTGAAGTCCATCCAGGTTGAGATGGCTAAATTCCAGTCCAT
ATTCTAACCAGGAGGTTTAT

Downstream 100 bases:

>100_bases
CTCAGGAACCTATCAGATTGAGAGTTACCGTTCTACTATGAGGACCGAATCCTTATATAAAACACTGAGGTAACTCTCAT
GCTTCATATCCAGTATTCAT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRSNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRAAANKEVLLCAGAIASPQILQRSGVGNAGLLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGIGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRAPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYHGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGMPVRAKKMSRD
VN

Sequences:

>Translated_562_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRSNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRAAANKEVLLCAGAIASPQILQRSGVGNAGLLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGIGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRAPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYHGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGMPVRAKKMSRD
VN
>Mature_562_residues
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRYNWAYETEPEPFMNNRRMECG
RGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLDCLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEA
MIEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPHGRRASTARGYLDQAKSRSNLTIRTHAMTDHIIFDGKRAVGVEWLEG
DSTIPTRAAANKEVLLCAGAIASPQILQRSGVGNAGLLAEFDIPLVHELPGVGENLQDHLEMYLQYECKEPVSLYPALQW
WNQPKIGAEWLFGGTGIGASNHFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIK
SRAPHQHPAILFNYMSHEQDWQEFRDAIRITREIMHQPALDQYHGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRSTAGYYVANGMPVRAKKMSRD
VN

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=48.0662983425414, Blast_Score=499, Evalue=1e-141,
Organism=Escherichia coli, GI1786503, Length=556, Percent_Identity=97.6618705035971, Blast_Score=1140, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=43.8721136767318, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24642048, Length=573, Percent_Identity=34.7294938917976, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=35.7267950963222, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=34.4405594405594, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI45549471, Length=574, Percent_Identity=34.4947735191638, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=34.8432055749129, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=35.1158645276292, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24642055, Length=586, Percent_Identity=33.9590443686007, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24650267, Length=579, Percent_Identity=32.9879101899827, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=33.6236933797909, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=33.9160839160839, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=33.2746478873239, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=32.3478260869565, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24642037, Length=576, Percent_Identity=32.4652777777778, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI18859993, Length=573, Percent_Identity=32.9842931937173, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=28.3505154639175, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24642057, Length=585, Percent_Identity=28.7179487179487, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62431; Mature: 62431

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPHGRRASTARGYLDQAKSRSNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRAAANKEVLLCAGAIASPQILQRSGVGNAGLLAEFDIPLVHELPGVGENLQDHL
CCCCCCHHCCCCEEEEEECCCCCHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRAPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHEEHHHHCHHH
WQEFRDAIRITREIMHQPALDQYHGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCCCCCCC
TAGYYVANGMPVRAKKMSRDVN
CCCEEEECCCCCHHHHHCCCCC
>Mature Secondary Structure
MQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAFPLQGKRY
CCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETEPEPFMNNRRMECGRGKGLGGSSLINGMCYIRGNALDLDNWAQEPGLENWSYLD
CCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCHHHHCCCCCCCCCHHH
CLPYYRKAETRDVGENDYHGGDGPVSVTTSKPGVNPLFEAMIEAGVQAGYPRTDDLNGYQ
CCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPHGRRASTARGYLDQAKSRSNLTIRTHAMTDHIIFDGKRAVGVEWLEG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCEECEEEECC
DSTIPTRAAANKEVLLCAGAIASPQILQRSGVGNAGLLAEFDIPLVHELPGVGENLQDHL
CCCCCCHHCCCCEEEEEECCCCCHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCCHHHHH
EMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNHFEAGGFIRSREEFAWPNI
HHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCHHHCCCCE
QYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRIKSRAPHQHPAILFNYMSHEQD
EEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHEEHHHHCHHH
WQEFRDAIRITREIMHQPALDQYHGREISPGVECQTDEQLDEFVRNHAETAFHPCGTCKM
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GYDEMSVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADMIRGKDALPRS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECHHHHHHHCCCCCCCCC
TAGYYVANGMPVRAKKMSRDVN
CCCEEEECCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA