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The map label for this gene is cadC [H]

Identifier: 170681004

GI number: 170681004

Start: 4705363

End: 4706901

Strand: Reverse

Name: cadC [H]

Synonym: EcSMS35_4602

Alternate gene names: 170681004

Gene position: 4706901-4705363 (Counterclockwise)

Preceding gene: 170679619

Following gene: 170681514

Centisome position: 92.87

GC content: 42.11

Gene sequence:

>1539_bases
ATGCAACAACCTGTAGTTCGCGTTGGCGAATGGCTTGTTACTCCGTCCATAAACCAAATTAGCCGCAATGGGCGTCAACT
TACCCTTGAGCCGAGATTAATCGATCTTCTGGTTTTCTTTGCTCAACACAGTGGCGAAGTACTTAGCAGGGATGAACTTA
TCGATAATGTCTGGAAGAGAAGTATTGTCACCAATCACGTTGTGACGCAGAGTATCTCAGAACTACGTAAGTCATTAAAA
GATAATGATGAAGATAGTCCTGTCTATATCGCTACTGTACCAAAGCGCGGCTATAAATTAATGGTGCCGGTTATCTGGTA
CAGCGAAGAAGAGGGAGAGGAAATAATGCTATCTTCGCCTCCCCCTATACCAGAGGCGGTTCCTGCCACAGATTCTCCCT
CCCACAGTCTTAACATTCAAAACACCACAGCGCCACCTGAACAATCCCCAGTTAAAAGCAAACGATTCACTACCTTTTGG
GTATGGTTTTTTTTCCTGTTGTCGTTAGGTATCTGTGTCGCACTGGTAGCGTTTTCAAGTCTTGAAACACGTCTTCCTAT
GAGCAAATCGCGTATTTTGCTCAATCCACGCGATATTGACATTAATATGGTTAATAAGAGTTGTAACAGCTGGAGTTCCC
CGTATCAGCTCTCTTACGCGATAGGCGTGGGTGATTTGGTGGCGACATCACTTAACACCTTCTCCACCTTTATGGTGCAT
GACAAAATCAACTACAACATTGATGAACCGAGCAGTTCCGGTAAAACATTATCTATTGCGTTTGTTAATCAGCGCCAATA
CCGTGCTCAACAATGCTTTATGTCGGTAAAATTGGTAGACAATGCAGATGGTTCAACCATGCTGGATAAACGTTATGTCA
TCACTAACGGTAATCAGCTGGCGATTCAAAATGATTTACTCCAGAGTTTATCAAAAGCGTTAAACCAACCGTGGCCACAA
CGAATGCAGGAGACGCTCCAGCAAATTTTGCCGCATCGTGGTGCGTTATTAACTAATTTTTATCAGGCTCATGATTATTT
ACTGCATGGCGATGATAAATCATTGAATCGTGCCAGTGAATTATTAGGTGAGATTGTTCAATCATCCCCAGAATTTACCT
ACGCGAGAGCAGAAAAAGCATTAGTTGATATCGTGCGCCATTCTCAACATCCTTTAGATGAAAAACAATTAGCAGCACTG
AATACAGAAATAGATAACATTGTTACACTGCCGGAATTGAATAACCTGTCCATTATATATCAAATAAAAGCGGTCAGTGC
TCTGGTAAAAGGTAAAACAGATGAGTCTTACCAGGCGATAAATACTGGCATTGATCTTGAAATGTCCTGGCTAAATTATG
TGTTGCTTGGCAAGGTTTATGAAATGAAGGGGATGAACCGGGAAGCAGCTGATGCATATCTCACCGCCTTTAATTTACGC
CCAGGGGCAAACACCCTTTACTGGATTGAAAATGGTATATTCCAGACTTCTGTTCCTTATGTTGTACCTTATCTCGACAA
ATTTCTCGCTTCAGAATAA

Upstream 100 bases:

>100_bases
TGCATTCACCAATAATATGTAAATAAACCCATCTATAGATGGAAAAAATAGATTATGGCAATTATCATTGCATCATTCCC
TTTTCGAATGAGTTTCTATT

Downstream 100 bases:

>100_bases
GTAACTCCCGGGTTGATTTATGCTCGGGAATATTTGTTGTTGAGTTTTTGTATGTTCCTGTTGGTATAATATGTTGCGGC
AATTTATTTGCCGCATAATT

Product: DNA-binding transcriptional activator CadC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLK
DNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSPPPIPEAVPATDSPSHSLNIQNTTAPPEQSPVKSKRFTTFW
VWFFFLLSLGICVALVAFSSLETRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVH
DKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSVKLVDNADGSTMLDKRYVITNGNQLAIQNDLLQSLSKALNQPWPQ
RMQETLQQILPHRGALLTNFYQAHDYLLHGDDKSLNRASELLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAAL
NTEIDNIVTLPELNNLSIIYQIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLR
PGANTLYWIENGIFQTSVPYVVPYLDKFLASE

Sequences:

>Translated_512_residues
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLK
DNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSPPPIPEAVPATDSPSHSLNIQNTTAPPEQSPVKSKRFTTFW
VWFFFLLSLGICVALVAFSSLETRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVH
DKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSVKLVDNADGSTMLDKRYVITNGNQLAIQNDLLQSLSKALNQPWPQ
RMQETLQQILPHRGALLTNFYQAHDYLLHGDDKSLNRASELLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAAL
NTEIDNIVTLPELNNLSIIYQIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLR
PGANTLYWIENGIFQTSVPYVVPYLDKFLASE
>Mature_512_residues
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKRSIVTNHVVTQSISELRKSLK
DNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSPPPIPEAVPATDSPSHSLNIQNTTAPPEQSPVKSKRFTTFW
VWFFFLLSLGICVALVAFSSLETRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVH
DKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSVKLVDNADGSTMLDKRYVITNGNQLAIQNDLLQSLSKALNQPWPQ
RMQETLQQILPHRGALLTNFYQAHDYLLHGDDKSLNRASELLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAAL
NTEIDNIVTLPELNNLSIIYQIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLR
PGANTLYWIENGIFQTSVPYVVPYLDKFLASE

Specific function: Required for Pcad induction, a promoter upstream of cadB that is responsible for the pH-regulated expression of cadA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790576, Length=512, Percent_Identity=98.828125, Blast_Score=1049, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR011990
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 57813; Mature: 57813

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKR
CCCCHHHHCCEEECCCHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SIVTNHVVTQSISELRKSLKDNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSP
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCEEEECCC
PPIPEAVPATDSPSHSLNIQNTTAPPEQSPVKSKRFTTFWVWFFFLLSLGICVALVAFSS
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LETRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVH
HHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHEEEEEE
DKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSVKLVDNADGSTMLDKRYVITNGNQL
ECCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHEEEEEEECCCCCEEECCEEEEECCCEE
AIQNDLLQSLSKALNQPWPQRMQETLQQILPHRGALLTNFYQAHDYLLHGDDKSLNRASE
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHHHHHH
LLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAALNTEIDNIVTLPELNNLSIIY
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCCCCEEEEE
QIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLR
EHHHHHHHHCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECC
PGANTLYWIENGIFQTSVPYVVPYLDKFLASE
CCCCEEEEEECCEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQQPVVRVGEWLVTPSINQISRNGRQLTLEPRLIDLLVFFAQHSGEVLSRDELIDNVWKR
CCCCHHHHCCEEECCCHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SIVTNHVVTQSISELRKSLKDNDEDSPVYIATVPKRGYKLMVPVIWYSEEEGEEIMLSSP
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEECCCCCCEEEECCC
PPIPEAVPATDSPSHSLNIQNTTAPPEQSPVKSKRFTTFWVWFFFLLSLGICVALVAFSS
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LETRLPMSKSRILLNPRDIDINMVNKSCNSWSSPYQLSYAIGVGDLVATSLNTFSTFMVH
HHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHEEEEEE
DKINYNIDEPSSSGKTLSIAFVNQRQYRAQQCFMSVKLVDNADGSTMLDKRYVITNGNQL
ECCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHEEEEEEECCCCCEEECCEEEEECCCEE
AIQNDLLQSLSKALNQPWPQRMQETLQQILPHRGALLTNFYQAHDYLLHGDDKSLNRASE
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCHHHHHHH
LLGEIVQSSPEFTYARAEKALVDIVRHSQHPLDEKQLAALNTEIDNIVTLPELNNLSIIY
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCCCCEEEEE
QIKAVSALVKGKTDESYQAINTGIDLEMSWLNYVLLGKVYEMKGMNREAADAYLTAFNLR
EHHHHHHHHCCCCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECC
PGANTLYWIENGIFQTSVPYVVPYLDKFLASE
CCCCEEEEEECCEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1370290; 7610040; 9278503 [H]