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The map label for this gene is ggt [H]

Identifier: 170680502

GI number: 170680502

Start: 3795500

End: 3797245

Strand: Reverse

Name: ggt [H]

Synonym: EcSMS35_3726

Alternate gene names: 170680502

Gene position: 3797245-3795500 (Counterclockwise)

Preceding gene: 170683164

Following gene: 170681404

Centisome position: 74.92

GC content: 53.78

Gene sequence:

>1746_bases
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGTTCACAGGAAGTTGTTTTAGTACGGTAGCCGCGCC
ACCTGCGCCGTCTCCTGTTTCTTACGGCGTGGAGGAAGATGTCTTTCATCCGGTACGCGCGAAACAGGGGATGGTGGCGT
CTGTCGATGCCACTGCCACCCAAGTGGGGGTAGATATTCTAAAGGAGGGCGGGAATGCCGTTGATGCTGCCGTGGCAGTG
GGCTACGCGCTGGCGGTAACGCATCCGCAGGCAGGAAATTTGGGCGGTGGTGGTTTTATGCTGATCCGCTCGAAAAATGG
CAATACCACCGCTATCGATTTCCGCGAAATGGCACCCGCCAAAGCGACCCGCGATATGTTCCTTGATGATCAGGGCAACC
CGGACAGCAAAAAATCACTCACTTCGCATCTGGCTTCTGGTACGCCCGGTACGGTAGCAGGTTTCTCGCTGGCGTTGGAG
AAGTACGGCACCATGCCGTTGAACAAAGTGGTGCAACCGGCGTTTAAACTGGCACGCGATGGTTTTATCGTTAACGACGC
GTTGGCTGACGATCTCAAAACCTACGGTAGCGAAGTATTGCCGAATCACGAAAACAGCAAGGCTATCTTCTGGAAAGAGG
GCGCGCCGCTGAAAAAGGGTGACAAGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCCGAAAACGGCCCG
GACGAATTCTACAAAGGCACGATAGCGGAACAGATTGCCCAGGAGATGCAGAAAAACGGTGGCTTGATCACTAAAGAAGA
TTTAGCGGCGTATAAAGCGGTCGAACGTACACCGATTAGCGGCGAATATCGCGGGTATCAGGTTTACTCGATGCCACCGC
CATCTTCCGGTGGGATTCATATCGTGCAGATCCTCAATATCCTGGAAAACTTCGATATGAAGAAATATGGCTTTGGCAGT
GCCGACGCGATGCAAATCATGGCAGAAGCTGAGAAATACGCCTACGCCGACCGCTCGGAATATCTTGGCGATCCGGATTT
TGTCAAAGTACCGTGGCAGGCGCTGACCAATAAAGCCTATGCCAAATCTATTGCCGATCAAATCGATATCAATAAAGCGA
AGCCATCCAGCGAAATTCGCCCCGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCAGTGGTGGATAAA
GACGGTAACGCGGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGCATTGTCGCGGGCGAGAGCGGTATTCT
GCTTAATAACCAGATGGATGATTTCTCCGCCAAACCGGGCGTACCGAACGTTTACGGGCTGGTGGGCGGCGATGCCAACG
CCGTCGGGCCGAATAAACGCCCGCTGTCGTCGATGTCACCAACCATTGTGGTCAAGGATGGTAAAACCTGGCTGGTCACC
GGAAGCCCAGGCGGTAGCCGGATTATCACCACTGTGCTGCAAATGGTGGTGAATAGCATCGATTATGGAATGAACGTCGC
CGAAGCGACCAATGCGCCGCGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATA
CGATCAAGCTGCTGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAAAGCATTATGGTTGGG
CCGGACGGTGAGCTGTACGGTGCATCCGACCCACGCTCGGTGGATGATTTAACTGCGGGGTATTAA

Upstream 100 bases:

>100_bases
ATATTCTTTAAGTTTACTCCTTTCCTGCAATCATCAGGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCC
TTAATCTCTGGAGAATAACG

Downstream 100 bases:

>100_bases
TATCTTAAGCCCTCTCCCGGTAGGTGAGGGCTTAAATGACAAACGTAGATTGCAAATTCTCTATTTCACCCGCGCCATAT
AATACGCATCGACATATTCA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALE
KYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGAPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGEYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYGASDPRSVDDLTAGY

Sequences:

>Translated_581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALE
KYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGAPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGEYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYGASDPRSVDDLTAGY
>Mature_581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALE
KYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGAPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGEYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=31.047619047619, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.8761384335155, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=28.3636363636364, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=28.3121597096189, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=26.8248175182482, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789856, Length=581, Percent_Identity=97.934595524957, Blast_Score=1150, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=572, Percent_Identity=34.2657342657343, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI72000294, Length=572, Percent_Identity=34.2657342657343, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI193208247, Length=558, Percent_Identity=32.4372759856631, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI193208245, Length=558, Percent_Identity=32.4372759856631, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=552, Percent_Identity=30.4347826086957, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.2705410821643, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.9909706546275, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=491, Percent_Identity=29.1242362525458, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551474, Length=515, Percent_Identity=32.0388349514563, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642670, Length=515, Percent_Identity=32.0388349514563, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642666, Length=515, Percent_Identity=32.0388349514563, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077880, Length=515, Percent_Identity=32.0388349514563, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077878, Length=515, Percent_Identity=32.0388349514563, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=30.9160305343511, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.8880308880309, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.6751361161525, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61977; Mature: 61977

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATAT
CCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHH
QVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPA
HHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCC
KATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVQPAFKLARD
HHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGAPLKKGDKLVQANLAKSLEMIAENGP
CEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGEYRGYQVYSMPPPSSGGIH
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCH
IVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHH
AKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEE
AGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
ECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
GSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCCHHHHHHC
KGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATAT
CCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHH
QVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPA
HHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCC
KATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVQPAFKLARD
HHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGAPLKKGDKLVQANLAKSLEMIAENGP
CEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGEYRGYQVYSMPPPSSGGIH
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCH
IVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHH
AKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEE
AGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
ECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
GSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCCHHHHHHC
KGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]