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The map label for this gene is tdcG [H]

Identifier: 170680456

GI number: 170680456

Start: 3488513

End: 3489883

Strand: Reverse

Name: tdcG [H]

Synonym: EcSMS35_3408

Alternate gene names: 170680456

Gene position: 3489883-3488513 (Counterclockwise)

Preceding gene: 170680786

Following gene: 170679999

Centisome position: 68.86

GC content: 53.39

Gene sequence:

>1371_bases
GTGGATATGATTAGTGCATTCGATATTTTCAAAATTGGGATTGGTCCCTCCAGTTCGCATACCGTGGGGCCAATGAATGC
CGGAAAAAGTTTTATTGATCGGCTGGAAAGTAGCGGCTTATTAACCGCGACGAGCCATATTGTGGTCGATCTGTACGGGT
CGTTGTCACTGACGGGCAAAGGCCATGCCACGGATGTCGCCATCATCATGGGACTGGCAGGAAACAGTCCGCAGGATGTT
GTCATTGATGAGATCCCTGCATTTATAGAGTTAGTGACGCGCAGCGGGCGGCTGCCAGTGGCATCTGGTGCGCATATTGT
TGATTTTCCTGTAGCAAAGAACATTATCTTCCATCCCGAAATGTTGCCTCGCCATGAGAACGGAATGCGGATCACTGCCT
GGAAGGGACAGGAAGCGCTATTAAGCAAAACCTATTACTCTGTCGGCGGCGGGTTTATTGTCGAAGAAGAACACTTCGGC
CTGTCGCACGATGTCGAAACGTCCGTACCTTACGATTTCCACTCAGCAGGAGAACTGCTGAAAATGTGTGATTACAACGG
CCTGTCTATTTCTGGCCTGATGATGCACAACGAGCTGGCGCTGCGCAGTAAAGCGGAAATTGATGCCGGTTTTGCCCGTA
TCTGGCAAGTGATGCATGACGGTATTGAACGCGGGATGAACACTGAAGGCGTGCTGCCTGGTCCGCTCAATGTGCCGCGC
CGTGCCGTAGCGCTGCGTCGTCAGTTGGTTTCCAGCGATAACATCTCTAACGATCCGATGAATGTCATCGACTGGATCAA
CATGTACGCGCTGGCGGTTAGTGAAGAAAACGCAGCTGGCGGGCGCGTGGTAACGGCACCGACTAACGGTGCGTGCGGCA
TTATTCCGGCAGTGCTGGCTTATTACGATAAGTTCCGTCGTCCGGTAAATGAGCGGTCAATTGCCCGCTATTTTCTTGCA
GCCGGGGCTATTGGCGCGCTGTATAAAATGAACGCCTCCATCTCTGGCGCGGAAGTCGGCTGTCAGGGGGAGATTGGCGT
GGCCTGTTCAATGGCGGCGGCAGGGTTAACTGAACTACTGGGCGGCAGTCCGGCGCAGGTATGCAATGCGGCGGAAATCG
CGATGGAGCATAACCTTGGGCTGACCTGCGATCCGGTTGCCGGACAGGTACAAATCCCGTGCATTGAACGTAATGCCATT
AATGCCGTGAAAGCAGTAAACGCCGCGCGGATGGCGATGCGCCGCACCTCGGCACCGCGTGTTTCACTCGATAAAGTGAT
CGAGACGATGTATGAAACCGGCAAAGATATGAACGATAAATACCGCGAAACATCACGCGGAGGACTGGCTATTAAAGTGG
TCTGCGGCTGA

Upstream 100 bases:

>100_bases
TGGAAATTGAAGCCATCGCAGTACGTAGTGCGTAAAGCCTCGTGAGCGGGACGGTCGCAAGGTCGTTCCGCTCCACTTCA
CTGAACGGCAATCCGAGGGT

Downstream 100 bases:

>100_bases
CATTGCTGTCAGCTTTCATCCTTGGGTGCACAAATGTGCACCTTTTTTTTGTGATCTGCCGCAAATAGAGAATGAATATT
CTCTTGCGATTAATTTAGTA

Product: L-serine ammonia-lyase TdcG

Products: NA

Alternate protein names: SDH; L-serine deaminase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MDMISAFDIFKIGIGPSSSHTVGPMNAGKSFIDRLESSGLLTATSHIVVDLYGSLSLTGKGHATDVAIIMGLAGNSPQDV
VIDEIPAFIELVTRSGRLPVASGAHIVDFPVAKNIIFHPEMLPRHENGMRITAWKGQEALLSKTYYSVGGGFIVEEEHFG
LSHDVETSVPYDFHSAGELLKMCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLPGPLNVPR
RAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLAYYDKFRRPVNERSIARYFLA
AGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELLGGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAI
NAVKAVNAARMAMRRTSAPRVSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG

Sequences:

>Translated_456_residues
MDMISAFDIFKIGIGPSSSHTVGPMNAGKSFIDRLESSGLLTATSHIVVDLYGSLSLTGKGHATDVAIIMGLAGNSPQDV
VIDEIPAFIELVTRSGRLPVASGAHIVDFPVAKNIIFHPEMLPRHENGMRITAWKGQEALLSKTYYSVGGGFIVEEEHFG
LSHDVETSVPYDFHSAGELLKMCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLPGPLNVPR
RAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLAYYDKFRRPVNERSIARYFLA
AGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELLGGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAI
NAVKAVNAARMAMRRTSAPRVSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG
>Mature_456_residues
MDMISAFDIFKIGIGPSSSHTVGPMNAGKSFIDRLESSGLLTATSHIVVDLYGSLSLTGKGHATDVAIIMGLAGNSPQDV
VIDEIPAFIELVTRSGRLPVASGAHIVDFPVAKNIIFHPEMLPRHENGMRITAWKGQEALLSKTYYSVGGGFIVEEEHFG
LSHDVETSVPYDFHSAGELLKMCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLPGPLNVPR
RAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLAYYDKFRRPVNERSIARYFLA
AGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELLGGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAI
NAVKAVNAARMAMRRTSAPRVSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=454, Percent_Identity=99.7797356828194, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI1788116, Length=453, Percent_Identity=73.9514348785872, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=452, Percent_Identity=72.787610619469, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48711; Mature: 48711

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMISAFDIFKIGIGPSSSHTVGPMNAGKSFIDRLESSGLLTATSHIVVDLYGSLSLTGK
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCEEEEEEECCEEECCC
GHATDVAIIMGLAGNSPQDVVIDEIPAFIELVTRSGRLPVASGAHIVDFPVAKNIIFHPE
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEECCC
MLPRHENGMRITAWKGQEALLSKTYYSVGGGFIVEEEHFGLSHDVETSVPYDFHSAGELL
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KMCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLPGPLNVPR
HHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
RAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCCCEEEECCCCCCCHHHHHHHH
YYDKFRRPVNERSIARYFLAAGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAINAVKAVNAARMAMRRTSAPR
CCCHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCC
VSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG
CCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MDMISAFDIFKIGIGPSSSHTVGPMNAGKSFIDRLESSGLLTATSHIVVDLYGSLSLTGK
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCEEEEEEECCEEECCC
GHATDVAIIMGLAGNSPQDVVIDEIPAFIELVTRSGRLPVASGAHIVDFPVAKNIIFHPE
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEECCC
MLPRHENGMRITAWKGQEALLSKTYYSVGGGFIVEEEHFGLSHDVETSVPYDFHSAGELL
CCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KMCDYNGLSISGLMMHNELALRSKAEIDAGFARIWQVMHDGIERGMNTEGVLPGPLNVPR
HHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
RAVALRRQLVSSDNISNDPMNVIDWINMYALAVSEENAAGGRVVTAPTNGACGIIPAVLA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCCCEEEECCCCCCCHHHHHHHH
YYDKFRRPVNERSIARYFLAAGAIGALYKMNASISGAEVGCQGEIGVACSMAAAGLTELL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GGSPAQVCNAAEIAMEHNLGLTCDPVAGQVQIPCIERNAINAVKAVNAARMAMRRTSAPR
CCCHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCC
VSLDKVIETMYETGKDMNDKYRETSRGGLAIKVVCG
CCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 9484901 [H]