Click here to switch to the map view.

The map label for this gene is ilvB [H]

Identifier: 170079383

GI number: 170079383

Start: 2919846

End: 2921621

Strand: Reverse

Name: ilvB [H]

Synonym: SYNPCC7002_A2797

Alternate gene names: 170079383

Gene position: 2921621-2919846 (Counterclockwise)

Preceding gene: 170079384

Following gene: 170079382

Centisome position: 97.13

GC content: 52.93

Gene sequence:

>1776_bases
GTGGTTTCAACAACTTCCCCCGCAGCAACTGAGACTGCTGTCCGTTCAGAGGTTCGTTCCGGTGCATACATTTTGATCGA
TAGCCTCAAGCGCCATGGTGTCGAATACATTTTTGGCTATCCCGGTGGTGCGATCCTGCCCATCTACGATGCCCTACACC
CAGTGGAAGAACGGGGAGAAATTAAGCACATCCTTGTGCGCCACGAACAGGGAGCTTCCCATGCCGCCGATGGCTATGCC
CGCGCAACTGGCAAAGTGGGGGTTTGTTTTGGTACCTCTGGCCCTGGGGCAACAAACCTCGTCACAGGGATTGCCACAGC
CCATATGGACTCAATTCCGATGGTGGTGATTACAGGCCAAGTCACCCGCGCGGCGATCGGTACAGATGCCTTCCAGGAGA
CAGATATTTTTGGCATTACCCTACCCGTAGTGAAACATTCCTACGTAGTGCGGGATCCGAAAGATATGGCCCGGATCGTT
GCCGAAGCCTTTTACATTGCAAGCACAGGTCGGCCCGGCCCTGTATTAGTAGATGTCCCCAAGGATGTCGGTTTGGAACT
GTGTGAATATATTCCCGTTGAACCCGGTGATGTGGATATCCCTGGTTACAAACCTCGCACCGAAGGAGATACCTCCAAAA
TTGGAGAAGCGGTACGTCTAATTTCTGAATCCCGCAAGCCATTACTTTACGTCGGGGGCGGTGCCATTACCTCTGGTGCC
CACGCAGAAATTAAAGAATTAGCTGAACAGTTCCAAATTCCGGTGACTACAACCCTGATGGGCTTGGGCGCTTTTGATGA
ACATAATCCCCTCTCCGTGGGGATGTTAGGGATGCATGGTTCGGCCTATGCTAATTTCGCCGTGAGTGAATGTGATCTTT
TGATTGCGGTGGGTGCCCGTTTCGATGACCGGGTGACTGGCAAATTAGACGAGTTTGCCTCGGAAGCGAAGGTGATTCAC
ATCGATATCGATCCCGCTGAGGTGGGTAAAAATCGTTTACCGGAAGTCGCCATTGTTGGTGATGTGCGCCATGTGTTGAT
TGAAATGTTGCAACAGCTAGGCGGCAAGGGTTTACCCCTCGGTAATAAGCCCACGGAAGAATGGCTCAATAAAATTCAAG
GTTGGAAAGAAAAACATCCTTTGGTCGCGCCTCGCTTTGCGGATTCGATCTCGCCCCAGTCGGTGATTGTGGAGTTAGAC
CGCCAGGCTCCCCATGCCTACTACACGACGGATGTGGGTCAACACCAGATGTGGGCGGCTCAGTTCTTGAAGAATGGTCC
CCGCCGCTGGATTTCTAGTGCAGGCTTGGGCACTATGGGCTTTGGTCTCCCGGCGGCTCTAGGAGCAAAGGTGGCGATCG
CCGACGAAGAGGTGATTTGTATCAGTGGCGATGCGAGCTTCCAGATGTGTTTACAGGAGCTGGCAACCCTGGCCCAATAT
CAAATTAAAGTGAAGACGGTGATCCTAAACAACGGCTGGCAGGGGATGGTGCGCCAGTGGCAGCAGAACTTCTACGGTCA
GCGCTATTCTTCCTCCAATATGGAAGCGGGGATGCCGAACTTTGAGCTACTCGCCCAAGCCTTCGGAGTGAAGGGCATGG
TGGTGGATCATCCGGATGATCTGTCGGGGGCGATCGCCGAAATGTTGGCCCATGATGGCCCTGTATTGTTGGACGTGCGG
GTGAAAAAAGACGAAAACTGTTATCCGATGGTCATCCCCGGCAAGAGCAACGCCCACATGATGGGTTTACAAGAGTCCTC
TGGAAAGGCTGAATAA

Upstream 100 bases:

>100_bases
CCAAAATAATCTATCCCCCTATCGGAAAAAATTATAGGGAAGCAGAGATCTTATTTCTGGTGTATTCTTCGTCCTTTAAG
TTATTCCTTAGGTAACTCCC

Downstream 100 bases:

>100_bases
TTTTTTCCCAGTGAAATAATAAAGAGATAAATGCCAGGAGTCGGGCTTTGCCTTGCTCCTTTTTTGTGGCTCGATTAGGA
TATAAGCCGCAGCGAATGGG

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVSTTSPAATETAVRSEVRSGAYILIDSLKRHGVEYIFGYPGGAILPIYDALHPVEERGEIKHILVRHEQGASHAADGYA
RATGKVGVCFGTSGPGATNLVTGIATAHMDSIPMVVITGQVTRAAIGTDAFQETDIFGITLPVVKHSYVVRDPKDMARIV
AEAFYIASTGRPGPVLVDVPKDVGLELCEYIPVEPGDVDIPGYKPRTEGDTSKIGEAVRLISESRKPLLYVGGGAITSGA
HAEIKELAEQFQIPVTTTLMGLGAFDEHNPLSVGMLGMHGSAYANFAVSECDLLIAVGARFDDRVTGKLDEFASEAKVIH
IDIDPAEVGKNRLPEVAIVGDVRHVLIEMLQQLGGKGLPLGNKPTEEWLNKIQGWKEKHPLVAPRFADSISPQSVIVELD
RQAPHAYYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAALGAKVAIADEEVICISGDASFQMCLQELATLAQY
QIKVKTVILNNGWQGMVRQWQQNFYGQRYSSSNMEAGMPNFELLAQAFGVKGMVVDHPDDLSGAIAEMLAHDGPVLLDVR
VKKDENCYPMVIPGKSNAHMMGLQESSGKAE

Sequences:

>Translated_591_residues
MVSTTSPAATETAVRSEVRSGAYILIDSLKRHGVEYIFGYPGGAILPIYDALHPVEERGEIKHILVRHEQGASHAADGYA
RATGKVGVCFGTSGPGATNLVTGIATAHMDSIPMVVITGQVTRAAIGTDAFQETDIFGITLPVVKHSYVVRDPKDMARIV
AEAFYIASTGRPGPVLVDVPKDVGLELCEYIPVEPGDVDIPGYKPRTEGDTSKIGEAVRLISESRKPLLYVGGGAITSGA
HAEIKELAEQFQIPVTTTLMGLGAFDEHNPLSVGMLGMHGSAYANFAVSECDLLIAVGARFDDRVTGKLDEFASEAKVIH
IDIDPAEVGKNRLPEVAIVGDVRHVLIEMLQQLGGKGLPLGNKPTEEWLNKIQGWKEKHPLVAPRFADSISPQSVIVELD
RQAPHAYYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAALGAKVAIADEEVICISGDASFQMCLQELATLAQY
QIKVKTVILNNGWQGMVRQWQQNFYGQRYSSSNMEAGMPNFELLAQAFGVKGMVVDHPDDLSGAIAEMLAHDGPVLLDVR
VKKDENCYPMVIPGKSNAHMMGLQESSGKAE
>Mature_591_residues
MVSTTSPAATETAVRSEVRSGAYILIDSLKRHGVEYIFGYPGGAILPIYDALHPVEERGEIKHILVRHEQGASHAADGYA
RATGKVGVCFGTSGPGATNLVTGIATAHMDSIPMVVITGQVTRAAIGTDAFQETDIFGITLPVVKHSYVVRDPKDMARIV
AEAFYIASTGRPGPVLVDVPKDVGLELCEYIPVEPGDVDIPGYKPRTEGDTSKIGEAVRLISESRKPLLYVGGGAITSGA
HAEIKELAEQFQIPVTTTLMGLGAFDEHNPLSVGMLGMHGSAYANFAVSECDLLIAVGARFDDRVTGKLDEFASEAKVIH
IDIDPAEVGKNRLPEVAIVGDVRHVLIEMLQQLGGKGLPLGNKPTEEWLNKIQGWKEKHPLVAPRFADSISPQSVIVELD
RQAPHAYYTTDVGQHQMWAAQFLKNGPRRWISSAGLGTMGFGLPAALGAKVAIADEEVICISGDASFQMCLQELATLAQY
QIKVKTVILNNGWQGMVRQWQQNFYGQRYSSSNMEAGMPNFELLAQAFGVKGMVVDHPDDLSGAIAEMLAHDGPVLLDVR
VKKDENCYPMVIPGKSNAHMMGLQESSGKAE

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=576, Percent_Identity=27.7777777777778, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI21361361, Length=605, Percent_Identity=24.9586776859504, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI87081685, Length=567, Percent_Identity=48.3245149911817, Blast_Score=527, Evalue=1e-150,
Organism=Escherichia coli, GI1790104, Length=578, Percent_Identity=43.598615916955, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=35.2313167259786, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=28.8288288288288, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788716, Length=553, Percent_Identity=26.5822784810127, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531299, Length=586, Percent_Identity=27.6450511945392, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=586, Percent_Identity=27.6450511945392, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=572, Percent_Identity=26.3986013986014, Blast_Score=145, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323755, Length=582, Percent_Identity=45.1890034364261, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320816, Length=485, Percent_Identity=26.8041237113402, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321524, Length=509, Percent_Identity=23.7721021611002, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323073, Length=520, Percent_Identity=23.6538461538462, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323163, Length=521, Percent_Identity=23.0326295585413, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19922626, Length=592, Percent_Identity=25, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 63620; Mature: 63620

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTTSPAATETAVRSEVRSGAYILIDSLKRHGVEYIFGYPGGAILPIYDALHPVEERGE
CCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCEEEEECCCCCEEEHHHHHCCHHHCCC
IKHILVRHEQGASHAADGYARATGKVGVCFGTSGPGATNLVTGIATAHMDSIPMVVITGQ
EEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
VTRAAIGTDAFQETDIFGITLPVVKHSYVVRDPKDMARIVAEAFYIASTGRPGPVLVDVP
HHHHHHCCCCCCCCCEEEEEHHHHCCCEEEECHHHHHHHHHHHHHEECCCCCCCEEEECC
KDVGLELCEYIPVEPGDVDIPGYKPRTEGDTSKIGEAVRLISESRKPLLYVGGGAITSGA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
HAEIKELAEQFQIPVTTTLMGLGAFDEHNPLSVGMLGMHGSAYANFAVSECDLLIAVGAR
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCHHCEEHHCCCEEEEECCC
FDDRVTGKLDEFASEAKVIHIDIDPAEVGKNRLPEVAIVGDVRHVLIEMLQQLGGKGLPL
CCCCCCCCHHHHCCCCEEEEEECCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCC
GNKPTEEWLNKIQGWKEKHPLVAPRFADSISPQSVIVELDRQAPHAYYTTDVGQHQMWAA
CCCCHHHHHHHHCCHHHCCCEECCHHHCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHH
QFLKNGPRRWISSAGLGTMGFGLPAALGAKVAIADEEVICISGDASFQMCLQELATLAQY
HHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHE
QIKVKTVILNNGWQGMVRQWQQNFYGQRYSSSNMEAGMPNFELLAQAFGVKGMVVDHPDD
EEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCC
LSGAIAEMLAHDGPVLLDVRVKKDENCYPMVIPGKSNAHMMGLQESSGKAE
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MVSTTSPAATETAVRSEVRSGAYILIDSLKRHGVEYIFGYPGGAILPIYDALHPVEERGE
CCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCEEEEECCCCCEEEHHHHHCCHHHCCC
IKHILVRHEQGASHAADGYARATGKVGVCFGTSGPGATNLVTGIATAHMDSIPMVVITGQ
EEEEEEECCCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
VTRAAIGTDAFQETDIFGITLPVVKHSYVVRDPKDMARIVAEAFYIASTGRPGPVLVDVP
HHHHHHCCCCCCCCCEEEEEHHHHCCCEEEECHHHHHHHHHHHHHEECCCCCCCEEEECC
KDVGLELCEYIPVEPGDVDIPGYKPRTEGDTSKIGEAVRLISESRKPLLYVGGGAITSGA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
HAEIKELAEQFQIPVTTTLMGLGAFDEHNPLSVGMLGMHGSAYANFAVSECDLLIAVGAR
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCHHCEEHHCCCEEEEECCC
FDDRVTGKLDEFASEAKVIHIDIDPAEVGKNRLPEVAIVGDVRHVLIEMLQQLGGKGLPL
CCCCCCCCHHHHCCCCEEEEEECCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCC
GNKPTEEWLNKIQGWKEKHPLVAPRFADSISPQSVIVELDRQAPHAYYTTDVGQHQMWAA
CCCCHHHHHHHHCCHHHCCCEECCHHHCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHH
QFLKNGPRRWISSAGLGTMGFGLPAALGAKVAIADEEVICISGDASFQMCLQELATLAQY
HHHHCCHHHHHHHCCCCCCCCCCHHHHCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHE
QIKVKTVILNNGWQGMVRQWQQNFYGQRYSSSNMEAGMPNFELLAQAFGVKGMVVDHPDD
EEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCC
LSGAIAEMLAHDGPVLLDVRVKKDENCYPMVIPGKSNAHMMGLQESSGKAE
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512571 [H]