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The map label for this gene is prs [H]

Identifier: 170079318

GI number: 170079318

Start: 2851667

End: 2852659

Strand: Reverse

Name: prs [H]

Synonym: SYNPCC7002_A2726

Alternate gene names: 170079318

Gene position: 2852659-2851667 (Counterclockwise)

Preceding gene: 170079320

Following gene: 170079317

Centisome position: 94.83

GC content: 54.28

Gene sequence:

>993_bases
GTGAGCCACTCCGCCACCCTCGCCTTACAATCTGTTCTGCAAACCCCCACCGATAGCAACCGTCTCCGGATTTTTTCGGG
ATCGGCGAATTTGCCCCTAGCCAACGAAGTGGCCCGTTATCTGGGCATGGATCTTGGCCCCATGATCCGGAAGCAGTTTG
CCGACGGTGAAATGTACATCCAGGTGCAAGAGTCGATCCGGGGTTGCGATGTTTACCTCATTCAACCCTCCTGCCGTCCG
GTCAACGATCACCTGATGGAACTGTTGATCATGATCGATGCCTGTCGTCGGGCTTCGGCACGCCAAATCACAGCGGTGAT
CCCCTACTACGGCTATGCTCGCGCTGACCGCAAAACCGCTGGTCGCGAATCCATTACAGCGAAACTGGTGGCTAACTTGA
TTACCCAGGCAGGGGCCGGTCGGGTGCTGGCGATGGATCTCCATTCGGCGCAAATCCAAGGGTATTTTGATATTCCCTGT
GACCATGTCTACGGTTCCCCGGTGATCATTGACTATCTCAAAAGCAAAAATTTAGAGGATATTGTGGTGGTCTCTCCCGA
TGTGGGGGGGGTGGCGCGGGCGCGGGCCTTTGCTAAAAAGTTAGACGATGCGCCCCTGGCCATTATTGATAAACGTCGCC
AGGCCCACAATGTCGCCGAAGTGATGAACGTCATCGGGGAAGTTAAAGGAAAAACCGCGATCCTTGTTGATGACATGATC
GACACCGCTGGGACGCTCCAGGAAGGGGCCAGACTATTGAAGAAGGAAGGGGCCAAGGAAGTGTATGCTTGTGCGACCCA
TCCAGTCTTCTCTGGGCCTGCGGTGGAACGGCTCTCTAGTGGCCTGTTTGAGGAAGTTATCGTAACCAATACGATTCCGG
TGCCTGCCGATAAGCAATTTGAAGAACTGACGGTGCTGACGGTGGCCAATCTCCTCGGTGAAACCATTTGGCGCATCCAC
GAAGAAAGTTCTGTGAGCAGTATGTTTCGGTAA

Upstream 100 bases:

>100_bases
TGGTAACACATATCATCGAAACGACCAAAAGGAGGATTATGGTGTCTGCACTGATCCCTTGGATGTCCTTTATCAAACCG
AAAGAGAGGTTTATTCTGCT

Downstream 100 bases:

>100_bases
ATTTTGGCTTGGCTAGAACAATCAATTGATTTTGGGGAGGGAAAGATCATTTGTCCCTCTTTTTTTTAGGCAATTTTCAA
CCAAAGGCGATCGCCCCCGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSHSATLALQSVLQTPTDSNRLRIFSGSANLPLANEVARYLGMDLGPMIRKQFADGEMYIQVQESIRGCDVYLIQPSCRP
VNDHLMELLIMIDACRRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITQAGAGRVLAMDLHSAQIQGYFDIPC
DHVYGSPVIIDYLKSKNLEDIVVVSPDVGGVARARAFAKKLDDAPLAIIDKRRQAHNVAEVMNVIGEVKGKTAILVDDMI
DTAGTLQEGARLLKKEGAKEVYACATHPVFSGPAVERLSSGLFEEVIVTNTIPVPADKQFEELTVLTVANLLGETIWRIH
EESSVSSMFR

Sequences:

>Translated_330_residues
MSHSATLALQSVLQTPTDSNRLRIFSGSANLPLANEVARYLGMDLGPMIRKQFADGEMYIQVQESIRGCDVYLIQPSCRP
VNDHLMELLIMIDACRRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITQAGAGRVLAMDLHSAQIQGYFDIPC
DHVYGSPVIIDYLKSKNLEDIVVVSPDVGGVARARAFAKKLDDAPLAIIDKRRQAHNVAEVMNVIGEVKGKTAILVDDMI
DTAGTLQEGARLLKKEGAKEVYACATHPVFSGPAVERLSSGLFEEVIVTNTIPVPADKQFEELTVLTVANLLGETIWRIH
EESSVSSMFR
>Mature_329_residues
SHSATLALQSVLQTPTDSNRLRIFSGSANLPLANEVARYLGMDLGPMIRKQFADGEMYIQVQESIRGCDVYLIQPSCRPV
NDHLMELLIMIDACRRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITQAGAGRVLAMDLHSAQIQGYFDIPCD
HVYGSPVIIDYLKSKNLEDIVVVSPDVGGVARARAFAKKLDDAPLAIIDKRRQAHNVAEVMNVIGEVKGKTAILVDDMID
TAGTLQEGARLLKKEGAKEVYACATHPVFSGPAVERLSSGLFEEVIVTNTIPVPADKQFEELTVLTVANLLGETIWRIHE
ESSVSSMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=44.6945337620579, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=44.6601941747573, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=43.4083601286174, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=44.5512820512821, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=33.6231884057971, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=33.4302325581395, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=50, Blast_Score=325, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=43.5897435897436, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=43.5897435897436, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=43.7299035369775, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.0129449838188, Blast_Score=266, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=30.2052785923754, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=42.0382165605096, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=42.0382165605096, Blast_Score=251, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=40.9523809523809, Blast_Score=242, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.3265306122449, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=39.4495412844037, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=43.4083601286174, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=41.0179640718563, Blast_Score=260, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24651458, Length=360, Percent_Identity=30.5555555555556, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24651456, Length=360, Percent_Identity=30.5555555555556, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281362873, Length=360, Percent_Identity=30.5555555555556, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24651454, Length=360, Percent_Identity=30.5555555555556, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24651462, Length=207, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24651464, Length=207, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45552010, Length=207, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36099; Mature: 35968

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSATLALQSVLQTPTDSNRLRIFSGSANLPLANEVARYLGMDLGPMIRKQFADGEMYI
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEE
QVQESIRGCDVYLIQPSCRPVNDHLMELLIMIDACRRASARQITAVIPYYGYARADRKTA
EEEHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCHHHC
GRESITAKLVANLITQAGAGRVLAMDLHSAQIQGYFDIPCDHVYGSPVIIDYLKSKNLED
CHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCEEECCCCHHCCCCCCEEEHHHCCCCCE
IVVVSPDVGGVARARAFAKKLDDAPLAIIDKRRQAHNVAEVMNVIGEVKGKTAILVDDMI
EEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
DTAGTLQEGARLLKKEGAKEVYACATHPVFSGPAVERLSSGLFEEVIVTNTIPVPADKQF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
EELTVLTVANLLGETIWRIHEESSVSSMFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHSATLALQSVLQTPTDSNRLRIFSGSANLPLANEVARYLGMDLGPMIRKQFADGEMYI
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEE
QVQESIRGCDVYLIQPSCRPVNDHLMELLIMIDACRRASARQITAVIPYYGYARADRKTA
EEEHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCHHHC
GRESITAKLVANLITQAGAGRVLAMDLHSAQIQGYFDIPCDHVYGSPVIIDYLKSKNLED
CHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCEEECCCCHHCCCCCCEEEHHHCCCCCE
IVVVSPDVGGVARARAFAKKLDDAPLAIIDKRRQAHNVAEVMNVIGEVKGKTAILVDDMI
EEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
DTAGTLQEGARLLKKEGAKEVYACATHPVFSGPAVERLSSGLFEEVIVTNTIPVPADKQF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
EELTVLTVANLLGETIWRIHEESSVSSMFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7764342 [H]