Click here to switch to the map view.

The map label for this gene is gmd [H]

Identifier: 170079159

GI number: 170079159

Start: 2672477

End: 2673556

Strand: Reverse

Name: gmd [H]

Synonym: SYNPCC7002_A2565

Alternate gene names: 170079159

Gene position: 2673556-2672477 (Counterclockwise)

Preceding gene: 170079160

Following gene: 170079157

Centisome position: 88.88

GC content: 51.67

Gene sequence:

>1080_bases
ATGGGTAATCGAAAAGCACTGGTAACAGGGATCACCGGACAAGATGGCTCTTATTTGGCGGAACTGCTCCTCGAAAAAGG
TTACGAAGTTCATGGCATTATCCGTCGCGCTTCTACTTTTAATACCGACCGCATTGACCATCTCTATGTCGATCCCCATA
TCCCCGACGCTCGGTTCTTTCTCCATTACGGGGATCTCACCGATGGCACATCCCTAGGAAAATTAATCGAAAAAATCCAG
CCCCATGAAGTTTACAATCTGGGTGCCCAATCCCATGTGCGGGTGAGCTTTGATTCGCCAGAATATACCGTGGATACCGT
GGCGATGGGGACGCTGCGTATCCTAGAAGCGATTCGGGACTACCAGGAACGGACGGGCAATGAAGTGCGCTTTTACCAGG
CCGGTTCGTCGGAAATGTTTGGCCTTGTGCAAGAGGTGCCCCAAAAGGAAACGACCCCCTTTTATCCCCGCAGTCCCTAC
GCCTGTGCCAAGGTCTATGGCTACTGGCAAACGGTGAACTACCGAGAATCCTATGATTTGTTCGCTTGCAATGGCATTTT
GTTTAACCATGAAGGGCCGCGCCGGGGGGAAACCTTCGTTACCCGAAAAATCACCAGGGCGATCGCCAGAATTATCGCCG
GACAGCAGGACAAACTGTATCTCGGCAACCTCGATTCCAAGCGGGACTGGGGTTATGCAAAAGACTATGTGCGGGCAATG
TGGCTGATGTTGCAGCAGGACAAACCCGACGACTATGTCATTGCCACAGGGGAAACCTATTCAGTCCGCCAATTTTTAGA
AACCGCCTTCGCCTACGTCAATCTGAACTGGGAAGATTATGTCGCCTTTGACCGCCGTTATCTCCGCCCTGCCGAGGTGG
ACTTACTCATTGGCGATCCCACGAAGGCTAAAAAACAACTAAACTGGGAGCCGAGTATTGATTTTCCGACCCTCGTCGGG
ATCATGGTCGAAGCAGATCTTGCCATTTTGGGTTTACCGCCCCACAATCCAGCCATGGGCAAACTTTATGAAGCAGATCA
AGCCTATATCCGCCAAGCAACCGGCAGCCGCGTTGATTAG

Upstream 100 bases:

>100_bases
GGTCTTTTTAAGGGCACCATGTAAATGGCGTCTTAAAGTCCATCTCGGTGAATACTGTTCTAAAATTGCTTAGTTGATAT
GTTGAGTAAACACGAGCTCC

Downstream 100 bases:

>100_bases
TGGGTGTGTCCATCCTCTGGTTCGTCTAGGTGCTCCGAAGCGTCACGATAGAGATTAAGAATGTGGTGATCCTTGAGGCG
ATAAATCACATTCCGCCCTT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MGNRKALVTGITGQDGSYLAELLLEKGYEVHGIIRRASTFNTDRIDHLYVDPHIPDARFFLHYGDLTDGTSLGKLIEKIQ
PHEVYNLGAQSHVRVSFDSPEYTVDTVAMGTLRILEAIRDYQERTGNEVRFYQAGSSEMFGLVQEVPQKETTPFYPRSPY
ACAKVYGYWQTVNYRESYDLFACNGILFNHEGPRRGETFVTRKITRAIARIIAGQQDKLYLGNLDSKRDWGYAKDYVRAM
WLMLQQDKPDDYVIATGETYSVRQFLETAFAYVNLNWEDYVAFDRRYLRPAEVDLLIGDPTKAKKQLNWEPSIDFPTLVG
IMVEADLAILGLPPHNPAMGKLYEADQAYIRQATGSRVD

Sequences:

>Translated_359_residues
MGNRKALVTGITGQDGSYLAELLLEKGYEVHGIIRRASTFNTDRIDHLYVDPHIPDARFFLHYGDLTDGTSLGKLIEKIQ
PHEVYNLGAQSHVRVSFDSPEYTVDTVAMGTLRILEAIRDYQERTGNEVRFYQAGSSEMFGLVQEVPQKETTPFYPRSPY
ACAKVYGYWQTVNYRESYDLFACNGILFNHEGPRRGETFVTRKITRAIARIIAGQQDKLYLGNLDSKRDWGYAKDYVRAM
WLMLQQDKPDDYVIATGETYSVRQFLETAFAYVNLNWEDYVAFDRRYLRPAEVDLLIGDPTKAKKQLNWEPSIDFPTLVG
IMVEADLAILGLPPHNPAMGKLYEADQAYIRQATGSRVD
>Mature_358_residues
GNRKALVTGITGQDGSYLAELLLEKGYEVHGIIRRASTFNTDRIDHLYVDPHIPDARFFLHYGDLTDGTSLGKLIEKIQP
HEVYNLGAQSHVRVSFDSPEYTVDTVAMGTLRILEAIRDYQERTGNEVRFYQAGSSEMFGLVQEVPQKETTPFYPRSPYA
CAKVYGYWQTVNYRESYDLFACNGILFNHEGPRRGETFVTRKITRAIARIIAGQQDKLYLGNLDSKRDWGYAKDYVRAMW
LMLQQDKPDDYVIATGETYSVRQFLETAFAYVNLNWEDYVAFDRRYLRPAEVDLLIGDPTKAKKQLNWEPSIDFPTLVGI
MVEADLAILGLPPHNPAMGKLYEADQAYIRQATGSRVD

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=349, Percent_Identity=58.4527220630373, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1788366, Length=354, Percent_Identity=60.4519774011299, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI48994969, Length=265, Percent_Identity=27.5471698113208, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788353, Length=351, Percent_Identity=24.2165242165242, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17507723, Length=347, Percent_Identity=59.6541786743516, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539424, Length=349, Percent_Identity=58.1661891117478, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI133901790, Length=349, Percent_Identity=58.1661891117478, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI133901788, Length=349, Percent_Identity=58.1661891117478, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17539422, Length=349, Percent_Identity=58.1661891117478, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI133901786, Length=351, Percent_Identity=57.8347578347578, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24158427, Length=352, Percent_Identity=58.2386363636364, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41017; Mature: 40886

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNRKALVTGITGQDGSYLAELLLEKGYEVHGIIRRASTFNTDRIDHLYVDPHIPDARFF
CCCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHCCCCCCCCEEEEECCCCCCCEEE
LHYGDLTDGTSLGKLIEKIQPHEVYNLGAQSHVRVSFDSPEYTVDTVAMGTLRILEAIRD
EEECCCCCCHHHHHHHHHCCCCHHEECCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHH
YQERTGNEVRFYQAGSSEMFGLVQEVPQKETTPFYPRSPYACAKVYGYWQTVNYRESYDL
HHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCE
FACNGILFNHEGPRRGETFVTRKITRAIARIIAGQQDKLYLGNLDSKRDWGYAKDYVRAM
EEECEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHH
WLMLQQDKPDDYVIATGETYSVRQFLETAFAYVNLNWEDYVAFDRRYLRPAEVDLLIGDP
HHHHHCCCCCCEEEECCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCEEEEECCC
TKAKKQLNWEPSIDFPTLVGIMVEADLAILGLPPHNPAMGKLYEADQAYIRQATGSRVD
CHHHHHCCCCCCCCCHHHHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GNRKALVTGITGQDGSYLAELLLEKGYEVHGIIRRASTFNTDRIDHLYVDPHIPDARFF
CCCEEEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHCCCCCCCCEEEEECCCCCCCEEE
LHYGDLTDGTSLGKLIEKIQPHEVYNLGAQSHVRVSFDSPEYTVDTVAMGTLRILEAIRD
EEECCCCCCHHHHHHHHHCCCCHHEECCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHH
YQERTGNEVRFYQAGSSEMFGLVQEVPQKETTPFYPRSPYACAKVYGYWQTVNYRESYDL
HHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCE
FACNGILFNHEGPRRGETFVTRKITRAIARIIAGQQDKLYLGNLDSKRDWGYAKDYVRAM
EEECEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHH
WLMLQQDKPDDYVIATGETYSVRQFLETAFAYVNLNWEDYVAFDRRYLRPAEVDLLIGDP
HHHHHCCCCCCEEEECCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHCCCCCEEEEECCC
TKAKKQLNWEPSIDFPTLVGIMVEADLAILGLPPHNPAMGKLYEADQAYIRQATGSRVD
CHHHHHCCCCCCCCCHHHHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]