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The map label for this gene is apt

Identifier: 170079143

GI number: 170079143

Start: 2657330

End: 2657848

Strand: Direct

Name: apt

Synonym: SYNPCC7002_A2549

Alternate gene names: 170079143

Gene position: 2657330-2657848 (Clockwise)

Preceding gene: 170079142

Following gene: 170079144

Centisome position: 88.34

GC content: 54.53

Gene sequence:

>519_bases
ATGGATCTAAAATCCCTGATTCGTGACATCCCTGATTTCCCCAAGCCCGGCATTCTCTTCCGCGACATTACCACCCTCCT
CAACCACCCCGAAGGTATGCGCTACACCATGGATGCCCTAGTGCAACTCTGCCTTGAAGCCAACCTCAAACCCGATCATG
TGGTGGGAATGGAGTCTAGGGGGTTTATCTTTGGGCCGACCCTCGCCTACAACCTCAATGCTGGTTTTGTCCCCGTGCGT
AAACCCGGCAAACTCCTCGCCGCCGTCCACACCGTCGAATACGAACTTGAATACGGCACCGACACCCTCGAAATTCACCA
GGATGCCGTGGGGTCTGGGGACAAAATTGTCATCGTCGATGACCTGATCGCCACCGGGGGTACCGCCAAAGCCACCGCAG
AACTGCTTACAAAAATTGGCTGTGACATCATTGGTTTTGTGTTTATCGTCGAACTCCTAGATCTCAAGGGCCGCGATCGC
CTGCCAGACGCCCCCGTGCTTTCCCTCATACAATACTAG

Upstream 100 bases:

>100_bases
AATCATGAAAATAAGCTGGCCGCCAGTGATGTTTACGCGCCAGAACTCGCTAAGATGAGGGGCGATCGCCTTTTATTCCC
GTTCAACCGCTCTAAAAACT

Downstream 100 bases:

>100_bases
GCAGGATTTGGAACACCCGATTTAACCCCCAATGAGCATTCGTAATCCCCTAACGATCTTTGACCGAGAAACGATTCTTT
ATATCTTAAAGCGTCTACTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDLKSLIRDIPDFPKPGILFRDITTLLNHPEGMRYTMDALVQLCLEANLKPDHVVGMESRGFIFGPTLAYNLNAGFVPVR
KPGKLLAAVHTVEYELEYGTDTLEIHQDAVGSGDKIVIVDDLIATGGTAKATAELLTKIGCDIIGFVFIVELLDLKGRDR
LPDAPVLSLIQY

Sequences:

>Translated_172_residues
MDLKSLIRDIPDFPKPGILFRDITTLLNHPEGMRYTMDALVQLCLEANLKPDHVVGMESRGFIFGPTLAYNLNAGFVPVR
KPGKLLAAVHTVEYELEYGTDTLEIHQDAVGSGDKIVIVDDLIATGGTAKATAELLTKIGCDIIGFVFIVELLDLKGRDR
LPDAPVLSLIQY
>Mature_172_residues
MDLKSLIRDIPDFPKPGILFRDITTLLNHPEGMRYTMDALVQLCLEANLKPDHVVGMESRGFIFGPTLAYNLNAGFVPVR
KPGKLLAAVHTVEYELEYGTDTLEIHQDAVGSGDKIVIVDDLIATGGTAKATAELLTKIGCDIIGFVFIVELLDLKGRDR
LPDAPVLSLIQY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=44.9101796407186, Blast_Score=147, Evalue=4e-36,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=45.4545454545455, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1786675, Length=166, Percent_Identity=49.3975903614458, Blast_Score=159, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=40, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=44.2528735632184, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=31.7919075144509, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=45.8823529411765, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SYNP2 (B1XL39)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735781.1
- ProteinModelPortal:   B1XL39
- SMR:   B1XL39
- GeneID:   6055354
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2549
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18849; Mature: 18849

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKSLIRDIPDFPKPGILFRDITTLLNHPEGMRYTMDALVQLCLEANLKPDHVVGMESR
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCC
GFIFGPTLAYNLNAGFVPVRKPGKLLAAVHTVEYELEYGTDTLEIHQDAVGSGDKIVIVD
CEEECCEEEEECCCCEEECCCCCHHHHHHHHEEEEEECCCCEEEEHHHHCCCCCEEEEEE
DLIATGGTAKATAELLTKIGCDIIGFVFIVELLDLKGRDRLPDAPVLSLIQY
CHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MDLKSLIRDIPDFPKPGILFRDITTLLNHPEGMRYTMDALVQLCLEANLKPDHVVGMESR
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCC
GFIFGPTLAYNLNAGFVPVRKPGKLLAAVHTVEYELEYGTDTLEIHQDAVGSGDKIVIVD
CEEECCEEEEECCCCEEECCCCCHHHHHHHHEEEEEECCCCEEEEHHHHCCCCCEEEEEE
DLIATGGTAKATAELLTKIGCDIIGFVFIVELLDLKGRDRLPDAPVLSLIQY
CHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA