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The map label for this gene is mnhD2 [H]

Identifier: 170078970

GI number: 170078970

Start: 2458017

End: 2459453

Strand: Direct

Name: mnhD2 [H]

Synonym: SYNPCC7002_A2375

Alternate gene names: 170078970

Gene position: 2458017-2459453 (Clockwise)

Preceding gene: 170078969

Following gene: 170078971

Centisome position: 81.71

GC content: 50.45

Gene sequence:

>1437_bases
ATGAATGAATTGACCATTGGCTGGGTAATTTTTCCCTTTGTGGTGGGCTTTAGTATTTATTTACTGCCCAAAATTGATCG
TTATCTGGCGATTTTCGTTTCTATTTGTTCGTTAATCTTTGGTTTTGTCCAAATTTTTCAGCCGGAACCCTACAGTCTCA
AGCTCCTGGGGATGTATGGGGTAGATCTGCTGGTGGATGACCAGAGCGGCTATTTTATTTTGACCAATGCGGCGGTGGCG
ATCGCCGTGACGGTGTATTGCTGGAAAAGCGCCAAGAGTGCTTTTTTCTTTACCCAGTTGGTGGTTTTGCAAGGGGCCCT
CAATGCCGTTTTTGTCTGCGCCGATCTGATTAGCCTCTACGTTGCCCTGGAGGCCATTAGCATCGCGGCTTTTTTGTTGA
TGACCTACCAGCGCACCGACCGTTCTATTTGGATTGGTCTCAGGTATTTATTCCTCAGCAATACGGCGATGCTGTTCTAT
CTGATTGGGGCGGTGCTGGTCTACCAAGCAACAAAATCCTTCGCTTTTGTGGGTCTCGCCGAAGCGCCTAGTGATGCGAT
CGCCCTGATTTTCCTGGGTTTGCTCACCAAGGGCGGTGTCTTTGTGTCGGGACTCTGGTTGCCCTTAACCCACTCCGAAG
CAGAAACCCCCGTATCGGCGATGTTGTCCGGTGTCGTGGTCAAAGCGGGAATTTTCCCCCTCCTGCGCTGCGGCATTTTA
GTGCCAGACCTGGACTTATGGCTGAGACTATTCGGGCTGGCCACTGCCCTGTTGGGGATTATCTTTGCCATTCTCGAAAC
CGATGCCAAACGTTTACTGGCTTTTAGCACCATCTCAAAATTAGGGTTGTTGCTCTCAGCACCAGCAGTGGCGGGTTTAG
CGGCCCTCTCCCATGGTTTAGTGAAATCTTCTTTATTTTTGATGGCAGGTCAATTGCCCACCCGCAATTTTCAGGAACTG
CGCCAAACCAAAATCGCGAGCAGTCTGTGGCTGCCCTTGGCGATCGCCTGCCTGTCGATGGTAGGGATGCCGTTACTGGT
TGGCTTCAGCTCAAAGGCCCTCCTACTCAAAAATATTGCCCCCTGGCAGGCAATGGGTCTGAATATTGCCGCCGTGGGGA
CAGCCCTGGCCTTCGCCAAATTCTTGTTCATTCCCCATGATGCCGCGACGAAATTTACTGCAAAAAGCACAACCTTTTGG
GGGGCGATCGCCTTTTTATTCAGTGGTGTCATCCTCGGCAATGGTTTTTATCTCGAAGCCTATCAACTGGACAATATCCC
CAAGGCCTTGATCAAAATTGCCATTGGTTGGGCGTTGTACTGGCTCATTATGAAGCGCATCGAGTTCAAGCTGCCCCGAA
TCTTCGAGGCGTTTGAGCAGTTGATCGGCGCCATGAGCGTTGTCTTAACTGGATTATTTTGGATGGTGACCCTATGA

Upstream 100 bases:

>100_bases
CATCTGGTGGGGGTGATGAGTCTTGTGTTGACGGGTTTGTTTTGGCTGGTGTTGGCTTAGGACAACTCTCAGTGGTCGTT
AGTTTAGGGAGGAGATAACC

Downstream 100 bases:

>100_bases
TCGGCATTCTCGATATTTTTCTAATTTTAATGATCTGGTTTCTGCTCACAGCAGACCTGAGTGCAGCCAATATTCTCATC
GGCGTGATCATTGCAATCTT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MNELTIGWVIFPFVVGFSIYLLPKIDRYLAIFVSICSLIFGFVQIFQPEPYSLKLLGMYGVDLLVDDQSGYFILTNAAVA
IAVTVYCWKSAKSAFFFTQLVVLQGALNAVFVCADLISLYVALEAISIAAFLLMTYQRTDRSIWIGLRYLFLSNTAMLFY
LIGAVLVYQATKSFAFVGLAEAPSDAIALIFLGLLTKGGVFVSGLWLPLTHSEAETPVSAMLSGVVVKAGIFPLLRCGIL
VPDLDLWLRLFGLATALLGIIFAILETDAKRLLAFSTISKLGLLLSAPAVAGLAALSHGLVKSSLFLMAGQLPTRNFQEL
RQTKIASSLWLPLAIACLSMVGMPLLVGFSSKALLLKNIAPWQAMGLNIAAVGTALAFAKFLFIPHDAATKFTAKSTTFW
GAIAFLFSGVILGNGFYLEAYQLDNIPKALIKIAIGWALYWLIMKRIEFKLPRIFEAFEQLIGAMSVVLTGLFWMVTL

Sequences:

>Translated_478_residues
MNELTIGWVIFPFVVGFSIYLLPKIDRYLAIFVSICSLIFGFVQIFQPEPYSLKLLGMYGVDLLVDDQSGYFILTNAAVA
IAVTVYCWKSAKSAFFFTQLVVLQGALNAVFVCADLISLYVALEAISIAAFLLMTYQRTDRSIWIGLRYLFLSNTAMLFY
LIGAVLVYQATKSFAFVGLAEAPSDAIALIFLGLLTKGGVFVSGLWLPLTHSEAETPVSAMLSGVVVKAGIFPLLRCGIL
VPDLDLWLRLFGLATALLGIIFAILETDAKRLLAFSTISKLGLLLSAPAVAGLAALSHGLVKSSLFLMAGQLPTRNFQEL
RQTKIASSLWLPLAIACLSMVGMPLLVGFSSKALLLKNIAPWQAMGLNIAAVGTALAFAKFLFIPHDAATKFTAKSTTFW
GAIAFLFSGVILGNGFYLEAYQLDNIPKALIKIAIGWALYWLIMKRIEFKLPRIFEAFEQLIGAMSVVLTGLFWMVTL
>Mature_478_residues
MNELTIGWVIFPFVVGFSIYLLPKIDRYLAIFVSICSLIFGFVQIFQPEPYSLKLLGMYGVDLLVDDQSGYFILTNAAVA
IAVTVYCWKSAKSAFFFTQLVVLQGALNAVFVCADLISLYVALEAISIAAFLLMTYQRTDRSIWIGLRYLFLSNTAMLFY
LIGAVLVYQATKSFAFVGLAEAPSDAIALIFLGLLTKGGVFVSGLWLPLTHSEAETPVSAMLSGVVVKAGIFPLLRCGIL
VPDLDLWLRLFGLATALLGIIFAILETDAKRLLAFSTISKLGLLLSAPAVAGLAALSHGLVKSSLFLMAGQLPTRNFQEL
RQTKIASSLWLPLAIACLSMVGMPLLVGFSSKALLLKNIAPWQAMGLNIAAVGTALAFAKFLFIPHDAATKFTAKSTTFW
GAIAFLFSGVILGNGFYLEAYQLDNIPKALIKIAIGWALYWLIMKRIEFKLPRIFEAFEQLIGAMSVVLTGLFWMVTL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=191, Percent_Identity=34.0314136125654, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1788827, Length=304, Percent_Identity=29.6052631578947, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788831, Length=251, Percent_Identity=30.6772908366534, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788829, Length=284, Percent_Identity=28.5211267605634, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693160, Length=234, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788613, Length=333, Percent_Identity=26.4264264264264, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52151; Mature: 52151

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELTIGWVIFPFVVGFSIYLLPKIDRYLAIFVSICSLIFGFVQIFQPEPYSLKLLGMYG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
VDLLVDDQSGYFILTNAAVAIAVTVYCWKSAKSAFFFTQLVVLQGALNAVFVCADLISLY
CEEEEECCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALEAISIAAFLLMTYQRTDRSIWIGLRYLFLSNTAMLFYLIGAVLVYQATKSFAFVGLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
EAPSDAIALIFLGLLTKGGVFVSGLWLPLTHSEAETPVSAMLSGVVVKAGIFPLLRCGIL
CCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VPDLDLWLRLFGLATALLGIIFAILETDAKRLLAFSTISKLGLLLSAPAVAGLAALSHGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VKSSLFLMAGQLPTRNFQELRQTKIASSLWLPLAIACLSMVGMPLLVGFSSKALLLKNIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHCCC
PWQAMGLNIAAVGTALAFAKFLFIPHDAATKFTAKSTTFWGAIAFLFSGVILGNGFYLEA
CHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCEECCCCHHHHHHHHHHHHHHCCCCEEEEE
YQLDNIPKALIKIAIGWALYWLIMKRIEFKLPRIFEAFEQLIGAMSVVLTGLFWMVTL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNELTIGWVIFPFVVGFSIYLLPKIDRYLAIFVSICSLIFGFVQIFQPEPYSLKLLGMYG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
VDLLVDDQSGYFILTNAAVAIAVTVYCWKSAKSAFFFTQLVVLQGALNAVFVCADLISLY
CEEEEECCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALEAISIAAFLLMTYQRTDRSIWIGLRYLFLSNTAMLFYLIGAVLVYQATKSFAFVGLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
EAPSDAIALIFLGLLTKGGVFVSGLWLPLTHSEAETPVSAMLSGVVVKAGIFPLLRCGIL
CCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
VPDLDLWLRLFGLATALLGIIFAILETDAKRLLAFSTISKLGLLLSAPAVAGLAALSHGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VKSSLFLMAGQLPTRNFQELRQTKIASSLWLPLAIACLSMVGMPLLVGFSSKALLLKNIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHCCC
PWQAMGLNIAAVGTALAFAKFLFIPHDAATKFTAKSTTFWGAIAFLFSGVILGNGFYLEA
CHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCEECCCCHHHHHHHHHHHHHHCCCCEEEEE
YQLDNIPKALIKIAIGWALYWLIMKRIEFKLPRIFEAFEQLIGAMSVVLTGLFWMVTL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA