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The map label for this gene is pyrC

Identifier: 170078698

GI number: 170078698

Start: 2172754

End: 2173794

Strand: Reverse

Name: pyrC

Synonym: SYNPCC7002_A2097

Alternate gene names: 170078698

Gene position: 2173794-2172754 (Counterclockwise)

Preceding gene: 170078699

Following gene: 170078696

Centisome position: 72.27

GC content: 53.89

Gene sequence:

>1041_bases
ATGGAAAAAATCACCCTCACCCGCCCCGATGACTGGCATTTGCACCTCCGCGACGGGGAAGCGCTCAAGGCTGTTTTGCC
CGATACGGTGCGCCAATTTGCCCGGGCCATTGTGATGCCCAACCTCAAGCCCCCCGTGCGTACCGTTGCTGAGGCCGCTG
CCTATCACGATCGCATTTTGGCTGCCATTCCCCCAGGGCGAACCTTTGAACCCCTGATGACCCTCTACCTCACGGACAAT
ACCAGTCCTGCTGAAATTCAGGCCGCGAAAGAATCCGGGTTTGTGAAAGCGGTGAAATATTATCCCGCTGGTGCCACAAC
CAACTCTGACCTTGGCGTCACAGATATCCGCAAATGTGATGCGGTGTTTGAGGCGATGCAAACGGTTGATCTACCCCTGC
TACTCCATGGAGAGGTGACCGATCATCGGGTGGATGTGTTTGACCGGGAAAAAGTTTTTATCGAAACCTATCTCCGTCCC
CTGAAGGAACGCTTTCCGCAGCTACGCATTGTTTTAGAGCACATCACCACCAAAGATGCGGTGGAATTTGTCCTGGCGAG
CGATGAAAAAGTGGCGGCGACGATTACACCCCAACATTTGCTGTTCAATCGCAACAGTATTTTCCAGGGCGGCATTCGGC
CCCATTTCTACTGTTTACCGATCTTGAAACGAGAGACCCACCGGGAAGCCCTGCTAGAAGCGGCAACCTCTGGCAATCCA
AAATTTTTCCTCGGCACCGATAGTGCGCCCCATGGCCGCGATCGCAAAGAAAGTGACTGTGGCTGTGCGGGGTGTTATTC
GGCGCTCCATGCCCTAGAGCTATATGCCACGGTGTTTGAAGCAGCAGACGCCCTGGATAAACTTGAAGGCTTTGCCAGTT
TCTATGGGCCAGATTTTTACCAACTGCCCCGCAACACCGAAAAAATTACTTTGACGAAAACCCCTTGGCAGATTCCCGAC
GCGCTGCCTTTTCCGGAATCAAGTCTTGTGCCCCTTTGGGCTGGCCAGGAATTAAGCTGGAAATTCGCCCCAGTCGCCTA
G

Upstream 100 bases:

>100_bases
TGCTACGTCGTTGTTTACCCACTGCCTTGAAGCCTAAAATCTAATTTTTAGCGTTAAATCGCCGCTTTTTCCCCTCCTTT
GACCAATTTATCTTGAAATA

Downstream 100 bases:

>100_bases
GAATTTTCGTACCAACTGGCGCGCCAGGCGGCCTCTGCTTCGGCGATCGCCAAATCCTGTTTCGCCTTTTGGTAATACTT
TTGCAAATTACGGAGCTTAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKITLTRPDDWHLHLRDGEALKAVLPDTVRQFARAIVMPNLKPPVRTVAEAAAYHDRILAAIPPGRTFEPLMTLYLTDN
TSPAEIQAAKESGFVKAVKYYPAGATTNSDLGVTDIRKCDAVFEAMQTVDLPLLLHGEVTDHRVDVFDREKVFIETYLRP
LKERFPQLRIVLEHITTKDAVEFVLASDEKVAATITPQHLLFNRNSIFQGGIRPHFYCLPILKRETHREALLEAATSGNP
KFFLGTDSAPHGRDRKESDCGCAGCYSALHALELYATVFEAADALDKLEGFASFYGPDFYQLPRNTEKITLTKTPWQIPD
ALPFPESSLVPLWAGQELSWKFAPVA

Sequences:

>Translated_346_residues
MEKITLTRPDDWHLHLRDGEALKAVLPDTVRQFARAIVMPNLKPPVRTVAEAAAYHDRILAAIPPGRTFEPLMTLYLTDN
TSPAEIQAAKESGFVKAVKYYPAGATTNSDLGVTDIRKCDAVFEAMQTVDLPLLLHGEVTDHRVDVFDREKVFIETYLRP
LKERFPQLRIVLEHITTKDAVEFVLASDEKVAATITPQHLLFNRNSIFQGGIRPHFYCLPILKRETHREALLEAATSGNP
KFFLGTDSAPHGRDRKESDCGCAGCYSALHALELYATVFEAADALDKLEGFASFYGPDFYQLPRNTEKITLTKTPWQIPD
ALPFPESSLVPLWAGQELSWKFAPVA
>Mature_346_residues
MEKITLTRPDDWHLHLRDGEALKAVLPDTVRQFARAIVMPNLKPPVRTVAEAAAYHDRILAAIPPGRTFEPLMTLYLTDN
TSPAEIQAAKESGFVKAVKYYPAGATTNSDLGVTDIRKCDAVFEAMQTVDLPLLLHGEVTDHRVDVFDREKVFIETYLRP
LKERFPQLRIVLEHITTKDAVEFVLASDEKVAATITPQHLLFNRNSIFQGGIRPHFYCLPILKRETHREALLEAATSGNP
KFFLGTDSAPHGRDRKESDCGCAGCYSALHALELYATVFEAADALDKLEGFASFYGPDFYQLPRNTEKITLTKTPWQIPD
ALPFPESSLVPLWAGQELSWKFAPVA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=340, Percent_Identity=53.2352941176471, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6323452, Length=364, Percent_Identity=36.2637362637363, Blast_Score=191, Evalue=2e-49,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_SYNP2 (B1XI96)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735336.1
- ProteinModelPortal:   B1XI96
- SMR:   B1XI96
- GeneID:   6055388
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2097
- HOGENOM:   HBG628648
- OMA:   KESACGC
- ProtClustDB:   PRK05451
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 38733; Mature: 38733

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKITLTRPDDWHLHLRDGEALKAVLPDTVRQFARAIVMPNLKPPVRTVAEAAAYHDRIL
CCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
AAIPPGRTFEPLMTLYLTDNTSPAEIQAAKESGFVKAVKYYPAGATTNSDLGVTDIRKCD
EECCCCCCCCCEEEEEEECCCCCHHEEEHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHH
AVFEAMQTVDLPLLLHGEVTDHRVDVFDREKVFIETYLRPLKERFPQLRIVLEHITTKDA
HHHHHHHHCCCCEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VEFVLASDEKVAATITPQHLLFNRNSIFQGGIRPHFYCLPILKRETHREALLEAATSGNP
HHHEEECCCEEEEEECHHHHEECCCCCEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCC
KFFLGTDSAPHGRDRKESDCGCAGCYSALHALELYATVFEAADALDKLEGFASFYGPDFY
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
QLPRNTEKITLTKTPWQIPDALPFPESSLVPLWAGQELSWKFAPVA
ECCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEECCCC
>Mature Secondary Structure
MEKITLTRPDDWHLHLRDGEALKAVLPDTVRQFARAIVMPNLKPPVRTVAEAAAYHDRIL
CCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
AAIPPGRTFEPLMTLYLTDNTSPAEIQAAKESGFVKAVKYYPAGATTNSDLGVTDIRKCD
EECCCCCCCCCEEEEEEECCCCCHHEEEHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHH
AVFEAMQTVDLPLLLHGEVTDHRVDVFDREKVFIETYLRPLKERFPQLRIVLEHITTKDA
HHHHHHHHCCCCEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VEFVLASDEKVAATITPQHLLFNRNSIFQGGIRPHFYCLPILKRETHREALLEAATSGNP
HHHEEECCCEEEEEECHHHHEECCCCCEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCC
KFFLGTDSAPHGRDRKESDCGCAGCYSALHALELYATVFEAADALDKLEGFASFYGPDFY
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
QLPRNTEKITLTKTPWQIPDALPFPESSLVPLWAGQELSWKFAPVA
ECCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA