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The map label for this gene is mdh [H]

Identifier: 170078694

GI number: 170078694

Start: 2169566

End: 2170537

Strand: Reverse

Name: mdh [H]

Synonym: SYNPCC7002_A2093

Alternate gene names: 170078694

Gene position: 2170537-2169566 (Counterclockwise)

Preceding gene: 170078695

Following gene: 170078693

Centisome position: 72.16

GC content: 52.98

Gene sequence:

>972_bases
ATGTGTGCGATCGCCGTCCCTTCCATTTCCTGTAAAGCACCCCAAGTGACGGTGATCGGTGCCGGGAAAGTCGGTAGCAC
CCTAGCCCAACGGGTCATCGAAAAAAACCTCGCGGATGTGGTCTTGCTCGATATTGTTGAAGGTCTTCCCCAAGGCATTG
CCCTTGATTTATACGAGGCCCAGGGTTTAGAAGGGCACCATAAAACCATTCTCGGCACCAATGATTATGCTGATACAACG
GGTTCCGACATTGTGGTGATTACTGCTGGGCTGGCCCGCAAGCCCGGCATGAGCCGAGAAGATCTGCTCCATTACAATGC
CAAGATCGTTGTCCATGCCGCAAGGGAAGCCATGGAGCGCAGCCCCCAAGCCATTTTTATCGTGGTGACAAACCCGATGG
ATGTGATGACCTACCTCACCTGGAAAGTGACGGGTTTGCCAGTGAACCATTTGTTGGGGATGGGGGGCGTCCTAGATTCA
GCCCGTTTACGCACCTTTATTGCGATGGAACTAGGAGTCAGTACTGGGGATGTTTCAACCCTCGTCCTTGGGGGCCATGG
GGATTTGATGGTGCCGTTGCCCCACTACTGTACGGTGAGTGGTATCCCAATTACTGAGTTGATGGATGCCACTAAAATTC
AAGGGTTAATTGAACGCACCCGGAACGGTGGCGCAGAGATTGTGTCCCTCCTTAAAACGGGCAGTGCTTTCTATGCCCCT
GCTTCGTCTGTTTGTCACATGATTGAGTCCCTCATTCAGGATCAATCCCGCCTGTTACCTGCCTCGGTGTATCTGCAAGG
TCAGTACGGTTTGACGGATTTGTTCTTGGGGGTGCCCTGTCGGTTGGGGTGCCGGGGCGTAGAAGCAATTGTTGAGATCC
CTTTGACCGATGCTGAACTGGCACAATTGCATCGCTCTGCGGCCTCGGTACGGGATAGCCTCGATAAAGCCCTCTCTAAA
CTGAGTCTTTAA

Upstream 100 bases:

>100_bases
TCTCGACGATGAATACGCCTTTGTGCGTTTCTATACCCCAACTCCCAGTGTTTGGCTCCGTCTCGATCAACTCGAAGCTG
TTTAAATTTGGAATAGTCCC

Downstream 100 bases:

>100_bases
CAGATCGATCCATGGCAGTGTCGGTGGAATATTGGTTAATTTCCCTGGAGCAACTGGGACTGTCAACAAAGCTGTGGTGG
CTCTTGAGCGACGACGAACA

Product: malate dehydrogenase, NAD-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MCAIAVPSISCKAPQVTVIGAGKVGSTLAQRVIEKNLADVVLLDIVEGLPQGIALDLYEAQGLEGHHKTILGTNDYADTT
GSDIVVITAGLARKPGMSREDLLHYNAKIVVHAAREAMERSPQAIFIVVTNPMDVMTYLTWKVTGLPVNHLLGMGGVLDS
ARLRTFIAMELGVSTGDVSTLVLGGHGDLMVPLPHYCTVSGIPITELMDATKIQGLIERTRNGGAEIVSLLKTGSAFYAP
ASSVCHMIESLIQDQSRLLPASVYLQGQYGLTDLFLGVPCRLGCRGVEAIVEIPLTDAELAQLHRSAASVRDSLDKALSK
LSL

Sequences:

>Translated_323_residues
MCAIAVPSISCKAPQVTVIGAGKVGSTLAQRVIEKNLADVVLLDIVEGLPQGIALDLYEAQGLEGHHKTILGTNDYADTT
GSDIVVITAGLARKPGMSREDLLHYNAKIVVHAAREAMERSPQAIFIVVTNPMDVMTYLTWKVTGLPVNHLLGMGGVLDS
ARLRTFIAMELGVSTGDVSTLVLGGHGDLMVPLPHYCTVSGIPITELMDATKIQGLIERTRNGGAEIVSLLKTGSAFYAP
ASSVCHMIESLIQDQSRLLPASVYLQGQYGLTDLFLGVPCRLGCRGVEAIVEIPLTDAELAQLHRSAASVRDSLDKALSK
LSL
>Mature_323_residues
MCAIAVPSISCKAPQVTVIGAGKVGSTLAQRVIEKNLADVVLLDIVEGLPQGIALDLYEAQGLEGHHKTILGTNDYADTT
GSDIVVITAGLARKPGMSREDLLHYNAKIVVHAAREAMERSPQAIFIVVTNPMDVMTYLTWKVTGLPVNHLLGMGGVLDS
ARLRTFIAMELGVSTGDVSTLVLGGHGDLMVPLPHYCTVSGIPITELMDATKIQGLIERTRNGGAEIVSLLKTGSAFYAP
ASSVCHMIESLIQDQSRLLPASVYLQGQYGLTDLFLGVPCRLGCRGVEAIVEIPLTDAELAQLHRSAASVRDSLDKALSK
LSL

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 3 family [H]

Homologues:

Organism=Homo sapiens, GI291575128, Length=307, Percent_Identity=34.2019543973941, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4557032, Length=307, Percent_Identity=34.2019543973941, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI47059044, Length=307, Percent_Identity=32.8990228013029, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI221136809, Length=307, Percent_Identity=32.8990228013029, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI5031857, Length=310, Percent_Identity=33.2258064516129, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI260099723, Length=310, Percent_Identity=33.2258064516129, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI15082234, Length=309, Percent_Identity=30.7443365695793, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=31.9218241042345, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=31.9218241042345, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI260099725, Length=194, Percent_Identity=35.5670103092784, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI260099727, Length=199, Percent_Identity=35.678391959799, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI207028494, Length=199, Percent_Identity=32.6633165829146, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI103472011, Length=307, Percent_Identity=27.0358306188925, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI21735621, Length=290, Percent_Identity=29.6551724137931, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI103472015, Length=175, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789632, Length=293, Percent_Identity=31.0580204778157, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=29.4520547945205, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17554310, Length=329, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322765, Length=298, Percent_Identity=29.8657718120805, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136226, Length=307, Percent_Identity=30.6188925081433, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45550422, Length=312, Percent_Identity=28.8461538461538, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24663599, Length=250, Percent_Identity=32.8, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24647881, Length=317, Percent_Identity=29.3375394321767, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24663595, Length=251, Percent_Identity=29.0836653386454, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR011275
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 34306; Mature: 34306

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAIAVPSISCKAPQVTVIGAGKVGSTLAQRVIEKNLADVVLLDIVEGLPQGIALDLYEA
CCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
QGLEGHHKTILGTNDYADTTGSDIVVITAGLARKPGMSREDLLHYNAKIVVHAAREAMER
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCEEEEEEHHHHHHC
SPQAIFIVVTNPMDVMTYLTWKVTGLPVNHLLGMGGVLDSARLRTFIAMELGVSTGDVST
CCCEEEEEEECCHHHHHEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LVLGGHGDLMVPLPHYCTVSGIPITELMDATKIQGLIERTRNGGAEIVSLLKTGSAFYAP
EEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
ASSVCHMIESLIQDQSRLLPASVYLQGQYGLTDLFLGVPCRLGCRGVEAIVEIPLTDAEL
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCHHEECCCCHHHH
AQLHRSAASVRDSLDKALSKLSL
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MCAIAVPSISCKAPQVTVIGAGKVGSTLAQRVIEKNLADVVLLDIVEGLPQGIALDLYEA
CCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
QGLEGHHKTILGTNDYADTTGSDIVVITAGLARKPGMSREDLLHYNAKIVVHAAREAMER
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCEEEEEEHHHHHHC
SPQAIFIVVTNPMDVMTYLTWKVTGLPVNHLLGMGGVLDSARLRTFIAMELGVSTGDVST
CCCEEEEEEECCHHHHHEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LVLGGHGDLMVPLPHYCTVSGIPITELMDATKIQGLIERTRNGGAEIVSLLKTGSAFYAP
EEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
ASSVCHMIESLIQDQSRLLPASVYLQGQYGLTDLFLGVPCRLGCRGVEAIVEIPLTDAEL
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCHHEECCCCHHHH
AQLHRSAASVRDSLDKALSKLSL
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA