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The map label for this gene is hisD [H]

Identifier: 170078653

GI number: 170078653

Start: 2135371

End: 2136684

Strand: Direct

Name: hisD [H]

Synonym: SYNPCC7002_A2049

Alternate gene names: 170078653

Gene position: 2135371-2136684 (Clockwise)

Preceding gene: 170078646

Following gene: 170078656

Centisome position: 70.99

GC content: 54.95

Gene sequence:

>1314_bases
ATGCTGCGCATTCTCTATCAGCAGACTGATGCCCCTTCTGAGTTACAACGTATTGCGAACCGCACCTCCCATGATGTAGC
TCTAACCCAAGAGGCGGCGGTGAAAGAGATTGTCACAGCGGTAAAAAATAGTGGCGATCGCGCGTTGGTTGATTTCACGG
CAAAATTTGATCGCCAAACCCTCACCCCCGAAAAATTAAGGGTTTCTGCCGCCGAGCTAGATGCGGCCTACCAACAAATT
GATCGTCCCCTGCTAGAGGCGATCCAACTGGCCAGTCGCCAGATCGAAGCCTTTCACCGCCAACGGGTACCCAAATCCTG
GGTGCAATTTGGCCTGAATGATGTGGTTTTAGGGAAACGTTACACGGCTGTGGATCGGGCAGGTCTGTATGTGCCAGGGG
GCCGCGCGGCCTATCCGAGTACGGTGCTGATGAATGCGATTCCGGCAAAGGTGGCTGGTGTGCCAAAAATTGTGATGGTG
ACGCCCCCAGGGCCAGAGCTCAAAATCAATCCGGCGGTTTTAGTCGCTGCCCAGGAAGCAGGTATTGAGGAAATTTATCG
CGTTGGGGGGGCCCAGGCGATCGCCGCCCTCGCCTACGGTACCGAAACAATTCCGGCAGTGGATGTGATTACTGGGCCGG
GGAATATTTTCGTCACCCTTGCCAAAAAAATGGTCTACGGTCGCGTGGGGATCGATTCCTTGGCAGGGCCTTCGGAAGTG
CTGGTGATTGCAGACAATAGTGCAAATCCGACCCATGTAGCAGCAGATTTGCTCGCCCAGGCAGAACATGACCCCCTAGC
AGCGGCGATCCTCCTTACCCCCGACCAAGAATTCGCCGAACAGGTACAAGCAGCGGTAGCCCAACAGTTAGAAAATCACC
CCCGTCAAGAGTTAACTGAAAAGGCGATCGCCCACTATGGCCTCGTGGTGGTGGTGGATTCCCTGGAGAAAGCAGCGGAA
CTCTCTAACCTTTTTGCCCCAGAACACCTCGAACTGGAAGTGGCAGAACCCTGGGAACTATTACCCTTAATTCGCCATGC
TGGCGCGATTTTCCTGGGCCACTCAACCCCGGAGGCGGTGGGAGATTATCTCGCCGGGCCAAACCATACTCTACCGACGG
CTGGGGCGGCCCGTTATGCCTCGGCCTTAGGGGTAGAAACTTTTATGAAGCACTCCAGCATTATTCAATATTCTGCGAAA
GCACTCCAAAACGTTGCCAGTGCCGTACAAACCCTGGCCGAAGCCGAAGGTCTACCCTCCCATGGGGATTCCGTGCGGTT
GCGGACCCAGAAAGGTCAATCTCTAGATCCCTAA

Upstream 100 bases:

>100_bases
TACCACGAAAACCGAGGATAAGCGCGGAATGGCTGCCATTGGTTAGAAAAATTCAGTAGAATGAGACAAGATTTTAAGCA
ATGAGTGATTGATATTTTCT

Downstream 100 bases:

>100_bases
TCCCAAAAATTTACGGAGGTAGAGGCCCCATTGGGCGGCTAATTCAATTTGGGTAAAGGGAATTTCGATTGTTTCTTGAT
CCTGGGTTTCGAGTAATAAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLRILYQQTDAPSELQRIANRTSHDVALTQEAAVKEIVTAVKNSGDRALVDFTAKFDRQTLTPEKLRVSAAELDAAYQQI
DRPLLEAIQLASRQIEAFHRQRVPKSWVQFGLNDVVLGKRYTAVDRAGLYVPGGRAAYPSTVLMNAIPAKVAGVPKIVMV
TPPGPELKINPAVLVAAQEAGIEEIYRVGGAQAIAALAYGTETIPAVDVITGPGNIFVTLAKKMVYGRVGIDSLAGPSEV
LVIADNSANPTHVAADLLAQAEHDPLAAAILLTPDQEFAEQVQAAVAQQLENHPRQELTEKAIAHYGLVVVVDSLEKAAE
LSNLFAPEHLELEVAEPWELLPLIRHAGAIFLGHSTPEAVGDYLAGPNHTLPTAGAARYASALGVETFMKHSSIIQYSAK
ALQNVASAVQTLAEAEGLPSHGDSVRLRTQKGQSLDP

Sequences:

>Translated_437_residues
MLRILYQQTDAPSELQRIANRTSHDVALTQEAAVKEIVTAVKNSGDRALVDFTAKFDRQTLTPEKLRVSAAELDAAYQQI
DRPLLEAIQLASRQIEAFHRQRVPKSWVQFGLNDVVLGKRYTAVDRAGLYVPGGRAAYPSTVLMNAIPAKVAGVPKIVMV
TPPGPELKINPAVLVAAQEAGIEEIYRVGGAQAIAALAYGTETIPAVDVITGPGNIFVTLAKKMVYGRVGIDSLAGPSEV
LVIADNSANPTHVAADLLAQAEHDPLAAAILLTPDQEFAEQVQAAVAQQLENHPRQELTEKAIAHYGLVVVVDSLEKAAE
LSNLFAPEHLELEVAEPWELLPLIRHAGAIFLGHSTPEAVGDYLAGPNHTLPTAGAARYASALGVETFMKHSSIIQYSAK
ALQNVASAVQTLAEAEGLPSHGDSVRLRTQKGQSLDP
>Mature_437_residues
MLRILYQQTDAPSELQRIANRTSHDVALTQEAAVKEIVTAVKNSGDRALVDFTAKFDRQTLTPEKLRVSAAELDAAYQQI
DRPLLEAIQLASRQIEAFHRQRVPKSWVQFGLNDVVLGKRYTAVDRAGLYVPGGRAAYPSTVLMNAIPAKVAGVPKIVMV
TPPGPELKINPAVLVAAQEAGIEEIYRVGGAQAIAALAYGTETIPAVDVITGPGNIFVTLAKKMVYGRVGIDSLAGPSEV
LVIADNSANPTHVAADLLAQAEHDPLAAAILLTPDQEFAEQVQAAVAQQLENHPRQELTEKAIAHYGLVVVVDSLEKAAE
LSNLFAPEHLELEVAEPWELLPLIRHAGAIFLGHSTPEAVGDYLAGPNHTLPTAGAARYASALGVETFMKHSSIIQYSAK
ALQNVASAVQTLAEAEGLPSHGDSVRLRTQKGQSLDP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=44.6650124069479, Blast_Score=304, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=425, Percent_Identity=39.2941176470588, Blast_Score=278, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46706; Mature: 46706

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRILYQQTDAPSELQRIANRTSHDVALTQEAAVKEIVTAVKNSGDRALVDFTAKFDRQT
CEEEEEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCC
LTPEKLRVSAAELDAAYQQIDRPLLEAIQLASRQIEAFHRQRVPKSWVQFGLNDVVLGKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCC
YTAVDRAGLYVPGGRAAYPSTVLMNAIPAKVAGVPKIVMVTPPGPELKINPAVLVAAQEA
CHHHCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCEEEEEEHHC
GIEEIYRVGGAQAIAALAYGTETIPAVDVITGPGNIFVTLAKKMVYGRVGIDSLAGPSEV
CHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCCCCCEE
LVIADNSANPTHVAADLLAQAEHDPLAAAILLTPDQEFAEQVQAAVAQQLENHPRQELTE
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHH
KAIAHYGLVVVVDSLEKAAELSNLFAPEHLELEVAEPWELLPLIRHAGAIFLGHSTPEAV
HHHHHCCHHEEEHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCEEEEECCCHHHH
GDYLAGPNHTLPTAGAARYASALGVETFMKHSSIIQYSAKALQNVASAVQTLAEAEGLPS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGDSVRLRTQKGQSLDP
CCCCEEEEECCCCCCCC
>Mature Secondary Structure
MLRILYQQTDAPSELQRIANRTSHDVALTQEAAVKEIVTAVKNSGDRALVDFTAKFDRQT
CEEEEEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCC
LTPEKLRVSAAELDAAYQQIDRPLLEAIQLASRQIEAFHRQRVPKSWVQFGLNDVVLGKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCC
YTAVDRAGLYVPGGRAAYPSTVLMNAIPAKVAGVPKIVMVTPPGPELKINPAVLVAAQEA
CHHHCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCEEEEEEHHC
GIEEIYRVGGAQAIAALAYGTETIPAVDVITGPGNIFVTLAKKMVYGRVGIDSLAGPSEV
CHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCCCCCEE
LVIADNSANPTHVAADLLAQAEHDPLAAAILLTPDQEFAEQVQAAVAQQLENHPRQELTE
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHH
KAIAHYGLVVVVDSLEKAAELSNLFAPEHLELEVAEPWELLPLIRHAGAIFLGHSTPEAV
HHHHHCCHHEEEHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCEEEEECCCHHHH
GDYLAGPNHTLPTAGAARYASALGVETFMKHSSIIQYSAKALQNVASAVQTLAEAEGLPS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HGDSVRLRTQKGQSLDP
CCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA