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The map label for this gene is ndhD1

Identifier: 170078604

GI number: 170078604

Start: 2079353

End: 2080933

Strand: Reverse

Name: ndhD1

Synonym: SYNPCC7002_A2000

Alternate gene names: 170078604

Gene position: 2080933-2079353 (Counterclockwise)

Preceding gene: 170078605

Following gene: 170078603

Centisome position: 69.18

GC content: 50.47

Gene sequence:

>1581_bases
ATGAACTTTGCAAATTTTCCGTGGTTATCCACGATTATTTTATTTCCCATTATTGCGGCATTATTTTTGCCCCTCATCCC
CGACAAAGATGGGAAAACAGTGCGCTGGTATGCCTTGACCATTGGCTTAATTGACTTTGTGATCATCGTGACAGCCTTTT
ACACGGGCTACGATTTTGGCAACCCGAATCTGCAACTGGTAGAGAGCTATACCTGGGTCGAAGCAATCGATCTGCGCTGG
TCAGTGGGGGCCGATGGCCTTTCCATGCCCTTGATTCTTCTCACGGGTTTTATCACAACTTTGGCGATCTTGGCAGCCTG
GCCCGTAAGCTTTAAGCCGAAGCTATTTTATTTCCTGATGCTGCTGATGTATGGCGGTCAAATCGCTGTCTTTGCCGTGC
AGGATATGTTGCTATTTTTCTTTACCTGGGAACTCGAACTGGTTCCGGTTTACCTGATTCTTTCCATTTGGGGCGGCAAA
AAACGGCTCTATGCCGCAACGAAATTCATTCTCTACACCGCCGGCGGTTCGTTATTTATTCTGATTGCCGCCCTAACCAT
GGCTTTCTATGGAGATACGGTCACCTTTGATATGACGGCGATCGCCCAAAAAGACTTTGGCATTAATCTCCAACTGCTGC
TCTATGGCGGCCTCCTCATCGCCTATGGGGTGAAGTTACCGATTTTTCCTCTGCATACCTGGCTCCCCGATGCCCACGGT
GAAGCCACGGCCCCGGCCCACATGCTCCTGGCAGGCATTCTCTTAAAAATGGGAGGCTATGCCCTGCTGCGAATGAATGC
CGGGATGCTCCCCGATGCCCATGCCCTGTTTGGCCCGGTGCTCGTCATCTTGGGGGTCGTCAATATCGTTTATGCGGCTC
TAACTTCCTTTGCTCAACGCAATCTCAAACGAAAAATCGCCTATTCCTCCATTTCCCACATGGGCTTTGTGCTGATTGGG
ATGGCTTCGTTTACCGATTTGGGCACCAGCGGCGCAATGTTGCAGATGATTTCCCACGGGCTAATTGGCGCAAGCCTCTT
CTTTATGGTTGGTGCCACCTATGACCGTACCCATACCCTCATGCTCGATGAAATGGGTGGAGTCGGCAAAAAGATGAAGA
AAATCTTTGCGATGTGGACGACCTGCTCGATGGCATCTTTGGCGTTGCCGGGGATGAGTGGTTTTGTTGCTGAATTAATG
GTGTTTGTTGGTTTTGCCACCAGTGACGCCTATAGCCCCACCTTCCGGGTGATTATCGTTTTCCTCGCAGCGGTGGGCGT
CATTTTAACGCCGATCTACCTGCTTTCAATGTTGCGGGAAATCCTCTACGGCCCTGAAAACAAAGAGCTTGTGGCGCATG
AAAAACTGATCGACGCTGAACCCCGCGAAGTCTTTGTGATTGCGTGCTTGTTGATTCCGATTATTGGGATTGGTCTGTAT
CCGAAGGCTGTGACCCAGATCTATGCTTCGACTACAGAAAATCTAACGGCGATCCTGCGTCAATCGGTGCCGAGTCTCCA
GCAAACGGCACAGGCACCTAGTTTAGATGTTGCGGTTCTGCGTGCCCCAGAGATTCGCTAA

Upstream 100 bases:

>100_bases
CAGGGTAAAGCATTCTGCTTGGCGATCGCCTTTATTCTGCGTTAACGATTTATAAATATTGCATTTTTTAAGAAACAGCC
ATTAATTTTTTTGAGTTTGT

Downstream 100 bases:

>100_bases
TCGTTCAAACTTGAGTCCATAATTTTTGCAAGGCGGTGTGTTAATGGGCACCGTCTTTTTTATTAGCTGGAGTTCGGCGA
TCGCCTTTATCAAAGGACTT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 2; NDH-1, chain 4 2

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MNFANFPWLSTIILFPIIAALFLPLIPDKDGKTVRWYALTIGLIDFVIIVTAFYTGYDFGNPNLQLVESYTWVEAIDLRW
SVGADGLSMPLILLTGFITTLAILAAWPVSFKPKLFYFLMLLMYGGQIAVFAVQDMLLFFFTWELELVPVYLILSIWGGK
KRLYAATKFILYTAGGSLFILIAALTMAFYGDTVTFDMTAIAQKDFGINLQLLLYGGLLIAYGVKLPIFPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALLRMNAGMLPDAHALFGPVLVILGVVNIVYAALTSFAQRNLKRKIAYSSISHMGFVLIG
MASFTDLGTSGAMLQMISHGLIGASLFFMVGATYDRTHTLMLDEMGGVGKKMKKIFAMWTTCSMASLALPGMSGFVAELM
VFVGFATSDAYSPTFRVIIVFLAAVGVILTPIYLLSMLREILYGPENKELVAHEKLIDAEPREVFVIACLLIPIIGIGLY
PKAVTQIYASTTENLTAILRQSVPSLQQTAQAPSLDVAVLRAPEIR

Sequences:

>Translated_526_residues
MNFANFPWLSTIILFPIIAALFLPLIPDKDGKTVRWYALTIGLIDFVIIVTAFYTGYDFGNPNLQLVESYTWVEAIDLRW
SVGADGLSMPLILLTGFITTLAILAAWPVSFKPKLFYFLMLLMYGGQIAVFAVQDMLLFFFTWELELVPVYLILSIWGGK
KRLYAATKFILYTAGGSLFILIAALTMAFYGDTVTFDMTAIAQKDFGINLQLLLYGGLLIAYGVKLPIFPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALLRMNAGMLPDAHALFGPVLVILGVVNIVYAALTSFAQRNLKRKIAYSSISHMGFVLIG
MASFTDLGTSGAMLQMISHGLIGASLFFMVGATYDRTHTLMLDEMGGVGKKMKKIFAMWTTCSMASLALPGMSGFVAELM
VFVGFATSDAYSPTFRVIIVFLAAVGVILTPIYLLSMLREILYGPENKELVAHEKLIDAEPREVFVIACLLIPIIGIGLY
PKAVTQIYASTTENLTAILRQSVPSLQQTAQAPSLDVAVLRAPEIR
>Mature_526_residues
MNFANFPWLSTIILFPIIAALFLPLIPDKDGKTVRWYALTIGLIDFVIIVTAFYTGYDFGNPNLQLVESYTWVEAIDLRW
SVGADGLSMPLILLTGFITTLAILAAWPVSFKPKLFYFLMLLMYGGQIAVFAVQDMLLFFFTWELELVPVYLILSIWGGK
KRLYAATKFILYTAGGSLFILIAALTMAFYGDTVTFDMTAIAQKDFGINLQLLLYGGLLIAYGVKLPIFPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALLRMNAGMLPDAHALFGPVLVILGVVNIVYAALTSFAQRNLKRKIAYSSISHMGFVLIG
MASFTDLGTSGAMLQMISHGLIGASLFFMVGATYDRTHTLMLDEMGGVGKKMKKIFAMWTTCSMASLALPGMSGFVAELM
VFVGFATSDAYSPTFRVIIVFLAAVGVILTPIYLLSMLREILYGPENKELVAHEKLIDAEPREVFVIACLLIPIIGIGLY
PKAVTQIYASTTENLTAILRQSVPSLQQTAQAPSLDVAVLRAPEIR

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=389, Percent_Identity=31.6195372750643, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1788613, Length=519, Percent_Identity=36.9942196531792, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=24.1496598639456, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788831, Length=296, Percent_Identity=28.0405405405405, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788829, Length=304, Percent_Identity=26.9736842105263, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788614, Length=494, Percent_Identity=23.8866396761134, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI2367154, Length=244, Percent_Identity=29.0983606557377, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693160, Length=218, Percent_Identity=30.2752293577982, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C2_SYNP2 (Q8KX53)

Other databases:

- EMBL:   AF381036
- EMBL:   CP000951
- RefSeq:   YP_001735242.1
- GeneID:   6057409
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2000
- HOGENOM:   HBG643593
- OMA:   TSFAQRN
- ProtClustDB:   PRK02546
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 57651; Mature: 57651

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1da77500)-; HASH(0x1da02ab8)-; HASH(0x1cdf3cb4)-; HASH(0x1b265268)-; HASH(0x1da7a8c4)-; HASH(0x1d86cbe8)-; HASH(0x1da77734)-; HASH(0x1daa81ac)-; HASH(0x1da58a54)-; HASH(0x1d95cc7c)-; HASH(0x1d4464b0)-; HASH(0x1ceac534)-; HASH(0x1da7a87c)-; HASH(0x1d5dd284)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFANFPWLSTIILFPIIAALFLPLIPDKDGKTVRWYALTIGLIDFVIIVTAFYTGYDFG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NPNLQLVESYTWVEAIDLRWSVGADGLSMPLILLTGFITTLAILAAWPVSFKPKLFYFLM
CCCCEEEEEEHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLMYGGQIAVFAVQDMLLFFFTWELELVPVYLILSIWGGKKRLYAATKFILYTAGGSLFI
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEECCCHHHH
LIAALTMAFYGDTVTFDMTAIAQKDFGINLQLLLYGGLLIAYGVKLPIFPLHTWLPDAHG
HHHHHHHHHCCCCEEEEHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCEEHHHHCCCCCC
EATAPAHMLLAGILLKMGGYALLRMNAGMLPDAHALFGPVLVILGVVNIVYAALTSFAQR
CCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRKIAYSSISHMGFVLIGMASFTDLGTSGAMLQMISHGLIGASLFFMVGATYDRTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
MLDEMGGVGKKMKKIFAMWTTCSMASLALPGMSGFVAELMVFVGFATSDAYSPTFRVIIV
EEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLAAVGVILTPIYLLSMLREILYGPENKELVAHEKLIDAEPREVFVIACLLIPIIGIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
PKAVTQIYASTTENLTAILRQSVPSLQQTAQAPSLDVAVLRAPEIR
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEECCCCCH
>Mature Secondary Structure
MNFANFPWLSTIILFPIIAALFLPLIPDKDGKTVRWYALTIGLIDFVIIVTAFYTGYDFG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NPNLQLVESYTWVEAIDLRWSVGADGLSMPLILLTGFITTLAILAAWPVSFKPKLFYFLM
CCCCEEEEEEHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLMYGGQIAVFAVQDMLLFFFTWELELVPVYLILSIWGGKKRLYAATKFILYTAGGSLFI
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEECCCHHHH
LIAALTMAFYGDTVTFDMTAIAQKDFGINLQLLLYGGLLIAYGVKLPIFPLHTWLPDAHG
HHHHHHHHHCCCCEEEEHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCEEHHHHCCCCCC
EATAPAHMLLAGILLKMGGYALLRMNAGMLPDAHALFGPVLVILGVVNIVYAALTSFAQR
CCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRKIAYSSISHMGFVLIGMASFTDLGTSGAMLQMISHGLIGASLFFMVGATYDRTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
MLDEMGGVGKKMKKIFAMWTTCSMASLALPGMSGFVAELMVFVGFATSDAYSPTFRVIIV
EEHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLAAVGVILTPIYLLSMLREILYGPENKELVAHEKLIDAEPREVFVIACLLIPIIGIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
PKAVTQIYASTTENLTAILRQSVPSLQQTAQAPSLDVAVLRAPEIR
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA