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The map label for this gene is ndhD2

Identifier: 170078578

GI number: 170078578

Start: 2054518

End: 2056122

Strand: Direct

Name: ndhD2

Synonym: SYNPCC7002_A1973

Alternate gene names: 170078578

Gene position: 2054518-2056122 (Clockwise)

Preceding gene: 170078577

Following gene: 170078580

Centisome position: 68.3

GC content: 50.22

Gene sequence:

>1605_bases
ATGGATAGCTTGCAAATCCCGTGGCTCACTACGGCGATCGCCTTTCCGCTTTTGGCCGCCCTTGTCATTCCCCTCATCCC
CGACAAAGAAGGTAAAACCATCCGCTGGTATACCCTAGGCGTTGCCCTCACCGATTTTGCCCTTTTAGTCACTGCTTTTT
GGCAAAACTACGATCTCGGTCGCACAGAATTTCAACTCACTGAAAATTTTGCATGGATTCCCCAATTGGGGTTGAACTGG
TCCCTAGGCGTTGACGGTTTGTCAATGCCTTTAATTATTTTGGCGACCCTGATCACTACCTTAGCGACCCTCGCGGCCTG
GAACGTCACCAAGAAGCCGAAACTCTTTGCTGGCCTCATCCTCGTGATGCTGAGTGCGCAAATCGGTGTTTTTGCCGTCC
AGGATTTGCTGCTGTTCTTCATTATGTGGGAATTAGAGCTAGTTCCTGTGTATCTGCTCATTTCCATTTGGGGCGGAAAA
AAACGCCTCTATGCGGCCACTAAATTTATTCTCTACACGGCCCTAGGTTCTGTTTTCATCCTCGCGTCTACCTTAGCCCT
TGCTTTCTATGGCGGTGACGTGACCTTTGATATGCAAGCCCTGGGATTAAAGGATTATCCGCTGGCGTTAGAATTACTGG
CCTATGCTGGATTTCTCATTGGCTTTGGCGTTAAATTGCCTATTTTCCCGCTCCACACTTGGCTACCGGATGCCCATAGT
GAAGCGTCTGCGCCGGTCTCCATGATCCTTGCTGGTGTGCTCTTAAAAATGGGTGGCTATGGTTTGATTCGGTTAAACAT
GGAAATGTTGCCGGATGCCCATATTCGTTTTGCTCCCCTGCTGATTGTTCTAGGGATTGTCAACATTGTCTATGGGGCGC
TGACCGCCTTTGGACAGACCAACTTAAAGCGACGTTTGGCTTCGTCTTCTATCTCCCACATGGGTTTTGTCCTCGTTGGG
ATTGCTTCATTCACCGATTTGGGAATGAATGGTGCCGTGTTACAGATGTTGTCCCATGGTTTCATTGCGGCGGCCCTGTT
CTTCCTGTCTGGGGTCACCTATGAACGCACCCATACTTTAATGATGGATGAAATGAGCGGTATTGCGCGGTTGATGCCCA
AAACCTTTGCGATGTTTACGGCGGCGGCGATGGCGTCTTTGGCACTGCCAGGGATGAGTGGTTTCGTCAGTGAACTGACT
GTCTTCCTCGGTTTAAGCAATAGTGATGCCTATAGCTATGGCTTTAAGGCGATCGCCATTTTCTTAACGGCGGTTGGGGT
GATTTTAACGCCCATTTACCTGCTTTCAATGCTGCGGGAAGTATTCTACGGCAAAGGCTCCCAGGCTCCACTCAGCCTTG
CGGCGGGGGAAGATGCCAAACCGAGAGAAATCTTTGTGGCAGTTTGTTTGCTGGCCCCGATTATTGCCATCGGCCTTTAT
CCAAAACTGGCAACGACTACCTATGATCTCAAAACCGTTGAGGTCGCCTCGAAGGTACGGGCCGCTTTACCGTTGTATGC
AGAGCAACTCCCCCAAAATGGCGATCGCCAAGCGCAAATGGGTTTAAGCTCGCAAATGCCGGCCCTGATTGCTCCTCGTT
TTTAG

Upstream 100 bases:

>100_bases
CATGACCATAAGAAGTTTTTACTTTAACCCCTTGGCAGGTTGTAACAAAAATTCATATAATCGGAGGCGAACGCAATAAT
AAGTATTTTTTCCTAGTCCT

Downstream 100 bases:

>100_bases
CAATTATTGGATGCTTTCCATTGATAAGCTCCTTGGGTTAGCACCATAAATTTAGGAAAATAATCTGAAACGGATGGGCT
CTAAGTAGCCCATTTTTTGT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MDSLQIPWLTTAIAFPLLAALVIPLIPDKEGKTIRWYTLGVALTDFALLVTAFWQNYDLGRTEFQLTENFAWIPQLGLNW
SLGVDGLSMPLIILATLITTLATLAAWNVTKKPKLFAGLILVMLSAQIGVFAVQDLLLFFIMWELELVPVYLLISIWGGK
KRLYAATKFILYTALGSVFILASTLALAFYGGDVTFDMQALGLKDYPLALELLAYAGFLIGFGVKLPIFPLHTWLPDAHS
EASAPVSMILAGVLLKMGGYGLIRLNMEMLPDAHIRFAPLLIVLGIVNIVYGALTAFGQTNLKRRLASSSISHMGFVLVG
IASFTDLGMNGAVLQMLSHGFIAAALFFLSGVTYERTHTLMMDEMSGIARLMPKTFAMFTAAAMASLALPGMSGFVSELT
VFLGLSNSDAYSYGFKAIAIFLTAVGVILTPIYLLSMLREVFYGKGSQAPLSLAAGEDAKPREIFVAVCLLAPIIAIGLY
PKLATTTYDLKTVEVASKVRAALPLYAEQLPQNGDRQAQMGLSSQMPALIAPRF

Sequences:

>Translated_534_residues
MDSLQIPWLTTAIAFPLLAALVIPLIPDKEGKTIRWYTLGVALTDFALLVTAFWQNYDLGRTEFQLTENFAWIPQLGLNW
SLGVDGLSMPLIILATLITTLATLAAWNVTKKPKLFAGLILVMLSAQIGVFAVQDLLLFFIMWELELVPVYLLISIWGGK
KRLYAATKFILYTALGSVFILASTLALAFYGGDVTFDMQALGLKDYPLALELLAYAGFLIGFGVKLPIFPLHTWLPDAHS
EASAPVSMILAGVLLKMGGYGLIRLNMEMLPDAHIRFAPLLIVLGIVNIVYGALTAFGQTNLKRRLASSSISHMGFVLVG
IASFTDLGMNGAVLQMLSHGFIAAALFFLSGVTYERTHTLMMDEMSGIARLMPKTFAMFTAAAMASLALPGMSGFVSELT
VFLGLSNSDAYSYGFKAIAIFLTAVGVILTPIYLLSMLREVFYGKGSQAPLSLAAGEDAKPREIFVAVCLLAPIIAIGLY
PKLATTTYDLKTVEVASKVRAALPLYAEQLPQNGDRQAQMGLSSQMPALIAPRF
>Mature_534_residues
MDSLQIPWLTTAIAFPLLAALVIPLIPDKEGKTIRWYTLGVALTDFALLVTAFWQNYDLGRTEFQLTENFAWIPQLGLNW
SLGVDGLSMPLIILATLITTLATLAAWNVTKKPKLFAGLILVMLSAQIGVFAVQDLLLFFIMWELELVPVYLLISIWGGK
KRLYAATKFILYTALGSVFILASTLALAFYGGDVTFDMQALGLKDYPLALELLAYAGFLIGFGVKLPIFPLHTWLPDAHS
EASAPVSMILAGVLLKMGGYGLIRLNMEMLPDAHIRFAPLLIVLGIVNIVYGALTAFGQTNLKRRLASSSISHMGFVLVG
IASFTDLGMNGAVLQMLSHGFIAAALFFLSGVTYERTHTLMMDEMSGIARLMPKTFAMFTAAAMASLALPGMSGFVSELT
VFLGLSNSDAYSYGFKAIAIFLTAVGVILTPIYLLSMLREVFYGKGSQAPLSLAAGEDAKPREIFVAVCLLAPIIAIGLY
PKLATTTYDLKTVEVASKVRAALPLYAEQLPQNGDRQAQMGLSSQMPALIAPRF

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=380, Percent_Identity=30.7894736842105, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI251831117, Length=360, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=435, Percent_Identity=38.6206896551724, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788827, Length=376, Percent_Identity=27.1276595744681, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788831, Length=282, Percent_Identity=32.6241134751773, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788829, Length=409, Percent_Identity=25.1833740831296, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI145693160, Length=322, Percent_Identity=31.3664596273292, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788614, Length=520, Percent_Identity=25.5769230769231, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI2367154, Length=324, Percent_Identity=27.4691358024691, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C1_SYNP2 (B1XHP2)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735216.1
- GeneID:   6055555
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1973
- HOGENOM:   HBG643593
- OMA:   YVVFEAM
- ProtClustDB:   PRK12561
- GO:   GO:0005739
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N

EC number: 1.6.5.3

Molecular weight: Translated: 57895; Mature: 57895

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d057138)-; HASH(0x1d2dfe0c)-; HASH(0x1da7d724)-; HASH(0x1da823a4)-; HASH(0x1d0ff8d0)-; HASH(0x1da7fc90)-; HASH(0x1da7fdc8)-; HASH(0x1d4ce790)-; HASH(0x1da7765c)-; HASH(0x1da588c8)-; HASH(0x1d0214f0)-; HASH(0x1d3f7400)-; HASH(0x1c99c6dc)-; HASH(0x1da7d7c0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLQIPWLTTAIAFPLLAALVIPLIPDKEGKTIRWYTLGVALTDFALLVTAFWQNYDLG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
RTEFQLTENFAWIPQLGLNWSLGVDGLSMPLIILATLITTLATLAAWNVTKKPKLFAGLI
CCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVMLSAQIGVFAVQDLLLFFIMWELELVPVYLLISIWGGKKRLYAATKFILYTALGSVFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LASTLALAFYGGDVTFDMQALGLKDYPLALELLAYAGFLIGFGVKLPIFPLHTWLPDAHS
HHHHHHHHHCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCCC
EASAPVSMILAGVLLKMGGYGLIRLNMEMLPDAHIRFAPLLIVLGIVNIVYGALTAFGQT
CCCCCHHHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRRLASSSISHMGFVLVGIASFTDLGMNGAVLQMLSHGFIAAALFFLSGVTYERTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MMDEMSGIARLMPKTFAMFTAAAMASLALPGMSGFVSELTVFLGLSNSDAYSYGFKAIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLTAVGVILTPIYLLSMLREVFYGKGSQAPLSLAAGEDAKPREIFVAVCLLAPIIAIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
PKLATTTYDLKTVEVASKVRAALPLYAEQLPQNGDRQAQMGLSSQMPALIAPRF
CHHHCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCH
>Mature Secondary Structure
MDSLQIPWLTTAIAFPLLAALVIPLIPDKEGKTIRWYTLGVALTDFALLVTAFWQNYDLG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCC
RTEFQLTENFAWIPQLGLNWSLGVDGLSMPLIILATLITTLATLAAWNVTKKPKLFAGLI
CCEEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVMLSAQIGVFAVQDLLLFFIMWELELVPVYLLISIWGGKKRLYAATKFILYTALGSVFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LASTLALAFYGGDVTFDMQALGLKDYPLALELLAYAGFLIGFGVKLPIFPLHTWLPDAHS
HHHHHHHHHCCCCEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCCC
EASAPVSMILAGVLLKMGGYGLIRLNMEMLPDAHIRFAPLLIVLGIVNIVYGALTAFGQT
CCCCCHHHHHHHHHHHHCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRRLASSSISHMGFVLVGIASFTDLGMNGAVLQMLSHGFIAAALFFLSGVTYERTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MMDEMSGIARLMPKTFAMFTAAAMASLALPGMSGFVSELTVFLGLSNSDAYSYGFKAIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLTAVGVILTPIYLLSMLREVFYGKGSQAPLSLAAGEDAKPREIFVAVCLLAPIIAIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
PKLATTTYDLKTVEVASKVRAALPLYAEQLPQNGDRQAQMGLSSQMPALIAPRF
CHHHCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA